Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance

Science

Volumn 355, Issue 6320, 2017, Pages

  Ku, Sheng Yu ^a   Rosario, Spencer ^a   Wang, Yanqing ^a   Mu, Ping ^b   Seshadri, Mukund ^a   Goodrich, Zachary W ^a   Goodrich, Maxwell M ^a   Labbé, David P ^c   Gomez, Eduardo Cortes ^a   Wang, Jianmin ^a   Long, Henry W ^c   Xu, Bo ^a   Brown, Myles ^c   Loda, Massimo ^c,d,e   Sawyers, Charles L ^b,f   Ellis, Leigh ^a   Goodrich, David W ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e KING'S COLLEGE LONDON   (United Kingdom)

^f HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; ANTIANDROGEN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; RB1 PROTEIN; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR EZH2; TRANSCRIPTION FACTOR SOX2; TRP53 PROTEIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; EZH2 PROTEIN, MOUSE; PROTEIN P107; PROTEIN P53; PTEN PROTEIN, MOUSE; RBL1 PROTEIN, MOUSE; SOX2 PROTEIN, MOUSE; TRANSCRIPTION FACTOR SOX;

ANCESTRY; ANDROGEN; CANCER; GENE EXPRESSION; GENETIC ANALYSIS; HISTOLOGY; MUTATION; RODENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIANDROGEN THERAPY; ARTICLE; CANCER CELL LINE; CANCER INHIBITION; CANCER TISSUE; CELL LINEAGE; CONTROLLED STUDY; EPIGENETICS; GENE EXPRESSION PROFILING; GENE MUTATION; METASTASIS; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; PLASTICITY; PRIORITY JOURNAL; PROSTATE CANCER; SURVIVAL RATE; ADENOCARCINOMA; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL PLASTICITY; DRUG RESISTANCE; GENETIC EPIGENESIS; GENETICS; HUMAN; MALE; MUTATION; NEOPLASMS, EXPERIMENTAL; NEUROENDOCRINE TUMORS; PATHOLOGY; PROSTATIC NEOPLASMS; SECONDARY; TUMOR CELL LINE;

ADENOCARCINOMA; ANDROGEN ANTAGONISTS; ANIMALS; CELL LINE, TUMOR; CELL LINEAGE; CELL PLASTICITY; DRUG RESISTANCE, NEOPLASM; ENHANCER OF ZESTE HOMOLOG 2 PROTEIN; EPIGENESIS, GENETIC; HUMANS; MALE; MICE; MUTATION; NEOPLASM METASTASIS; NEOPLASMS, EXPERIMENTAL; NEUROENDOCRINE TUMORS; PROSTATIC NEOPLASMS; PTEN PHOSPHOHYDROLASE; RETINOBLASTOMA-LIKE PROTEIN P107; SOXB1 TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 85009286726     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aah4199     Document Type: Article

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