Berberine and limonin suppress IgE production by human B cells and peripheral blood mononuclear cells from food-allergic patients

Annals of Allergy, Asthma and Immunology

Volumn 113, Issue 5, 2014, Pages 556-564.e4

  Yang, Nan ^a   Wang, Julie ^a   Liu, Changda ^a   Song, Ying ^a   Zhang, Shuwei ^b   Zi, Jiachen ^b   Zhan, Jixun ^b   Masilamani, Madhan ^a   Cox, Amanda ^a   Nowak Wegrzyn, Anna ^a   Sampson, Hugh ^a   Li, Xiu Min ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b Utah State University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BERBERINE; BINDING PROTEIN; BUTANOL; GAMMA INTERFERON; I KAPPA B ALPHA; IMMUNOGLOBULIN E; INTERLEUKIN 10; INTERLEUKIN 5; LIMONIN; MESSENGER RNA; PLANT EXTRACT; STAT3 PROTEIN; T BOX TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR GATA BINDING PROTEIN 3; TRANSCRIPTION FACTOR TBX21; UNCLASSIFIED DRUG; FOOD ALLERGY HERBAL FORMULA-2; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; I KAPPA B; IL5 PROTEIN, HUMAN; LIMONOID; STAT3 PROTEIN, HUMAN; T-BOX TRANSCRIPTION FACTOR TBX21;

ADOLESCENT; ANGELICA SINENSIS; ARTICLE; B LYMPHOCYTE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL VIABILITY; CHILD; CINNAMOMUM CASSIA; CLINICAL ARTICLE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; COPTIS CHINENSIS; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; FEMALE; FOOD ALLERGY; GANODERMA LUCIDUM; GENE EXPRESSION; GERM LINE; GINGER; GINSENG; HUMAN; HUMAN CELL; IMMUNOGLOBULIN PRODUCTION; INHIBITION KINETICS; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; PEANUT ALLERGY; PERIPHERAL BLOOD MONONUCLEAR CELL; PHILODENDRON; PHILODENDRON CHINENSIS; PRESCHOOL CHILD; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTON NUCLEAR MAGNETIC RESONANCE; PRUNUS; PRUNUS MUME; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ZANTHOXYLUM; ZANTHOXYLUM SCHINIFOLIUM; BIOSYNTHESIS; BLOOD; CHEMISTRY; DRUG EFFECTS; IMMUNOLOGY; MONONUCLEAR CELL; PEANUT HYPERSENSITIVITY; TUMOR CELL LINE;

ADOLESCENT; B-LYMPHOCYTES; BERBERINE; CELL LINE, TUMOR; CHILD; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; I-KAPPA B PROTEINS; IMMUNOGLOBULIN E; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-5; LEUKOCYTES, MONONUCLEAR; LIMONINS; MALE; PEANUT HYPERSENSITIVITY; PLANT EXTRACTS; REAL-TIME POLYMERASE CHAIN REACTION; STAT3 TRANSCRIPTION FACTOR; T-BOX DOMAIN PROTEINS;

EID: 84913588787     PISSN: 10811206     EISSN: 15344436     Source Type: Journal    
DOI: 10.1016/j.anai.2014.07.021     Document Type: Article

References (39)

1. A.M. Branum, and S.L. Lukacs Food allergy among children in the United States Pediatrics 124 2009 1549 1555
2. D.Y. Leung, H.A. Sampson, and J.W. Yunginger Effect of anti-IgE therapy in patients with peanut allergy N Engl J Med 348 2003 986 993
3. H.A. Sampson, D.Y. Leung, and A.W. Burks A phase II, randomized, double-blind, parallel-group, placebo-controlled oral food challenge trial of Xolair (omalizumab) in peanut allergy J Allergy Clin Immunol 127 2011 1309 1310
4. K.C. Nadeau, L.C. Schneider, L. Hoyte, I. Borras, and D.T. Umetsu Rapid oral desensitization in combination with omalizumab therapy in patients with cow's milk allergy J Allergy Clin Immunol 127 2011 1622 1624
5. L.C. Schneider, R. Rachid, and J. LeBovidge A pilot study of omalizumab to facilitate rapid oral desensitization in high-risk peanut-allergic patients J Allergy Clin Immunol 132 2013 1368 1374
6. K.D. Srivastava, J.D. Kattan, and Z.M. Zou The Chinese herbal medicine formula FAHF-2 completely blocks anaphylactic reactions in a murine model of peanut allergy J Allergy Clin Immunol 115 2005 171 178
7. Y. Song, C. Qu, and K. Srivastava Food allergy herbal formula 2 protection against peanut anaphylactic reaction is via inhibition of mast cells and basophils J Allergy Clin Immunol 126 2010 1208 1217
8. K. Srivastava, N. Yang, and Y. Chen Efficacy, safety and immunological actions of butanol-extracted Food Allergy Herbal Formula-2 on peanut anaphylaxis Clin Exp Allergy 41 2010 582 591
9. S.P. Patil, J. Wang, and Y. Song Clinical safety of Food Allergy Herbal Formula-2 (FAHF-2) and inhibitory effect on basophils from patients with food allergy: extended phase I study J Allergy Clin Immunol 128 2011 1259 1265.e2
10. J. Wang, S. Patil, and N. Yang Safety, tolerability, and immunologic effects of a food allergy herbal formula (FAHF-2) in food allergic individuals: a randomized, double-blinded, placebo-controlled, dose escalation phase I study Ann Allergy Asthma Immunol 105 2010 75 84
11. The State Pharmacopoeia Commission of The People's Republic of China Bejing, China: People's Republic of China 2005 1 791
12. J.D. Kattan, K.D. Srivastava, and Z.M. Zou Pharmacological and immunological effects of individual herbs in the Food Allergy Herbal Formula-2 (FAHF-2) on peanut allergy Phytother Res 22 2008 651 659
13. US Food and Drug Administration (FDA) Center for Drug Evaluation and Research Guidance for Industry Botanical Drug Products Revised 2004
14. B. Jayaprakasam, S. Doddaga, and R. Wang Licorice flavonoids inhibit eotaxin-1 secretion by human fetal lung fibroblasts in vitro J Agric Food Chem 57 2009 820 825
15. I. Lopez-Exposito, A. Castillo, N. Yang, B. Liang, and X.M. Li Chinese herbal extracts of Rubia cordifolia and Dianthus superbus suppress IgE production and prevent peanut-induced anaphylaxis Chin Med 6 2011 35
16. N. Yang, S. Patil, and J. Zhuge Glycyrrhiza uralensis flavonoids present in anti-asthma formula, ASHMI, inhibit memory Th2 responses in vitro and in vivo Phytother Res 27 2013 1381 1391
17. A.P. Breksa III, K. Dragull, and R.Y. Wong Isolation and identification of the first C-17 limonin epimer, epilimonin J Agric Food Chem 56 2008 5595 5598
18. K. Hasada, T. Yoshida, and T. Yamazaki Application of 1H-NMR spectroscopy to validation of berberine alkaloid reagents and to chemical evaluation of Coptidis rhizoma J Nat Med 65 2011 262 267
19. M. Chalubinski, J. Grzegorczyk, and M.L. Kowalski Glucocorticoid-induced immunoglobulin E synthesis by peripheral blood mononuclear cells from allergic and nonallergic subjects Ann Allergy Asthma Immunol 107 2011 251 257
20. K. Iwamoto, T. Hiragun, and S. Takahagi Fucoidan suppresses IgE production in peripheral blood mononuclear cells from patients with atopic dermatitis Arch Dermatol Res 303 2011 425 431
21. H.C. Oettgen Regulation of the IgE isotype switch: new insights on cytokine signals and the functions of epsilon germline transcripts Curr Opin Immunol 12 2000 618 623
22. R.S. Geha, H.H. Jabara, and S.R. Brodeur The regulation of immunoglobulin E class-switch recombination Nat Rev Immunol 3 2003 721 732
23. K.D. Srivastava, L. Bardina, H.A. Sampson, and X.M. Li Efficacy and immunological actions of FAHF-2 in a murine model of multiple food allergies Ann Allergy Asthma Immunol 108 2012 351 358
24. T.M. Ehrman, D.J. Barlow, and P.J. Hylands Phytochemical databases of Chinese herbal constituents and bioactive plant compounds with known target specificities J Chem Inf Model 47 2007 254 263
25. T.M. Ehrman, D.J. Barlow, and P.J. Hylands Phytochemical informatics of traditional Chinese medicine and therapeutic relevance J Chem Inf Model 47 2007 2316 2334
26. P.R. Vuddanda, S. Chakraborty, and S. Singh Berberine: a potential phytochemical with multispectrum therapeutic activities Expert Opin Investig Drugs 19 2010 1297 1307
27. T. Lou, Z. Zhang, and Z. Xi Berberine inhibits inflammatory response and ameliorates insulin resistance in hepatocytes Inflammation 34 2011 659 667
28. W. Shang, J. Liu, X. Yu, and J. Zhao [Effects of berberine on serum levels of inflammatory factors and inflammatory signaling pathway in obese mice induced by high fat diet] Zhongguo Zhong Yao Za Zhi 35 2010 1474 1477
29. T.P. Hamsa, and G. Kuttan Antiangiogenic activity of berberine is mediated through the downregulation of hypoxia-inducible factor-1, VEGF, and proinflammatory mediators Drug Chem Toxicol 35 2012 57 70
30. T. Lan, T. Wu, and C. Chen Berberine attenuates high glucose-induced proliferation and extracellular matrix accumulation in mesangial cells: Involvement of suppression of cell cycle progression and NF-kappaB/AP-1 pathways Mol Cell Endocrinol 384 2014 109 116
31. L.B. Bacharier, and R.S. Geha Molecular mechanisms of IgE regulation J Allergy Clin Immunol 105 2000 S547 S558
32. J. Altin, C. Shen, and A. Liston Understanding the genetic regulation of IgE production Blood Rev 24 2010 163 169
33. T.R. Torgerson, A. Linane, and N. Moes Severe food allergy as a variant of IPEX syndrome caused by a deletion in a noncoding region of the FOXP3 gene Gastroenterology 132 2007 1705 1717
34. S. Vale-Pereira, A. Todo-Bom, and L. Geraldes FoxP3, GATA-3 and T-bet expression in elderly asthma Clin Exp Allergy 41 2011 490 496
35. S.K. Mantena, S.D. Sharma, and S.K. Katiyar Berberine, a natural product, induces G1-phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells Mol Cancer Ther 5 2006 296 308
36. Y.S. Chai, Z.Y. Yuan, and F. Lei Inhibition of retinoblastoma mRNA degradation through poly (A) involved in the neuroprotective effect of berberine against cerebral ischemia PLoS One 9 2014 e90850
37. A. Roy, and S. Saraf Limonoids: overview of significant bioactive triterpenes distributed in plants kingdom Biol Pharm Bull 29 2006 191 201
38. G.D. Manners Citrus limonoids: analysis, bioactivity, and biomedical prospects J Agric Food Chem 55 2007 8285 8294
39. K. Srivastava, N. Yang, and Y. Chen Efficacy, safety and immunological actions of butanol-extracted Food Allergy Herbal Formula-2 on peanut anaphylaxis Clin Exp Allergy 41 2010 582 591