메뉴 건너뛰기




Volumn 19, Issue 21, 2013, Pages 5814-5821

New strategies in neuroblastoma: Therapeutic targeting of MYCN and ALK

Author keywords

[No Author keywords available]

Indexed keywords

1 (1 CYANO 1 METHYLETHYL) 3 METHYL 8 (3 QUINOLINYL)IMIDAZO[4,5 C]QUINOLIN 2(1H,3H) ONE; 1 CYCLOPROPYL 3 [3 (5 MORPHOLINOMETHYL 1H BENZIMIDAZOL 2 YL) 1H PYRAZOL 4 YL]UREA; 4 (4 AMINO 5 (7 METHOXY 1H INDOL 2 YL)IMIDAZO[5,1 F][1,2,4]TRIAZIN 7 YL)CYCLOHEXANECARBOXYLIC ACID; 8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; ALISERTIB; ANAPLASTIC LYMPHOMA KINASE; ANTINEOPLASTIC AGENT; APITOLISIB; AZD 2014; BUPARLISIB; CCT 244747; CRIZOTINIB; DINACICLIB; ETOPOSIDE; EVEROLIMUS; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 2; ISOTRETINOIN; JQ 1; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MYC PROTEIN; OTX 015; PERIFOSINE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; RAPAMYCIN; RIDAFOROLIMUS; TEMSIROLIMUS; UNCLASSIFIED DRUG;

EID: 84887091635     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-13-0680     Document Type: Article
Times cited : (109)

References (70)
  • 1
    • 38649093611 scopus 로고    scopus 로고
    • Neuroblastoma: Biology, prognosis, and treatment
    • Park JR, Eggert A, Caron H. Neuroblastoma: biology, prognosis, and treatment. Pediatr Clin North Am 2008;55: 97-120.
    • (2008) Pediatr Clin North Am , vol.55 , pp. 97-120
    • Park, J.R.1    Eggert, A.2    Caron, H.3
  • 3
    • 80051979836 scopus 로고    scopus 로고
    • Clinical and biologic features predictive of survival after relapse of neuroblastoma: A report from the International Neuroblastoma Risk Group project
    • London WB, Castel V, Monclair T, Ambros PF, Pearson AD, Cohn SL, et al. Clinical and biologic features predictive of survival after relapse of neuroblastoma: a report from the International Neuroblastoma Risk Group project. J Clin Oncol 2011;29: 3286-92.
    • (2011) J Clin Oncol , vol.29 , pp. 3286-3292
    • London, W.B.1    Castel, V.2    Monclair, T.3    Ambros, P.F.4    Pearson, A.D.5    Cohn, S.L.6
  • 8
    • 84871982155 scopus 로고    scopus 로고
    • Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma
    • Sausen M, Leary RJ, Jones S, Wu J, Reynolds CP, Liu X, et al. Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma. Nat Genet 2013;45: 12-7.
    • (2013) Nat Genet , vol.45 , pp. 12-17
    • Sausen, M.1    Leary, R.J.2    Jones, S.3    Wu, J.4    Reynolds, C.P.5    Liu, X.6
  • 9
    • 0021261878 scopus 로고
    • Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage
    • Brodeur GM, Seeger RC, Schwab M, Varmus HE, Bishop JM. Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage. Science 1984;224: 1121-4.
    • (1984) Science , vol.224 , pp. 1121-1124
    • Brodeur, G.M.1    Seeger, R.C.2    Schwab, M.3    Varmus, H.E.4    Bishop, J.M.5
  • 10
    • 0035889955 scopus 로고    scopus 로고
    • Histopathology (International Neuroblastoma Pathology Classification) and MYCN status in patients with peripheral neuroblastic tumors: A report from the Children's Cancer Group
    • Goto S, Umehara S, Gerbing RB, Stram DO, Brodeur GM, Seeger RC, et al. Histopathology (International Neuroblastoma Pathology Classification) and MYCN status in patients with peripheral neuroblastic tumors: a report from the Children's Cancer Group. Cancer 2001;92: 2699-708.
    • (2001) Cancer , vol.92 , pp. 2699-2708
    • Goto, S.1    Umehara, S.2    Gerbing, R.B.3    Stram, D.O.4    Brodeur, G.M.5    Seeger, R.C.6
  • 12
    • 0034327928 scopus 로고    scopus 로고
    • MYCN expression is not prognostic of adverse outcome in advanced-stage neuroblastoma with nonamplified MYCN
    • Cohn SL, London WB, Huang D, Katzenstein HM, Salwen HR, Reinhart T, et al. MYCN expression is not prognostic of adverse outcome in advanced-stage neuroblastoma with nonamplified MYCN. J Clin Oncol 2000;18: 3604-13.
    • (2000) J Clin Oncol , vol.18 , pp. 3604-3613
    • Cohn, S.L.1    London, W.B.2    Huang, D.3    Katzenstein, H.M.4    Salwen, H.R.5    Reinhart, T.6
  • 13
    • 84887029028 scopus 로고    scopus 로고
    • Pediatric neuroblastoma: Molecular detection of minimal residual disease
    • Hayat MA, editor. The Netherlands: Springer;
    • Stutterheim J, Tytgat GM, Schoot CE. Pediatric neuroblastoma: molecular detection of minimal residual disease. In:Hayat MA, editor. Neuroblastoma. The Netherlands: Springer; 2012. p. 47-63.
    • (2012) Neuroblastoma , pp. 47-63
    • Stutterheim, J.1    Tytgat, G.M.2    Schoot, C.E.3
  • 15
    • 33748068792 scopus 로고    scopus 로고
    • Inhibition of phosphatidylinositol 3-kinase destabilizes Mycn protein and blocks malignant progression in neuroblastoma
    • Chesler L, Schlieve C, Goldenberg DD, Kenney A, Kim G, McMillan A, et al. Inhibition of phosphatidylinositol 3-kinase destabilizes Mycn protein and blocks malignant progression in neuroblastoma. Cancer Res 2006;66: 8139-46.
    • (2006) Cancer Res , vol.66 , pp. 8139-8146
    • Chesler, L.1    Schlieve, C.2    Goldenberg, D.D.3    Kenney, A.4    Kim, G.5    McMillan, A.6
  • 16
    • 79959327886 scopus 로고    scopus 로고
    • Progress in the preclinical discovery and clinical development of class i and dual class I/IV phosphoinositide 3-kinase (PI3K) inhibitors
    • Shuttleworth SJ, Silva FA, Cecil AR, Tomassi CD, Hill TJ, Raynaud FI, et al. Progress in the preclinical discovery and clinical development of class I and dual class I/IV phosphoinositide 3-kinase (PI3K) inhibitors. Curr Med Chem 2011;18: 2686-714.
    • (2011) Curr Med Chem , vol.18 , pp. 2686-2714
    • Shuttleworth, S.J.1    Silva, F.A.2    Cecil, A.R.3    Tomassi, C.D.4    Hill, T.J.5    Raynaud, F.I.6
  • 17
    • 0030925596 scopus 로고    scopus 로고
    • Regulation of the neural crest cell fate by N-myc: Promotion of ventral migration and neuronal differentiation
    • Wakamatsu Y, Watanabe Y, Nakamura H, Kondoh H. Regulation of the neural crest cell fate by N-myc: promotion of ventral migration and neuronal differentiation. Development 1997;124: 1953-62.
    • (1997) Development , vol.124 , pp. 1953-1962
    • Wakamatsu, Y.1    Watanabe, Y.2    Nakamura, H.3    Kondoh, H.4
  • 18
    • 54049094708 scopus 로고    scopus 로고
    • Identification of ALK as a major familial neuroblastoma predisposition gene
    • Mosse YP, Laudenslager M, Longo L, Cole KA, Wood A, Attiyeh EF, et al. Identification of ALK as a major familial neuroblastoma predisposition gene. Nature 2008;455: 930-5.
    • (2008) Nature , vol.455 , pp. 930-935
    • Mosse, Y.P.1    Laudenslager, M.2    Longo, L.3    Cole, K.A.4    Wood, A.5    Attiyeh, E.F.6
  • 20
    • 54049120220 scopus 로고    scopus 로고
    • Activating mutations in ALK provide a therapeutic target in neuroblastoma
    • George RE, Sanda T, Hanna M, Frohling S, Luther WII, Zhang J, et al. Activating mutations in ALK provide a therapeutic target in neuroblastoma. Nature 2008;455: 975-8.
    • (2008) Nature , vol.455 , pp. 975-978
    • George, R.E.1    Sanda, T.2    Hanna, M.3    Frohling, S.4    Luther, W.I.I.5    Zhang, J.6
  • 22
  • 27
    • 34547858913 scopus 로고    scopus 로고
    • Structure and acetyl-lysine recognition of the bromodomain
    • Mujtaba S, Zeng L, Zhou MM. Structure and acetyl-lysine recognition of the bromodomain. Oncogene 2007;26: 5521-7.
    • (2007) Oncogene , vol.26 , pp. 5521-5527
    • Mujtaba, S.1    Zeng, L.2    Zhou, M.M.3
  • 28
    • 80055000824 scopus 로고    scopus 로고
    • RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
    • Zuber J, Shi J, Wang E, Rappaport AR, Herrmann H, Sison EA, et al. RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature 2011;478: 524-8.
    • (2011) Nature , vol.478 , pp. 524-528
    • Zuber, J.1    Shi, J.2    Wang, E.3    Rappaport, A.R.4    Herrmann, H.5    Sison, E.A.6
  • 31
    • 79952775174 scopus 로고    scopus 로고
    • RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma
    • Cole KA, Huggins J, Laquaglia M, Hulderman CE, Russell MR, Bosse K, et al. RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma. Proc Natl Acad Sci U S A 2011;108: 3336-41.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 3336-3341
    • Cole, K.A.1    Huggins, J.2    Laquaglia, M.3    Hulderman, C.E.4    Russell, M.R.5    Bosse, K.6
  • 33
    • 57849107571 scopus 로고    scopus 로고
    • Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma
    • Otto T, Horn S, Brockmann M, Eilers U, Schuttrumpf L, Popov N, et al. Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma. Cancer Cell 2009;15: 67-78.
    • (2009) Cancer Cell , vol.15 , pp. 67-78
    • Otto, T.1    Horn, S.2    Brockmann, M.3    Eilers, U.4    Schuttrumpf, L.5    Popov, N.6
  • 35
    • 84867534947 scopus 로고    scopus 로고
    • CCT244747 is a novel potent and selectiveCHK1 inhibitor with oral efficacy alone and in combination with genotoxic anticancer drugs
    • Walton MI, Eve PD, Hayes A, Valenti MR, De Haven Brandon AK, Box G, et al. CCT244747 is a novel potent and selectiveCHK1 inhibitor with oral efficacy alone and in combination with genotoxic anticancer drugs. Clin Cancer Res 2012;18: 5650-61.
    • (2012) Clin Cancer Res , vol.18 , pp. 5650-5661
    • Walton, M.I.1    Eve, P.D.2    Hayes, A.3    Valenti, M.R.4    De Haven Brandon, A.K.5    Box, G.6
  • 36
    • 24144441250 scopus 로고    scopus 로고
    • The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors
    • Sjostrom SK, Finn G, Hahn WC, Rowitch DH, Kenney AM. The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors. Dev Cell 2005;9: 327-38.
    • (2005) Dev Cell , vol.9 , pp. 327-338
    • Sjostrom, S.K.1    Finn, G.2    Hahn, W.C.3    Rowitch, D.H.4    Kenney, A.M.5
  • 37
    • 2342526543 scopus 로고    scopus 로고
    • A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells
    • Yeh E, Cunningham M, Arnold H, Chasse D, Monteith T, Ivaldi G, et al. A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells. Nat Cell Biol 2004;6: 308-18.
    • (2004) Nat Cell Biol , vol.6 , pp. 308-318
    • Yeh, E.1    Cunningham, M.2    Arnold, H.3    Chasse, D.4    Monteith, T.5    Ivaldi, G.6
  • 38
    • 84870864690 scopus 로고    scopus 로고
    • Inhibition of cyclin-dependent kinase 1- induced cell death in neuroblastoma cells through the microRNA-34a- MYCN-survivin pathway
    • Chen Y, Tsai YH, Tseng SH. Inhibition of cyclin-dependent kinase 1- induced cell death in neuroblastoma cells through the microRNA-34a- MYCN-survivin pathway. Surgery 2013;153: 4-16.
    • (2013) Surgery , vol.153 , pp. 4-16
    • Chen, Y.1    Tsai, Y.H.2    Tseng, S.H.3
  • 39
    • 84875910082 scopus 로고    scopus 로고
    • CDK4 inhibition restores G(1)-S arrest in MYCN-amplified neuroblastoma cells in the context of doxorubicin-induced DNA damage
    • Gogolin S, Ehemann V, Becker G, Brueckner LM, Dreidax D, Bannert S, et al. CDK4 inhibition restores G(1)-S arrest in MYCN-amplified neuroblastoma cells in the context of doxorubicin-induced DNA damage. Cell Cycle 2013;12: 1091-104.
    • (2013) Cell Cycle , vol.12 , pp. 1091-1104
    • Gogolin, S.1    Ehemann, V.2    Becker, G.3    Brueckner, L.M.4    Dreidax, D.5    Bannert, S.6
  • 40
    • 2942650133 scopus 로고    scopus 로고
    • The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation- dependent c-Myc protein degradation
    • Welcker M, Orian A, Jin J, Grim JE, Harper JW, Eisenman RN, et al. The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation- dependent c-Myc protein degradation. Proc Natl Acad Sci U S A 2004;101: 9085-90.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 9085-9090
    • Welcker, M.1    Orian, A.2    Jin, J.3    Grim, J.E.4    Harper, J.W.5    Eisenman, R.N.6
  • 41
    • 44649201561 scopus 로고    scopus 로고
    • The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein
    • Zhao X, Heng JI, Guardavaccaro D, Jiang R, Pagano M, Guillemot F, et al. The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein. Nat Cell Biol 2008;10: 643-53.
    • (2008) Nat Cell Biol , vol.10 , pp. 643-653
    • Zhao, X.1    Heng, J.I.2    Guardavaccaro, D.3    Jiang, R.4    Pagano, M.5    Guillemot, F.6
  • 42
  • 43
    • 84879872430 scopus 로고    scopus 로고
    • A multicenter, first-in-pediatrics, phase 1, pharmacokinetic and pharmacodynamic study of ridaforolimus in patients with refractory solid tumors
    • Gore L, Trippett TM, Katzenstein H, Boklan J, Narendran A, Smith A, et al. A multicenter, first-in-pediatrics, phase 1, pharmacokinetic and pharmacodynamic study of ridaforolimus in patients with refractory solid tumors. Clin Cancer Res 2013;19: 3649-58.
    • (2013) Clin Cancer Res , vol.19 , pp. 3649-3658
    • Gore, L.1    Trippett, T.M.2    Katzenstein, H.3    Boklan, J.4    Narendran, A.5    Smith, A.6
  • 45
  • 46
    • 84876703624 scopus 로고    scopus 로고
    • AZD2014, a dualmTORC1 andmTORC2 inhibitor is differentiated from allosteric inhibitors ofmTORC1inER+breast cancer
    • Guichard SM, Howard Z, Heathcote D, Roth M, Hughes G, Curwen J, et al. AZD2014, a dualmTORC1 andmTORC2 inhibitor is differentiated from allosteric inhibitors ofmTORC1inER+breast cancer. Cancer Res 2012;72: 917.
    • (2012) Cancer Res , vol.72 , pp. 917
    • Guichard, S.M.1    Howard, Z.2    Heathcote, D.3    Roth, M.4    Hughes, G.5    Curwen, J.6
  • 47
    • 84863299954 scopus 로고    scopus 로고
    • Combination of an allosteric Akt Inhibitor MK-2206 with etoposide or rapamycin enhances the antitumor growth effect in neuroblastoma
    • Li Z, Yan S, Attayan N, Ramalingam S, Thiele CJ. Combination of an allosteric Akt Inhibitor MK-2206 with etoposide or rapamycin enhances the antitumor growth effect in neuroblastoma. Clin Cancer Res 2012;18: 3603-15.
    • (2012) Clin Cancer Res , vol.18 , pp. 3603-3615
    • Li, Z.1    Yan, S.2    Attayan, N.3    Ramalingam, S.4    Thiele, C.J.5
  • 48
    • 84880042989 scopus 로고    scopus 로고
    • Small molecule inhibitors of aurora - A induce proteasomal degradation of N-myc in childhood neuroblastoma
    • Brockmann M, Poon E, Berry T, Carstensen A, Deubzer HE, Rycak L, et al. Small molecule inhibitors of aurora-a induce proteasomal degradation of N-myc in childhood neuroblastoma. Cancer Cell 2013;24: 75-89.
    • (2013) Cancer Cell , vol.24 , pp. 75-89
    • Brockmann, M.1    Poon, E.2    Berry, T.3    Carstensen, A.4    Deubzer, H.E.5    Rycak, L.6
  • 49
    • 77952703733 scopus 로고    scopus 로고
    • Initial testing of the aurora kinase A inhibitor MLN8237 by the Pediatric Preclinical Testing Program (PPTP)
    • Maris JM, Morton CL, Gorlick R, Kolb EA, Lock R, Carol H, et al. Initial testing of the aurora kinase A inhibitor MLN8237 by the Pediatric Preclinical Testing Program (PPTP). Pediatr Blood Cancer 2010;55: 26-34.
    • (2010) Pediatr Blood Cancer , vol.55 , pp. 26-34
    • Maris, J.M.1    Morton, C.L.2    Gorlick, R.3    Kolb, E.A.4    Lock, R.5    Carol, H.6
  • 50
    • 84868542839 scopus 로고    scopus 로고
    • Pediatric phase i trial and pharmacokinetic study of MLN8237, an investigational oral selective small-molecule inhibitor of Aurora kinase A: A Children's Oncology Group Phase i Consortium study
    • Mosse YP, Lipsitz E, Fox E, Teachey DT, Maris JM, Weigel B, et al. Pediatric phase I trial and pharmacokinetic study of MLN8237, an investigational oral selective small-molecule inhibitor of Aurora kinase A: a Children's Oncology Group Phase I Consortium study. Clin Cancer Res 2012;18: 6058-64.
    • (2012) Clin Cancer Res , vol.18 , pp. 6058-6064
    • Mosse, Y.P.1    Lipsitz, E.2    Fox, E.3    Teachey, D.T.4    Maris, J.M.5    Weigel, B.6
  • 51
    • 61449106633 scopus 로고    scopus 로고
    • Long-term results for children with high-risk neuroblastoma treated on a randomized trial of myeloablative therapy followed by 13-cis-retinoic acid: A children's oncology group study
    • Matthay KK, Reynolds CP, Seeger RC, Shimada H, Adkins ES, Haas- Kogan D, et al. Long-term results for children with high-risk neuroblastoma treated on a randomized trial of myeloablative therapy followed by 13-cis-retinoic acid: a children's oncology group study. J Clin Oncol 2009;27: 1007-13.
    • (2009) J Clin Oncol , vol.27 , pp. 1007-1013
    • Matthay, K.K.1    Reynolds, C.P.2    Seeger, R.C.3    Shimada, H.4    Adkins, E.S.5    Haas- Kogan, D.6
  • 52
    • 0021947043 scopus 로고
    • Decreased expression of N-myc precedes retinoic acid-induced morphological differentiation of human neuroblastoma
    • Thiele CJ, Reynolds CP, Israel MA. Decreased expression of N-myc precedes retinoic acid-induced morphological differentiation of human neuroblastoma. Nature 1985;313: 404-6.
    • (1985) Nature , vol.313 , pp. 404-406
    • Thiele, C.J.1    Reynolds, C.P.2    Israel, M.A.3
  • 54
    • 81055126433 scopus 로고    scopus 로고
    • Differential inhibitor sensitivity of anaplastic lymphoma kinase variants found in neuroblastoma
    • Bresler SC,WoodAC, Haglund EA, Courtright J, Belcastro LT, Plegaria JS, et al.Differential inhibitor sensitivity of anaplastic lymphoma kinase variants found in neuroblastoma. Sci Transl Med 2011;3: 108ra14.
    • (2011) Sci Transl Med , vol.3
    • Scwoodac, B.1    Haglund, E.A.2    Courtright, J.3    Belcastro, L.T.4    Plegaria, J.S.5
  • 56
    • 84866934606 scopus 로고    scopus 로고
    • Activity and safety of crizotinib in patients with ALK-positive nonsmall- cell lung cancer: Updated results from a phase 1 study
    • Camidge DR, Bang YJ, Kwak EL, Iafrate AJ, Varella-Garcia M, Fox SB, et al. Activity and safety of crizotinib in patients with ALK-positive nonsmall- cell lung cancer: updated results from a phase 1 study. Lancet Oncol 2012;13: 1011-9.
    • (2012) Lancet Oncol , vol.13 , pp. 1011-1019
    • Camidge, D.R.1    Bang, Y.J.2    Kwak, E.L.3    Iafrate, A.J.4    Varella-Garcia, M.5    Fox, S.B.6
  • 58
    • 84876966952 scopus 로고    scopus 로고
    • Safety and activity of crizotinib for paediatric patients with refractory solid tumours or anaplastic large-cell lymphoma: A Children's Oncology Group phase 1 consortium study
    • Mosse YP, Lim MS, Voss SD, Wilner K, Ruffner K, Laliberte J, et al. Safety and activity of crizotinib for paediatric patients with refractory solid tumours or anaplastic large-cell lymphoma: a Children's Oncology Group phase 1 consortium study. Lancet Oncol 2013;14: 472-80.
    • (2013) Lancet Oncol , vol.14 , pp. 472-480
    • Mosse, Y.P.1    Lim, M.S.2    Voss, S.D.3    Wilner, K.4    Ruffner, K.5    Laliberte, J.6
  • 59
    • 84866901075 scopus 로고    scopus 로고
    • First-in-human phase 1 study of the ALK inhibitor LDK378 in ALK+ solid tumors
    • (suppl; abstr 3007)
    • Mehra R, Camidge DR, Sharma S, Felip E, Tan DS, Vansteenkiste JF, et al. First-in-human phase 1 study of the ALK inhibitor LDK378 in ALK+ solid tumors. J Clin Oncol 30, 2012 (suppl; abstr 3007).
    • (2012) J Clin Oncol , vol.30
    • Mehra, R.1    Camidge, D.R.2    Sharma, S.3    Felip, E.4    Tan, D.S.5    Vansteenkiste, J.F.6
  • 60
    • 84878347085 scopus 로고    scopus 로고
    • CH5424802 (RO5424802) for patients with ALK-rearranged advanced non-small-cell lung cancer (AF-001JP study): A single-arm, open-label, phase 1-2 study
    • Seto T, Kiura K, Nishio M, Nakagawa K, Maemondo M, Inoue A, et al. CH5424802 (RO5424802) for patients with ALK-rearranged advanced non-small-cell lung cancer (AF-001JP study): a single-arm, open-label, phase 1-2 study. Lancet Oncol 2013;14: 590-8.
    • (2013) Lancet Oncol , vol.14 , pp. 590-598
    • Seto, T.1    Kiura, K.2    Nishio, M.3    Nakagawa, K.4    Maemondo, M.5    Inoue, A.6
  • 61
    • 79956318797 scopus 로고    scopus 로고
    • Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK
    • Katayama R, Khan TM, Benes C, Lifshits E, Ebi H, Rivera VM, et al. Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK. Proc Natl Acad Sci U S A 2011;108: 7535-40.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 7535-7540
    • Katayama, R.1    Khan, T.M.2    Benes, C.3    Lifshits, E.4    Ebi, H.5    Rivera, V.M.6
  • 62
    • 33947236179 scopus 로고    scopus 로고
    • CD4 T-helper responses to the anaplastic lymphoma kinase (ALK) protein in patients with ALKpositive anaplastic large-cell lymphoma
    • Ait-Tahar K, Barnardo MC, Pulford K. CD4 T-helper responses to the anaplastic lymphoma kinase (ALK) protein in patients with ALKpositive anaplastic large-cell lymphoma. Cancer Res 2007;67: 1898-901.
    • (2007) Cancer Res , vol.67 , pp. 1898-1901
    • Ait-Tahar, K.1    Barnardo, M.C.2    Pulford, K.3
  • 63
    • 22544440004 scopus 로고    scopus 로고
    • Activation and inhibition of anaplastic lymphoma kinase receptor tyrosine kinase by monoclonal antibodies and absence of agonist activity of pleiotrophin
    • Moog-Lutz C, Degoutin J, Gouzi JY, Frobert Y, Brunet-de Carvalho N, Bureau J, et al. Activation and inhibition of anaplastic lymphoma kinase receptor tyrosine kinase by monoclonal antibodies and absence of agonist activity of pleiotrophin. J Biol Chem 2005; 280: 26039-48.
    • (2005) J Biol Chem , vol.280 , pp. 26039-26048
    • Moog-Lutz, C.1    Degoutin, J.2    Gouzi, J.Y.3    Frobert, Y.4    Brunet-De Carvalho, N.5    Bureau, J.6
  • 64
    • 84869502105 scopus 로고    scopus 로고
    • Antibody targeting of anaplastic lymphoma kinase induces cytotoxicity of human neuroblastoma
    • Carpenter EL, Haglund EA, Mace EM, Deng D, Martinez D, Wood AC, et al. Antibody targeting of anaplastic lymphoma kinase induces cytotoxicity of human neuroblastoma. Oncogene 2012; 31: 4859-67.
    • (2012) Oncogene , vol.31 , pp. 4859-4867
    • Carpenter, E.L.1    Haglund, E.A.2    MacE, E.M.3    Deng, D.4    Martinez, D.5    Wood, A.C.6
  • 65
    • 80051720194 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia
    • Porter DL, Levine BL, Kalos M, Bagg A, June CH. Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. N Engl J Med 2011;365: 725-33.
    • (2011) N Engl J Med , vol.365 , pp. 725-733
    • Porter, D.L.1    Levine, B.L.2    Kalos, M.3    Bagg, A.4    June, C.H.5
  • 66
    • 84863753157 scopus 로고    scopus 로고
    • The ALK(F1174L) mutation potentiates the oncogenic activity of MYCN in neuroblastoma
    • Berry T, Luther W, Bhatnagar N, Jamin Y, Poon E, Sanda T, et al. The ALK(F1174L) mutation potentiates the oncogenic activity of MYCN in neuroblastoma. Cancer Cell 2012;22: 117-30.
    • (2012) Cancer Cell , vol.22 , pp. 117-130
    • Berry, T.1    Luther, W.2    Bhatnagar, N.3    Jamin, Y.4    Poon, E.5    Sanda, T.6
  • 67
    • 77956244494 scopus 로고    scopus 로고
    • Meta-analysis of neuroblastomas reveals a skewed ALK mutation spectrum in tumors with MYCN amplification
    • De Brouwer S, De Preter K,KumpsC, Zabrocki P, Porcu M, Westerhout EM, et al. Meta-analysis of neuroblastomas reveals a skewed ALK mutation spectrum in tumors with MYCN amplification. Clin Cancer Res 2010;16: 4353-62.
    • (2010) Clin Cancer Res , vol.16 , pp. 4353-4362
    • De Brouwer, S.1    De Preter Kkumpsc2    Zabrocki, P.3    Porcu, M.4    Westerhout, E.M.5
  • 70
    • 84871212519 scopus 로고    scopus 로고
    • Anaplastic Lymphoma Kinase (ALK) regulates initiation of transcription of MYCN in neuroblastoma cells
    • Schonherr C,Ruuth K,Kamaraj S,WangCL,Yang HL,Combaret V, et al. Anaplastic Lymphoma Kinase (ALK) regulates initiation of transcription of MYCN in neuroblastoma cells. Oncogene 2012;31: 5193-200.
    • (2012) Oncogene , vol.31 , pp. 5193-5200
    • Schonherr, C.1    Ruuth, K.2    Kamaraj, S.3    Wang, C.L.4    Yang, H.L.5    Combaret, V.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.