Ubiquitin-Dependent Turnover of MYC Antagonizes MYC/PAF1C Complex Accumulation to Drive Transcriptional Elongation

Molecular Cell

Volumn 61, Issue 1, 2016, Pages 54-67

  Jaenicke, Laura A ^a   von Eyss, Björn ^a   Carstensen, Anne ^a   Wolf, Elmar ^a   Xu, Wenshan ^b   Greifenberg, Ann Katrin ^c   Geyer, Matthias ^c   Eilers, Martin ^a,b   Popov, Nikita ^b,d  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b Comprehensive Cancer Center Mainfranken ^*  (Germany)

^c UNIVERSITY OF BONN   (Germany)

^d UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

Author keywords

MYC; PAF1C; Proteasomal degradation; RNA polymerase; Transcriptional elongation; Ubiquitin

Indexed keywords

BRD4 PROTEIN; MYC PROTEIN; PAF1C PROTEIN; RNA POLYMERASE II; UBIQUITIN; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; BRD4 PROTEIN, HUMAN; CDC73 PROTEIN, HUMAN; CTR9 PROTEIN, HUMAN; HISTONE; MULTIPROTEIN COMPLEX; MYC PROTEIN, HUMAN; NUCLEAR PROTEIN; PAF1 PROTEIN, HUMAN; PHOSPHOPROTEIN; POSITIVE TRANSCRIPTION ELONGATION FACTOR B; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TRANSCRIPTION FACTOR; TRANSFORMATION-TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; TUMOR SUPPRESSOR PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HISTONE ACETYLATION; HUMAN; HUMAN CELL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN METABOLISM; PROTEIN PROTEIN INTERACTION; TRANSACTIVATION; TRANSCRIPTION ELONGATION; TRANSCRIPTION INITIATION; UBIQUITINATION; ACETYLATION; BINDING SITE; CELL PROLIFERATION; CHROMATIN ASSEMBLY AND DISASSEMBLY; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; HELA CELL LINE; METABOLISM; MUTATION; PROTEIN DEGRADATION; RNA INTERFERENCE; TIME FACTOR;

ACETYLATION; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BINDING SITES; CELL PROLIFERATION; CHROMATIN ASSEMBLY AND DISASSEMBLY; HEK293 CELLS; HELA CELLS; HISTONES; HUMANS; MULTIPROTEIN COMPLEXES; MUTATION; NUCLEAR PROTEINS; PHOSPHOPROTEINS; POSITIVE TRANSCRIPTIONAL ELONGATION FACTOR B; PROMOTER REGIONS, GENETIC; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS C-MYC; RNA INTERFERENCE; RNA POLYMERASE II; TIME FACTORS; TRANSCRIPTION ELONGATION, GENETIC; TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR SUPPRESSOR PROTEINS; UBIQUITINATION;

EID: 84953637969     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2015.11.007     Document Type: Article

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