Innate immunity and asthma risk in amish and hutterite farm children

New England Journal of Medicine

Volumn 375, Issue 5, 2016, Pages 411-421

  Stein, Michelle M ^a   Hrusch, Cara L ^a   Gozdz, Justyna ^a,b   Igartua, Catherine ^a   Pivniouk, Vadim ^d,h   Murray, Sean E ^h   Ledford, Julie G ^e,h   Dos Santos, Mauricius Marques ^f   Anderson, Rebecca L ^a   Metwali, Nervana ⁱ   Neilson, Julia W ^e   Maier, Raina M ^g   Gilbert, Jack A ^c,h   Holbreich, Mark ⁱ   Thorne, Peter S ^h   Martinez, Fernando D ^h   Von Mutius, Erika ^j   Vercelli, Donata ^d,h   Ober, Carole ^a   Sperling, Anne I ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b ARGONNE NATIONAL LABORATORY   (United States)

^c Graduate Program in Cellular and Molecular Medicine   (United States)

^d UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^e UNIVERSITY OF ARIZONA   (United States)

^f University of Arizona   (United States)

^g UNIVERSITY OF ARIZONA   (United States)

^h UNIVERSITY OF IOWA   (United States)

ⁱ Allergy and Asthma Consultants   (United States)

^j LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; ENDOTOXIN; IMMUNOGLOBULIN E; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; CYTOKINE; DUST; MYD88 PROTEIN, MOUSE; TICAM-1 PROTEIN, MOUSE; VESICULAR TRANSPORT ADAPTOR PROTEIN;

ADAPTIVE IMMUNITY; ADOLESCENT; AGRICULTURAL WORKER; AIRWAY; ALLERGIC ASTHMA; ALLERGIC REACTION; AMISH; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; CHILD; CONTROLLED STUDY; CYTOKINE RESPONSE; DUST EXPOSURE; ENVIRONMENTAL EXPOSURE; EOSINOPHILIA; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETIC ASSOCIATION; GENETICS; HEALTH DISPARITY; HOME; HUMAN; HUTTERITE; HYPERACTIVITY; IMMUNOGLOBULIN BLOOD LEVEL; INFANT; INNATE IMMUNITY; LEUKOCYTE; LIFESTYLE; MAJOR CLINICAL STUDY; MALE; MICROBIOLOGY; MICROBIOME; MOUSE; NONHUMAN; PHENOTYPE; PREVALENCE; PRIORITY JOURNAL; RISK FACTOR; SCHOOL CHILD; SENSITIZATION; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SPECIES COMPOSITION; AGRICULTURE; ANIMAL; BAGG ALBINO MOUSE; BLOOD; C57BL MOUSE; CHRISTIANITY; CROSS-SECTIONAL STUDY; DEFICIENCY; DISEASE MODEL; DUST; IMMUNOLOGY; LEUKOCYTE COUNT; PHYSIOLOGY;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ADOLESCENT; AGRICULTURE; ANIMALS; ASTHMA; CHILD; CHRISTIANITY; CROSS-SECTIONAL STUDIES; CYTOKINES; DISEASE MODELS, ANIMAL; DUST; ENVIRONMENTAL EXPOSURE; FEMALE; GENE EXPRESSION; HUMANS; IMMUNITY, INNATE; IMMUNOGLOBULIN E; LEUKOCYTE COUNT; LEUKOCYTES; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MODELS, ANIMAL; MYELOID DIFFERENTIATION FACTOR 88; PREVALENCE;

EID: 84982085604     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa1508749     Document Type: Article

References (32)

1. Ober C, Yao TC. The genetics of asthma and allergic disease: a 21st century perspective. Immunol Rev 2011; 242: 10-30.
2. Meyers DA, Bleecker ER, Holloway J W, Holgate ST. Asthma genetics and personalised medicine. Lancet Respir Med 2014;2:405-15.
3. Bach JF. The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med 2002; 347: 911-20.
4. Braun-Fahrländer C, Riedler J, Herz U, et al. Environmental exposure to endo-toxin and its relation to asthma in school-age children. N Engl J Med 2002; 347: 869-7 7.
5. Ege MJ, Mayer M, Normand AC, et al. Exposure to environmental microorganisms and childhood asthma. N Engl J Med 2011;364:701-9.
6. Ege MJ, Frei R, Bieli C, et al. Not all farming environments protect against the development of asthma and wheeze in children. J Allergy Clin Immunol 2007; 119:1140-7.
7. Ege MJ, Strachan DP, Cookson WO, et al. Gene-environment interaction for childhood asthma and exposure to farming in Central Europe. J Allergy Clin Immunol 2011;127:138-44
8. Hostetler JA. Hutterite society. Baltimore: Johns Hopkins University Press, 1974.
9. Hostetler JA. Amish society. 4th ed. Baltimore: Johns Hopkins University Press, 1993.
10. Holbreich M, Genuneit J, Weber J, Braun-Fahrländer C, Waser M, von Mutius E. Amish children living in northern Indiana have a very low prevalence of allergic sensitization. J Allergy Clin Immunol 2012;129:1671-3.
11. Motika CA, Papachristou C, Abney M, Lester LA, Ober C. Rising prevalence of asthma is sex-specific in a US farming population. J Allergy Clin Immunol 2011; 1 28:7 74-9.
12. Adachi O, Kawai T, Takeda K, et al. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 1998;9:143-50.
13. Yamamoto M, Sato S, Hemmi H, et al. Role of adaptor TRIF in the MyD88-inde-pendent toll-like receptor signaling pathway. Science 2003; 301: 640-3.
14. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Ser B 1995; 57: 289-300.
15. Cann HM, de Toma C, Cazes L, et al. A human genome diversity cell line panel. Science 2002;296:261-2.
16. Kim-Schulze S, Scotto L, Vlad G, et al. Recombinant Ig-like transcript 3-Fc modulates T cell responses via induction of Th anergy and differentiation of CD8+ T suppressor cells. J Immunol 2006; 176: 2790-8.
17. Velten F W, Duperrier K, Bohlender J, Metharom P, Goerdt S. A gene signature of inhibitory MHC receptors identifies a BDCA3(+) subset of IL-10-induced dendritic cells with reduced allostimulatory capacity in vitro. Eur J Immunol 2004; 34: 2800-11.
18. Lluis A, Depner M, Gaugler B, et al. Increased regulatory T-cell numbers are associated with farm milk exposure and lower atopic sensitization and asthma in childhood. J Allergy Clin Immunol 2014; 133:551-9.
19. Schaub B, Liu J, Höppler S, et al. Maternal farm exposure modulates neonatal immune mechanisms through regulatory T cells. J Allergy Clin Immunol 2009; 123(4):774-82.e5.
20. Ma A, Malynn BA. A20: linking a complex regulator of ubiquitylation to immunity and human disease. Nat Rev Immunol 2012;12:774-85.
21. Schuijs MJ, Willart MA, Vergote K, et al. Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells. Science 2015; 349: 1106-10.
22. Bosco A, Ehteshami S, Panyala S, Martinez FD. Interferon regulatory factor 7 is a major hub connecting interferon-mediated responses in virus-induced asthma exacerbations in vivo. J Allergy Clin Immunol 2012;129:88-94.
23. Loss GJ, Depner M, Hose AJ, et al. The early development of wheeze: environmental determinants and genetic susceptibility at 17q21. Am J Respir Crit Care Med 2016;193:889-97.
24. Calişkan M, Bochkov YA, Kreiner-Møller E, et al. Rhinovirus wheezing illness and genetic risk of childhood-onset asthma. N Engl J Med 2013; 368: 1398-407.
25. Li Q, Yan J, Mao A P, et al. Tripartite motif 8 (TRIM8) modulates TNFα- and IL-1β-triggered NF-κB activation by targeting TAK1 for K63-linked polyubiquiti-nation. Proc Natl Acad Sci U S A 2011; 108: 19341-6.
26. Meisel C, Schefold JC, Pschowski R, et al. Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind, randomized, placebo-controlled multi-center trial. Am J Respir Crit Care Med 2009;180:640-8.
27. Gomez HG, Gonzalez SM, Londoño JM, et al. Immunological characterization of compensatory anti-inflammatory response syndrome in patients with severe sepsis: a longitudinal study. Crit Care Med 2014;42:771-80.
28. Fortunati E, Kazemier KM, Grutters JC, Koenderman L, Van den Bosch J. Human neutrophils switch to an activated phenotype after homing to the lung irrespective of inflammatory disease. Clin Exp Immunol 2009;155:559-66.
29. Orden S, De Pablo C, Rios-Navarro C, et al. Efavirenz induces interactions between leucocytes and endothelium through the activation of Mac-1 and gp150,95. J Antimicrob Chemother 2014; 69: 995-1004.
30. Devi S, Wang Y, Chew WK, et al. Neu-trophil mobilization via plerixafor-medi-ated CXCR4 inhibition arises from lung demargination and blockade of neutro-phil homing to the bone marrow. J Exp Med 2013;210:2321-36.
31. Yamada M, Kubo H, Kobayashi S, et al. The increase in surface CXCR4 expression on lung extravascular neutrophils and its effects on neutrophils during endotoxin-induced lung injury. Cell Mol Immunol 2011;8:305-14.
32. Netea MG, Wijmenga C, O'Neill LAJ. Genetic variation in toll-like receptors and disease susceptibility. Nat Immunol 2012; 13: 535-42.