Filaggrin loss-of-function mutations are associated with food allergy in childhood and adolescence

Journal of Allergy and Clinical Immunology

Volumn 134, Issue 4, 2014, Pages 876-882.e4

  Venkataraman, Devasmitha ^a,b   Soto Ramírez, Nelís ^c   Kurukulaaratchy, Ramesh J ^d,e   Holloway, John W ^a,d   Karmaus, Wilfried ^c   Ewart, Susan L ^f   Arshad, S Hasan ^d,e   Erlewyn Lajeunesse, Mich ^d,e  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b JAMES COOK UNIVERSITY HOSPITAL   (United Kingdom)

^c UNIVERSITY OF MEMPHIS   (United States)

^d UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^e UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

^f MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

eczema; filaggrin; FLG LOF; food allergen sensitization; Food allergy; path analysis; prediction

Indexed keywords

FILAGGRIN; FOOD ALLERGEN; ALLERGEN; INTERMEDIATE FILAMENT PROTEIN;

ADOLESCENT; ADOLESCENT DISEASE; ADULT; AGE; ARTICLE; CHILD; CHILDHOOD DISEASE; COHORT ANALYSIS; CONTROLLED STUDY; ECZEMA; EXPLORATORY RESEARCH; FEMALE; FOOD ALLERGY; GENOTYPE; HUMAN; LONGITUDINAL STUDY; LOSS OF FUNCTION MUTATION; MAJOR CLINICAL STUDY; MALE; PATH ANALYSIS; PRICK TEST; RISK ASSESSMENT; FOLLOW UP; GENETICS; IMMUNOLOGY; INFANT; MUTATION; PRESCHOOL CHILD; SKIN; UNITED KINGDOM;

ADOLESCENT; ALLERGENS; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; FEMALE; FOLLOW-UP STUDIES; FOOD HYPERSENSITIVITY; GENOTYPE; GREAT BRITAIN; HUMANS; INFANT; INTERMEDIATE FILAMENT PROTEINS; MALE; MUTATION; SKIN;

EID: 84908099467     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2014.07.033     Document Type: Article

References (32)

1. M.J. Cork, S.G. Danby, Y. Vasilopoulos, J. Hadgraft, M.E. Lane, and M. Moustafa Epidermal barrier dysfunction in atopic dermatitis J Invest Dermatol 129 2009 1892 1908
2. A.V. Rawlings, and C.R. Harding Moisturization and skin barrier function Dermatol Ther 17 suppl 1 2004 43 48
3. C.N. Palmer, A.D. Irvine, A. Terron-Kwiatkowski, Y. Zhao, H. Liao, and S.P. Lee Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis Nat Genet 38 2006 441 446
4. F.J. Smith, A.D. Irvine, A. Terron-Kwiatkowski, A. Sandilands, L.E. Campbell, and Y. Zhao Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris Nat Genet 38 2006 337 342
5. S. Kezic, P.M. Kemperman, E.S. Koster, C.M. de Jongh, H.B. Thio, and L.E. Campbell Loss-of-function mutations in the filaggrin gene lead to reduced level of natural moisturizing factor in the stratum corneum J Invest Dermatol 128 2008 2117 2119
6. C. Flohr, K. England, S. Radulovic, W.H. McLean, L.E. Campbel, and J. Barker Filaggrin loss-of-function mutations are associated with early-onset eczema, eczema severity and transepidermal water loss at 3 months of age Br J Dermatol 163 2010 1333 1336
7. G. Lack Epidemiologic risks for food allergy J Allergy Clin Immunol 121 2008 1331 1336
8. G. Lack, D. Fox, K. Northstone, and J. Golding Factors associated with the development of peanut allergy in childhood N Engl J Med 348 2003 977 985
9. J. Strid, J. Hourihane, I. Kimber, R. Callard, and S. Strobel Disruption of the stratum corneum allows potent epicutaneous immunization with protein antigens resulting in a dominant systemic Th2 response Eur J Immunol 34 2004 2100 2109
10. P.G. Fallon, T. Sasaki, A. Sandilands, L.E. Campbell, S.P. Saunders, and N.E. Mangan A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming Nat Genet 41 2009 602 608
11. I. Marenholz, T. Kerscher, A. Bauerfeind, J. Esparza-Gordillo, R. Nickel, and T. Keil An interaction between filaggrin mutations and early food sensitization improves the prediction of childhood asthma J Allergy Clin Immunol 123 2009 911 916
12. S. Weidinger, M. O'Sullivan, T. Illig, H. Baurecht, M. Depner, and E. Rodriguez Filaggrin mutations, atopic eczema, hay fever, and asthma in children J Allergy Clin Immunol 121 2008 1203 1209.e1
13. R.A. van den Oord, and A. Sheikh Filaggrin gene defects and risk of developing allergic sensitisation and allergic disorders: systematic review and meta-analysis BMJ 339 2009 b2433
14. H. Bisgaard, A. Simpson, C.N. Palmer, K. Bonnelykke, I. McLean, and S. Mukhopadhyay Gene-environment interaction in the onset of eczema in infancy: filaggrin loss-of-function mutations enhanced by neonatal cat exposure PLoS Med 5 2008 e131
15. M.L. Schuttelaar, M. Kerkhof, M.F. Jonkman, G.H. Koppelman, B. Brunekreef, and J.C. de Jongste Filaggrin mutations in the onset of eczema, sensitization, asthma, hay fever and the interaction with cat exposure Allergy 64 2009 1758 1765
16. S.J. Brown, Y. Asai, H.J. Cordell, L.E. Campbell, Y. Zhao, and H. Liao Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy J Allergy Clin Immunol 127 2011 661 667
17. A.H. Ziyab, W. Karmaus, M. Yousefi, S. Ewart, E. Schauberger, and J.W. Holloway Interplay of filaggrin loss-of-function variants, allergic sensitization, and eczema in a longitudinal study covering infancy to 18 years of age PLoS One 7 2012 e32721
18. S.H. Arshad, S.M. Tariq, S. Matthews, and E. Hakim Sensitization to common allergens and its association with allergic disorders at age 4 years: a whole population birth cohort study Pediatrics 108 2001 E33
19. G. Roberts, H. Zhang, W. Karmaus, A. Raza, M. Scott, and S. Matthews Trends in cutaneous sensitization in the first 18 years of life: results from the 1989 Isle of Wight birth cohort study Clin Exp Allergy 42 2012 1501 1509
20. B. Pereira, C. Venter, J. Grundy, C.B. Clayton, S.H. Arshad, and T. Dean Prevalence of sensitization to food allergens, reported adverse reaction to foods, food avoidance, and food hypersensitivity among teenagers J Allergy Clin Immunol 116 2005 884 892
21. Food Allergen Labelling Food Standards Agency. Available at: http://www.food.gov.uk/safereating/allergyintol/label/groups. Accessed August 7, 2014.
22. H.F. Wood, and P.J. Agget Committee on toxicity of chemicals in foods, consumer products and the environment: allergic reactions to food and food ingredients 2000 Crown Publications Available at: http://cot.food.gov.uk. Accessed August 7, 2014
23. B. Niggemann When is an oral food challenge positive? Allergy 65 2010 2 6
24. J.M. Hanifin, and G. Rajka Diagnostic features of atopic dermatitis Acta Derm Venereol Suppl (Stockh) 92 1980 44 47
25. Lleras C. Path analysis. Encyclopedia of social measurement. 3. Philadelphia; Elsevier: 2005.
26. Muthén LK, Muthén BO. Mplus User's guide (1998-2012). 7th ed. Los Angeles, CA: Muthén & Muthén.
27. T.J. Hudson Skin barrier function and allergic risk Nat Genet 38 2006 399 400
28. P.M. Elias, and M. Schmuth Abnormal skin barrier in the etiopathogenesis of atopic dermatitis Curr Opin Allergy Clin Immunol 9 2009 437 446
29. J.M. Hanifin Evolving concepts of pathogenesis in atopic dermatitis and other eczemas J Invest Dermatol 129 2009 320 322
30. A.T. Fox, P. Sasieni, G. du Toit, H. Syed, and G. Lack Household peanut consumption as a risk factor for the development of peanut allergy J Allergy Clin Immunol 123 2009 417 423
31. M.K. Oyoshi, G.F. Murphy, and R.S. Geha Filaggrin-deficient mice exhibit TH17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen J Allergy Clin Immunol 124 2009 485 493.e1
32. C. Flohr, M. Perkin, K. Logan, T. Marrs, S. Radulovic, and L.E. Campbell Atopic dermatitis and disease severity are the main risk factors for food sensitization in exclusively breastfed infants J Invest Dermatol 134 2014 345 350