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Volumn 42, Issue 2, 2011, Pages 76-84

Pancreatic ductal adenocarcinoma and transcription factors: Role of c-Myc

Author keywords

c Myc; Ela myc transgenic mouse; Pancreatic development; Pancreatic ductal adenocarcinoma; Transcription factor

Indexed keywords

PROTEIN P16; PROTEIN P53; SMAD4 PROTEIN; TRANSCRIPTION FACTOR;

EID: 79956207689     PISSN: 19416628     EISSN: 19416636     Source Type: Journal    
DOI: 10.1007/s12029-011-9258-0     Document Type: Article
Times cited : (48)

References (78)
  • 1
    • 52149123619 scopus 로고    scopus 로고
    • Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    • 18772397 10.1126/science.1164368 1:CAS:528:DC%2BD1cXhtFCrtLrL
    • S Jones X Zhang DW Parsons, et al. 2008 Core signaling pathways in human pancreatic cancers revealed by global genomic analyses Science 321 1801 1806 18772397 10.1126/science.1164368 1:CAS:528:DC%2BD1cXhtFCrtLrL
    • (2008) Science , vol.321 , pp. 1801-1806
    • Jones, S.1    Zhang, X.2    Parsons, D.W.3
  • 2
    • 0036469065 scopus 로고    scopus 로고
    • Transcription: Signal transduction and the control of gene expression
    • DOI 10.1126/science.1066355
    • AH Brivanlou JE Darnell 2002 Signal transduction and the control of gene expression Science 295 813 818 11823631 10.1126/science.1066355 1:CAS:528:DC%2BD38XhtFams70%3D (Pubitemid 34118354)
    • (2002) Science , vol.295 , Issue.5556 , pp. 813-818
    • Brivanlou, A.H.1    Darnell Jr., J.E.2
  • 3
    • 56749184298 scopus 로고    scopus 로고
    • Reflecting on 25 years with MYC
    • 19029958 10.1038/nrc2231 1:CAS:528:DC%2BD1cXhsVWhu7rJ
    • N Meyer LZ Penn 2008 Reflecting on 25 years with MYC Nat Rev Cancer 8 976 990 19029958 10.1038/nrc2231 1:CAS:528:DC%2BD1cXhsVWhu7rJ
    • (2008) Nat Rev Cancer , vol.8 , pp. 976-990
    • Meyer, N.1    Penn, L.Z.2
  • 4
    • 0000538165 scopus 로고
    • Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells
    • DOI 10.1073/pnas.79.24.7824
    • R Dalla-Favera M Bregni J Erikson D Patterson RC Gallo CM Croce 1982 Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells Proc Natl Acad Sci U S A 79 7824 7827 6961453 10.1073/pnas.79.24.7824 1:CAS:528:DyaL3sXkslyqtQ%3D%3D (Pubitemid 13182471)
    • (1982) Proceedings of the National Academy of Sciences of the United States of America , vol.79 , Issue.24 , pp. 7824-7827
    • Dalla-Favera, R.1    Bregni, M.2    Erikson, J.3
  • 5
    • 0001292985 scopus 로고
    • Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells
    • DOI 10.1073/pnas.79.24.7837
    • R Taub I Kirsch C Morton G Lenoir D Swan S Tronick S Aaronson P Leder 1982 Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells Proc Natl Acad Sci U S A 79 7837 7841 6818551 10.1073/pnas.79.24.7837 1:CAS:528:DyaL3sXms1emtg%3D%3D (Pubitemid 13182474)
    • (1982) Proceedings of the National Academy of Sciences of the United States of America , vol.79 , Issue.24 , pp. 7837-7841
    • Taub, R.1    Kirsch, I.2    Morton, C.3
  • 6
    • 3042781552 scopus 로고    scopus 로고
    • Analysis of genomic targets reveals complex functions of MYC
    • JH Patel AP Loboda MK Showe LC Showe SB McMahon 2004 Analysis of genomic targets reveals complex functions of MYC Nat Rev Cancer 4 562 568 15229481 10.1038/nrc1393 1:CAS:528:DC%2BD2cXlt1Oktrc%3D (Pubitemid 38868625)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.7 , pp. 562-568
    • Patel, J.H.1    Loboda, A.P.2    Showe, M.K.3    Showe, L.C.4    McMahon, S.B.5
  • 7
    • 54349087788 scopus 로고    scopus 로고
    • Myc's broad reach
    • 18923074 10.1101/gad.1712408 1:CAS:528:DC%2BD1cXht12ht7zE
    • M Eilers RN Eisenman 2008 Myc's broad reach Genes Dev 22 2755 2766 18923074 10.1101/gad.1712408 1:CAS:528:DC%2BD1cXht12ht7zE
    • (2008) Genes Dev , vol.22 , pp. 2755-2766
    • Eilers, M.1    Eisenman, R.N.2
  • 9
    • 33947285072 scopus 로고    scopus 로고
    • The Myc transactivation domain promotes global phosphorylation of the RNA polymerase II carboxy-terminal domain independently of direct DNA binding
    • DOI 10.1128/MCB.01828-06
    • VH Cowling MD Cole 2007 The Myc transactivation domain promotes global phosphorylation of the RNA polymerase II carboxy-terminal domain independently of direct DNA binding Mol Cell Biol 27 2059 2073 17242204 10.1128/MCB.01828-06 1:CAS:528:DC%2BD2sXjsVSrsrc%3D (Pubitemid 46418464)
    • (2007) Molecular and Cellular Biology , vol.27 , Issue.6 , pp. 2059-2073
    • Cowling, V.H.1    Cole, M.D.2
  • 10
    • 33845919326 scopus 로고    scopus 로고
    • The ins and outs of MYC regulation by posttranslational mechanisms
    • DOI 10.1074/jbc.R600017200
    • J Vervoorts J Luscher-Firzlaff B Luscher 2006 The ins and outs of MYC regulation by posttranslational mechanisms J Biol Chem 281 34725 34729 16987807 10.1074/jbc.R600017200 1:CAS:528:DC%2BD28XhtF2gtbrK (Pubitemid 46036511)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.46 , pp. 34725-34729
    • Vervoorts, J.1    Luscher-Firzlaff, J.2    Luscher, B.3
  • 11
    • 56849087082 scopus 로고    scopus 로고
    • Ratcheting Myc
    • 19061831 10.1016/j.ccr.2008.11.008 1:CAS:528:DC%2BD1cXhsFahsrfN
    • BW Freie RN Eisenman 2008 Ratcheting Myc Cancer Cell 14 425 426 19061831 10.1016/j.ccr.2008.11.008 1:CAS:528:DC%2BD1cXhsFahsrfN
    • (2008) Cancer Cell , vol.14 , pp. 425-426
    • Freie, B.W.1    Eisenman, R.N.2
  • 14
    • 0032575705 scopus 로고    scopus 로고
    • A matter of life and cell death
    • G Evan T Littlewood 1998 A matter of life and cell death Science 281 1317 1322 9721090 10.1126/science.281.5381.1317 1:CAS:528:DyaK1cXlvVegsLY%3D (Pubitemid 28406818)
    • (1998) Science , vol.281 , Issue.5381 , pp. 1317-1322
    • Evan, G.1    Littlewood, T.2
  • 15
    • 9244224723 scopus 로고    scopus 로고
    • Intrinsic tumour suppression
    • DOI 10.1038/nature03098
    • SW Lowe E Cepero G Evan 2004 Intrinsic tumour suppression Nature 432 307 315 15549092 10.1038/nature03098 1:CAS:528:DC%2BD2cXpvVCjtLg%3D (Pubitemid 39551658)
    • (2004) Nature , vol.432 , Issue.7015 , pp. 307-315
    • Lowe, S.W.1    Cepero, E.2    Evan, G.3
  • 16
    • 16844364151 scopus 로고    scopus 로고
    • LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism
    • DOI 10.1242/dev.01670
    • P Cartwright C McLean A Sheppard D Rivett K Jones S Dalton 2005 LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism Development 132 885 896 15673569 10.1242/dev.01670 1:CAS:528: DC%2BD2MXjtFCht7k%3D (Pubitemid 40484924)
    • (2005) Development , vol.132 , Issue.5 , pp. 885-896
    • Cartwright, P.1    McLean, C.2    Sheppard, A.3    Rivett, D.4    Jones, K.5    Dalton, S.6
  • 17
    • 0037108268 scopus 로고    scopus 로고
    • N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation
    • 12381668 10.1101/gad.1021202 1:CAS:528:DC%2BD38XotFeksr4%3D
    • PS Knoepfler PF Cheng RN Eisenman 2002 N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation Genes Dev 16 2699 2712 12381668 10.1101/gad.1021202 1:CAS:528:DC%2BD38XotFeksr4%3D
    • (2002) Genes Dev , vol.16 , pp. 2699-2712
    • Knoepfler, P.S.1    Cheng, P.F.2    Eisenman, R.N.3
  • 18
    • 0035901594 scopus 로고    scopus 로고
    • c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny
    • DOI 10.1016/S0960-9822(01)00154-3
    • I Arnold FM Watt 2001 c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny Curr Biol 11 558 568 11369200 10.1016/S0960-9822(01)00154-3 1:CAS:528: DC%2BD3MXjtlenurc%3D (Pubitemid 32324758)
    • (2001) Current Biology , vol.11 , Issue.8 , pp. 558-568
    • Arnold, I.1    Watt, F.M.2
  • 19
    • 0034978920 scopus 로고    scopus 로고
    • Deregulated expression of c-Myc depletes epidermal stem cells
    • DOI 10.1038/88889
    • RL Waikel Y Kawachi PA Waikel XJ Wang DR Roop 2001 Deregulated expression of c-Myc depletes epidermal stem cells Nat Genet 28 165 168 11381265 10.1038/88889 1:CAS:528:DC%2BD3MXktFOrtLc%3D (Pubitemid 32538063)
    • (2001) Nature Genetics , vol.28 , Issue.2 , pp. 165-168
    • Waikel, R.L.1    Kawachi, Y.2    Waikel, P.A.3    Wang, X.-J.4    Roop, D.R.5
  • 22
    • 58549093915 scopus 로고    scopus 로고
    • Developmental biology of the pancreas: A comprehensive review
    • 19013144 10.1016/j.ydbio.2008.10.024 1:CAS:528:DC%2BD1MXhtlKgs7o%3D
    • GK Gittes 2009 Developmental biology of the pancreas: a comprehensive review Dev Biol 326 4 35 19013144 10.1016/j.ydbio.2008.10.024 1:CAS:528:DC%2BD1MXhtlKgs7o%3D
    • (2009) Dev Biol , vol.326 , pp. 4-35
    • Gittes, G.K.1
  • 23
    • 58749102383 scopus 로고    scopus 로고
    • Genes controlling pancreas ontogeny
    • 18956314 10.1387/ijdb.072444cb 1:CAS:528:DC%2BD1cXhsVKju7jE
    • C Bonal PL Herrera 2008 Genes controlling pancreas ontogeny Int J Dev Biol 52 823 835 18956314 10.1387/ijdb.072444cb 1:CAS:528:DC%2BD1cXhsVKju7jE
    • (2008) Int J Dev Biol , vol.52 , pp. 823-835
    • Bonal, C.1    Herrera, P.L.2
  • 24
    • 0348047628 scopus 로고    scopus 로고
    • Gene Regulatory Factors in Pancreatic Development
    • DOI 10.1002/dvdy.10460
    • J Jensen 2004 Gene regulatory factors in pancreatic development Dev Dyn 229 176 200 14699589 10.1002/dvdy.10460 1:CAS:528:DC%2BD2cXht1egsLw%3D (Pubitemid 38036833)
    • (2004) Developmental Dynamics , vol.229 , Issue.1 , pp. 176-200
    • Jensen, J.1
  • 25
    • 45849093670 scopus 로고    scopus 로고
    • The what, where, when and how of Wnt/β-catenin signaling in pancreas development
    • LC Murtaugh 2008 The what, where, when and how of Wnt/beta-catenin signaling in pancreas development Organogenesis 4 81 86 18953422 10.4161/org.4.2.5853 (Pubitemid 351881304)
    • (2008) Organogenesis , vol.4 , Issue.2 , pp. 81-86
    • Murtaugh, L.C.1
  • 28
    • 25844530871 scopus 로고    scopus 로고
    • Attenuated Wnt signaling perturbs pancreatic growth but not pancreatic function
    • DOI 10.2337/diabetes.54.10.2844
    • S Papadopoulou H Edlund 2005 Attenuated Wnt signaling perturbs pancreatic growth but not pancreatic function Diabetes 54 2844 2851 16186384 10.2337/diabetes.54.10.2844 1:CAS:528:DC%2BD2MXhtV2rs77P (Pubitemid 41401078)
    • (2005) Diabetes , vol.54 , Issue.10 , pp. 2844-2851
    • Papadopoulou, S.1    Edlund, H.2
  • 29
    • 34250893048 scopus 로고    scopus 로고
    • A Multipotent Progenitor Domain Guides Pancreatic Organogenesis
    • DOI 10.1016/j.devcel.2007.06.001, PII S1534580707002316
    • Q Zhou AC Law J Rajagopal WJ Anderson PA Gray DA Melton 2007 A multipotent progenitor domain guides pancreatic organogenesis Dev Cell 13 103 114 17609113 10.1016/j.devcel.2007.06.001 1:CAS:528:DC%2BD2sXns1yiurc%3D (Pubitemid 46972038)
    • (2007) Developmental Cell , vol.13 , Issue.1 , pp. 103-114
    • Zhou, Q.1    Law, A.C.2    Rajagopal, J.3    Anderson, W.J.4    Gray, P.A.5    Melton, D.A.6
  • 30
    • 0036777339 scopus 로고    scopus 로고
    • Signaling and transcriptional control of pancreatic organogenesis
    • DOI 10.1016/S0959-437X(02)00338-6
    • SK Kim RJ MacDonald 2002 Signaling and transcriptional control of pancreatic organogenesis Curr Opin Genet Dev 12 540 547 12200159 10.1016/S0959-437X(02)00338-6 1:CAS:528:DC%2BD38XmsVChsbo%3D (Pubitemid 35013536)
    • (2002) Current Opinion in Genetics and Development , vol.12 , Issue.5 , pp. 540-547
    • Kim, S.K.1    MacDonald, R.J.2
  • 31
    • 33745084564 scopus 로고    scopus 로고
    • Stabilization of β-catenin impacts pancreas growth
    • DOI 10.1242/dev.02366
    • PW Heiser J Lau MM Taketo PL Herrera M Hebrok 2006 Stabilization of beta-catenin impacts pancreas growth Development 133 2023 2032 16611688 10.1242/dev.02366 1:CAS:528:DC%2BD28XmtV2itb8%3D (Pubitemid 43881267)
    • (2006) Development , vol.133 , Issue.10 , pp. 2023-2032
    • Heiser, P.W.1    Lau, J.2    Taketo, M.M.3    Herrera, P.L.4    Hebrok, M.5
  • 33
    • 59849105832 scopus 로고    scopus 로고
    • Pancreatic inactivation of c-Myc decreases acinar mass and transdifferentiates acinar cells into adipocytes in mice
    • 19022256 10.1053/j.gastro.2008.10.015 1:CAS:528:DC%2BD1MXht1Cqs7Y%3D
    • C Bonal F Thorel A Ait-Lounis W Reith A Trumpp PL Herrera 2009 Pancreatic inactivation of c-Myc decreases acinar mass and transdifferentiates acinar cells into adipocytes in mice Gastroenterology 136 309 319 19022256 10.1053/j.gastro.2008.10.015 1:CAS:528:DC%2BD1MXht1Cqs7Y%3D
    • (2009) Gastroenterology , vol.136 , pp. 309-319
    • Bonal, C.1    Thorel, F.2    Ait-Lounis, A.3    Reith, W.4    Trumpp, A.5    Herrera, P.L.6
  • 34
    • 58149402376 scopus 로고    scopus 로고
    • Conditional inactivation of Myc impairs development of the exocrine pancreas
    • 18715949 10.1242/dev.017137 1:CAS:528:DC%2BD1cXhtlCntbrF
    • H Nakhai JT Siveke L Mendoza-Torres RM Schmid 2008 Conditional inactivation of Myc impairs development of the exocrine pancreas Development 135 3191 3196 18715949 10.1242/dev.017137 1:CAS:528:DC%2BD1cXhtlCntbrF
    • (2008) Development , vol.135 , pp. 3191-3196
    • Nakhai, H.1    Siveke, J.T.2    Mendoza-Torres, L.3    Schmid, R.M.4
  • 40
    • 0022641345 scopus 로고
    • Amplifications of both c-Ki-ras with a point mutation and c- myc in a primary pancreatic cancer and its metastatic tumors in lymph nodes
    • H Yamada H Sakamoto M Taira S Nishimura Y Shimosato M Terada T Sugimura 1986 Amplifications of both c-Ki-ras with a point mutation and c- myc in a primary pancreatic cancer and its metastatic tumors in lymph nodes Jpn J Cancer Res 77 370 375 3009377 1:CAS:528:DyaL28Xit1akt7g%3D (Pubitemid 16095449)
    • (1986) Japanese Journal of Cancer Research , vol.77 , Issue.4 , pp. 370-375
    • Yamada, H.1    Sakamoto, H.2    Taira, M.3
  • 43
    • 6844258849 scopus 로고    scopus 로고
    • Chromosomal imbalances in primary and metastatic pancreatic carcinoma as detected by interphase cytogenetics: Basic findings and clinical aspects
    • N Zojer M Fiegl L Mullauer A Chott S Roka J Ackermann M Raderer H Kaufmann A Reiner H Huber J Drach 1998 Chromosomal imbalances in primary and metastatic pancreatic carcinoma as detected by interphase cytogenetics: basic findings and clinical aspects Br J Cancer 77 1337 1342 9579843 10.1038/bjc.1998.223 1:STN:280:DyaK1c3jvFCntA%3D%3D (Pubitemid 28140626)
    • (1998) British Journal of Cancer , vol.77 , Issue.8 , pp. 1337-1342
    • Zojer, N.1    Fiegl, M.2    Mullauer, L.3    Chott, A.4    Roka, S.5    Ackermann, J.6    Raderer, M.7    Kaufmann, H.8    Reiner, A.9    Huber, H.10    Drach, J.11
  • 44
    • 17444408560 scopus 로고    scopus 로고
    • Beta-catenin up-regulates the expression of cyclinD1, c-myc and MMP-7 in human pancreatic cancer: Relationships with carcinogenesis and metastasis
    • 15810077 1:CAS:528:DC%2BD2MXktlWrsbc%3D
    • YJ Li ZM Wei YX Meng XR Ji 2005 Beta-catenin up-regulates the expression of cyclinD1, c-myc and MMP-7 in human pancreatic cancer: relationships with carcinogenesis and metastasis World J Gastroenterol 11 2117 2123 15810077 1:CAS:528:DC%2BD2MXktlWrsbc%3D
    • (2005) World J Gastroenterol , vol.11 , pp. 2117-2123
    • Li, Y.J.1    Wei, Z.M.2    Meng, Y.X.3    Ji, X.R.4
  • 45
    • 49849101934 scopus 로고    scopus 로고
    • Pancreatic ductal adenocarcinoma: Cellular origin, signaling pathways and stroma contribution
    • 18724072 10.1159/000151537
    • I Hernandez-Munoz A Skoudy FX Real P Navarro 2008 Pancreatic ductal adenocarcinoma: cellular origin, signaling pathways and stroma contribution Pancreatology 8 462 469 18724072 10.1159/000151537
    • (2008) Pancreatology , vol.8 , pp. 462-469
    • Hernandez-Munoz, I.1    Skoudy, A.2    Real, F.X.3    Navarro, P.4
  • 48
    • 0033991993 scopus 로고    scopus 로고
    • DNA copy number changes and evaluation of MYC, IGF1R, and FES amplification in xenografts of pancreatic adenocarcinoma
    • 10640145 10.1016/S0165-4608(99)00118-1 1:CAS:528:DyaK1MXotVKrtLc%3D
    • G Armengol S Knuutila F Lluis G Capella R Miro MR Caballin 2000 DNA copy number changes and evaluation of MYC, IGF1R, and FES amplification in xenografts of pancreatic adenocarcinoma Cancer Genet Cytogenet 116 133 141 10640145 10.1016/S0165-4608(99)00118-1 1:CAS:528:DyaK1MXotVKrtLc%3D
    • (2000) Cancer Genet Cytogenet , vol.116 , pp. 133-141
    • Armengol, G.1    Knuutila, S.2    Lluis, F.3    Capella, G.4    Miro, R.5    Caballin, M.R.6
  • 49
    • 0036229486 scopus 로고    scopus 로고
    • c-MYC activation in primary and metastatic ductal adenocarcinoma of the pancreas: Incidence, mechanisms, and clinical significance
    • DOI 10.1038/modpathol.3880547
    • C Schleger C Verbeke R Hildenbrand H Zentgraf U Bleyl 2002 c-MYC activation in primary and metastatic ductal adenocarcinoma of the pancreas: incidence, mechanisms, and clinical significance Mod Pathol 15 462 469 11950922 10.1038/modpathol.3880547 1:STN:280:DC%2BD383hsVGhsQ%3D%3D (Pubitemid 34326956)
    • (2002) Modern Pathology , vol.15 , Issue.4 , pp. 462-469
    • Schleger, C.1    Verbeke, C.2    Hildenbrand, R.3    Zentgraf, H.4    Bleyl, U.5
  • 50
    • 0033551374 scopus 로고    scopus 로고
    • MYC oncogenes and human neoplastic disease
    • DOI 10.1038/sj.onc.1202746
    • CE Nesbit JM Tersak EV Prochownik 1999 MYC oncogenes and human neoplastic disease Oncogene 18 3004 3016 10378696 10.1038/sj.onc.1202746 1:CAS:528:DyaK1MXjs12qtLg%3D (Pubitemid 29276540)
    • (1999) Oncogene , vol.18 , Issue.19 , pp. 3004-3016
    • Nesbit, C.E.1    Tersak, J.M.2    Prochownik, E.V.3
  • 51
    • 0022462112 scopus 로고
    • Gene amplification of c-myc and N-myc in small cell carcinoma of the lung
    • AJ Wong JM Ruppert J Eggleston SR Hamilton SB Baylin B Vogelstein 1986 Gene amplification of c-myc and N-myc in small cell carcinoma of the lung Science 233 461 464 3014659 10.1126/science.3014659 1:CAS:528:DyaL28XkslKrt7s%3D (Pubitemid 16046305)
    • (1986) Science , vol.233 , Issue.4762 , pp. 461-464
    • Wong, A.J.1    Ruppert, J.M.2    Eggleston, J.3
  • 52
  • 53
    • 33747616250 scopus 로고    scopus 로고
    • 2+/calcineurin signaling pathway
    • DOI 10.1038/sj.emboj.7601246, PII 7601246
    • M Buchholz A Schatz M Wagner P Michl T Linhart G Adler TM Gress V Ellenrieder 2006 Overexpression of c-myc in pancreatic cancer caused by ectopic activation of NFATc1 and the Ca2+/calcineurin signaling pathway EMBO J 25 3714 3724 16874304 10.1038/sj.emboj.7601246 1:CAS:528:DC%2BD28XnvVGlsLk%3D (Pubitemid 44264881)
    • (2006) EMBO Journal , vol.25 , Issue.15 , pp. 3714-3724
    • Buchholz, M.1    Schatz, A.2    Wagner, M.3    Michl, P.4    Linhart, T.5    Adler, G.6    Gress, T.M.7    Ellenrieder, V.8
  • 54
    • 0141483523 scopus 로고    scopus 로고
    • Transcriptional regulation by calcium, calcineurin, and NFAT
    • DOI 10.1101/gad.1102703
    • PG Hogan L Chen J Nardone A Rao 2003 Transcriptional regulation by calcium, calcineurin, and NFAT Genes Dev 17 2205 2232 12975316 10.1101/gad.1102703 1:CAS:528:DC%2BD3sXnsFaitbo%3D (Pubitemid 37128637)
    • (2003) Genes and Development , vol.17 , Issue.18 , pp. 2205-2232
    • Hogan, P.G.1    Chen, L.2    Nardone, J.3    Rao, A.4
  • 56
    • 77249176619 scopus 로고    scopus 로고
    • NFAT-induced histone acetylation relay switch promotes c-Myc-dependent growth in pancreatic cancer cells
    • 10.1053/j.gastro.2009.10.045
    • A Konig T Linhart K Schlengemann, et al. 2010 NFAT-induced histone acetylation relay switch promotes c-Myc-dependent growth in pancreatic cancer cells Gastroenterology 138 1189 1199 10.1053/j.gastro.2009.10.045
    • (2010) Gastroenterology , vol.138 , pp. 1189-1199
    • Konig, A.1    Linhart, T.2    Schlengemann, K.3
  • 58
    • 0035918538 scopus 로고    scopus 로고
    • Reduced membranous and ectopic cytoplasmic expression of β-catenin correlate with cyclin D1 overexpression and poor prognosis in pancreatic cancer
    • DOI 10.1002/1097-0215(20010520)95:3<194::AID-IJC1033>3.0.CO;2-M
    • Q Qiao M Ramadani S Gansauge F Gansauge G Leder HG Beger 2001 Reduced membranous and ectopic cytoplasmic expression of beta-catenin correlate with cyclin D1 overexpression and poor prognosis in pancreatic cancer Int J Cancer 95 194 197 11307154 10.1002/1097-0215(20010520)95:3<194::AID-IJC1033>3.0. CO;2-M 1:CAS:528:DC%2BD3MXjvFOmtr0%3D (Pubitemid 32477236)
    • (2001) International Journal of Cancer , vol.95 , Issue.3 , pp. 194-197
    • Qiao, Q.1    Ramadani, M.2    Gansauge, S.3    Gansauge, F.4    Leder, G.5    Beger, H.G.6
  • 59
    • 0035572340 scopus 로고    scopus 로고
    • Expression patterns of α-, β- and -catenin in pancreatic cancer: Correlation with E-cadherin expression, pathological features and prognosis
    • AJ Karayiannakis KN Syrigos A Polychronidis C Simopoulos 2001 Expression patterns of alpha-, beta- and gamma-catenin in pancreatic cancer: correlation with E-cadherin expression, pathological features and prognosis Anticancer Res 21 4127 4134 11911306 1:CAS:528:DC%2BD38Xis1artbw%3D (Pubitemid 34229299)
    • (2001) Anticancer Research , vol.21 , Issue.6 A , pp. 4127-4134
    • Karayiannakis, A.J.1    Syrigos, K.N.2    Polychronidis, A.3    Simopoulos, C.4
  • 60
    • 0036284906 scopus 로고    scopus 로고
    • Expression of E-cadherin, alpha- and beta-catenins in patients with pancreatic adenocarcinoma
    • DOI 10.1159/000055903
    • YE Joo JS Rew CS Park SJ Kim 2002 Expression of E-cadherin, alpha- and beta-catenins in patients with pancreatic adenocarcinoma Pancreatology 2 129 137 12123093 10.1159/000055903 1:CAS:528:DC%2BD38XjtlSjtL4%3D (Pubitemid 34639088)
    • (2002) Pancreatology , vol.2 , Issue.2 , pp. 129-137
    • Joo, Y.-E.1    Rew, J.-S.2    Park, C.-S.3    Kim, S.-J.4
  • 61
    • 0038133109 scopus 로고    scopus 로고
    • Dysregulation of β-catenin expression correlates with tumor differentiation in pancreatic duct adenocarcinoma
    • DOI 10.1245/ASO.2003.05.003
    • AM Lowy C Fenoglio-Preiser OJ Kim J Kordich A Gomez J Knight L James J Groden 2003 Dysregulation of beta-catenin expression correlates with tumor differentiation in pancreatic duct adenocarcinoma Ann Surg Oncol 10 284 290 12679314 10.1245/ASO.2003.05.003 (Pubitemid 40486962)
    • (2003) Annals of Surgical Oncology , vol.10 , Issue.3 , pp. 284-290
    • Lowy, A.M.1    Fenoglio-Preiser, C.2    Kim, O.J.3    Kordich, J.4    Gomez, A.5    Knight, J.6    James, L.7    Groden, J.8
  • 62
    • 0037442044 scopus 로고    scopus 로고
    • Relationship between expression of E-cadherin-catenin complex and clinicopathologic characteristics of pancreatic cancer
    • 12532469 1:CAS:528:DC%2BD3sXhsFymsrk%3D
    • YJ Li XR Ji 2003 Relationship between expression of E-cadherin-catenin complex and clinicopathologic characteristics of pancreatic cancer World J Gastroenterol 9 368 372 12532469 1:CAS:528:DC%2BD3sXhsFymsrk%3D
    • (2003) World J Gastroenterol , vol.9 , pp. 368-372
    • Li, Y.J.1    Ji, X.R.2
  • 63
    • 74049142841 scopus 로고    scopus 로고
    • Lef-1 isoforms regulate different target genes and reduce cellular adhesion
    • 19653274 1:CAS:528:DC%2BC3cXjsFCl
    • S Jesse A Koenig V Ellenrieder A Menke 2010 Lef-1 isoforms regulate different target genes and reduce cellular adhesion Int J Cancer 126 1109 1120 19653274 1:CAS:528:DC%2BC3cXjsFCl
    • (2010) Int J Cancer , vol.126 , pp. 1109-1120
    • Jesse, S.1    Koenig, A.2    Ellenrieder, V.3    Menke, A.4
  • 64
    • 51849128358 scopus 로고    scopus 로고
    • Class i PI3K in oncogenic cellular transformation
    • 18794883 10.1038/onc.2008.244 1:CAS:528:DC%2BD1cXhtFWiur%2FP
    • L Zhao PK Vogt 2008 Class I PI3K in oncogenic cellular transformation Oncogene 27 5486 5496 18794883 10.1038/onc.2008.244 1:CAS:528: DC%2BD1cXhtFWiur%2FP
    • (2008) Oncogene , vol.27 , pp. 5486-5496
    • Zhao, L.1    Vogt, P.K.2
  • 65
    • 0348049845 scopus 로고    scopus 로고
    • Incidence, mechanism and prognostic value of activated AKT in pancreas cancer
    • DOI 10.1038/sj.bjc.6601396
    • MG Schlieman BN Fahy R Ramsamooj L Beckett RJ Bold 2003 Incidence, mechanism and prognostic value of activated AKT in pancreas cancer Br J Cancer 89 2110 2115 14647146 10.1038/sj.bjc.6601396 1:STN:280:DC%2BD3srmsFOjsg%3D%3D (Pubitemid 38030911)
    • (2003) British Journal of Cancer , vol.89 , Issue.11 , pp. 2110-2115
    • Schlieman, M.G.1    Fahy, B.N.2    Ramsamooj, R.3    Beckett, L.4    Bold, R.J.5
  • 66
    • 41449091030 scopus 로고    scopus 로고
    • Immunohistochemical analysis of changes in signaling pathway activation downstream of growth factor receptors in pancreatic duct cell carcinogenesis
    • DOI 10.1186/1471-2407-8-43
    • NA Pham J Schwock V Iakovlev G Pond DW Hedley MS Tsao 2008 Immunohistochemical analysis of changes in signaling pathway activation downstream of growth factor receptors in pancreatic duct cell carcinogenesis BMC Cancer 8 43 18254976 10.1186/1471-2407-8-43 (Pubitemid 351454858)
    • (2008) BMC Cancer , vol.8 , pp. 43
    • Pham, N.-A.1    Schwock, J.2    Iakovlev, V.3    Pond, G.4    Hedley, D.W.5    Tsao, M.-S.6
  • 67
    • 9644253003 scopus 로고    scopus 로고
    • The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-B and c-Myc in pancreatic cancer cells
    • DOI 10.1038/sj.onc.1207902
    • T Asano Y Yao J Zhu D Li JL Abbruzzese SA Reddy 2004 The PI 3- kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cells Oncogene 23 8571 8580 15467756 10.1038/sj.onc.1207902 1:CAS:528:DC%2BD2cXpsF2msrk%3D (Pubitemid 39576463)
    • (2004) Oncogene , vol.23 , Issue.53 , pp. 8571-8580
    • Asano, T.1    Yao, Y.2    Zhu, J.3    Li, D.4    Abbruzzese, J.L.5    Reddy, S.A.G.6
  • 68
    • 34249335357 scopus 로고    scopus 로고
    • Phosphoinositide-3-kinase signaling controls S-phase kinase-associated protein 2 transcription via E2F1 in pancreatic ductal adenocarcinoma cells
    • DOI 10.1158/0008-5472.CAN-06-4484
    • M Reichert D Saur R Hamacher RM Schmid G Schneider 2007 Phosphoinositide-3-kinase signaling controls S-phase kinase-associated protein 2 transcription via E2F1 in pancreatic ductal adenocarcinoma cells Cancer Res 67 4149 4156 17483325 10.1158/0008-5472.CAN-06-4484 1:CAS:528:DC%2BD2sXltVyrsrg%3D (Pubitemid 46815060)
    • (2007) Cancer Research , vol.67 , Issue.9 , pp. 4149-4156
    • Reichert, M.1    Saur, D.2    Hamacher, R.3    Schmid, R.M.4    Schneider, G.5
  • 69
    • 73349115238 scopus 로고    scopus 로고
    • PI3K signaling maintains c-myc expression to regulate transcription of E2F1 in pancreatic cancer cells
    • 19603422 10.1002/mc.20569 1:CAS:528:DC%2BD1MXhsVyls7vL
    • C Schild M Wirth RM Schmid D Saur G Schneider 2009 PI3K signaling maintains c-myc expression to regulate transcription of E2F1 in pancreatic cancer cells Mol Carcinog 48 12 1149 1158 19603422 10.1002/mc.20569 1:CAS:528:DC%2BD1MXhsVyls7vL
    • (2009) Mol Carcinog , vol.48 , Issue.12 , pp. 1149-1158
    • Schild, C.1    Wirth, M.2    Schmid, R.M.3    Saur, D.4    Schneider, G.5
  • 70
    • 0025672704 scopus 로고
    • Expression of c-myc, c-raf-1, and c-Ki-ras in azaserine-induced pancreatic carcinomas and growing pancreas in rats
    • 2278633 10.1002/mc.2940030610 1:CAS:528:DyaK3MXitVCksL8%3D
    • JA Silverman ET Kuhlmann J Zurlo JD Yager DS Longnecker 1990 Expression of c-myc, c-raf-1, and c-Ki-ras in azaserine-induced pancreatic carcinomas and growing pancreas in rats Mol Carcinog 3 379 386 2278633 10.1002/mc.2940030610 1:CAS:528:DyaK3MXitVCksL8%3D
    • (1990) Mol Carcinog , vol.3 , pp. 379-386
    • Silverman, J.A.1    Kuhlmann, E.T.2    Zurlo, J.3    Yager, J.D.4    Longnecker, D.S.5
  • 72
    • 0027965548 scopus 로고
    • Pancreatic carcinomas of acinar and mixed acinar/ductal phenotypes in Ela-1-myc transgenic mice do not contain c-K-ras mutations
    • 8080049 1:CAS:528:DyaK2cXmslOksr4%3D
    • BK Schaeffer PG Terhune DS Longnecker 1994 Pancreatic carcinomas of acinar and mixed acinar/ductal phenotypes in Ela-1-myc transgenic mice do not contain c-K-ras mutations Am J Pathol 145 696 701 8080049 1:CAS:528: DyaK2cXmslOksr4%3D
    • (1994) Am J Pathol , vol.145 , pp. 696-701
    • Schaeffer, B.K.1    Terhune, P.G.2    Longnecker, D.S.3
  • 73
    • 33748693361 scopus 로고    scopus 로고
    • Characterization of pancreatic lesions from MT-tgfα, Ela-myc and MT-tgfα/Ela-myc single and double transgenic mice
    • DOI 10.1186/1477-3163-5-19
    • DJ Liao Y Wang J Wu NV Adsay D Grignon F Khanani FH Sarkar 2006 Characterization of pancreatic lesions from MT-TGF alpha, Ela-myc and MT-TGF alpha/Ela-myc single and double transgenic mice J Carcinog 5 19 16822304 10.1186/1477-3163-5-19 (Pubitemid 44390028)
    • (2006) Journal of Carcinogenesis , vol.5 , pp. 19
    • Liao, D.J.1    Wang, Y.2    Wu, J.3    Adsay, N.V.4    Grignon, D.5    Khanani, F.6    Sarkar, F.H.7
  • 74
    • 34247465590 scopus 로고    scopus 로고
    • Histological complexities of pancreatic lesions from transgenic mouse models are consistent with biological and morphological heterogeneity of human pancreatic cancer
    • JD Liao NV Adsay F Khannani D Grignon A Thakur FH Sarkar 2007 Histological complexities of pancreatic lesions from transgenic mouse models are consistent with biological and morphological heterogeneity of human pancreatic cancer Histol Histopathol 22 661 676 17357096 1:STN:280:DC%2BD2s7ls1Ohsw%3D%3D (Pubitemid 46647278)
    • (2007) Histology and Histopathology , vol.22 , Issue.4-6 , pp. 661-676
    • Liao, J.D.1    Adsay, N.V.2    Khannani, F.3    Grignon, D.4    Thakur, A.5    Sarkar, F.H.6
  • 75
    • 4644267868 scopus 로고    scopus 로고
    • Tissue plasminogen activator in murine exocrine pancreas cancer: Selective expression in ductal tumors and contribution to cancer progression
    • 10.1016/S0002-9440(10)63374-3
    • S Aguilar JM Corominas N Malats M Dufresne FX Real P Navarro 2003 Tissue plasminogen activator in murine exocrine pancreas cancer: selective expression in ductal tumors and contribution to cancer progression Am J Pathol 165 1129 1139 10.1016/S0002-9440(10)63374-3
    • (2003) Am J Pathol , vol.165 , pp. 1129-1139
    • Aguilar, S.1    Corominas, J.M.2    Malats, N.3    Dufresne, M.4    Real, F.X.5    Navarro, P.6
  • 76
    • 0346731132 scopus 로고    scopus 로고
    • The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer
    • DOI 10.1101/gad.1140403
    • BC Lewis DS Klimstra HE Varmus 2003 The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer Genes Dev 17 3127 3138 14681205 10.1101/gad.1140403 1:CAS:528:DC%2BD2cXhs1Sgsw%3D%3D (Pubitemid 38040775)
    • (2003) Genes and Development , vol.17 , Issue.24 , pp. 3127-3138
    • Lewis, B.C.1    Klimstra, D.S.2    Varmus, H.E.3
  • 77
    • 0037013147 scopus 로고    scopus 로고
    • Suppression of Myc-induced apoptosis in β cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression
    • DOI 10.1016/S0092-8674(02)00738-9
    • S Pelengaris M Khan GI Evan 2002 Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression Cell 109 321 334 12015982 10.1016/S0092-8674(02)00738-9 1:CAS:528:DC%2BD38XjvV2lsLk%3D (Pubitemid 34606875)
    • (2002) Cell , vol.109 , Issue.3 , pp. 321-334
    • Pelengaris, S.1    Khan, M.2    Evan, G.I.3
  • 78
    • 41449118521 scopus 로고    scopus 로고
    • Module Map of Stem Cell Genes Guides Creation of Epithelial Cancer Stem Cells
    • DOI 10.1016/j.stem.2008.02.009, PII S1934590908000738
    • DJ Wong H Liu TW Ridky D Cassarino E Segal HY Chang 2008 Module map of stem cell genes guides creation of epithelial cancer stem cells Cell Stem Cell 2 333 344 18397753 10.1016/j.stem.2008.02.009 1:CAS:528:DC%2BD1cXltVOnsLo%3D (Pubitemid 351455242)
    • (2008) Cell Stem Cell , vol.2 , Issue.4 , pp. 333-344
    • Wong, D.J.1    Liu, H.2    Ridky, T.W.3    Cassarino, D.4    Segal, E.5    Chang, H.Y.6


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