-
1
-
-
38649093611
-
Neuroblastoma: Biology, prognosis, and treatment
-
Park JR, Eggert A, Caron H. Neuroblastoma: biology, prognosis, and treatment. Pediatr Clin North Am 2008;55: 97-120.
-
(2008)
Pediatr Clin North Am
, vol.55
, pp. 97-120
-
-
Park, J.R.1
Eggert, A.2
Caron, H.3
-
2
-
-
77957341503
-
Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma
-
Yu AL, Gilman AL, Ozkaynak MF, London WB, Kreissman SG, Chen HX, et al. Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma. N Engl J Med 2010;363: 1324-34.
-
(2010)
N Engl J Med
, vol.363
, pp. 1324-1334
-
-
Yu, A.L.1
Gilman, A.L.2
Ozkaynak, M.F.3
London, W.B.4
Kreissman, S.G.5
Chen, H.X.6
-
3
-
-
80051979836
-
Clinical and biologic features predictive of survival after relapse of neuroblastoma: A report from the International Neuroblastoma Risk Group project
-
London WB, Castel V, Monclair T, Ambros PF, Pearson AD, Cohn SL, et al. Clinical and biologic features predictive of survival after relapse of neuroblastoma: a report from the International Neuroblastoma Risk Group project. J Clin Oncol 2011;29: 3286-92.
-
(2011)
J Clin Oncol
, vol.29
, pp. 3286-3292
-
-
London, W.B.1
Castel, V.2
Monclair, T.3
Ambros, P.F.4
Pearson, A.D.5
Cohn, S.L.6
-
4
-
-
84874664731
-
The genetic landscape of high-risk neuroblastoma
-
Pugh TJ, Morozova O, Attiyeh EF, Asgharzadeh S, Wei JS, Auclair D, et al. The genetic landscape of high-risk neuroblastoma. Nat Genet 2013;45: 279-84.
-
(2013)
Nat Genet
, vol.45
, pp. 279-284
-
-
Pugh, T.J.1
Morozova, O.2
Attiyeh, E.F.3
Asgharzadeh, S.4
Wei, J.S.5
Auclair, D.6
-
5
-
-
4544265599
-
Germline PHOX2B mutation in hereditary neuroblastoma
-
Mosse YP, Laudenslager M, Khazi D, Carlisle AJ, Winter CL, Rappaport E, et al. Germline PHOX2B mutation in hereditary neuroblastoma. Am J Hum Genet 2004;75: 727-30.
-
(2004)
Am J Hum Genet
, vol.75
, pp. 727-730
-
-
Mosse, Y.P.1
Laudenslager, M.2
Khazi, D.3
Carlisle, A.J.4
Winter, C.L.5
Rappaport, E.6
-
6
-
-
58149240253
-
Rare occurrence of PHOX2b mutations in sporadic neuroblastomas
-
Serra A, Haberle B, Konig IR, Kappler R, Suttorp M, Schackert HK, et al. Rare occurrence of PHOX2b mutations in sporadic neuroblastomas. J Pediatr Hematol Oncol 2008;30: 728-32.
-
(2008)
J Pediatr Hematol Oncol
, vol.30
, pp. 728-732
-
-
Serra, A.1
Haberle, B.2
Konig, I.R.3
Kappler, R.4
Suttorp, M.5
Schackert, H.K.6
-
7
-
-
84859216598
-
Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes
-
Molenaar JJ, Koster J, Zwijnenburg DA, van Sluis P, Valentijn LJ, van der Ploeg I, et al. Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes. Nature 2012;483: 589-93.
-
(2012)
Nature
, vol.483
, pp. 589-593
-
-
Molenaar, J.J.1
Koster, J.2
Zwijnenburg, D.A.3
Van Sluis, P.4
Valentijn, L.J.5
Van Der Ploeg, I.6
-
8
-
-
84871982155
-
Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma
-
Sausen M, Leary RJ, Jones S, Wu J, Reynolds CP, Liu X, et al. Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma. Nat Genet 2013;45: 12-7.
-
(2013)
Nat Genet
, vol.45
, pp. 12-17
-
-
Sausen, M.1
Leary, R.J.2
Jones, S.3
Wu, J.4
Reynolds, C.P.5
Liu, X.6
-
9
-
-
0021261878
-
Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage
-
Brodeur GM, Seeger RC, Schwab M, Varmus HE, Bishop JM. Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage. Science 1984;224: 1121-4.
-
(1984)
Science
, vol.224
, pp. 1121-1124
-
-
Brodeur, G.M.1
Seeger, R.C.2
Schwab, M.3
Varmus, H.E.4
Bishop, J.M.5
-
10
-
-
0035889955
-
Histopathology (International Neuroblastoma Pathology Classification) and MYCN status in patients with peripheral neuroblastic tumors: A report from the Children's Cancer Group
-
Goto S, Umehara S, Gerbing RB, Stram DO, Brodeur GM, Seeger RC, et al. Histopathology (International Neuroblastoma Pathology Classification) and MYCN status in patients with peripheral neuroblastic tumors: a report from the Children's Cancer Group. Cancer 2001;92: 2699-708.
-
(2001)
Cancer
, vol.92
, pp. 2699-2708
-
-
Goto, S.1
Umehara, S.2
Gerbing, R.B.3
Stram, D.O.4
Brodeur, G.M.5
Seeger, R.C.6
-
11
-
-
84867021989
-
Transcriptional amplification in tumor cells with elevated c-Myc
-
Lin CY, Loven J, Rahl PB, Paranal RM, Burge CB, Bradner JE, et al. Transcriptional amplification in tumor cells with elevated c-Myc. Cell 2012;151: 56-67.
-
(2012)
Cell
, vol.151
, pp. 56-67
-
-
Lin, C.Y.1
Loven, J.2
Rahl, P.B.3
Paranal, R.M.4
Burge, C.B.5
Bradner, J.E.6
-
12
-
-
0034327928
-
MYCN expression is not prognostic of adverse outcome in advanced-stage neuroblastoma with nonamplified MYCN
-
Cohn SL, London WB, Huang D, Katzenstein HM, Salwen HR, Reinhart T, et al. MYCN expression is not prognostic of adverse outcome in advanced-stage neuroblastoma with nonamplified MYCN. J Clin Oncol 2000;18: 3604-13.
-
(2000)
J Clin Oncol
, vol.18
, pp. 3604-3613
-
-
Cohn, S.L.1
London, W.B.2
Huang, D.3
Katzenstein, H.M.4
Salwen, H.R.5
Reinhart, T.6
-
13
-
-
84887029028
-
Pediatric neuroblastoma: Molecular detection of minimal residual disease
-
Hayat MA, editor. The Netherlands: Springer;
-
Stutterheim J, Tytgat GM, Schoot CE. Pediatric neuroblastoma: molecular detection of minimal residual disease. In:Hayat MA, editor. Neuroblastoma. The Netherlands: Springer; 2012. p. 47-63.
-
(2012)
Neuroblastoma
, pp. 47-63
-
-
Stutterheim, J.1
Tytgat, G.M.2
Schoot, C.E.3
-
14
-
-
84869779376
-
Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification
-
Valentijn LJ, Koster J, Haneveld F, Aissa RA, van Sluis P, Broekmans ME, et al. Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification. Proc Natl Acad Sci U S A 2012;109: 19190-5.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 19190-19195
-
-
Valentijn, L.J.1
Koster, J.2
Haneveld, F.3
Aissa, R.A.4
Van Sluis, P.5
Broekmans, M.E.6
-
15
-
-
33748068792
-
Inhibition of phosphatidylinositol 3-kinase destabilizes Mycn protein and blocks malignant progression in neuroblastoma
-
Chesler L, Schlieve C, Goldenberg DD, Kenney A, Kim G, McMillan A, et al. Inhibition of phosphatidylinositol 3-kinase destabilizes Mycn protein and blocks malignant progression in neuroblastoma. Cancer Res 2006;66: 8139-46.
-
(2006)
Cancer Res
, vol.66
, pp. 8139-8146
-
-
Chesler, L.1
Schlieve, C.2
Goldenberg, D.D.3
Kenney, A.4
Kim, G.5
McMillan, A.6
-
16
-
-
79959327886
-
Progress in the preclinical discovery and clinical development of class i and dual class I/IV phosphoinositide 3-kinase (PI3K) inhibitors
-
Shuttleworth SJ, Silva FA, Cecil AR, Tomassi CD, Hill TJ, Raynaud FI, et al. Progress in the preclinical discovery and clinical development of class I and dual class I/IV phosphoinositide 3-kinase (PI3K) inhibitors. Curr Med Chem 2011;18: 2686-714.
-
(2011)
Curr Med Chem
, vol.18
, pp. 2686-2714
-
-
Shuttleworth, S.J.1
Silva, F.A.2
Cecil, A.R.3
Tomassi, C.D.4
Hill, T.J.5
Raynaud, F.I.6
-
17
-
-
0030925596
-
Regulation of the neural crest cell fate by N-myc: Promotion of ventral migration and neuronal differentiation
-
Wakamatsu Y, Watanabe Y, Nakamura H, Kondoh H. Regulation of the neural crest cell fate by N-myc: promotion of ventral migration and neuronal differentiation. Development 1997;124: 1953-62.
-
(1997)
Development
, vol.124
, pp. 1953-1962
-
-
Wakamatsu, Y.1
Watanabe, Y.2
Nakamura, H.3
Kondoh, H.4
-
18
-
-
54049094708
-
Identification of ALK as a major familial neuroblastoma predisposition gene
-
Mosse YP, Laudenslager M, Longo L, Cole KA, Wood A, Attiyeh EF, et al. Identification of ALK as a major familial neuroblastoma predisposition gene. Nature 2008;455: 930-5.
-
(2008)
Nature
, vol.455
, pp. 930-935
-
-
Mosse, Y.P.1
Laudenslager, M.2
Longo, L.3
Cole, K.A.4
Wood, A.5
Attiyeh, E.F.6
-
19
-
-
54049118823
-
Oncogenic mutations of ALK kinase in neuroblastoma
-
Chen Y, Takita J, Choi YL, Kato M, Ohira M, Sanada M, et al. Oncogenic mutations of ALK kinase in neuroblastoma. Nature 2008;455: 971-4.
-
(2008)
Nature
, vol.455
, pp. 971-974
-
-
Chen, Y.1
Takita, J.2
Choi, Y.L.3
Kato, M.4
Ohira, M.5
Sanada, M.6
-
20
-
-
54049120220
-
Activating mutations in ALK provide a therapeutic target in neuroblastoma
-
George RE, Sanda T, Hanna M, Frohling S, Luther WII, Zhang J, et al. Activating mutations in ALK provide a therapeutic target in neuroblastoma. Nature 2008;455: 975-8.
-
(2008)
Nature
, vol.455
, pp. 975-978
-
-
George, R.E.1
Sanda, T.2
Hanna, M.3
Frohling, S.4
Luther, W.I.I.5
Zhang, J.6
-
21
-
-
54049149961
-
Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma
-
Janoueix-Lerosey I, Lequin D, Brugieres L, Ribeiro A, de Pontual L, Combaret V, et al. Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma. Nature 2008;455: 967-70.
-
(2008)
Nature
, vol.455
, pp. 967-970
-
-
Janoueix-Lerosey, I.1
Lequin, D.2
Brugieres, L.3
Ribeiro, A.4
De Pontual, L.5
Combaret, V.6
-
23
-
-
53349103292
-
Modelling Myc inhibition as a cancer therapy
-
Soucek L, Whitfield J, Martins CP, Finch AJ, Murphy DJ, Sodir NM, et al. Modelling Myc inhibition as a cancer therapy. Nature 2008;455: 679-83.
-
(2008)
Nature
, vol.455
, pp. 679-683
-
-
Soucek, L.1
Whitfield, J.2
Martins, C.P.3
Finch, A.J.4
Murphy, D.J.5
Sodir, N.M.6
-
24
-
-
84874835799
-
Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice
-
Soucek L, Whitfield JR, Sodir NM, Masso-Valles D, Serrano E, Karnezis AN, et al. Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice. Genes Dev 2013;27: 504-13.
-
(2013)
Genes Dev
, vol.27
, pp. 504-513
-
-
Soucek, L.1
Whitfield, J.R.2
Sodir, N.M.3
Masso-Valles, D.4
Serrano, E.5
Karnezis, A.N.6
-
25
-
-
84879289434
-
MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells
-
Zirath H, Frenzel A, Oliynyk G, Segerstrom L, Westermark UK, Larsson K, et al. MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells. Proc Natl Acad Sci U S A 2013;110: 10258-63.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 10258-10263
-
-
Zirath, H.1
Frenzel, A.2
Oliynyk, G.3
Segerstrom, L.4
Westermark, U.K.5
Larsson, K.6
-
26
-
-
0030999641
-
Targeted expression of MYCN causes neuroblastoma in transgenic mice
-
Weiss WA, Aldape K, Mohapatra G, Feuerstein BG, Bishop JM. Targeted expression of MYCN causes neuroblastoma in transgenic mice. EMBO J 1997;16: 2985-95.
-
(1997)
EMBO J
, vol.16
, pp. 2985-2995
-
-
Weiss, W.A.1
Aldape, K.2
Mohapatra, G.3
Feuerstein, B.G.4
Bishop, J.M.5
-
27
-
-
34547858913
-
Structure and acetyl-lysine recognition of the bromodomain
-
Mujtaba S, Zeng L, Zhou MM. Structure and acetyl-lysine recognition of the bromodomain. Oncogene 2007;26: 5521-7.
-
(2007)
Oncogene
, vol.26
, pp. 5521-5527
-
-
Mujtaba, S.1
Zeng, L.2
Zhou, M.M.3
-
28
-
-
80055000824
-
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
-
Zuber J, Shi J, Wang E, Rappaport AR, Herrmann H, Sison EA, et al. RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature 2011;478: 524-8.
-
(2011)
Nature
, vol.478
, pp. 524-528
-
-
Zuber, J.1
Shi, J.2
Wang, E.3
Rappaport, A.R.4
Herrmann, H.5
Sison, E.A.6
-
29
-
-
84876033650
-
Targeting MYCN in neuroblastoma by BET bromodomain inhibition
-
Puissant A, Frumm SM, Alexe G, Bassil CF, Qi J, Chanthery YH, et al. Targeting MYCN in neuroblastoma by BET bromodomain inhibition. Cancer Discov 2013;3: 308-23.
-
(2013)
Cancer Discov
, vol.3
, pp. 308-323
-
-
Puissant, A.1
Frumm, S.M.2
Alexe, G.3
Bassil, C.F.4
Qi, J.5
Chanthery, Y.H.6
-
30
-
-
84886276286
-
The brd-inhibitor OTX015 shows pre-clinical activity in anaplastic large T-cell lymphoma (ALCL)
-
Boi M, Bonetti P, Ponzoni M, Tibiletti MG, Stathis A, Cvitkovic E, et al. The brd-inhibitor OTX015 shows pre-clinical activity in anaplastic large T-cell lymphoma (ALCL). ASH Annual Meeting Abstracts 2012; 120: 4872.
-
(2012)
ASH Annual Meeting Abstracts
, vol.120
, pp. 4872
-
-
Boi, M.1
Bonetti, P.2
Ponzoni, M.3
Tibiletti, M.G.4
Stathis, A.5
Cvitkovic, E.6
-
31
-
-
79952775174
-
RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma
-
Cole KA, Huggins J, Laquaglia M, Hulderman CE, Russell MR, Bosse K, et al. RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma. Proc Natl Acad Sci U S A 2011;108: 3336-41.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 3336-3341
-
-
Cole, K.A.1
Huggins, J.2
Laquaglia, M.3
Hulderman, C.E.4
Russell, M.R.5
Bosse, K.6
-
32
-
-
69149108005
-
Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells
-
Molenaar JJ, Ebus ME, Geerts D, Koster J, Lamers F, Valentijn LJ, et al. Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells. Proc Natl Acad Sci U S A 2009;106: 12968-73.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 12968-12973
-
-
Molenaar, J.J.1
Ebus, M.E.2
Geerts, D.3
Koster, J.4
Lamers, F.5
Valentijn, L.J.6
-
33
-
-
57849107571
-
Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma
-
Otto T, Horn S, Brockmann M, Eilers U, Schuttrumpf L, Popov N, et al. Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma. Cancer Cell 2009;15: 67-78.
-
(2009)
Cancer Cell
, vol.15
, pp. 67-78
-
-
Otto, T.1
Horn, S.2
Brockmann, M.3
Eilers, U.4
Schuttrumpf, L.5
Popov, N.6
-
34
-
-
34547232986
-
Non-transcriptional control of DNA replication by c-Myc
-
Dominguez-Sola D, Ying CY, Grandori C, Ruggiero L, Chen B, Li M, et al. Non-transcriptional control of DNA replication by c-Myc. Nature 2007;448: 445-51.
-
(2007)
Nature
, vol.448
, pp. 445-451
-
-
Dominguez-Sola, D.1
Ying, C.Y.2
Grandori, C.3
Ruggiero, L.4
Chen, B.5
Li, M.6
-
35
-
-
84867534947
-
CCT244747 is a novel potent and selectiveCHK1 inhibitor with oral efficacy alone and in combination with genotoxic anticancer drugs
-
Walton MI, Eve PD, Hayes A, Valenti MR, De Haven Brandon AK, Box G, et al. CCT244747 is a novel potent and selectiveCHK1 inhibitor with oral efficacy alone and in combination with genotoxic anticancer drugs. Clin Cancer Res 2012;18: 5650-61.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 5650-5661
-
-
Walton, M.I.1
Eve, P.D.2
Hayes, A.3
Valenti, M.R.4
De Haven Brandon, A.K.5
Box, G.6
-
36
-
-
24144441250
-
The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors
-
Sjostrom SK, Finn G, Hahn WC, Rowitch DH, Kenney AM. The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors. Dev Cell 2005;9: 327-38.
-
(2005)
Dev Cell
, vol.9
, pp. 327-338
-
-
Sjostrom, S.K.1
Finn, G.2
Hahn, W.C.3
Rowitch, D.H.4
Kenney, A.M.5
-
37
-
-
2342526543
-
A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells
-
Yeh E, Cunningham M, Arnold H, Chasse D, Monteith T, Ivaldi G, et al. A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells. Nat Cell Biol 2004;6: 308-18.
-
(2004)
Nat Cell Biol
, vol.6
, pp. 308-318
-
-
Yeh, E.1
Cunningham, M.2
Arnold, H.3
Chasse, D.4
Monteith, T.5
Ivaldi, G.6
-
38
-
-
84870864690
-
Inhibition of cyclin-dependent kinase 1- induced cell death in neuroblastoma cells through the microRNA-34a- MYCN-survivin pathway
-
Chen Y, Tsai YH, Tseng SH. Inhibition of cyclin-dependent kinase 1- induced cell death in neuroblastoma cells through the microRNA-34a- MYCN-survivin pathway. Surgery 2013;153: 4-16.
-
(2013)
Surgery
, vol.153
, pp. 4-16
-
-
Chen, Y.1
Tsai, Y.H.2
Tseng, S.H.3
-
39
-
-
84875910082
-
CDK4 inhibition restores G(1)-S arrest in MYCN-amplified neuroblastoma cells in the context of doxorubicin-induced DNA damage
-
Gogolin S, Ehemann V, Becker G, Brueckner LM, Dreidax D, Bannert S, et al. CDK4 inhibition restores G(1)-S arrest in MYCN-amplified neuroblastoma cells in the context of doxorubicin-induced DNA damage. Cell Cycle 2013;12: 1091-104.
-
(2013)
Cell Cycle
, vol.12
, pp. 1091-1104
-
-
Gogolin, S.1
Ehemann, V.2
Becker, G.3
Brueckner, L.M.4
Dreidax, D.5
Bannert, S.6
-
40
-
-
2942650133
-
The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation- dependent c-Myc protein degradation
-
Welcker M, Orian A, Jin J, Grim JE, Harper JW, Eisenman RN, et al. The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation- dependent c-Myc protein degradation. Proc Natl Acad Sci U S A 2004;101: 9085-90.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 9085-9090
-
-
Welcker, M.1
Orian, A.2
Jin, J.3
Grim, J.E.4
Harper, J.W.5
Eisenman, R.N.6
-
41
-
-
44649201561
-
The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein
-
Zhao X, Heng JI, Guardavaccaro D, Jiang R, Pagano M, Guillemot F, et al. The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein. Nat Cell Biol 2008;10: 643-53.
-
(2008)
Nat Cell Biol
, vol.10
, pp. 643-653
-
-
Zhao, X.1
Heng, J.I.2
Guardavaccaro, D.3
Jiang, R.4
Pagano, M.5
Guillemot, F.6
-
42
-
-
33846694864
-
Activation of Akt predicts poor outcome in neuroblastoma
-
Opel D, Poremba C, Simon T, Debatin KM, Fulda S. Activation of Akt predicts poor outcome in neuroblastoma. Cancer Res 2007;67: 735-45.
-
(2007)
Cancer Res
, vol.67
, pp. 735-745
-
-
Opel, D.1
Poremba, C.2
Simon, T.3
Debatin, K.M.4
Fulda, S.5
-
43
-
-
84879872430
-
A multicenter, first-in-pediatrics, phase 1, pharmacokinetic and pharmacodynamic study of ridaforolimus in patients with refractory solid tumors
-
Gore L, Trippett TM, Katzenstein H, Boklan J, Narendran A, Smith A, et al. A multicenter, first-in-pediatrics, phase 1, pharmacokinetic and pharmacodynamic study of ridaforolimus in patients with refractory solid tumors. Clin Cancer Res 2013;19: 3649-58.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 3649-3658
-
-
Gore, L.1
Trippett, T.M.2
Katzenstein, H.3
Boklan, J.4
Narendran, A.5
Smith, A.6
-
44
-
-
79959926021
-
ATP-competitive inhibitors of mTOR: An update
-
Schenone S, Brullo C, Musumeci F, Radi M, Botta M. ATP-competitive inhibitors of mTOR: an update. Curr Med Chem 2011;18: 2995-3014.
-
(2011)
Curr Med Chem
, vol.18
, pp. 2995-3014
-
-
Schenone, S.1
Brullo, C.2
Musumeci, F.3
Radi, M.4
Botta, M.5
-
45
-
-
77952931508
-
INK128 is a potent and selective TORC1/2 inhibitor with broad oral antitumor activity
-
Jessen K, Wang S, Kessler L, Guo X, Kucharski J, Staunton J, et al. INK128 is a potent and selective TORC1/2 inhibitor with broad oral antitumor activity. Mol Cancer Ther 2009;8:B148
-
(2009)
Mol Cancer Ther
, vol.8
-
-
Jessen, K.1
Wang, S.2
Kessler, L.3
Guo, X.4
Kucharski, J.5
Staunton, J.6
-
46
-
-
84876703624
-
AZD2014, a dualmTORC1 andmTORC2 inhibitor is differentiated from allosteric inhibitors ofmTORC1inER+breast cancer
-
Guichard SM, Howard Z, Heathcote D, Roth M, Hughes G, Curwen J, et al. AZD2014, a dualmTORC1 andmTORC2 inhibitor is differentiated from allosteric inhibitors ofmTORC1inER+breast cancer. Cancer Res 2012;72: 917.
-
(2012)
Cancer Res
, vol.72
, pp. 917
-
-
Guichard, S.M.1
Howard, Z.2
Heathcote, D.3
Roth, M.4
Hughes, G.5
Curwen, J.6
-
47
-
-
84863299954
-
Combination of an allosteric Akt Inhibitor MK-2206 with etoposide or rapamycin enhances the antitumor growth effect in neuroblastoma
-
Li Z, Yan S, Attayan N, Ramalingam S, Thiele CJ. Combination of an allosteric Akt Inhibitor MK-2206 with etoposide or rapamycin enhances the antitumor growth effect in neuroblastoma. Clin Cancer Res 2012;18: 3603-15.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 3603-3615
-
-
Li, Z.1
Yan, S.2
Attayan, N.3
Ramalingam, S.4
Thiele, C.J.5
-
48
-
-
84880042989
-
Small molecule inhibitors of aurora - A induce proteasomal degradation of N-myc in childhood neuroblastoma
-
Brockmann M, Poon E, Berry T, Carstensen A, Deubzer HE, Rycak L, et al. Small molecule inhibitors of aurora-a induce proteasomal degradation of N-myc in childhood neuroblastoma. Cancer Cell 2013;24: 75-89.
-
(2013)
Cancer Cell
, vol.24
, pp. 75-89
-
-
Brockmann, M.1
Poon, E.2
Berry, T.3
Carstensen, A.4
Deubzer, H.E.5
Rycak, L.6
-
49
-
-
77952703733
-
Initial testing of the aurora kinase A inhibitor MLN8237 by the Pediatric Preclinical Testing Program (PPTP)
-
Maris JM, Morton CL, Gorlick R, Kolb EA, Lock R, Carol H, et al. Initial testing of the aurora kinase A inhibitor MLN8237 by the Pediatric Preclinical Testing Program (PPTP). Pediatr Blood Cancer 2010;55: 26-34.
-
(2010)
Pediatr Blood Cancer
, vol.55
, pp. 26-34
-
-
Maris, J.M.1
Morton, C.L.2
Gorlick, R.3
Kolb, E.A.4
Lock, R.5
Carol, H.6
-
50
-
-
84868542839
-
Pediatric phase i trial and pharmacokinetic study of MLN8237, an investigational oral selective small-molecule inhibitor of Aurora kinase A: A Children's Oncology Group Phase i Consortium study
-
Mosse YP, Lipsitz E, Fox E, Teachey DT, Maris JM, Weigel B, et al. Pediatric phase I trial and pharmacokinetic study of MLN8237, an investigational oral selective small-molecule inhibitor of Aurora kinase A: a Children's Oncology Group Phase I Consortium study. Clin Cancer Res 2012;18: 6058-64.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 6058-6064
-
-
Mosse, Y.P.1
Lipsitz, E.2
Fox, E.3
Teachey, D.T.4
Maris, J.M.5
Weigel, B.6
-
51
-
-
61449106633
-
Long-term results for children with high-risk neuroblastoma treated on a randomized trial of myeloablative therapy followed by 13-cis-retinoic acid: A children's oncology group study
-
Matthay KK, Reynolds CP, Seeger RC, Shimada H, Adkins ES, Haas- Kogan D, et al. Long-term results for children with high-risk neuroblastoma treated on a randomized trial of myeloablative therapy followed by 13-cis-retinoic acid: a children's oncology group study. J Clin Oncol 2009;27: 1007-13.
-
(2009)
J Clin Oncol
, vol.27
, pp. 1007-1013
-
-
Matthay, K.K.1
Reynolds, C.P.2
Seeger, R.C.3
Shimada, H.4
Adkins, E.S.5
Haas- Kogan, D.6
-
52
-
-
0021947043
-
Decreased expression of N-myc precedes retinoic acid-induced morphological differentiation of human neuroblastoma
-
Thiele CJ, Reynolds CP, Israel MA. Decreased expression of N-myc precedes retinoic acid-induced morphological differentiation of human neuroblastoma. Nature 1985;313: 404-6.
-
(1985)
Nature
, vol.313
, pp. 404-406
-
-
Thiele, C.J.1
Reynolds, C.P.2
Israel, M.A.3
-
53
-
-
84868210731
-
LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression
-
Molenaar JJ, Domingo-Fernandez R, Ebus ME, Lindner S, Koster J, Drabek K, et al. LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression. Nat Genet 2012;44: 1199-206.
-
(2012)
Nat Genet
, vol.44
, pp. 1199-1206
-
-
Molenaar, J.J.1
Domingo-Fernandez, R.2
Ebus, M.E.3
Lindner, S.4
Koster, J.5
Drabek, K.6
-
54
-
-
81055126433
-
Differential inhibitor sensitivity of anaplastic lymphoma kinase variants found in neuroblastoma
-
Bresler SC,WoodAC, Haglund EA, Courtright J, Belcastro LT, Plegaria JS, et al.Differential inhibitor sensitivity of anaplastic lymphoma kinase variants found in neuroblastoma. Sci Transl Med 2011;3: 108ra14.
-
(2011)
Sci Transl Med
, vol.3
-
-
Scwoodac, B.1
Haglund, E.A.2
Courtright, J.3
Belcastro, L.T.4
Plegaria, J.S.5
-
56
-
-
84866934606
-
Activity and safety of crizotinib in patients with ALK-positive nonsmall- cell lung cancer: Updated results from a phase 1 study
-
Camidge DR, Bang YJ, Kwak EL, Iafrate AJ, Varella-Garcia M, Fox SB, et al. Activity and safety of crizotinib in patients with ALK-positive nonsmall- cell lung cancer: updated results from a phase 1 study. Lancet Oncol 2012;13: 1011-9.
-
(2012)
Lancet Oncol
, vol.13
, pp. 1011-1019
-
-
Camidge, D.R.1
Bang, Y.J.2
Kwak, E.L.3
Iafrate, A.J.4
Varella-Garcia, M.5
Fox, S.B.6
-
57
-
-
78049428879
-
Crizotinib in ALK-rearranged inflammatory myofibroblastic tumor
-
Butrynski JE, D'Adamo DR, Hornick JL, Dal Cin P, Antonescu CR, Jhanwar SC, et al. Crizotinib in ALK-rearranged inflammatory myofibroblastic tumor. N Engl J Med 2010;363: 1727-33.
-
(2010)
N Engl J Med
, vol.363
, pp. 1727-1733
-
-
Butrynski, J.E.1
D'Adamo, D.R.2
Hornick, J.L.3
Dal Cin, P.4
Antonescu, C.R.5
Jhanwar, S.C.6
-
58
-
-
84876966952
-
Safety and activity of crizotinib for paediatric patients with refractory solid tumours or anaplastic large-cell lymphoma: A Children's Oncology Group phase 1 consortium study
-
Mosse YP, Lim MS, Voss SD, Wilner K, Ruffner K, Laliberte J, et al. Safety and activity of crizotinib for paediatric patients with refractory solid tumours or anaplastic large-cell lymphoma: a Children's Oncology Group phase 1 consortium study. Lancet Oncol 2013;14: 472-80.
-
(2013)
Lancet Oncol
, vol.14
, pp. 472-480
-
-
Mosse, Y.P.1
Lim, M.S.2
Voss, S.D.3
Wilner, K.4
Ruffner, K.5
Laliberte, J.6
-
59
-
-
84866901075
-
First-in-human phase 1 study of the ALK inhibitor LDK378 in ALK+ solid tumors
-
(suppl; abstr 3007)
-
Mehra R, Camidge DR, Sharma S, Felip E, Tan DS, Vansteenkiste JF, et al. First-in-human phase 1 study of the ALK inhibitor LDK378 in ALK+ solid tumors. J Clin Oncol 30, 2012 (suppl; abstr 3007).
-
(2012)
J Clin Oncol
, vol.30
-
-
Mehra, R.1
Camidge, D.R.2
Sharma, S.3
Felip, E.4
Tan, D.S.5
Vansteenkiste, J.F.6
-
60
-
-
84878347085
-
CH5424802 (RO5424802) for patients with ALK-rearranged advanced non-small-cell lung cancer (AF-001JP study): A single-arm, open-label, phase 1-2 study
-
Seto T, Kiura K, Nishio M, Nakagawa K, Maemondo M, Inoue A, et al. CH5424802 (RO5424802) for patients with ALK-rearranged advanced non-small-cell lung cancer (AF-001JP study): a single-arm, open-label, phase 1-2 study. Lancet Oncol 2013;14: 590-8.
-
(2013)
Lancet Oncol
, vol.14
, pp. 590-598
-
-
Seto, T.1
Kiura, K.2
Nishio, M.3
Nakagawa, K.4
Maemondo, M.5
Inoue, A.6
-
61
-
-
79956318797
-
Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK
-
Katayama R, Khan TM, Benes C, Lifshits E, Ebi H, Rivera VM, et al. Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK. Proc Natl Acad Sci U S A 2011;108: 7535-40.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 7535-7540
-
-
Katayama, R.1
Khan, T.M.2
Benes, C.3
Lifshits, E.4
Ebi, H.5
Rivera, V.M.6
-
62
-
-
33947236179
-
CD4 T-helper responses to the anaplastic lymphoma kinase (ALK) protein in patients with ALKpositive anaplastic large-cell lymphoma
-
Ait-Tahar K, Barnardo MC, Pulford K. CD4 T-helper responses to the anaplastic lymphoma kinase (ALK) protein in patients with ALKpositive anaplastic large-cell lymphoma. Cancer Res 2007;67: 1898-901.
-
(2007)
Cancer Res
, vol.67
, pp. 1898-1901
-
-
Ait-Tahar, K.1
Barnardo, M.C.2
Pulford, K.3
-
63
-
-
22544440004
-
Activation and inhibition of anaplastic lymphoma kinase receptor tyrosine kinase by monoclonal antibodies and absence of agonist activity of pleiotrophin
-
Moog-Lutz C, Degoutin J, Gouzi JY, Frobert Y, Brunet-de Carvalho N, Bureau J, et al. Activation and inhibition of anaplastic lymphoma kinase receptor tyrosine kinase by monoclonal antibodies and absence of agonist activity of pleiotrophin. J Biol Chem 2005; 280: 26039-48.
-
(2005)
J Biol Chem
, vol.280
, pp. 26039-26048
-
-
Moog-Lutz, C.1
Degoutin, J.2
Gouzi, J.Y.3
Frobert, Y.4
Brunet-De Carvalho, N.5
Bureau, J.6
-
64
-
-
84869502105
-
Antibody targeting of anaplastic lymphoma kinase induces cytotoxicity of human neuroblastoma
-
Carpenter EL, Haglund EA, Mace EM, Deng D, Martinez D, Wood AC, et al. Antibody targeting of anaplastic lymphoma kinase induces cytotoxicity of human neuroblastoma. Oncogene 2012; 31: 4859-67.
-
(2012)
Oncogene
, vol.31
, pp. 4859-4867
-
-
Carpenter, E.L.1
Haglund, E.A.2
MacE, E.M.3
Deng, D.4
Martinez, D.5
Wood, A.C.6
-
65
-
-
80051720194
-
Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia
-
Porter DL, Levine BL, Kalos M, Bagg A, June CH. Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. N Engl J Med 2011;365: 725-33.
-
(2011)
N Engl J Med
, vol.365
, pp. 725-733
-
-
Porter, D.L.1
Levine, B.L.2
Kalos, M.3
Bagg, A.4
June, C.H.5
-
66
-
-
84863753157
-
The ALK(F1174L) mutation potentiates the oncogenic activity of MYCN in neuroblastoma
-
Berry T, Luther W, Bhatnagar N, Jamin Y, Poon E, Sanda T, et al. The ALK(F1174L) mutation potentiates the oncogenic activity of MYCN in neuroblastoma. Cancer Cell 2012;22: 117-30.
-
(2012)
Cancer Cell
, vol.22
, pp. 117-130
-
-
Berry, T.1
Luther, W.2
Bhatnagar, N.3
Jamin, Y.4
Poon, E.5
Sanda, T.6
-
67
-
-
77956244494
-
Meta-analysis of neuroblastomas reveals a skewed ALK mutation spectrum in tumors with MYCN amplification
-
De Brouwer S, De Preter K,KumpsC, Zabrocki P, Porcu M, Westerhout EM, et al. Meta-analysis of neuroblastomas reveals a skewed ALK mutation spectrum in tumors with MYCN amplification. Clin Cancer Res 2010;16: 4353-62.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 4353-4362
-
-
De Brouwer, S.1
De Preter Kkumpsc2
Zabrocki, P.3
Porcu, M.4
Westerhout, E.M.5
-
68
-
-
84863569496
-
Targeted expression of mutated ALK induces neuroblastoma in transgenic mice
-
Heukamp LC, Thor T, Schramm A, De Preter K, Kumps C, De Wilde B, et al. Targeted expression of mutated ALK induces neuroblastoma in transgenic mice. Sci Transl Med 2012;4: 141ra91.
-
(2012)
Sci Transl Med
, vol.4
-
-
Heukamp, L.C.1
Thor, T.2
Schramm, A.3
De Preter, K.4
Kumps, C.5
De Wilde, B.6
-
69
-
-
84863343584
-
Activated ALK collaborates with MYCN in neuroblastoma pathogenesis
-
Zhu S, Lee JS, Guo F, Shin J, Perez-Atayde AR, Kutok JL, et al. Activated ALK collaborates with MYCN in neuroblastoma pathogenesis. Cancer Cell 2012;21: 362-73.
-
(2012)
Cancer Cell
, vol.21
, pp. 362-373
-
-
Zhu, S.1
Lee, J.S.2
Guo, F.3
Shin, J.4
Perez-Atayde, A.R.5
Kutok, J.L.6
-
70
-
-
84871212519
-
Anaplastic Lymphoma Kinase (ALK) regulates initiation of transcription of MYCN in neuroblastoma cells
-
Schonherr C,Ruuth K,Kamaraj S,WangCL,Yang HL,Combaret V, et al. Anaplastic Lymphoma Kinase (ALK) regulates initiation of transcription of MYCN in neuroblastoma cells. Oncogene 2012;31: 5193-200.
-
(2012)
Oncogene
, vol.31
, pp. 5193-5200
-
-
Schonherr, C.1
Ruuth, K.2
Kamaraj, S.3
Wang, C.L.4
Yang, H.L.5
Combaret, V.6
|