Histone H3.3 mutations drive pediatric glioblastoma through upregulation of MYCN

Cancer Discovery

Volumn 3, Issue 5, 2013, Pages 512-519

  Bjerke, Lynn ^a   Mackay, Alan ^a   Nandhabalan, Meera ^a   Burford, Anna ^a   Jury, Alexa ^a   Popov, Sergey ^a   Bax, Dorine A ^a   Carvalho, Diana ^a,d,e   Taylor, Kathryn R ^a   Vinci, Maria ^a   Bajrami, Ilirjana ^a   McGonnell, Imelda M ^b   Lord, Christopher J ^a   Reis, Rui M ^e,f   Hargrave, Darren ^c   Ashworth, Alan ^a   Workman, Paul ^a   Jones, Chris ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b ROYAL VETERINARY COLLEGE   (United Kingdom)

^c GREAT ORMOND STREET HOSPITAL   (United Kingdom)

^d UNIVERSITY OF COIMBRA   (Portugal)

^e UNIVERSITY OF MINHO   (Portugal)

^f BARRETOS CANCER HOSPITAL   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE H3; HISTONE H3F3A; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; HISTONE; MYCN PROTEIN, HUMAN; NUCLEAR PROTEIN; ONCOPROTEIN; PROTEIN BINDING;

ARTICLE; CELL SCREENING; CELL VIABILITY; CHROMATIN IMMUNOPRECIPITATION; CLINICAL ARTICLE; DNA SEQUENCE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GLIOBLASTOMA; HIGH THROUGHPUT SEQUENCING; HISTONE METHYLATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; POLYMERASE CHAIN REACTION; SURVIVAL RATE; TISSUE MICROARRAY; UPREGULATION; ADOLESCENT; BIOLOGY; CHILD; CLUSTER ANALYSIS; DNA MUTATIONAL ANALYSIS; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; GENOTYPE; INFORMATION PROCESSING; METABOLISM; MUTATION; NUCLEIC ACID DATABASE; PATHOLOGY; TUMOR CELL LINE;

ADOLESCENT; CELL LINE, TUMOR; CHILD; CHROMATIN IMMUNOPRECIPITATION; CLUSTER ANALYSIS; COMPUTATIONAL BIOLOGY; DATABASES, NUCLEIC ACID; DATASETS AS TOPIC; DNA MUTATIONAL ANALYSIS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENOTYPE; GLIOBLASTOMA; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HISTONES; HUMANS; MUTATION; NUCLEAR PROTEINS; ONCOGENE PROTEINS; PROTEIN BINDING; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 84877621282     PISSN: 21598274     EISSN: 21598290     Source Type: Journal    
DOI: 10.1158/2159-8290.CD-12-0426     Document Type: Article

References (25)

1. Jones C, Perryman L, Hargrave D. Paediatric and adult malignant glioma: close relatives or distant cousins? Nat Rev Clin Oncol 2012; 9: 400-13.
2. Schwartzentruber J, Korshunov A, Liu XY, Jones DT, Pfaff E, Jacob K, et al. Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature 2012; 482: 226-31.
3. Paugh BS, Qu C, Jones C, Liu Z, Adamowicz-Brice M, Zhang J, et al. Integrated molecular genetic profi ling of pediatric high-grade gliomas reveals key differences with the adult disease. J Clin Oncol 2010; 28: 3061-8.
4. Bax DA, Mackay A, Little SE, Carvalho D, Viana-Pereira M, Tamber N, et al. Molecular and phenotypic characterisation of paediatric glioma cell lines as models for preclinical drug development. PloS ONE 2009; 4: e5209.
5. Wagner EJ, Carpenter PB. Understanding the language of Lys36 methylation at histone H3. Nat Rev Mol Cell Biol 2012; 13: 115-26.
6. Kang HJ, Kawasawa YI, Cheng F, Zhu Y, Xu X, Li M, et al. Spatiotemporal transcriptome of the human brain. Nature 2011; 478: 483-9.
7. Panganiban G, Rubenstein JL. Developmental functions of the Distal-less/Dlx homeobox genes. Development 2002; 129: 4371-86.
8. Kitamura K, Yanazawa M, Sugiyama N, Miura H, Iizuka-Kogo A, Kuaka M, et al. Mutation of ARX causes abnormal development of forebrain and testes in mice and X-linked lissencephaly with abnormal genitalia in humans. Nat Genet 2002; 32: 359-69.
9. Chatterjee S, Bourque G, Lufkin T. Conserved and non-conserved enhancers direct tissue specifi c transcription in ancient germ layer specifi c developmental control genes. BMC Dev Biol 2011; 11: 63.
10. Monaghan AP, Bock D, Gass P, Schwaeger A, Wolfer DP, Lipp HP, et al. Defective limbic system in mice lacking the tailless gene. Nature 1997; 390: 515-7.
11. McEvilly RJ, de Diaz MO, Schonemann MD, Hooshmand F, Rosenfeld MG. Transcriptional regulation of cortical neuron migration by POU domain factors. Science 2002; 295: 1528-32.
12. Zembrzycki A, Griesel G, Stoykova A, Mansouri A. Genetic interplay between the transcription factors Sp8 and Emx2 in the patterning of the forebrain. Neural Dev 2007; 2: 8.
13. Okano H, Kawahara H, Toriya M, Nakao K, Shibata S, Imai T. Function of RNA-binding protein Musashi-1 in stem cells. Exp Cell Res 2005; 306: 349-56.
14. Li X, Oghi KA, Zhang J, Krones A, Bush KT, Glass CK, et al. Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis. Nature 2003; 426: 247-54.
15. Khuong-Quang DA, Buczkowicz P, Rakopoulos P, Liu XY, Fontebasso AM, Bouffet E, et al. K27M mutation in histone H3.3 defi nes clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas. Acta Neuropathol 2012; 124: 439-7.
16. Gustafson WC, Weiss WA. Myc proteins as therapeutic targets. Oncogene 2010; 29: 1249-59.
17. Cole KA, Huggins J, Laquaglia M, Hulderman CE, Russell MR, Bosse K, et al. RNAi screen of the protein kinome identifi es checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma. Proc Natl Acad Sci U S A 2011; 108: 3336-41.
18. Otto T, Horn S, Brockmann M, Eilers U, Schuettrumpf L, Popov N, et al. Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma. Cancer Cell 2009; 15: 67-78.
19. Shimomura T, Hasako S, Nakatsuru Y, Mita T, Ichikawa K, Kodera T, et al. MK-5108, a highly selective Aurora-A kinase inhibitor, shows antitumor activity alone and in combination with docetaxel. Mol Cancer Ther 2010; 9: 157-66.
20. Miyoshi G, Hjerling-Leffler J, Karayannis T, Sousa VH, Butt SJ, Battiste J, et al. Genetic fate mapping reveals that the caudal ganglionic eminence produces a large and diverse population of superfi cial cortical interneurons. J Neurosci 2010; 30: 1582-94.
21. Johnson RA, Wright KD, Poppleton H, Mohankumar KM, Finkelstein D, Pounds SB, et al. Cross-species genomics matches driver mutations and cell compartments to model ependymoma. Nature 2010; 466: 632-6.
22. Gibson P, Tong Y, Robinson G, Thompson MC, Currle DS, Eden C, et al. Subtypes of medulloblastoma have distinct developmental origins. Nature 2010; 468: 1095-9.
23. Gaspar N, Marshall L, Perryman L, Bax DA, Little SE, Viana-Pereira M, et al. MGMT-independent temozolomide resistance in pediatric glioblastoma cells associated with a PI3-kinase-mediated HOX/stem cell gene signature. Cancer Res 2010; 70: 9243-52.
24. Swartling FJ, Savov V, Persson AI, Chen J, Hackett CS, Northcott PA, et al. Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC. Cancer Cell 2012; 21: 601-13.
25. Phoenix TN, Gilbertson RJ. There's a time and a place for MYCN. Cancer Cell 2012; 21: 593-5.