Immunology of Food Allergy

Immunity

Volumn 47, Issue 1, 2017, Pages 32-50

  Tordesillas, Leticia ^a   Berin, M Cecilia ^a   Sampson, Hugh A ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; FOOD ALLERGEN; HERBACEOUS AGENT; IMMUNOGLOBULIN E; INTERLEUKIN 9; MONOCLONAL ANTIBODY; PEPTIDE DERIVATIVE; PROBIOTIC AGENT; RAPAMYCIN; RECOMBINANT ALLERGEN; ALLERGEN;

ANAPHYLAXIS; ANTIBODY RESPONSE; ANTIGEN SPECIFICITY; CELLULAR IMMUNITY; CHINESE MEDICINE; DENDRITIC CELL; EXPERIMENTAL MODEL; FOOD ALLERGY; GENETIC RISK; HUMAN; IMMUNOLOGY; IMMUNOPATHOGENESIS; IMMUNOTHERAPY; MAST CELL; MICROBIOME; MOLECULAR PATHOLOGY; NONHUMAN; PHYSICAL TOLERANCE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; REVIEW; SENSITIZATION; T LYMPHOCYTE; ANIMAL; DESENSITIZATION; FOOD HYPERSENSITIVITY; METABOLISM; PROCEDURES; RESPIRATORY HYPERSENSITIVITY; UNITED STATES;

ALLERGENS; ANIMALS; DESENSITIZATION, IMMUNOLOGIC; FOOD HYPERSENSITIVITY; HUMANS; IMMUNOGLOBULIN E; RESPIRATORY HYPERSENSITIVITY; UNITED STATES;

EID: 85030094038     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2017.07.004     Document Type: Review

References (177)

1. Abernathy-Carver, K.J., Sampson, H.A., Picker, L.J., Leung, D.Y., Milk-induced eczema is associated with the expansion of T cells expressing cutaneous lymphocyte antigen. J. Clin. Invest. 95 (1995), 913–918.
2. Apostolovic, D., Stanic-Vucinic, D., de Jongh, H.H., de Jong, G.A., Mihailovic, J., Radosavljevic, J., Radibratovic, M., Nordlee, J.A., Baumert, J.L., Milcic, M., et al. Conformational stability of digestion-resistant peptides of peanut conglutins reveals the molecular basis of their allergenicity. Sci. Rep., 6, 2016, 29249.
3. Arias, K., Baig, M., Colangelo, M., Chu, D., Walker, T., Goncharova, S., Coyle, A., Vadas, P., Waserman, S., Jordana, M., Concurrent blockade of platelet-activating factor and histamine prevents life-threatening peanut-induced anaphylactic reactions. J. Allergy Clin. Immunol. 124 (2009), 307–314 314.e1–314.e2.
4. Arrieta, M.C., Stiemsma, L.T., Dimitriu, P.A., Thorson, L., Russell, S., Yurist-Doutsch, S., Kuzeljevic, B., Gold, M.J., Britton, H.M., Lefebvre, D.L., et al., CHILD Study Investigators. Early infancy microbial and metabolic alterations affect risk of childhood asthma. Sci. Transl. Med., 7, 2015, 307ra152.
5. Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., et al. Induction of colonic regulatory T cells by indigenous Clostridium species. Science 331 (2011), 337–341.
6. Atarashi, K., Tanoue, T., Oshima, K., Suda, W., Nagano, Y., Nishikawa, H., Fukuda, S., Saito, T., Narushima, S., Hase, K., et al. Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota. Nature 500 (2013), 232–236.
7. Azad, M.B., Konya, T., Guttman, D.S., Field, C.J., Sears, M.R., HayGlass, K.T., Mandhane, P.J., Turvey, S.E., Subbarao, P., Becker, A.B., et al., CHILD Study Investigators. Infant gut microbiota and food sensitization: associations in the first year of life. Clin. Exp. Allergy 45 (2015), 632–643.
8. Bedoret, D., Singh, A.K., Shaw, V., Hoyte, E.G., Hamilton, R., DeKruyff, R.H., Schneider, L.C., Nadeau, K.C., Umetsu, D.T., Changes in antigen-specific T-cell number and function during oral desensitization in cow's milk allergy enabled with omalizumab. Mucosal Immunol. 5 (2012), 267–276.
9. Bellach, J., Schwarz, V., Ahrens, B., Trendelenburg, V., Aksunger, O., Kalb, B., Niggemann, B., Keil, T., Beyer, K., Randomized placebo-controlled trial of hen's egg consumption for primary prevention in infants. J. Allergy Clin. Immunol. 139 (2017), 1591–1599.
10. Beyer, K., Grabenhenrich, L., Härtl, M., Beder, A., Kalb, B., Ziegert, M., Finger, A., Harandi, N., Schlags, R., Gappa, M., et al. Predictive values of component-specific IgE for the outcome of peanut and hazelnut food challenges in children. Allergy 70 (2015), 90–98.
11. Blázquez, A.B., Berin, M.C., Gastrointestinal dendritic cells promote Th2 skewing via OX40L. J. Immunol. 180 (2008), 4441–4450.
12. Bolhaar, S.T., Zuidmeer, L., Ma, Y., Ferreira, F., Bruijnzeel-Koomen, C.A., Hoffmann-Sommergruber, K., van Ree, R., Knulst, A.C., A mutant of the major apple allergen, Mal d 1, demonstrating hypo-allergenicity in the target organ by double-blind placebo-controlled food challenge. Clin. Exp. Allergy 35 (2005), 1638–1644.
13. Boyano-Martínez, T., García-Ara, C., Pedrosa, M., Díaz-Pena, J.M., Quirce, S., Accidental allergic reactions in children allergic to cow's milk proteins. J. Allergy Clin. Immunol. 123 (2009), 883–888.
14. Brightbill, H.D., Jeet, S., Lin, Z., Yan, D., Zhou, M., Tan, M., Nguyen, A., Yeh, S., Delarosa, D., Leong, S.R., et al. Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice. J. Clin. Invest. 120 (2010), 2218–2229.
15. Brough, H.A., Cousins, D.J., Munteanu, A., Wong, Y.F., Sudra, A., Makinson, K., Stephens, A.C., Arno, M., Ciortuz, L., Lack, G., Turcanu, V., IL-9 is a key component of memory TH cell peanut-specific responses from children with peanut allergy. J. Allergy Clin. Immunol. 134 (2014), 1329–1338.e10.
16. Brough, H.A., Simpson, A., Makinson, K., Hankinson, J., Brown, S., Douiri, A., Belgrave, D.C., Penagos, M., Stephens, A.C., McLean, W.H., et al. Peanut allergy: effect of environmental peanut exposure in children with filaggrin loss-of-function mutations. J. Allergy Clin. Immunol. 134 (2014), 867–875.e1.
17. Brown, S.J., Asai, Y., Cordell, H.J., Campbell, L.E., Zhao, Y., Liao, H., Northstone, K., Henderson, J., Alizadehfar, R., Ben-Shoshan, M., et al. Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy. J. Allergy Clin. Immunol. 127 (2011), 661–667.
18. Bryce, P.J., Falahati, R., Kenney, L.L., Leung, J., Bebbington, C., Tomasevic, N., Krier, R.A., Hsu, C.L., Shultz, L.D., Greiner, D.L., Brehm, M.A., Humanized mouse model of mast cell-mediated passive cutaneous anaphylaxis and passive systemic anaphylaxis. J. Allergy Clin. Immunol. 138 (2016), 769–779.
19. Bunyavanich, S., Shen, N., Grishin, A., Wood, R., Burks, W., Dawson, P., Jones, S.M., Leung, D.Y., Sampson, H., Sicherer, S., Clemente, J.C., Early-life gut microbiome composition and milk allergy resolution. J. Allergy Clin. Immunol. 138 (2016), 1122–1130.
20. Burton, O.T., Logsdon, S.L., Zhou, J.S., Medina-Tamayo, J., Abdel-Gadir, A., Noval Rivas, M., Koleoglou, K.J., Chatila, T.A., Schneider, L.C., Rachid, R., et al. Oral immunotherapy induces IgG antibodies that act through FcγRIIb to suppress IgE-mediated hypersensitivity. J. Allergy Clin. Immunol. 134 (2014), 1310–1317.e6.
21. Burton, O.T., Noval Rivas, M., Zhou, J.S., Logsdon, S.L., Darling, A.R., Koleoglou, K.J., Roers, A., Houshyar, H., Crackower, M.A., Chatila, T.A., Oettgen, H.C., Immunoglobulin E signal inhibition during allergen ingestion leads to reversal of established food allergy and induction of regulatory T cells. Immunity 41 (2014), 141–151.
22. Burton, O.T., Stranks, A.J., Tamayo, J.M., Koleoglou, K.J., Schwartz, L.B., Oettgen, H.C., A humanized mouse model of anaphylactic peanut allergy. J. Allergy Clin. Immunol. 139 (2017), 314–322.e9.
23. Cahenzli, J., Köller, Y., Wyss, M., Geuking, M.B., McCoy, K.D., Intestinal microbial diversity during early-life colonization shapes long-term IgE levels. Cell Host Microbe 14 (2013), 559–570.
24. Caubet, J.C., Nowak-Węgrzyn, A., Moshier, E., Godbold, J., Wang, J., Sampson, H.A., Utility of casein-specific IgE levels in predicting reactivity to baked milk. J. Allergy Clin. Immunol., 131, 2013 222–4.e1, 4.
25. Chan, S.M., Turcanu, V., Stephens, A.C., Fox, A.T., Grieve, A.P., Lack, G., Cutaneous lymphocyte antigen and α4β7 T-lymphocyte responses are associated with peanut allergy and tolerance in children. Allergy 67 (2012), 336–342.
26. Chen, C.Y., Lee, J.B., Liu, B., Ohta, S., Wang, P.Y., Kartashov, A.V., Mugge, L., Abonia, J.P., Barski, A., Izuhara, K., et al. Induction of interleukin-9-producing mucosal mast cells promotes susceptibility to IgE-mediated experimental food allergy. Immunity 43 (2015), 788–802.
27. Chu, D.K., Llop-Guevara, A., Walker, T.D., Flader, K., Goncharova, S., Boudreau, J.E., Moore, C.L., In, T.S., Waserman, S., Coyle, A.J., et al. IL-33, but not thymic stromal lymphopoietin or IL-25, is central to mite and peanut allergic sensitization. J. Allergy Clin. Immunol. 131 (2013), 187–200.
28. DeLong, J.H., Simpson, K.H., Wambre, E., James, E.A., Robinson, D., Kwok, W.W., Ara h 1-reactive T cells in individuals with peanut allergy. J. Allergy Clin. Immunol., 127, 2011 1211–8.e3.
29. Dioszeghy, V., Mondoulet, L., Puteaux, E., Dhelft, V., Ligouis, M., Plaquet, C., Dupont, C., Benhamou, P.H., Differences in phenotype, homing properties and suppressive activities of regulatory T cells induced by epicutaneous, oral or sublingual immunotherapy in mice sensitized to peanut. Cell. Mol. Immunol., 2016, 10.1038/cmi.2016.14 Published online April 11, 2016.
30. Du Toit, G., Katz, Y., Sasieni, P., Mesher, D., Maleki, S.J., Fisher, H.R., Fox, A.T., Turcanu, V., Amir, T., Zadik-Mnuhin, G., et al. Early consumption of peanuts in infancy is associated with a low prevalence of peanut allergy. J. Allergy Clin. Immunol. 122 (2008), 984–991.
31. Du Toit, G., Roberts, G., Sayre, P.H., Bahnson, H.T., Radulovic, S., Santos, A.F., Brough, H.A., Phippard, D., Basting, M., Feeney, M., et al., LEAP Study Team. Randomized trial of peanut consumption in infants at risk for peanut allergy. N. Engl. J. Med. 372 (2015), 803–813.
32. Du Toit, G., Sayre, P.H., Roberts, G., Sever, M.L., Lawson, K., Bahnson, H.T., Brough, H.A., Santos, A.F., Harris, K.M., Radulovic, S., et al., Immune Tolerance Network LEAP-On Study Team. Effect of avoidance on peanut allergy after early peanut consumption. N. Engl. J. Med. 374 (2016), 1435–1443.
33. Eggel, A., Baravalle, G., Hobi, G., Kim, B., Buschor, P., Forrer, P., Shin, J.S., Vogel, M., Stadler, B.M., Dahinden, C.A., Jardetzky, T.S., Accelerated dissociation of IgE-FcεRI complexes by disruptive inhibitors actively desensitizes allergic effector cells. J. Allergy Clin. Immunol., 133, 2014 1709–19.e8.
34. Egger, M., Hauser, M., Mari, A., Ferreira, F., Gadermaier, G., The role of lipid transfer proteins in allergic diseases. Curr. Allergy Asthma Rep. 10 (2010), 326–335.
35. Faith, J.J., Ahern, P.P., Ridaura, V.K., Cheng, J., Gordon, J.I., Identifying gut microbe-host phenotype relationships using combinatorial communities in gnotobiotic mice. Sci. Transl. Med., 6, 2014, 220ra11.
36. Ferreira, F., Ebner, C., Kramer, B., Casari, G., Briza, P., Kungl, A.J., Grimm, R., Jahn-Schmid, B., Breiteneder, H., Kraft, D., et al. Modulation of IgE reactivity of allergens by site-directed mutagenesis: potential use of hypoallergenic variants for immunotherapy. FASEB J. 12 (1998), 231–242.
37. Finkelman, F.D., Khodoun, M.V., Strait, R., Human IgE-independent systemic anaphylaxis. J. Allergy Clin. Immunol. 137 (2016), 1674–1680.
38. Flinterman, A.E., Knol, E.F., Lencer, D.A., Bardina, L., den Hartog Jager, C.F., Lin, J., Pasmans, S.G., Bruijnzeel-Koomen, C.A., Sampson, H.A., van Hoffen, E., Shreffler, W.G., Peanut epitopes for IgE and IgG4 in peanut-sensitized children in relation to severity of peanut allergy. J. Allergy Clin. Immunol. 121 (2008), 737–743.e10.
39. Forbes, E.E., Groschwitz, K., Abonia, J.P., Brandt, E.B., Cohen, E., Blanchard, C., Ahrens, R., Seidu, L., McKenzie, A., Strait, R., et al. IL-9- and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity. J. Exp. Med. 205 (2008), 897–913.
40. Foster, B., Foroughi, S., Yin, Y., Prussin, C., Effect of anti-IgE therapy on food allergen specific T cell responses in eosinophil associated gastrointestinal disorders. Clin. Mol. Allergy, 9, 2011, 7.
41. Fox, A.T., Sasieni, P., du Toit, G., Syed, H., Lack, G., Household peanut consumption as a risk factor for the development of peanut allergy. J. Allergy Clin. Immunol. 123 (2009), 417–423.
42. Francis, A., Bosio, E., Stone, S.F., Fatovich, D.M., Arendts, G., Nagree, Y., Macdonald, S.P., Mitenko, H., Rajee, M., Burrows, S., Brown, S.G., Neutrophil activation during acute human anaphylaxis: analysis of MPO and sCD62L. Clin. Exp. Allergy 47 (2017), 361–370.
43. Frischmeyer-Guerrerio, P.A., Guerrerio, A.L., Chichester, K.L., Bieneman, A.P., Hamilton, R.A., Wood, R.A., Schroeder, J.T., Dendritic cell and T cell responses in children with food allergy. Clin. Exp. Allergy 41 (2011), 61–71.
44. Frischmeyer-Guerrerio, P.A., Keet, C.A., Guerrerio, A.L., Chichester, K.L., Bieneman, A.P., Hamilton, R.G., Wood, R.A., Schroeder, J.T., Modulation of dendritic cell innate and adaptive immune functions by oral and sublingual immunotherapy. Clin. Immunol. 155 (2014), 47–59.
45. Fujimura, K.E., Sitarik, A.R., Havstad, S., Lin, D.L., Levan, S., Fadrosh, D., Panzer, A.R., LaMere, B., Rackaityte, E., Lukacs, N.W., et al. Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation. Nat. Med. 22 (2016), 1187–1191.
46. Fukutomi, Y., Taniguchi, M., Nakamura, H., Akiyama, K., Epidemiological link between wheat allergy and exposure to hydrolyzed wheat protein in facial soap. Allergy 69 (2014), 1405–1411.
47. Galand, C., Leyva-Castillo, J.M., Yoon, J., Han, A., Lee, M.S., McKenzie, A.N., Stassen, M., Oyoshi, M.K., Finkelman, F.D., Geha, R.S., IL-33 promotes food anaphylaxis in epicutaneously sensitized mice by targeting mast cells. J. Allergy Clin. Immunol. 138 (2016), 1356–1366.
48. Ganeshan, K., Bryce, P.J., Regulatory T cells enhance mast cell production of IL-6 via surface-bound TGF-β. J. Immunol. 188 (2012), 594–603.
49. Ganeshan, K., Neilsen, C.V., Hadsaitong, A., Schleimer, R.P., Luo, X., Bryce, P.J., Impairing oral tolerance promotes allergy and anaphylaxis: a new murine food allergy model. J. Allergy Clin. Immunol. 123 (2009), 231–238.e4.
50. Gauvreau, G.M., Harris, J.M., Boulet, L.P., Scheerens, H., Fitzgerald, J.M., Putnam, W.S., Cockcroft, D.W., Davis, B.E., Leigh, R., Zheng, Y., et al. Targeting membrane-expressed IgE B cell receptor with an antibody to the M1 prime epitope reduces IgE production. Sci. Transl. Med., 6, 2014, 243ra85.
51. Gauvreau, G.M., Arm, J.P., Boulet, L.P., Leigh, R., Cockcroft, D.W., Davis, B.E., Mayers, I., FitzGerald, J.M., Dahlen, B., Killian, K.J., et al. Efficacy and safety of multiple doses of QGE031 (ligelizumab) versus omalizumab and placebo in inhibiting allergen-induced early asthmatic responses. J. Allergy Clin. Immunol. 138 (2016), 1051–1059.
52. Gorelik, M., Narisety, S.D., Guerrerio, A.L., Chichester, K.L., Keet, C.A., Bieneman, A.P., Hamilton, R.G., Wood, R.A., Schroeder, J.T., Frischmeyer-Guerrerio, P.A., Suppression of the immunologic response to peanut during immunotherapy is often transient. J. Allergy Clin. Immunol. 135 (2015), 1283–1292.
53. Gupta, R.S., Springston, E.E., Warrier, M.R., Smith, B., Kumar, R., Pongracic, J., Holl, J.L., The prevalence, severity, and distribution of childhood food allergy in the United States. Pediatrics 128 (2011), e9–e17.
54. Hadis, U., Wahl, B., Schulz, O., Hardtke-Wolenski, M., Schippers, A., Wagner, N., Müller, W., Sparwasser, T., Förster, R., Pabst, O., Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria. Immunity 34 (2011), 237–246.
55. Han, H., Thelen, T.D., Comeau, M.R., Ziegler, S.F., Thymic stromal lymphopoietin-mediated epicutaneous inflammation promotes acute diarrhea and anaphylaxis. J. Clin. Invest. 124 (2014), 5442–5452.
56. Harris, J.M., Maciuca, R., Bradley, M.S., Cabanski, C.R., Scheerens, H., Lim, J., Cai, F., Kishnani, M., Liao, X.C., Samineni, D., et al. A randomized trial of the efficacy and safety of quilizumab in adults with inadequately controlled allergic asthma. Respir. Res., 17, 2016, 29.
57. Haselden, B.M., Kay, A.B., Larché M., Immunoglobulin E-independent major histocompatibility complex-restricted T cell peptide epitope-induced late asthmatic reactions. J. Exp. Med. 189 (1999), 1885–1894.
58. Hill, D.A., Siracusa, M.C., Abt, M.C., Kim, B.S., Kobuley, D., Kubo, M., Kambayashi, T., Larosa, D.F., Renner, E.D., Orange, J.S., et al. Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation. Nat. Med. 18 (2012), 538–546.
59. Hoh, R.A., Joshi, S.A., Liu, Y., Wang, C., Roskin, K.M., Lee, J.Y., Pham, T., Looney, T.J., Jackson, K.J., Dixit, V.P., et al. Single B-cell deconvolution of peanut-specific antibody responses in allergic patients. J. Allergy Clin. Immunol. 137 (2016), 157–167.
60. Hong, X., Hao, K., Ladd-Acosta, C., Hansen, K.D., Tsai, H.J., Liu, X., Xu, X., Thornton, T.A., Caruso, D., Keet, C.A., et al. Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children. Nat. Commun., 6, 2015, 6304.
61. Hua, X., Goedert, J.J., Pu, A., Yu, G., Shi, J., Allergy associations with the adult fecal microbiota: Analysis of the American Gut Project. EBioMedicine 3 (2015), 172–179.
62. James, L.K., Shamji, M.H., Walker, S.M., Wilson, D.R., Wachholz, P.A., Francis, J.N., Jacobson, M.R., Kimber, I., Till, S.J., Durham, S.R., Long-term tolerance after allergen immunotherapy is accompanied by selective persistence of blocking antibodies. J. Allergy Clin. Immunol. 127 (2011), 509–516.e1 5.
63. Järvinen, K.M., Beyer, K., Vila, L., Chatchatee, P., Busse, P.J., Sampson, H.A., B-cell epitopes as a screening instrument for persistent cow's milk allergy. J. Allergy Clin. Immunol. 110 (2002), 293–297.
64. Järvinen, K.M., Beyer, K., Vila, L., Bardina, L., Mishoe, M., Sampson, H.A., Specificity of IgE antibodies to sequential epitopes of hen's egg ovomucoid as a marker for persistence of egg allergy. Allergy 62 (2007), 758–765.
65. Jiménez-Saiz, R., Chu, D.K., Mandur, T.S., Walker, T.D., Gordon, M.E., Chaudhary, R., Koenig, J., Saliba, S., Galipeau, H.J., Utley, A., et al. Lifelong memory responses perpetuate humoral TH2 immunity and anaphylaxis in patients with food allergy. J. Allergy Clin. Immunol., 2017 Published online February 16, 2017. S0091-6749(17)30235-X.
66. Jin, H., Oyoshi, M.K., Le, Y., Bianchi, T., Koduru, S., Mathias, C.B., Kumar, L., Le Bras, S., Young, D., Collins, M., et al. IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice. J. Clin. Invest. 119 (2009), 47–60.
67. Johansson, M.E., Larsson, J.M., Hansson, G.C., The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions. Proc. Natl. Acad. Sci. USA 108:Suppl 1 (2011), 4659–4665.
68. Jones, S.M., Burks, A.W., Keet, C., Vickery, B.P., Scurlock, A.M., Wood, R.A., Liu, A.H., Sicherer, S.H., Henning, A.K., Lindblad, R.W., et al., Consortium of Food Allergy Research. Long-term treatment with egg oral immunotherapy enhances sustained unresponsiveness that persists after cessation of therapy. J. Allergy Clin. Immunol., 137, 2016 1117–27.e1, 10.
69. Jönsson, F., Mancardi, D.A., Kita, Y., Karasuyama, H., Iannascoli, B., Van Rooijen, N., Shimizu, T., Daëron, M., Bruhns, P., Mouse and human neutrophils induce anaphylaxis. J. Clin. Invest. 121 (2011), 1484–1496.
70. Katz, Y., Rajuan, N., Goldberg, M.R., Eisenberg, E., Heyman, E., Cohen, A., Leshno, M., Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy. J. Allergy Clin. Immunol. 126 (2010), 77–82.e1.
71. Khodoun, M.V., Strait, R., Armstrong, L., Yanase, N., Finkelman, F.D., Identification of markers that distinguish IgE- from IgG-mediated anaphylaxis. Proc. Natl. Acad. Sci. USA 108 (2011), 12413–12418.
72. Kim, J.S., Nowak-Węgrzyn, A., Sicherer, S.H., Noone, S., Moshier, E.L., Sampson, H.A., Dietary baked milk accelerates the resolution of cow's milk allergy in children. J. Allergy Clin. Immunol. 128 (2011), 125–131.e2.
73. Kim, B., Eggel, A., Tarchevskaya, S.S., Vogel, M., Prinz, H., Jardetzky, T.S., Accelerated disassembly of IgE-receptor complexes by a disruptive macromolecular inhibitor. Nature 491 (2012), 613–617.
74. Kosoy, R., Agashe, C., Grishin, A., Leung, D.Y., Wood, R.A., Sicherer, S.H., Jones, S.M., Burks, A.W., Davidson, W.F., Lindblad, R.W., et al. Transcriptional profiling of egg allergy and relationship to disease Phenotype. PLoS ONE, 11, 2016, e0163831.
75. Kulis, M., Macqueen, I., Li, Y., Guo, R., Zhong, X.P., Burks, A.W., Pepsinized cashew proteins are hypoallergenic and immunogenic and provide effective immunotherapy in mice with cashew allergy. J. Allergy Clin. Immunol. 130 (2012), 716–723.
76. Kulis, M., Saba, K., Kim, E.H., Bird, J.A., Kamilaris, N., Vickery, B.P., Staats, H., Burks, A.W., Increased peanut-specific IgA levels in saliva correlate with food challenge outcomes after peanut sublingual immunotherapy. J. Allergy Clin. Immunol. 129 (2012), 1159–1162.
77. Kulis, M., Gorentla, B., Burks, A.W., Zhong, X.P., Type B CpG oligodeoxynucleotides induce Th1 responses to peanut antigens: modulation of sensitization and utility in a truncated immunotherapy regimen in mice. Mol. Nutr. Food Res. 57 (2013), 906–915.
78. Kull, I., Bergström, A., Lilja, G., Pershagen, G., Wickman, M., Fish consumption during the first year of life and development of allergic diseases during childhood. Allergy 61 (2006), 1009–1015.
79. Lack, G., Update on risk factors for food allergy. J. Allergy Clin. Immunol. 129 (2012), 1187–1197.
80. Lack, G., Fox, D., Northstone, K., Golding, J., Avon Longitudinal Study of Parents and Children Study Team. Factors associated with the development of peanut allergy in childhood. N. Engl. J. Med. 348 (2003), 977–985.
81. Lee, J.B., Chen, C.Y., Liu, B., Mugge, L., Angkasekwinai, P., Facchinetti, V., Dong, C., Liu, Y.J., Rothenberg, M.E., Hogan, S.P., et al. IL-25 and CD4(+) TH2 cells enhance type 2 innate lymphoid cell-derived IL-13 production, which promotes IgE-mediated experimental food allergy. J. Allergy Clin. Immunol., 137, 2016 1216–25.e1, 5.
82. Leonard, S.A., Sampson, H.A., Sicherer, S.H., Noone, S., Moshier, E.L., Godbold, J., Nowak-Węgrzyn, A., Dietary baked egg accelerates resolution of egg allergy in children. J. Allergy Clin. Immunol., 130, 2012 473–80.e1.
83. Leyva-Castillo, J.M., Hener, P., Michea, P., Karasuyama, H., Chan, S., Soumelis, V., Li, M., Skin thymic stromal lymphopoietin initiates Th2 responses through an orchestrated immune cascade. Nat. Commun., 4, 2013, 2847.
84. Li, X.M., Srivastava, K., Grishin, A., Huang, C.K., Schofield, B., Burks, W., Sampson, H.A., Persistent protective effect of heat-killed Escherichia coli producing “engineered,” recombinant peanut proteins in a murine model of peanut allergy. J. Allergy Clin. Immunol. 112 (2003), 159–167.
85. Lieberman, J.A., Glaumann, S., Batelson, S., Borres, M.P., Sampson, H.A., Nilsson, C., The utility of peanut components in the diagnosis of IgE-mediated peanut allergy among distinct populations. J. Allergy Clin. Immunol. Pract. 1 (2013), 75–82.
86. Ling, Z., Li, Z., Liu, X., Cheng, Y., Luo, Y., Tong, X., Yuan, L., Wang, Y., Sun, J., Li, L., Xiang, C., Altered fecal microbiota composition associated with food allergy in infants. Appl. Environ. Microbiol. 80 (2014), 2546–2554.
87. Liu, Y., Sun, Y., Chang, L.J., Li, N., Li, H., Yu, Y., Bryce, P.J., Grammer, L.C., Schleimer, R.P., Zhu, D., Blockade of peanut allergy with a novel Ara h 2-Fcγ fusion protein in mice. J. Allergy Clin. Immunol., 131, 2013 213–21.e1, 5.
88. Loo, E.X., Sim, J.Z., Goh, A., Teoh, O.H., Chan, Y.H., Saw, S.M., Kwek, K., Gluckman, P.D., Godfrey, K.M., Van Bever, H., et al. Predictors of allergen sensitization in Singapore children from birth to 3 years. Allergy Asthma Clin. Immunol., 12, 2016, 56.
89. MacGinnitie, A.J., Rachid, R., Gragg, H., Little, S.V., Lakin, P., Cianferoni, A., Heimall, J., Makhija, M., Robison, R., Chinthrajah, R.S., et al. Omalizumab facilitates rapid oral desensitization for peanut allergy. J. Allergy Clin. Immunol. 139 (2017), 873–881.
90. Maldonado, R.A., LaMothe, R.A., Ferrari, J.D., Zhang, A.H., Rossi, R.J., Kolte, P.N., Griset, A.P., O'Neil, C., Altreuter, D.H., Browning, E., et al. Polymeric synthetic nanoparticles for the induction of antigen-specific immunological tolerance. Proc. Natl. Acad. Sci. USA 112 (2015), E156–E165.
91. Martin, P.E., Eckert, J.K., Koplin, J.J., Lowe, A.J., Gurrin, L.C., Dharmage, S.C., Vuillermin, P., Tang, M.L., Ponsonby, A.L., Matheson, M., et al., HealthNuts Study Investigators. Which infants with eczema are at risk of food allergy? Results from a population-based cohort. Clin. Exp. Allergy 45 (2015), 255–264.
92. Martino, D.J., Ashley, S., Koplin, J., Ellis, J., Saffery, R., Dharmage, S.C., Gurrin, L., Matheson, M.C., Kalb, B., Marenholz, I., et al. Genomewide association study of peanut allergy reproduces association with amino acid polymorphisms in HLA-DRB1. Clin. Exp. Allergy 47 (2017), 217–223.
93. Masthoff, L.J., Mattsson, L., Zuidmeer-Jongejan, L., Lidholm, J., Andersson, K., Akkerdaas, J.H., Versteeg, S.A., Garino, C., Meijer, Y., Kentie, P., et al. Sensitization to Cor a 9 and Cor a 14 is highly specific for a hazelnut allergy with objective symptoms in Dutch children and adults. J. Allergy Clin. Immunol. 132 (2013), 393–399.
94. Mondoulet, L., Dioszeghy, V., Puteaux, E., Ligouis, M., Dhelft, V., Plaquet, C., Dupont, C., Benhamou, P.H., Specific epicutaneous immunotherapy prevents sensitization to new allergens in a murine model. J. Allergy Clin. Immunol., 135, 2015 1546–57.e4.
95. Monti, G., Tonetto, P., Mostert, M., Oggero, R., Staphylococcus aureus skin colonization in infants with atopic dermatitis. Dermatology (Basel) 193 (1996), 83–87.
96. Mortha, A., Chudnovskiy, A., Hashimoto, D., Bogunovic, M., Spencer, S.P., Belkaid, Y., Merad, M., Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis. Science, 343, 2014, 1249288.
97. Moutsoglou, D.M., Dreskin, S.C., B cells establish, but do not maintain, long-lived murine anti-peanut IgE(a). Clin. Exp. Allergy 46 (2016), 640–653.
98. Nadeau, K.C., Schneider, L.C., Hoyte, L., Borras, I., Umetsu, D.T., Rapid oral desensitization in combination with omalizumab therapy in patients with cow's milk allergy. J. Allergy Clin. Immunol. 127 (2011), 1622–1624.
99. National Academies of Sciences Engineering and Medicine (U.S.). Finding a path to safety in food allergy: assessment of the global burden, causes, prevention, management, and public policy. 2016, The National Academies Press, Washington, DC, 10.17226/23658.
100. Natsume, O., Kabashima, S., Nakazato, J., Yamamoto-Hanada, K., Narita, M., Kondo, M., Saito, M., Kishino, A., Takimoto, T., Inoue, E., et al. Two-step egg introduction for prevention of egg allergy in high-risk infants with eczema (PETIT): a randomised, double-blind, placebo-controlled trial. Lancet 389 (2017), 276–286.
101. Nicolaou, N., Murray, C., Belgrave, D., Poorafshar, M., Simpson, A., Custovic, A., Quantification of specific IgE to whole peanut extract and peanut components in prediction of peanut allergy. J. Allergy Clin. Immunol. 127 (2011), 684–685.
102. Noti, M., Wojno, E.D., Kim, B.S., Siracusa, M.C., Giacomin, P.R., Nair, M.G., Benitez, A.J., Ruymann, K.R., Muir, A.B., Hill, D.A., et al. Thymic stromal lymphopoietin-elicited basophil responses promote eosinophilic esophagitis. Nat. Med. 19 (2013), 1005–1013.
103. Noval Rivas, M., Burton, O.T., Wise, P., Zhang, Y.Q., Hobson, S.A., Garcia Lloret, M., Chehoud, C., Kuczynski, J., DeSantis, T., Warrington, J., et al. A microbiota signature associated with experimental food allergy promotes allergic sensitization and anaphylaxis. J. Allergy Clin. Immunol. 131 (2013), 201–212.
104. Noval Rivas, M., Burton, O.T., Wise, P., Charbonnier, L.M., Georgiev, P., Oettgen, H.C., Rachid, R., Chatila, T.A., Regulatory T cell reprogramming toward a Th2-cell-like lineage impairs oral tolerance and promotes food allergy. Immunity 42 (2015), 512–523.
105. Noval Rivas, M., Burton, O.T., Oettgen, H.C., Chatila, T., IL-4 production by group 2 innate lymphoid cells promotes food allergy by blocking regulatory T-cell function. J. Allergy Clin. Immunol. 138 (2016), 801–811.e9.
106. + T cells. Science 349 (2015), 989–993.
107. Osterfeld, H., Ahrens, R., Strait, R., Finkelman, F.D., Renauld, J.C., Hogan, S.P., Differential roles for the IL-9/IL-9 receptor alpha-chain pathway in systemic and oral antigen-induced anaphylaxis. J. Allergy Clin. Immunol. 125 (2010), 469–476.e2.
108. Oyoshi, M.K., Larson, R.P., Ziegler, S.F., Geha, R.S., Mechanical injury polarizes skin dendritic cells to elicit a T(H)2 response by inducing cutaneous thymic stromal lymphopoietin expression. J. Allergy Clin. Immunol. 126 (2010), 976–984 984.e1–984.e5.
109. Pali-Schöll, I., Szöllösi, H., Starkl, P., Scheicher, B., Stremnitzer, C., Hofmeister, A., Roth-Walter, F., Lukschal, A., Diesner, S.C., Zimmer, A., Jensen-Jarolim, E., Protamine nanoparticles with CpG-oligodeoxynucleotide prevent an allergen-induced Th2-response in BALB/c mice. Eur. J. Pharm. Biopharm. 85:3 Pt A (2013), 656–664.
110. Palmer, D.J., Metcalfe, J., Makrides, M., Gold, M.S., Quinn, P., West, C.E., Loh, R., Prescott, S.L., Early regular egg exposure in infants with eczema: A randomized controlled trial. J. Allergy Clin. Immunol., 132, 2013 387–92.e1.
111. Palmer, D.J., Sullivan, T.R., Gold, M.S., Prescott, S.L., Makrides, M., Randomized controlled trial of early regular egg intake to prevent egg allergy. J. Allergy Clin. Immunol. 139 (2017), 1600–1607.
112. Patil, S.P., Wang, J., Song, Y., Noone, S., Yang, N., Wallenstein, S., Sampson, H.A., Li, X.M., Clinical safety of Food Allergy Herbal Formula-2 (FAHF-2) and inhibitory effect on basophils from patients with food allergy: Extended phase I study. J. Allergy Clin. Immunol. 128 (2011), 1259–1265.e2.
113. Patil, S.U., Ogunniyi, A.O., Calatroni, A., Tadigotla, V.R., Ruiter, B., Ma, A., Moon, J., Love, J.C., Shreffler, W.G., Peanut oral immunotherapy transiently expands circulating Ara h 2-specific B cells with a homologous repertoire in unrelated subjects. J. Allergy Clin. Immunol. 136 (2015), 125–134.e12.
114. Perkin, M.R., Logan, K., Tseng, A., Raji, B., Ayis, S., Peacock, J., Brough, H., Marrs, T., Radulovic, S., Craven, J., et al., EAT Study Team. Randomized trial of introduction of allergenic foods in breast-fed infants. N. Engl. J. Med. 374 (2016), 1733–1743.
115. Pinckard, R.N., Halonen, M., Palmer, J.D., Butler, C., Shaw, J.O., Henson, P.M., Intravascular aggregation and pulmonary sequestration of platelets during IgE-induced systemic anaphylaxis in the rabbit: abrogation of lethal anaphylactic shock by platelet depletion. J. Immunol. 119 (1977), 2185–2193.
116. Platzer, B., Baker, K., Vera, M.P., Singer, K., Panduro, M., Lexmond, W.S., Turner, D., Vargas, S.O., Kinet, J.P., Maurer, D., et al. Dendritic cell-bound IgE functions to restrain allergic inflammation at mucosal sites. Mucosal Immunol. 8 (2015), 516–532.
117. Poole, J.A., Barriga, K., Leung, D.Y., Hoffman, M., Eisenbarth, G.S., Rewers, M., Norris, J.M., Timing of initial exposure to cereal grains and the risk of wheat allergy. Pediatrics 117 (2006), 2175–2182.
118. Prescott, S., Allen, K.J., Food allergy: riding the second wave of the allergy epidemic. Pediatr. Allergy Immunol. 22 (2011), 155–160.
119. Prussin, C., Griffith, D.T., Boesel, K.M., Lin, H., Foster, B., Casale, T.B., Omalizumab treatment downregulates dendritic cell FcepsilonRI expression. J. Allergy Clin. Immunol. 112 (2003), 1147–1154.
120. Qamar, N., Fishbein, A.B., Erickson, K.A., Cai, M., Szychlinski, C., Bryce, P.J., Schleimer, R.P., Fuleihan, R.L., Singh, A.M., Naturally occurring tolerance acquisition to foods in previously allergic children is characterized by antigen specificity and associated with increased subsets of regulatory T cells. Clin. Exp. Allergy 45 (2015), 1663–1672.
121. Reber, L.L., Marichal, T., Mukai, K., Kita, Y., Tokuoka, S.M., Roers, A., Hartmann, K., Karasuyama, H., Nadeau, K.C., Tsai, M., Galli, S.J., Selective ablation of mast cells or basophils reduces peanut-induced anaphylaxis in mice. J. Allergy Clin. Immunol., 132, 2013 881–8.e1, 11.
122. Roulias, A., Pichler, U., Hauser, M., Himly, M., Hofer, H., Lackner, P., Ebner, C., Briza, P., Bohle, B., Egger, M., et al. Differences in the intrinsic immunogenicity and allergenicity of Bet v 1 and related food allergens revealed by site-directed mutagenesis. Allergy 69 (2014), 208–215.
123. Ryan, J.F., Hovde, R., Glanville, J., Lyu, S.C., Ji, X., Gupta, S., Tibshirani, R.J., Jay, D.C., Boyd, S.D., Chinthrajah, R.S., et al. Successful immunotherapy induces previously unidentified allergen-specific CD4+ T-cell subsets. Proc. Natl. Acad. Sci. USA 113 (2016), E1286–E1295.
124. Sampson, H.A., Aceves, S., Bock, S.A., James, J., Jones, S., Lang, D., Nadeau, K., Nowak-Wegrzyn, A., Oppenheimer, J., Perry, T.T., et al. Joint Task Force on Practice Parameters, Practice Parameter Workgroup. Food allergy: a practice parameter update-2014. J. Allergy Clin. Immunol., 134, 2014 1016–25.e43.
125. San Román, B., Irache, J.M., Gómez, S., Gamazo, C., Espuelas, S., Co-delivery of ovalbumin and CpG motifs into microparticles protected sensitized mice from anaphylaxis. Int. Arch. Allergy Immunol. 149 (2009), 111–118.
126. Sastre, J., Molecular diagnosis in allergy. Clin. Exp. Allergy 40 (2010), 1442–1460.
127. Savage, J.H., Courneya, J.P., Sterba, P.M., Macglashan, D.W., Saini, S.S., Wood, R.A., Kinetics of mast cell, basophil, and oral food challenge responses in omalizumab-treated adults with peanut allergy. J. Allergy Clin. Immunol. 130 (2012), 1123–1129.e2.
128. Savvatianos, S., Konstantinopoulos, A.P., Borgå Å., Stavroulakis, G., Lidholm, J., Borres, M.P., Manousakis, E., Papadopoulos, N.G., Sensitization to cashew nut 2S albumin, Ana o 3, is highly predictive of cashew and pistachio allergy in Greek children. J. Allergy Clin. Immunol. 136 (2015), 192–194.
129. Schroeder, J.T., Bieneman, A.P., Chichester, K.L., Hamilton, R.G., Xiao, H., Saini, S.S., Liu, M.C., Decreases in human dendritic cell-dependent T(H)2-like responses after acute in vivo IgE neutralization. J. Allergy Clin. Immunol. 125 (2010), 896–901.e6.
130. Shan, M., Gentile, M., Yeiser, J.R., Walland, A.C., Bornstein, V.U., Chen, K., He, B., Cassis, L., Bigas, A., Cols, M., et al. Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals. Science 342 (2013), 447–453.
131. Shreffler, W.G., Lencer, D.A., Bardina, L., Sampson, H.A., IgE and IgG4 epitope mapping by microarray immunoassay reveals the diversity of immune response to the peanut allergen, Ara h 2. J. Allergy Clin. Immunol. 116 (2005), 893–899.
132. Shreffler, W.G., Castro, R.R., Kucuk, Z.Y., Charlop-Powers, Z., Grishina, G., Yoo, S., Burks, A.W., Sampson, H.A., The major glycoprotein allergen from Arachis hypogaea, Ara h 1, is a ligand of dendritic cell-specific ICAM-grabbing nonintegrin and acts as a Th2 adjuvant in vitro. J. Immunol. 177 (2006), 3677–3685.
133. Sicherer, S.H., Furlong, T.J., Maes, H.H., Desnick, R.J., Sampson, H.A., Gelb, B.D., Genetics of peanut allergy: a twin study. J. Allergy Clin. Immunol. 106 (2000), 53–56.
134. Siracusa, M.C., Saenz, S.A., Hill, D.A., Kim, B.S., Headley, M.B., Doering, T.A., Wherry, E.J., Jessup, H.K., Siegel, L.A., Kambayashi, T., et al. TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation. Nature 477 (2011), 229–233.
135. Smarr, C.B., Hsu, C.L., Byrne, A.J., Miller, S.D., Bryce, P.J., Antigen-fixed leukocytes tolerize Th2 responses in mouse models of allergy. J. Immunol. 187 (2011), 5090–5098.
136. Smith, P.M., Howitt, M.R., Panikov, N., Michaud, M., Gallini, C.A., Bohlooly-Y, M., Glickman, J.N., Garrett, W.S., The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science 341 (2013), 569–573.
137. Song, Y., Qu, C., Srivastava, K., Yang, N., Busse, P., Zhao, W., Li, X.M., Food allergy herbal formula 2 protection against peanut anaphylactic reaction is via inhibition of mast cells and basophils. J. Allergy Clin. Immunol., 126, 2010 1208–17.e3.
138. Soumelis, V., Reche, P.A., Kanzler, H., Yuan, W., Edward, G., Homey, B., Gilliet, M., Ho, S., Antonenko, S., Lauerma, A., et al. Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat. Immunol. 3 (2002), 673–680.
139. Srivastava, K.D., Qu, C., Zhang, T., Goldfarb, J., Sampson, H.A., Li, X.M., Food Allergy Herbal Formula-2 silences peanut-induced anaphylaxis for a prolonged posttreatment period via IFN-gamma-producing CD8+ T cells. J. Allergy Clin. Immunol. 123 (2009), 443–451.
140. Srivastava, K.D., Siefert, A., Fahmy, T.M., Caplan, M.J., Li, X.M., Sampson, H.A., Investigation of peanut oral immunotherapy with CpG/peanut nanoparticles in a murine model of peanut allergy. J. Allergy Clin. Immunol. 138 (2016), 536–543.e4.
141. Stefka, A.T., Feehley, T., Tripathi, P., Qiu, J., McCoy, K., Mazmanian, S.K., Tjota, M.Y., Seo, G.Y., Cao, S., Theriault, B.R., et al. Commensal bacteria protect against food allergen sensitization. Proc. Natl. Acad. Sci. USA 111 (2014), 13145–13150.
142. Stein, M.M., Hrusch, C.L., Gozdz, J., Igartua, C., Pivniouk, V., Murray, S.E., Ledford, J.G., Marques dos Santos, M., Anderson, R.L., Metwali, N., et al. Innate immunity and asthma risk in Amish and Hutterite farm children. N. Engl. J. Med. 375 (2016), 411–421.
143. Stone, S.F., Bosco, A., Jones, A., Cotterell, C.L., van Eeden, P.E., Arendts, G., Fatovich, D.M., Brown, S.G., Genomic responses during acute human anaphylaxis are characterized by upregulation of innate inflammatory gene networks. PLoS ONE, 9, 2014, e101409.
144. Strait, R.T., Morris, S.C., Yang, M., Qu, X.W., Finkelman, F.D., Pathways of anaphylaxis in the mouse. J. Allergy Clin. Immunol. 109 (2002), 658–668.
145. Strait, R.T., Morris, S.C., Finkelman, F.D., IgG-blocking antibodies inhibit IgE-mediated anaphylaxis in vivo through both antigen interception and Fc gamma RIIb cross-linking. J. Clin. Invest. 116 (2006), 833–841.
146. Sun, J., Arias, K., Alvarez, D., Fattouh, R., Walker, T., Goncharova, S., Kim, B., Waserman, S., Reed, J., Coyle, A.J., Jordana, M., Impact of CD40 ligand, B cells, and mast cells in peanut-induced anaphylactic responses. J. Immunol. 179 (2007), 6696–6703.
147. Syed, A., Garcia, M.A., Lyu, S.C., Bucayu, R., Kohli, A., Ishida, S., Berglund, J.P., Tsai, M., Maecker, H., O'Riordan, G., et al. Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3). J. Allergy Clin. Immunol. 133 (2014), 500–510.
148. Tan, J., McKenzie, C., Vuillermin, P.J., Goverse, G., Vinuesa, C.G., Mebius, R.E., Macia, L., Mackay, C.R., Dietary fiber and bacterial SCFA enhance oral tolerance and protect against food allergy through diverse cellular pathways. Cell Rep. 15 (2016), 2809–2824.
149. Tang, M.L., Ponsonby, A.L., Orsini, F., Tey, D., Robinson, M., Su, E.L., Licciardi, P., Burks, W., Donath, S., Administration of a probiotic with peanut oral immunotherapy: A randomized trial. J. Allergy Clin. Immunol., 135, 2015 737–44.e8.
150. Togias, A., Cooper, S.F., Acebal, M.L., Assa'ad, A., Baker, J.R. Jr., Beck, L.A., Block, J., Byrd-Bredbenner, C., Chan, E.S., Eichenfield, L.F., et al. Addendum guidelines for the prevention of peanut allergy in the United States: Report of the National Institute of Allergy and Infectious Diseases-sponsored expert panel. J. Allergy Clin. Immunol. 139 (2017), 29–44.
151. Tordesillas, L., Gamboa, P., Sanz, M.L., Palacín, A., Gómez-Casado, C., Cuesta-Herranz, J., Pacios, L.F., Salcedo, G., Díaz-Perales, A., A mutant of the major melon allergen, Cuc m 2, with reduced IgE binding capacity is a good candidate for specific immunotherapy. Mol. Immunol. 49 (2011), 504–511.
152. Tordesillas, L., Goswami, R., Benedé S., Grishina, G., Dunkin, D., Järvinen, K.M., Maleki, S.J., Sampson, H.A., Berin, M.C., Skin exposure promotes a Th2-dependent sensitization to peanut allergens. J. Clin. Invest. 124 (2014), 4965–4975.
153. Tordesillas, L., Rahman, A.H., Hartmann, B.M., Sampson, H.A., Berin, M.C., Mass cytometry profiling the response of basophils and the complete peripheral blood compartment to peanut. J. Allergy Clin. Immunol. 138 (2016), 1741–1744.e9.
154. Tordesillas, L., Mondoulet, L., Blazquez, A.B., Benhamou, P.H., Sampson, H.A., Berin, M.C., Epicutaneous immunotherapy induces gastrointestinal LAP+ regulatory T cells and prevents food-induced anaphylaxis. J. Allergy Clin. Immunol. 139 (2017), 189–201.
155. Tsujimura, Y., Obata, K., Mukai, K., Shindou, H., Yoshida, M., Nishikado, H., Kawano, Y., Minegishi, Y., Shimizu, T., Karasuyama, H., Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis. Immunity 28 (2008), 581–589.
156. Vadas, P., Gold, M., Perelman, B., Liss, G.M., Lack, G., Blyth, T., Simons, F.E., Simons, K.J., Cass, D., Yeung, J., Platelet-activating factor, PAF acetylhydrolase, and severe anaphylaxis. N. Engl. J. Med. 358 (2008), 28–35.
157. Vadas, P., Perelman, B., Liss, G., Platelet-activating factor, histamine, and tryptase levels in human anaphylaxis. J. Allergy Clin. Immunol. 131 (2013), 144–149.
158. Valenta, R., Campana, R., Focke-Tejkl, M., Niederberger, V., Vaccine development for allergen-specific immunotherapy based on recombinant allergens and synthetic allergen peptides: Lessons from the past and novel mechanisms of action for the future. J. Allergy Clin. Immunol. 137 (2016), 351–357.
159. Varshney, P., Jones, S.M., Scurlock, A.M., Perry, T.T., Kemper, A., Steele, P., Hiegel, A., Kamilaris, J., Carlisle, S., Yue, X., et al. A randomized controlled study of peanut oral immunotherapy: clinical desensitization and modulation of the allergic response. J. Allergy Clin. Immunol. 127 (2011), 654–660.
160. Venkataraman, D., Soto-Ramírez, N., Kurukulaaratchy, R.J., Holloway, J.W., Karmaus, W., Ewart, S.L., Arshad, S.H., Erlewyn-Lajeunesse, M., Filaggrin loss-of-function mutations are associated with food allergy in childhood and adolescence. J. Allergy Clin. Immunol. 134 (2014), 876–882.e4.
161. Vickery, B.P., Lin, J., Kulis, M., Fu, Z., Steele, P.H., Jones, S.M., Scurlock, A.M., Gimenez, G., Bardina, L., Sampson, H.A., Burks, A.W., Peanut oral immunotherapy modifies IgE and IgG4 responses to major peanut allergens. J. Allergy Clin. Immunol., 131, 2013 128–34.e1, 3.
162. Vickery, B.P., Berglund, J.P., Burk, C.M., Fine, J.P., Kim, E.H., Kim, J.I., Keet, C.A., Kulis, M., Orgel, K.G., Guo, R., et al. Early oral immunotherapy in peanut-allergic preschool children is safe and highly effective. J. Allergy Clin. Immunol. 139 (2017), 173–181.e8.
163. Wai, C.Y., Leung, N.Y., Leung, P.S., Chu, K.H., T cell epitope immunotherapy ameliorates allergic responses in a murine model of shrimp allergy. Clin. Exp. Allergy 46 (2016), 491–503.
164. Wang, J., Lin, J., Bardina, L., Goldis, M., Nowak-Wegrzyn, A., Shreffler, W.G., Sampson, H.A., Correlation of IgE/IgG4 milk epitopes and affinity of milk-specific IgE antibodies with different phenotypes of clinical milk allergy. J. Allergy Clin. Immunol. 125 (2010), 695–702 702.e1–702.e6.
165. Wang, M., Takeda, K., Shiraishi, Y., Okamoto, M., Dakhama, A., Joetham, A., Gelfand, E.W., Peanut-induced intestinal allergy is mediated through a mast cell-IgE-FcepsilonRI-IL-13 pathway. J. Allergy Clin. Immunol. 126 (2010), 306–316 316.e1–316.e12.
166. Wang, J., Jones, S.M., Pongracic, J.A., Song, Y., Yang, N., Sicherer, S.H., Makhija, M.M., Robison, R.G., Moshier, E., Godbold, J., et al. Safety, clinical, and immunologic efficacy of a Chinese herbal medicine (Food Allergy Herbal Formula-2) for food allergy. J. Allergy Clin. Immunol. 136 (2015), 962–970.e1.
167. Wang, S., Charbonnier, L.M., Noval Rivas, M., Georgiev, P., Li, N., Gerber, G., Bry, L., Chatila, T.A., MyD88 adaptor-dependent microbial sensing by regulatory T cells promotes mucosal tolerance and enforces commensalism. Immunity 43 (2015), 289–303.
168. Wesemann, D.R., Nagler, C.R., The microbiome, timing, and barrier function in the context of allergic disease. Immunity 44 (2016), 728–738.
169. Wood, R.A., Sicherer, S.H., Burks, A.W., Grishin, A., Henning, A.K., Lindblad, R., Stablein, D., Sampson, H.A., A phase 1 study of heat/phenol-killed, E. coli-encapsulated, recombinant modified peanut proteins Ara h 1, Ara h 2, and Ara h 3 (EMP-123) for the treatment of peanut allergy. Allergy 68 (2013), 803–808.
170. Wood, R.A., Kim, J.S., Lindblad, R., Nadeau, K., Henning, A.K., Dawson, P., Plaut, M., Sampson, H.A., A randomized, double-blind, placebo-controlled study of omalizumab combined with oral immunotherapy for the treatment of cow's milk allergy. J. Allergy Clin. Immunol., 137, 2016 1103–10.e1, 11.
171. Wright, B.L., Kulis, M., Orgel, K.A., Burks, A.W., Dawson, P., Henning, A.K., Jones, S.M., Wood, R.A., Sicherer, S.H., Lindblad, R.W., et al., Consortium of Food Allergy Research. Component-resolved analysis of IgA, IgE, and IgG4 during egg OIT identifies markers associated with sustained unresponsiveness. Allergy 71 (2016), 1552–1560.
172. Yamaki, K., Yoshino, S., Preventive and therapeutic effects of rapamycin, a mammalian target of rapamycin inhibitor, on food allergy in mice. Allergy 67 (2012), 1259–1270.
173. Yamaki, K., Yoshino, S., Tyrosine kinase inhibitor sunitinib relieves systemic and oral antigen-induced anaphylaxes in mice. Allergy 67 (2012), 114–122.
174. Yang, M., Yang, C., Mine, Y., Multiple T cell epitope peptides suppress allergic responses in an egg allergy mouse model by the elicitation of forkhead box transcription factor 3- and transforming growth factor-beta-associated mechanisms. Clin. Exp. Allergy 40 (2010), 668–678.
175. Yang, N., Wang, J., Liu, C., Song, Y., Zhang, S., Zi, J., Zhan, J., Masilamani, M., Cox, A., Nowak-Wegrzyn, A., et al. Berberine and limonin suppress IgE production by human B cells and peripheral blood mononuclear cells from food-allergic patients. Ann. Allergy Asthma Immunol. 113 (2014), 556–564.e4.
176. Yin, Y., Mitson-Salazar, A., Wansley, D.L., Singh, S.P., Prussin, C., Rapamycin preferentially inhibits human IL-5+ TH2-cell proliferation via an mTORC1/S6 kinase-1-dependent pathway. J. Allergy Clin. Immunol. 139 (2017), 1701–1704.
177. Zuidmeer-Jongejan, L., Huber, H., Swoboda, I., Rigby, N., Versteeg, S.A., Jensen, B.M., Quaak, S., Akkerdaas, J.H., Blom, L., Asturias, J., et al. Development of a hypoallergenic recombinant parvalbumin for first-in-man subcutaneous immunotherapy of fish allergy. Int. Arch. Allergy Immunol. 166 (2015), 41–51.