Malignant gliomas with primitive neuroectodermal tumor-like components: A clinicopathologic and genetic study of 53 cases

Brain Pathology

Volumn 19, Issue 1, 2009, Pages 81-90

  Perry, Arie ^a   Miller, C Ryan ^b   Gujrati, Meena ^c   Scheithauer, Bernd W ^d   Zambrano, Sandro Casavilca ^e   Jost, Sarah C ^a   Raghavan, Ravi ^f   Qian, Jiang ^g   Cochran, Elizabeth J ^h   Huse, Jason T ⁱ   Holland, Eric C ⁱ   Burger, Peter C ^j   Rosenblum, Marc K ⁱ  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF ILLINOIS   (United States)

^d MAYO CLINIC   (United States)

^e INSTITUTO NACIONAL DE ENFERMEDADES NEOPLÁSICAS   (Peru)

^f LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g ALBANY MEDICAL COLLEGE   (United States)

^h RUSH UNIVERSITY MEDICAL CENTER   (United States)

ⁱ MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^j JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

more..

Author keywords

Genetics; Glioblastoma; Gliosarcoma; Metastases; MYC; Neuroblastoma; Oligodendroglioma; Primitive neuroectodermal tumor; Prognosis; Small cell; Stem cell

Indexed keywords

CARMUSTINE; PLATINUM; TEMOZOLOMIDE;

ADOLESCENT; ADULT; AGED; ANAPLASTIC CARCINOMA; ARTICLE; CANCER STEM CELL; CELL CLONE; CEREBROSPINAL FLUID ANALYSIS; CHILD; CHROMOSOME 10Q; DRUG SUBSTITUTION; FEMALE; FOLLOW UP; GENE AMPLIFICATION; GLIOBLASTOMA; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MEDULLOBLASTOMA; NERVE CELL DIFFERENTIATION; NEUROECTODERM TUMOR; NEUROPATHOLOGY; ONCOGENE C MYB; ONCOGENE C MYC; SCHOOL CHILD; SURVIVAL; TREATMENT RESPONSE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS, ALKYLATING; BRAIN NEOPLASMS; COMBINED MODALITY THERAPY; DACARBAZINE; FEMALE; FOLLOW-UP STUDIES; GENES, MYC; GLIOMA; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MEDULLOBLASTOMA; NEOPLASM METASTASIS; NEOPLASMS, MULTIPLE PRIMARY; NEUROECTODERMAL TUMORS, PRIMITIVE; PROGNOSIS; PROTO-ONCOGENE PROTEINS; RADIOTHERAPY; TREATMENT OUTCOME; YOUNG ADULT;

EID: 57449090950     PISSN: 10156305     EISSN: 17503639     Source Type: Journal    
DOI: 10.1111/j.1750-3639.2008.00167.x     Document Type: Article

References (40)

1. Actor B, Cobbers JM, Buschges R, Wolter M, Knobbe CB, Lichter P et al (2002) Comprehensive analysis of genomic alterations in gliosarcoma and its two tissue components. Genes Chromosomes Cancer 34 : 416 427.
2. Bailey P, Cushing H (1926) A Classification of Tumors of the Glioma Group on a Histogenetic Basis With a Correlation Study of Prognosis. Lippincott : Philadelphia, PA.
3. Barbashina V, Salazar P, Ladanyi M, Rosenblum MK, Edgar MA (2007) Glioneuronal tumor with neuropil-like islands (GTNI): a report of 8 cases with chromosome 1p/19q deletion analysis. Am J Surg Pathol 31 : 1196 1202.
4. Biernat W, Aguzzi A, Sure U, Grant JW, Kleihues P, Hegi ME (1995) Identical mutations of the p53 tumour suppressor gene in the glial and sarcomatous part of gliosarcomas suggest a common origin from glial cells. J Neuropathol Exp Neurol 54 : 651 656.
5. Boerman RH, anderl K, Herath J et al (1996) The glial and mesenchymal elements of gliosarcomas share similar genetic alterations. J Neuropathol Exp Neurol 55 : 973 981.
6. Boldrini L, Pistolesi S, Gisfredi S, Ursino S, Ali G, Pieracci N et al (2006) Telomerase activity and hTERT mRNA expression in glial tumors. Int J Oncol 28 : 1555 1560.
7. Burger PC, Pearl DK, Aldape K, Yates AJ, Scheithauer BW, Passe SM et al (2001) Small cell architecture - a histological equivalent of EGFR amplification in glioblastoma multiforme? J Neuropathol Exp Neurol 60 : 1099 1104.
8. Cenacchi G, Giangaspero F (2004) Emerging tumor entities and variants of CNS neoplasms. J Neuropathol Exp Neurol 63 : 185 192.
9. du Plessis DG, Rutherfoord GS, Joyce KA, Walker C (2004) Phenotypic and genotypic characterization of glioblastoma multiforme with epithelial differentiation and adenoid formations. Clin Neuropathol 23 : 141 148.
10. Dulai MS, Bosanko CM, Wang AM, Horoupian DS, Boodin S, Chen PY, Wilson JD (2004) Mixed cystic gliosarcoma and primitive neuroectodermal tumor: a case report. Clin Neuropathol 23 : 218 222.
11. Dunham C, Sugo E, Tobias V, Wills E, Perry A (2007) Embryonal tumor with abundant neuropil and true rosettes (ETANTR): report of a case with prominent neurocytic differentiation. J Neurooncol 84 : 91 98.
12. Giangaspero F, Eberhart CG, Haapasalo H, Pietsch T, Wiestler OD, Ellison DW (2007) Medulloblastoma. In : WHO Classification of Tumours of the Central Nervous System. DN Louis, H Ohgaki, OD Wiestler, WK Cavenee (eds), pp. 132 140. IARC : Lyon.
13. Gilbertson RJ, Rich JN (2007) Making a tumour's bed: glioblastoma stem cells and the vascular niche. Nat Rev Cancer 7 : 733 736.
14. Hong TS, Mehta MP, Boyett JM, Donahue B, Rorke LB, Zeltzer PM (2005) Patterns of treatment failure in infants with primitive neuroectodermal tumors who were treated on CCG-921: a phase III combined modality study. Pediatr Blood Cancer 45 : 676 682.
15. Horiguchi H, Hirose T, Kannuki S, Nagahiro S, Sano T (1998) Gliosarcoma: an immunohistochemical, ultrastructural and fluorescence in situ hybridization study. Pathol Int 48 : 595 602.
16. Ishizawa K, Kan-nuki S, Kumagai H, Komori T, Hirose T (2002) Lipomatous primitive neuroectodermal tumor with a glioblastoma component: a case report. Acta Neuropathol (Berl) 103 : 193 198.
17. Johnston DL, Keene DL, Lafay-Cousin L, Steinbok P, Sung L, Carret AS et al (2008) Supratentorial primitive neuroectodermal tumors: a Canadian pediatric brain tumor consortium report. J Neurooncol 86 : 101 108.
18. Kaplan KJ, Perry A (2007) Gliosarcoma with primitive neuroectodermal differentiation: case report and review of the literature. J Neurooncol 83 : 313 318.
19. Kepes JJ (2002) Gliosarcoma with areas of primitive neuroepithelial differentiation and extracranial metastasis. Clin Neuropathol 21 : 193 195. author reply 5-6.
20. Kleihues P, Burger PC, Aldape KD, Brat DJ, Biernat W, Bigner DD et al (2007) Glioblastoma. In : WHO Classification of Tumours of the Central Nervous System. DN Louis, H Ohgaki, OD Wiestler, WK Cavenee (eds), pp. 33 49. IARC : Lyon.
21. Lassman AB, Dai C, Fuller GN, Vickers AJ, Holland EC (2004) Overexpression of c-MYC promotes an undifferentiated phenotype in cultured astrocytes and allows elevated Ras and Akt signaling to induce gliomas from GFAP-expressing cells in mice. Neuron Glia Biol 1 : 157 163.
22. McLendon RE, Bentley RC, Parisi JE, Tien RD, Harrison JC, Tarbell NJ et al (1997) Malignant supratentorial glial-neuronal neoplasms: report of two cases and review of the literature. Arch Pathol Lab Med 121 : 485 492.
23. McLendon RE, Judkins AR, Eberhart CG, Fuller GN, Sarkar C, Ng HK (2007) Central nervous system primitive neuroectodermal tumours. In : WHO Classification of Tumours of the Central Nervous System. DN Louis, H Ohgaki, OD Wiestler, WK Cavenee (eds), pp. 141 146. IARC : Lyon.
24. McLendon RE, Provenzale J (2002) Glioneuronal tumors of the central nervous system. Brain Tumor Pathol 19 : 51 58.
25. Miller CR, Dunham CP, Scheithauer BW, Perry A (2006) Significance of necrosis in grading of oligodendroglial neoplasms: a clinicopathologic and genetic study of newly diagnosed high-grade gliomas. J Clin Oncol 24 : 5419 5426.
26. Mork SJ, Rubinstein LJ, Kepes JJ, Perentes E, Uphoff DF (1988) Patterns of epithelial metaplasia in malignant gliomas. II. Squamous differentiation of epithelial-like formations in gliosarcomas and glioblastomas. J Neuropathol Exp Neurol 47 : 101 118.
27. Mueller W, Lass U, Herms J, Kuchelmeister K, Bergmann M, von Deimling A (2001) Clonal analysis in glioblastoma with epithelial differentiation. Brain Pathol 11 : 39 43.
28. Ohgaki H, Kleihues P (2007) Genetic pathways to primary and secondary glioblastoma. Am J Pathol 170 : 1445 1453.
29. Paulus W, Bayas A, Ott G, Roggendorf W (1994) Interphase cytogenetics of glioblastoma and gliosarcoma. Acta Neuropathol (Berl) 88 : 420 425.
30. Perry A, Aldape KD, George DH, Burger PC (2004) Small cell astrocytoma: an aggressive variant that is clinicopathologically and genetically distinct from anaplastic oligodendroglioma. Cancer 101 : 2318 2326.
31. Perry A, Scheithauer BW, Macaulay RJ, Raffel C, Roth KA, Kros JM (2002) Oligodendrogliomas with neurocytic differentiation. A report of 4 cases with diagnostic and histogenetic implications. J Neuropathol Exp Neurol 61 : 947 955.
32. Reddy AT, Janss AJ, Phillips PC, Weiss HL, Packer RJ (2000) Outcome for children with supratentorial primitive neuroectodermal tumors treated with surgery, radiation, and chemotherapy. Cancer 88 : 2189 2193.
33. Reis RM, Konu-Lebleblicioglu D, Lopes JM, Kleihues P, Ohgaki H (2000) Genetic profile of gliosarcomas. Am J Pathol 156 : 425 432.
34. Rodriguez FJ, Scheithauer BW, Jenkins R, Burger PC, Rudzinskiy P, Vlodavsky E et al (2007) Gliosarcoma arising in oligodendroglial tumors ("oligosarcoma"): a clinicopathologic study. Am J Surg Pathol 31 : 351 362.
35. Rodriguez FJ, Scheithauer BW, Perry A, Oliveira AM, Jenkins RB, Oviedo A et al (in press) Ependymal tumors with sarcomatous change (" ependymosarcoma"): a clinicopathologic and molecular cytogenetic study. Am J Surg Pathol.
36. Rodriguez FJ, Scheithauer BW, Robbins PD, Burger PC, Hessler RB, Perry A et al (2007) Ependymomas with neuronal differentiation: a morphologic and immunohistochemical spectrum. Acta Neuropathol (Berl) 113 : 313 324.
37. Shibahara J, Fukayama M (2005) Secondary glioblastoma with advanced neuronal immunophenotype. Virchows Arch 447 : 665 668.
38. Stark AM, Nabavi A, Mehdorn HM, Blomer U (2005) Glioblastoma multiforme-report of 267 cases treated at a single institution. Surg Neurol 63 : 162 169. discussion 9.
39. Visee S, Soltner C, Rialland X, Machet MC, Loussouarn D, Milinkevitch S et al (2005) Supratentorial primitive neuroectodermal tumours of the brain: multidirectional differentiation does not influence prognosis. A clinicopathological report of 18 patients. Histopathology 46 : 403 412.
40. Wharton SB, Whittle IR, Collie DA, Bell HS, Ironside JW (2001) Gliosarcoma with areas of primitive neuroepithelial differentiation and extracranial metastasis. Clin Neuropathol 20 : 212 218.