Naturally occurring tolerance acquisition to foods in previously allergic children is characterized by antigen specificity and associated with increased subsets of regulatory T cells

Clinical and Experimental Allergy

Volumn 45, Issue 11, 2015, Pages 1663-1672

  Qamar, N ^a   Fishbein, A B ^a   Erickson, K A ^a   Cai, M ^a   Szychlinski, C ^a   Bryce, P J ^a   Schleimer, R P ^a   Fuleihan, R L ^a   Singh, A M ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Antigen specificity; Food allergy; IL 10; Natural tolerance; T regulatory cells

Indexed keywords

CD14 ANTIGEN; CD19 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 5; INTERLEUKIN 7 RECEPTOR; TRANSCRIPTION FACTOR FOXP3; ALLERGEN; IL10 PROTEIN, HUMAN; IMMUNOGLOBULIN E; MEMBRANE ANTIGEN;

ADOLESCENT; ADULT; ANTIGEN SPECIFICITY; ARTICLE; CHILD; CONTROLLED STUDY; EGG ALLERGY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; MAJOR CLINICAL STUDY; MALE; PEANUT ALLERGY; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; UPREGULATION; ADVERSE EFFECTS; ARACHIS; BIOSYNTHESIS; CASE CONTROL STUDY; CD4 LYMPHOCYTE COUNT; FOOD; FOOD ALLERGY; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; IMMUNOPHENOTYPING; INFANT; METABOLISM; PHENOTYPE; PRESCHOOL CHILD; T LYMPHOCYTE SUBPOPULATION;

ADOLESCENT; ALLERGENS; ANTIGENS, SURFACE; ARACHIS; CASE-CONTROL STUDIES; CD4 LYMPHOCYTE COUNT; CHILD; CHILD, PRESCHOOL; FEMALE; FOOD; FOOD HYPERSENSITIVITY; HUMANS; IMMUNE TOLERANCE; IMMUNOGLOBULIN E; IMMUNOPHENOTYPING; INFANT; INTERLEUKIN-10; MALE; PHENOTYPE; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY;

EID: 84944200718     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/cea.12570     Document Type: Article

References (33)

1. Sicherer SH, Sampson HA. Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment. J Allergy Clin Immunol 2014; 133: 291-307; quiz 308.
2. Vickery BP, Chin S, Burks AW. Pathophysiology of food allergy. Pediatr Clin North Am 2011; 58:363-76, ix-x.
3. Kumar S et al. Molecular mechanisms of IgE mediated food allergy. Int Immunopharmacol 2012; 13:432-9.
4. Berin MC. Mechanisms of allergic sensitization to foods: bypassing immune tolerance pathways. Immunol Allergy Clin North Am 2012; 32:1-10.
5. Vissers JL et al. Allergen immunotherapy induces a suppressive memory response mediated by IL-10 in a mouse asthma model. J Allergy Clin Immunol 2004; 113:1204-10.
6. Meiler F et al. In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure. J Exp Med 2008; 205:2887-98.
7. Enrique E et al. Sublingual immunotherapy for hazelnut food allergy: a randomized, double-blind, placebo-controlled study with a standardized hazelnut extract. J Allergy Clin Immunol 2005; 116:1073-9.
8. Fishbein AB et al. Cytokine responses to egg protein in previously allergic children who developed tolerance naturally. Ann Allergy Asthma Immunol 2014; 113:(6)667-670.e4.
9. Tiemessen MM et al. Cow's milk-specific T-cell reactivity of children with and without persistent cow's milk allergy: key role for IL-10. J Allergy Clin Immunol 2004; 113:932-9.
10. Jones SM et al. Clinical efficacy and immune regulation with peanut oral immunotherapy. J Allergy Clin Immunol 2009; 124: 292-300, 300.e1-97.
11. Roncarolo MG et al. Interleukin-10-secreting type 1 regulatory T cells in rodents and humans. Immunol Rev 2006; 212:28-50.
12. Chen W et al. Conversion of peripheral CD4 + CD25- naive T cells to CD4 + CD25 + regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 2003; 198:1875-86.
13. Levings MK et al. Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25 + CD4 + Tr cells. Blood 2005; 105:1162-9.
14. Liu W et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4 + T reg cells. J Exp Med 2006; 203:1701-11.
15. Beyer M, Schultze JL. Plasticity of T(reg) cells: is reprogramming of T(reg) cells possible in the presence of FOXP3? Int Immunopharmacol 2011; 11:555-60.
16. Pabst O, Mowat AM. Oral tolerance to food protein. Mucosal Immunol 2012; 5:232-9.
17. Sletten GB et al. Memory T cell proliferation in cow's milk allergy after CD25 + regulatory T cell removal suggests a role for casein-specific cellular immunity in IgE-mediated but not in non-IgE-mediated cow's milk allergy. Int Arch Allergy Immunol 2007; 142:190-8.
18. Shreffler WG et al., Association of allergen-specific regulatory T cells with the onset of clinical tolerance to milk protein. J Allergy Clin Immunol 2009; 123: 43-52.e7.
19. Karlsson MR, Rugtveit J, Brandtzaeg P. Allergen-responsive CD4 + CD25 + regulatory T cells in children who have outgrown cow's milk allergy. J Exp Med 2004; 199:1679-88.
20. Turcanu V, Maleki SJ, Lack G. Characterization of lymphocyte responses to peanuts in normal children, peanut-allergic children, and allergic children who acquired tolerance to peanuts. J Clin Invest 2003; 111:1065-72.
21. Thottingal TB et al. Human subjects without peanut allergy demonstrate T cell-dependent, TH2-biased, peanut-specific cytokine and chemokine responses independent of TH1 expression. J Allergy Clin Immunol 2006; 118:905-14.
22. Koppelman SJ et al. Peanut allergen Ara h 3: isolation from peanuts and biochemical characterization. Allergy 2003; 58:1144-51.
23. Hulse KE et al. Targeting Fel d 1 to FcgammaRI induces a novel variation of the T(H)2 response in subjects with cat allergy. J Allergy Clin Immunol 2008; 121:756-62.e4.
24. Nettenstrom L et al. An optimized multi-parameter flow cytometry protocol for human T regulatory cell analysis on fresh and viably frozen cells, correlation with epigenetic analysis, and comparison of cord and adult blood. J Immunol Methods 2013; 387:81-8.
25. Vieira PL et al. IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+ CD25+ regulatory T cells. J Immunol 2004; 172:5986-93.
26. Passerini L et al. Functional type 1 regulatory T cells develop regardless of FOXP3 mutations in patients with IPEX syndrome. Eur J Immunol 2011; 41:1120-31.
27. Akdis CA et al. Role of interleukin 10 in specific immunotherapy. J Clin Invest 1998; 102:98-106.
28. Akdis M et al. Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells. J Exp Med 2004; 199:1567-75.
29. Syed A et al. Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3). J Allergy Clin Immunol 2014; 133:500-10.
30. Sabat R et al. Biology of interleukin-10. Cytokine Growth Factor Rev 2010; 21:331-44.
31. Noyan F et al. Isolation of human antigen-specific regulatory T cells with high suppressive function. Eur J Immunol 2014; 44(9):2592-602.
32. Dhamne C et al. Peripheral and thymic Foxp3+ regulatory T cells in search of origin, distinction and function. Front Immunol 2013; 4:253. doi:10.3389/fimmu.2013.00253
33. Morikawa H, Sakaguchi S. Genetic and epigenetic basis of Treg cell development and function: from a FoxP3-centered view to an epigenome-defined view of natural Treg cells. Immunol Rev 2014; 259:192-205.