Accelerated dissociation of IgE-FcεRI complexes by disruptive inhibitors actively desensitizes allergic effector cells

Journal of Allergy and Clinical Immunology

Volumn 133, Issue 6, 2014, Pages

  Eggel, Alexander ^a   Baravalle, Günther ^b   Hobi, Gabriel ^a   Kim, Beomkyu ^c   Buschor, Patrick ^a   Forrer, Patrik ^d   Shin, Jeoung Sook ^b   Vogel, Monique ^a   Stadler, Beda M ^a   Dahinden, Clemens A ^a   Jardetzky, Theodore S ^c  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d MOLECULAR PARTNERS AG   (Switzerland)

Author keywords

Allergy; basophils; designed ankyrin repeat proteins; Fc RI ; IgE; inhibitors; mast cells

Indexed keywords

ALLERGEN; ANKYRIN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN E ANTIBODY; IMMUNOGLOBULIN E RECEPTOR; OMALIZUMAB; PROTEIN INHIBITOR; PROTEIN INHIBITOR BI53 79; PROTEIN INHIBITOR E2 79; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; ANTIALLERGIC AGENT; BI53 79; DESIGNED ANKYRIN REPEAT PROTEIN; E2 79; E3 58; FC EPSILON RECEPTOR; LEUKOTRIENE C4; PROTEIN;

ALLERGIC REACTION; ALLERGY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BASOPHIL; CELL ACTIVATION; CONTROLLED STUDY; DESENSITIZATION; DISSOCIATION; DRUG MECHANISM; DRUG POTENCY; EFFECTOR CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; PASSIVE SKIN ANAPHYLAXIS; PRIORITY JOURNAL; PROTEIN ENGINEERING; SURFACE PLASMON RESONANCE; TRANSGENIC MOUSE; ALLERGIC DISEASE; ALLERGIC EFFECTOR CELL; ANTIBODY AFFINITY; DRUG EFFICACY; EX VIVO STUDY; IN VIVO STUDY;

ALLERGY; BASOPHILS; DESIGNED ANKYRIN REPEAT PROTEINS; FCΕRIΑ; IGE; INHIBITORS; MAST CELLS;

ANAPHYLAXIS; ANIMALS; ANKYRIN REPEAT; ANTIBODIES, ANTI-IDIOTYPIC; ANTIBODIES, MONOCLONAL, HUMANIZED; ANTIGENS; BASOPHILS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; IMMUNOGLOBULIN E; MAST CELLS; MICE; MICE, TRANSGENIC; MODELS, MOLECULAR; MOLECULAR MIMICRY; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, IGE; RECOMBINANT FUSION PROTEINS;

EID: 84901802292     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2014.02.005     Document Type: Article

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