A mutant of the major apple allergen, Mal d 1, demonstrating hypo-allergenicity in the target organ by double-blind placebo-controlled food challenge

Clinical and Experimental Allergy

Volumn 35, Issue 12, 2005, Pages 1638-1644

  Bolhaar, S T H P ^a   Zuidmeer, L ^b   Ma, Y ^c   Ferreira, F ^d   Bruijnzeel Koomen, C A F M ^a   Hoffmann Sommergruber, K ^c   Van Ree, R ^b   Knulst, A C ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b SANQUIN RESEARCH   (Netherlands)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

^d UNIVERSITY OF SALZBURG   (Austria)

Author keywords

Apple; DBPCFC; Hypo allergenicity; Mal d1

Indexed keywords

FOOD ALLERGEN; HISTAMINE; IMMUNOGLOBULIN E; MAL D 1 ALLERGEN; MUTANT PROTEIN; UNCLASSIFIED DRUG; ALLERGEN; MALD1 PROTEIN, MALUS DOMESTICA; VEGETABLE PROTEIN;

ADULT; ARTICLE; BASOPHIL; BINDING AFFINITY; BIRCH; CONTROLLED STUDY; FEMALE; FOOD ALLERGY; HISTAMINE RELEASE; HUMAN; IMMUNOBLOTTING; IMMUNOTHERAPY; IN VITRO STUDY; IN VIVO STUDY; MAJOR CLINICAL STUDY; MALE; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; POLLEN ALLERGY; PRICK TEST; PRIORITY JOURNAL; PROVOCATION TEST; RADIOALLERGOSORBENT TEST; SITE DIRECTED MUTAGENESIS; ADOLESCENT; APPLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; GENETICALLY MODIFIED FOOD; GENETICS; IMMUNOLOGY; MIDDLE AGED; MUTATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; RADIOIMMUNOASSAY; RANDOMIZED CONTROLLED TRIAL; SECRETION; SKIN TEST;

ADOLESCENT; ADULT; ALLERGENS; BASOPHILS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FEMALE; FOOD HYPERSENSITIVITY; FOOD, GENETICALLY MODIFIED; HISTAMINE RELEASE; HUMANS; IMMUNOBLOTTING; IMMUNOGLOBULIN E; MALE; MALUS; MIDDLE AGED; MUTATION; PLANT PROTEINS; RADIOIMMUNOSORBENT TEST; SKIN TESTS;

EID: 33646184019     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2005.02390.x     Document Type: Article

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