Miz1 is required to maintain autophagic flux

Nature Communications

Volumn 4, Issue , 2013, Pages

  Wolf, Elmar ^a   Gebhardt, Anneli ^a   Kawauchi, Daisuke ^b   Walz, Susanne ^a   Von Eyss, Björn ^a   Wagner, Nicole ^c   Renninger, Christoph ^c   Krohne, Georg ^a   Asan, Esther ^c   Roussel, Martine F ^b   Eilers, Martin ^a,d  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^c UNIVERSITY OF WÜRZBURG   (Germany)

^d Comprehensive Cancer Center Mainfranken ^*  (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; MIZ1 PROTEIN; NESTIN; PROTEIN; PROTEIN P62; SQTM1 PROTEIN; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

BIOCHEMISTRY; CYTOLOGY; FUNCTIONAL ROLE; GENE EXPRESSION; NERVOUS SYSTEM; NEUROLOGY; PHYSIOLOGY; PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CELL LOSS; CENTRAL NERVOUS SYSTEM; CHEMICAL ANALYSIS; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DNA BINDING; FIBROBLAST; GENE TARGETING; GENETIC TRANSCRIPTION; MOUSE; NERVE DEGENERATION; NONHUMAN; PHENOTYPE; PROMOTER REGION; PROTEIN BINDING; PURKINJE CELL; TRANSGENE; TRANSPORT VESICLE; UBIQUITINATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; AUTOPHAGY; BINDING SITES; CEREBELLUM; FEMALE; GENE EXPRESSION REGULATION; HEAT-SHOCK PROTEINS; INTEGRASES; MICE; MICE, KNOCKOUT; NUCLEAR PROTEINS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN INHIBITORS OF ACTIVATED STAT; PROTEIN STRUCTURE, TERTIARY; PURKINJE CELLS; RIBOSOMES; SEQUENCE ANALYSIS, DNA; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSPORT VESICLES; UBIQUITINATION;

EID: 84885125941     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms3535     Document Type: Article

References (51)

1. Gebhardt, A. et al. Myc regulates keratinocyte adhesion and differentiation via complex formation with Miz1. J. Cell. Biol. 172, 139-149 (2006).
2. van Riggelen, J. et al. The interaction between Myc and Miz1 is required to antagonize TGFbeta-Dependent autocrine signaling during lymphoma formation and maintenance. Genes Dev. 24, 1281-1294 (2010).
3. Phan, R. T., Saito, M., Basso, K., Niu, H. & Dalla-favera, R. BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-Dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells. Nat. Immunol. 6, 1054-1060 (2005).
4. Saito, M. et al. BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse large B cell lymphoma. Proc. Natl Acad. Sci. USA 106, 11294-11299 (2009).
5. Basu, S., Liu, Q., Qiu, Y. & Dong, F. Gfi-1 represses CDKN2B encoding p15INK4B through interaction with Miz-1. Proc. Natl Acad. Sci. USA 106, 1433-1438 (2009).
6. Gebhardt, A. et al. Miz1 is required for hair follicle structure and hair morphogenesis. J. Cell Sci. 120(Pt 15): 2586-2593 (2007).
7. Kosan, C. et al. Transcription factor miz-1 is required to regulate interleukin-7 receptor signaling at early commitment stages of B cell differentiation. Immunity 33, 917-928 (2010).
8. Herold, S. et al. Negative regulation of the mammalian UV response by Myc through association with Miz-1. Mol. Cell 10, 509-521 (2002).
9. Oskarsson, T. et al. Skin epidermis lacking the c-myc gene is resistant to Rasdriven tumorigenesis but can reacquire sensitivity upon additional loss of the p21Cip1 gene. Genes Dev. 20, 2024-2029 (2006).
10. Honnemann, J., Sanz-moreno, A., Wolf, E., Eilers, M. & Elsasser, H. P. Miz1 is a critical repressor of cdkn1a during skin tumorigenesis. PLoS One 7, e34885 (2012).
11. Saba, I., Kosan, C., Vassen, L. & Moroy, T. IL-7R-Dependent survival and differentiation of early T-Lineage progenitors is regulated by the BTB/POZ domain transcription factor Miz-1. Blood 117, 3370-3381 (2011).
12. Saba, I., Kosan, C., Vassen, L., Klein-hitpass, L. & Moroy, T. Miz-1 is required to coordinate the expression of TCRbeta and p53 effector genes at the pre-tCR ?beta-selection? checkpoint. J. Immunol. 187, 2982-2992 (2011).
13. Lein, E. S. et al. Genome-wide atlas of gene expression in the adult mouse brain. Nature 445, 168-176 (2007).
14. Tronche, F. et al. Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat. Genet. 23, 99-103 (1999).
15. Lossi, L., Mioletti, S. & Merighi, A. Synapse-independent and synapsedependent apoptosis of cerebellar granule cells in postnatal rabbits occur at two subsequent but partly overlapping developmental stages. Neuroscience 112, 509-523 (2002).
16. Machanick, P. & Bailey, T. L. MEME-chIP: Motif analysis of large DNA datasets. Bioinformatics 27, 1696-1697 (2011).
17. Staller, P. et al. Repression of p15INK4b expression by Myc through association with Miz-1. Nat. Cell Biol. 3, 392-399 (2001).
18. Subramanian, A. et al. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl Acad. Sci. USA 102, 15545-15550 (2005).
19. Katzmann, D. J., Babst, M. & Emr, S. D. Ubiquitin-Dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-i. Cell 106, 145-155 (2001).
20. Langevin, J. et al. Drosophila exocyst components Sec5, Sec6, and Sec15 regulate DE-cadherin trafficking from recycling endosomes to the plasma membrane. Dev. Cell 9, 365-376 (2005).
21. Ikonomov, O. C., Sbrissa, D., Foti, M., Carpentier, J. L. & Shisheva, A. PIKfyve controls fluid phase endocytosis but not recycling/degradation of endocytosed receptors or sorting of procathepsin D by regulating multivesicular body morphogenesis. Mol. Biol. Cell 14, 4581-4591 (2003).
22. Rubinsztein, D. C., Shpilka, T. & Elazar, Z. Mechanisms of autophagosome biogenesis. Curr. Biol. 22, R29-r34 (2012).
23. Hara, T. et al. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 441, 885-889 (2006).
24. Komatsu, M. et al. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 441, 880-884 (2006).
25. Kirkin, V., McEwan, D. G., Novak, I. & Dikic, I. A role for ubiquitin in selective autophagy. Mol. Cell 34, 259-269 (2009).
26. Komatsu, M. et al. Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-Deficient mice. Cell 131, 1149-1163 (2007).
27. Liang, C. C., Wang, C., Peng, X., Gan, B. & Guan, J. L. Neural-specific deletion of FIP200 leads to cerebellar degeneration caused by increased neuronal death and axon degeneration. J. Biol. Chem. 285, 3499-3509 (2010).
28. Curcio-morelli, C. et al. Macroautophagy is defective in mucolipin-1-Deficient mouse neurons. Neurobiol. Dis. 40, 370-377 (2010).
29. Mizushima, N., Yoshimori, T. & Levine, B. Methods in mammalian autophagy research. Cell 140, 313-326 (2010).
30. Fimia, G. M. et al. Ambra1 regulates autophagy and development of the nervous system. Nature 447, 1121-1125 (2007).
31. Rusten, T. E. et al. ESCRTs and Fab1 regulate distinct steps of autophagy. Curr. Biol. 17, 1817-1825 (2007).
32. Jaeger, P. A. & Wyss-coray, T. All-you-can-eat: Autophagy in neurodegeneration and neuroprotection. Mol. Neurodegener. 4, 16 (2009).
33. Kroemer, G. & White, E. Autophagy for the avoidance of degenerative, inflammatory, infectious, and neoplastic disease. Curr. Opin. Cell Biol. 22, 121-123 (2010).
34. Eskelinen, E. L. Maturation of autophagic vacuoles in Mammalian cells. Autophagy 1, 1-10 (2005).
35. Lee, J. A., Beigneux, A., Ahmad, S. T., Young, S. G. & Gao, F. B. ESCRT-iII dysfunction causes autophagosome accumulation and neurodegeneration. Curr. Biol. 17, 1561-1567 (2007).
36. Levine, B. & Kroemer, G. Autophagy in the pathogenesis of disease. Cell 132, 27-42 (2008).
37. Madeo, F., Eisenberg, T. & Kroemer, G. Autophagy for the avoidance of neurodegeneration. Genes Dev. 23, 2253-2259 (2009).
38. Rusten, T. E. et al. Fab1 phosphatidylinositol 3-phosphate 5-Kinase controls trafficking but not silencing of endocytosed receptors. Mol. Biol. Cell 17, 3989-4001 (2006).
39. Vaccari, T. et al. Comparative analysis of ESCRT-i, ESCRT-iI and ESCRT-iII function in Drosophila by efficient isolation of ESCRT mutants. J. Cell Sci. 122(Pt 14): 2413-2423 (2009).
40. Guertin, D. A. et al. Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-fOXO and PKCalpha, but not S6K1. Dev. Cell 11, 859-871 (2006).
41. McLeod, I. X., Zhou, X., Li, Q. J., Wang, F. & He, Y. W. The class III kinase Vps34 promotes T lymphocyte survival through regulating IL-7Ralpha surface expression. J. Immunol. 187, 5051-5061 (2011).
42. Geisler, C. TCR trafficking in resting and stimulated T cells. Crit. Rev. Immunol. 24, 67-86 (2004).
43. Crighton, D. et al. DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell 126, 121-134 (2006).
44. Settembre, C. et al. TFEB links autophagy to lysosomal biogenesis. Science 332, 1429-1433 (2011).
45. Zhao, J. et al. FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells. Cell Metab. 6, 472-483 (2007).
46. Wanzel, M. et al. A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth. Nat. Cell Biol. 10, 1051-1061 (2008).
47. Langmead, B., Trapnell, C., Pop, M. & Salzberg, S. L. Ultrafast and memoryefficient alignment of short DNA sequences to the human genome. Genome Biol. 10, R25 (2009).
48. Feng, J., Liu, T., Qin, B., Zhang, Y. & Liu, X. S. Identifying ChIP-seq enrichment using MACS. Nat. Protoc. 7, 1728-1740 (2012).
49. Fung, C., Lock, R., Gao, S., Salas, E. & Debnath, J. Induction of autophagy during extracellular matrix detachment promotes cell survival. Mol. Biol. Cell 19, 797-806 (2008).
50. Zoncu, R. & Sabatini, D. M. Cell biology. The TASCC of secretion. Science 332, 923-925 (2011).
51. Bauvy, C., Meijer, A. J. & Codogno, P. Assaying of autophagic protein degradation. Methods Enzymol. 452, 47-61 (2009).