Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma

Cancer Cell

Volumn 5, Issue 6, 2004, Pages 539-551

  Chen, Danian ^a   Livne bar, Izhar ^a   Vanderluit, Jackie L ^b   Slack, Ruth S ^b   Agochiya, Mahima ^a   Bremner, Rod ^a  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P107; RETINOBLASTOMA PROTEIN;

ARTICLE; CARCINOGENESIS; CELL CYCLE; CELL DEATH; CELL DIVISION; CELL PROLIFERATION; CELL SPECIFICITY; GANGLION; GENE INACTIVATION; GENE MUTATION; NONHUMAN; PHOTORECEPTOR; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; RETINA AMACRINE CELL; RETINA CELL; RETINOBLASTOMA; STEM CELL;

EID: 2942574955     PISSN: 15356108     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ccr.2004.05.025     Document Type: Article

References (51)

1. Al-Ubaidi M.R., Font R.L., Quiambao A.B., Keener M.J., Liou G.I., Overbeek P.A., Baehr W. Bilateral retinal and brain tumors in transgenic mice expressing simian virus 40 large T antigen under control of the human interphotoreceptor retinoid-binding protein promoter. J. Cell Biol. 119:1992;1681-1687. a
2. Al-Ubaidi M.R., Hollyfield J.G., Overbeek P.A., Baehr W. Photoreceptor degeneration induced by the expression of simian virus 40 large tumor antigen in the retina of transgenic mice. Proc. Natl. Acad. Sci. USA. 89:1992;1194-1198. b
3. Baetscher M., Schmidt E., Shimizu A., Leder P., Fishman M.C. SV40 T antigen transforms calcitonin cells of the thyroid but not CGRP-containing neurons in transgenic mice. Oncogene. 6:1991;1133-1138
4. Bibb L.C., Holt J.K., Tarttelin E.E., Hodges M.D., Gregory-Evans K., Rutherford A., Lucas R.J., Sowden J.C., Gregory-Evans C.Y. Temporal and spatial expression patterns of the CRX transcription factor and its downstream targets. Critical differences during human and mouse eye development. Hum. Mol. Genet. 10:2001;1571-1579
5. Burmeister M., Novak J., Liang M.Y., Basu S., Ploder L., Hawes N.L., Vidgen D., Hoover F., Goldman D., Kalnins V.I., et al. Ocular retardation mouse caused by Chx10 homeobox null allele. Impaired retinal progenitor proliferation and bipolar cell differentiation Nat. Genet. 12:1996;376-384
6. Chen S., Wang Q.L., Nie Z., Sun H., Lennon G., Copeland N.G., Gilbert D.J., Jenkins N.A., Zack D.J. Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes. Neuron. 19:1997;1017-1030
7. Chen D., Gallie B.L., Squire J.A. Minimal regions of chromosomal imbalance in retinoblastoma detected by comparative genomic hybridization. Cancer Genet. Cytogenet. 129:2001;57-63
8. Chen D., Pajovic S., Duckett A., Brown V.D., Squire J.A., Gallie B.L. Genomic amplification in retinoblastoma narrowed to 0.6 megabase on chromosome 6p containing a kinesin-like gene, RBKIN. Cancer Res. 62:2002;967-971
9. Clarke A.R., Maandag E.R., Van Roon M., Van der Lugt N.M.T., Van der Valk M., Hooper M.L., Berns A., Te Riele H. Requirement for a functional Rb-1 gene in murine development. Nature. 359:1992;328-330
10. Dyer M.A., Livesey F.J., Cepko C.L., Oliver G. Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina. Nat. Genet. 34:2003;53-58
11. Efrat S., Teitelman G., Anwar M., Ruggiero D., Hanahan D. Glucagon gene regulatory region directs oncoprotein expression to neurons and pancreatic alpha cells. Neuron. 1:1988;605-613
12. Erkman L., McEvilly R.J., Luo L., Ryan A.K., Hooshmand F., O'Connell S.M., Keithley E.M., Rapaport D.H., Ryan A.F., Rosenfeld M.G. Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development. Nature. 381:1996;603-606
13. Ferguson K.L., Vanderluit J.L., Hebert J.M., McIntosh W.C., Tibbo E., MacLaurin J.G., Park D.S., Wallace V.A., Vooijs M., McConnell S.K., Slack R.S. Telencephalon-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical development. EMBO J. 21:2002;3337-3346
14. Freund C.L., Gregory-Evans C.Y., Furukawa T., Papaioannou M., Looser J., Ploder L., Bellingham J., Ng D., Herbrick J.A., Duncan A., et al. Cone-rod dystrophy due to mutations in a novel photoreceptor-specific homeobox gene (CRX) essential for maintenance of the photoreceptor. Cell. 91:1997;543-553
15. Friend S.H., Bernards R., Rogelj S., Weinberg R.A., Rapaport J.M., Albert D.M., Dryja T.P. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature. 323:1986;643-646
16. Furukawa T., Morrow E.M., Cepko C.L. Crx, a novel otx-like homeobox gene, shows photoreceptor-specific expression and regulates photoreceptor differentiation. Cell. 91:1997;531-541
17. Gallie B.L., Campbell C., Devlin H., Duckett A., Squire J.A. Developmental basis of retinal-specific induction of cancer by RB mutation. Cancer Res. 59:1999;1731s-1735s
18. Gan L., Xiang M., Zhou L., Wagner D.S., Klein W.H., Nathans J. POU domain factor Brn-3b is required for the development of a large set of retinal ganglion cells. Proc. Natl. Acad. Sci. USA. 93:1996;3920-3925
19. Hanahan D., Weinberg R.A. The hallmarks of cancer. Cell. 100:2000;57-70
20. Harris H. Tumour suppression. putting on the brakes Nature. 427:2004;201
21. Herwig S., Strauss M. The retinoblastoma protein. A master regulator of cell cycle, differentiation and apoptosis Eur. J. Biochem. 246:1997;581-601
22. Hojo M., Ohtsuka T., Hashimoto N., Gradwohl G., Guillemot F., Kageyama R. Glial cell fate specification modulated by the bHLH gene Hes5 in mouse retina. Development. 127:2000;2515-2522
23. Howes K.A., Ransom N., Papermaster D.S., Lasudry J.G., Albert D.M., Windle J.J. Apoptosis or retinoblastoma. alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53 Genes Dev. 8:1994;1300-1310
24. Inoue T., Hojo M., Bessho Y., Tano Y., Lee J.E., Kageyama R. Math3 and NeuroD regulate amacrine cell fate specification in the retina. Development. 129:2002;831-842
25. Jacks T., Fazeli A., Schmitt E.M., Bronson R.T., Goodell M.A., Weinberg R.A. Effects of an Rb mutation in the mouse. Nature. 359:1992;295-300
26. Jiang Z., Zacksenhaus E., Gallie B.L., Phillips R.A. The retinoblastoma gene family is differentially expressed during embryogenesis. Oncogene. 14:1997;1789-1797
27. Knudson A.G.J. Mutation and cancer. statistical study of retinoblastoma Proc. Natl. Acad. Sci. USA. 68:1971;820-823
28. LeCouter J.E., Kablar B., Hardy W.R., Ying C., Megeney L.A., May L.L., Rudnicki M.A. Strain-dependent myeloid hyperplasia, growth deficiency, and accelerated cell cycle in mice lacking the Rb-related p107 gene. Mol. Cell. Biol. 18:1998;7455-7465
29. Lee E.Y.H.P., Chang C.Y., Hu N., Wang Y.C.J., Lai C.C., Herrup K., Lee W.H., Bradley A. Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis. Nature. 359:1992;288-294
30. Lee M.H., Williams B.O., Mulligan G., Mukai S., Bronson R.T., Dyson N., Harlow E., Jacks T. Targeted disruption of p107. Functional overlap between p107 and Rb Genes Dev. 10:1996;1621-1632
31. Liu I.S.C., Chen J., Ploder L., Vidgen D., van der Kooy D., Kalnins V.I., McInnes R.R. Developmental expression of a novel murine homeobox gene (Chx10). Evidence for roles in determination of the neuroretina and inner nuclear layer Neuron. 13:1994;377-393
32. Macpherson D., Sage J., Kim T., Ho D., Jacks T. Cell-type specific effects of Rb deletion in the murine retina. Genes Dev. in press:2004
33. Marino S., Vooijs M., van Der Gulden H., Jonkers J., Berns A. Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes Dev. 14:2000;994-1004
34. Marino S., Hoogervoorst D., Brandner S., Berns A. Rb and p107 are required for normal cerebellar development and granule cell survival but not for Purkinje cell persistence. Development. 130:2003;3359-3368
35. Marquardt T., Ashery-Padan R., Andrejewski N., Scardigli R., Guillemot F., Gruss P. Pax6 is required for the multipotent state of retinal progenitor cells. Cell. 105:2001;43-55
36. Mulligan G., Jacks T. The retinoblastoma gene family. Cousins with overlapping interests Trends Genet. 14:1998;223-229
37. Ng L., Hurley J.B., Dierks B., Srinivas M., Salto C., Vennstrom B., Reh T.A., Forrest D. A thyroid hormone receptor that is required for the development of green cone photoreceptors. Nat. Genet. 27:2001;94-98
38. Nork T.M., Schwartz T.L., Doshi H.M., Millecchia L.L. Retinoblastoma. Cell of origin. Arch. Ophthalmol. 113:1995;791-802
39. Rakic S., Zecevic N. Programmed cell death in the developing human telencephalon. Eur. J. Neurosci. 12:2000;2721-2734
40. Robanus-Maandag E.C., Van der Valk M., Vlaar M., Feltkamp C., O'Brien J., Van Roon M., Van der Lugt N., Berns A., Te Reile H. Developmental rescue of an embryonic-lethal mutation in the retinoblastoma gene in chimeric mice. EMBO J. 13:1994;4260-4268
41. Robanus-Maandag E., Dekker M., van der Valk M., Carrozza M.L., Jeanny J.C., Dannenberg J.H., Berns A., te Riele H. p107 is a suppressor of retinoblastoma development in pRb-deficient mice. Genes Dev. 12:1998;1599-1609
42. Saavedra H.I., Wu L., de Bruin A., Timmers C., Rosol T.J., Weinstein M., Robinson M.L., Leone G. Specificity of E2F1, E2F2, and E2F3 in mediating phenotypes induced by loss of Rb. Cell Growth Differ. 13:2002;215-225
43. Schaeren-Wiemers N., Gerfin-Moser A. A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells. in situ hybridization using digoxigenin-labelled cRNA probes Histochemistry. 100:1993;431-440
44. Usukura J., Khoo W., Abe T., Breitman M.L., Shinohara T. Cone cells fail to develop normally in transgenic mice showing ablation of rod photoreceptor cells. Cell Tissue Res. 275:1994;79-90
45. Vooijs M., Te Riele H., Van Der Valk M., Berns A. Tumor formation in mice with somatic inactivation of the retinoblastoma gene in interphotoreceptor retinol binding protein-expressing cells. Oncogene. 21:2002;4635-4645
46. Watanabe M., Hitomi M., van der Wee K., Rothenberg F., Fisher S.A., Zucker R., Svoboda K.K., Goldsmith E.C., Heiskanen K.M., Nieminen A.L. The pros and cons of apoptosis assays for use in the study of cells, tissues, and organs. Microsc. Microanal. 8:2002;375-391
47. Wu L., De Bruin A., Saavedra H.I., Starovic M., Trimboli A., Yang Y., Opavska J., Wilson P., Thompson J.C., Ostrowski M.C., et al. Extra-embryonic function of Rb is essential for embryonic development and viability. Nature. 421:2003;942-947
48. Xiang M., Zhou L., Peng Y.W., Eddy R.L., Shows T.B., Nathans J. Brn-3b. A POU domain gene expressed in a subset of retinal ganglion cells Neuron. 11:1993;689-701
49. Young R.W. Cell proliferation during postnatal development of the retina in the mouse. Brain Res. 353:1985;229-239
50. Zacksenhaus E. Alternative reading frame supports an alternative model for retinoblastoma. Cell Cycle. 2:2003;27-30
51. Zhang J., Gray J., Wu L., Leone G., Rowan S., Cepko C.L., Zhu X., Craft C.M., Dyer M.A. Rb regulates proliferation and rod photoreceptor development in the mouse retina. Nat. Genet. 36:2004;351-360