Correlation of IgE/IgG4 milk epitopes and affinity of milk-specific IgE antibodies with different phenotypes of clinical milk allergy

Journal of Allergy and Clinical Immunology

Volumn 125, Issue 3, 2010, Pages

  Wang, Julie ^a   Lin, Jing ^a   Bardina, Ludmilla ^a   Goldis, Marina ^a   Nowak Wegrzyn, Anna ^a   Shreffler, Wayne G ^b   Sampson, Hugh A ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

IgE affinity; IgE epitope; IgG4 epitope; Milk allergy; peptide microarray

Indexed keywords

EPITOPE; IMMUNOGLOBULIN BINDING FACTOR; IMMUNOGLOBULIN E; IMMUNOGLOBULIN E ANTIBODY; IMMUNOGLOBULIN G4; MILK PROTEIN;

ANTIBODY SPECIFICITY; ARTICLE; BINDING AFFINITY; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HUMAN; MALE; MILK ALLERGY; OUTCOME ASSESSMENT; PHENOTYPE; PREDICTION; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; VOLUNTEER;

EID: 77649245857     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2009.12.017     Document Type: Article

References (20)

1. Sampson H.A. Food allergy. Part 1: immunopathogenesis and clinical disorders. J Allergy Clin Immunol 103 (1999) 717-728
2. Skripak J.M., Matsui E.C., Mudd K., and Wood R.A. The natural history of IgE-mediated cow's milk allergy. J Allergy Clin Immunol 120 (2007) 1172-1177
3. Jarvinen K.M., Beyer K., Vila L., Chatchatee P., Busse P.J., and Sampson H.A. B-cell epitopes as a screening instrument for persistent cow's milk allergy. J Allergy Clin Immunol 110 (2002) 293-297
4. Nowak-Wegrzyn A., Bloom K.A., Sicherer S.H., Shreffler W.G., Noone S., Wanich N., et al. Tolerance to extensively heated milk in children with cow's milk allergy. J Allergy Clin Immunol 122 (2008) 342-347
5. Chatchatee P., Jarvinen K.M., Bardina L., Beyer K., and Sampson H.A. Identification of IgE- and IgG-binding epitopes on alpha(s1)-casein: differences in patients with persistent and transient cow's milk allergy. J Allergy Clin Immunol 107 (2001) 379-383
6. Järvinen K.M., Chatchatee P., Bardina L., Beyer K., and Sampson H.A. IgE and IgG binding epitopes on alpha-lactalbumin and beta-lactoglobulin in cow's milk allergy. Int Arch Allergy Immunol 126 (2001) 111-118
7. Chatchatee P., Järvinen K.M., Bardina L., Vila L., Beyer K., and Sampson H.A. Identification of IgE and IgG binding epitopes on beta- and kappa-casein in cow's milk allergic patients. Clin Exp Allergy 31 (2001) 1256-1262
8. Lin J., Bardina L., Shreffler W.G., Andreae D.A., Ge Y., Wang J., et al. Development of a novel peptide microarray for large scale epitope mapping of food allergens. J Allergy Clin Immunol 124 (2009) 315-322
9. Shreffler W.G., Beyer K., Chu T.H., Burks A.W., and Sampson H.A. Microarray immunoassay: association of clinical history, in vitro IgE function, and heterogeneity of allergenic peanut epitopes. J Allergy Clin Immunol 113 (2004) 776-782
10. Flinterman A.E., Knol E.F., Lencer D.A., Bardina L., den Hartog Jager C.F., Lin J., et al. Peanut epitopes for IgE and IgG4 in peanut-sensitized children in relation to severity of peanut allergy. J Allergy Clin Immunol 121 (2008) 737-743
11. Cerecedo I., Zamora J., Shreffler W.G., Lin J., Bardina L., Dieguez M.C., et al. Mapping of the IgE and IgG4 sequential epitopes of milk allergens with a peptide microarray-based immunoassay. J Allergy Clin Immunol 122 (2008) 589-594
12. Pecora V., Nucera E., Schiavino D., Lombardo C., Bardina L., Lin J., et al. Evaluation of specific sequential IgE- and IgG4-binding epitopes, recognized in cow's milk allergic patients during specific oral desensitization, using peptide microarray immunoassay. J Allergy Clin Immunol 123 suppl (2009) S178
13. Lin J, Bardina L, Shreffler WG. Microarrayed allergen molecules for diagnostics of allergy. In: Reineke U, editor. Methods in molecular biology-epitope mapping protocols. Berlin, Germany: Springer Science+Business Media.
14. Shreffler W.G., Wanich N., Moloney M., Nowak-Wegrzyn A., and Sampson H.A. Association of allergen-specific regulatory T cells with the onset of clinical tolerance to milk protein. J Allergy Clin Immunol 123 (2009) 43-52
15. Wanich N., Nowak-Wegrzyn A., Sampson H.A., and Shreffler W.G. Allergen-specific basophil suppression associated with clinical tolerance in patients with milk allergy. J Allergy Clin Immunol 123 (2009) 789-794
16. Lewis S.A., Grimshaw K.E., Warner J.O., and Hourihane J.O. The promiscuity of immunoglobulin E binding to peanut allergens, as determined by Western blotting, correlates with the severity of clinical symptoms. Clin Exp Allergy 35 (2005) 767-773
17. Peeters K.A., Koppelman S.J., van Hoffen E., van der Tas C.W., den Hartog Jager C.F., Penninks A.H., et al. Does skin prick test reactivity to purified allergens correlate with clinical severity of peanut allergy?. Clin Exp Allergy 37 (2007) 108-115
18. Mita H., Yasueda H., and Akiyama K. Affinity of IgE antibody to antigen influences allergen-induced histamine release. Clin Exp Allergy 30 (2000) 1583-1589
19. Christensen L.H., Holm J., Lund G., Riise E., and Lund K. Several distinct properties of the IgE repertoire determine effector cell degranulation in response to allergen challenge. J Allergy Clin Immunol 122 (2008) 298-304
20. El-Khouly F., Lewis S.A., Pons L., Burks A.W., and Hourihane J.O. IgG and IgE avidity characteristics of peanut allergic individuals. Pediatr Allergy Immunol 18 (2007) 607-613