Pepsinized cashew proteins are hypoallergenic and immunogenic and provide effective immunotherapy in mice with cashew allergy

Journal of Allergy and Clinical Immunology

Volumn 130, Issue 3, 2012, Pages 716-723

  Kulis, Mike ^a   MacQueen, Ian ^a   Li, Yifan ^a   Guo, Rishu ^a   Zhong, Xiao Ping ^a   Burks, A Wesley ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

cashew; Food allergy; immunotherapy; murine model; pepsin; tree nut allergy

Indexed keywords

IMMUNOMODULATING AGENT; PEPSINIZED CASHEW PROTEIN; UNCLASSIFIED DRUG;

ALLERGENICITY; ANIMAL EXPERIMENT; ARTICLE; BODY TEMPERATURE; CASHEW ALLERGY; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; FOOD ALLERGY; IMMUNOGENICITY; IMMUNOTHERAPY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROVOCATION TEST; SENSITIZATION;

ANACARDIUM; ANIMALS; DESENSITIZATION, IMMUNOLOGIC; DISEASE MODELS, ANIMAL; FEMALE; IMMUNOGLOBULIN G; MICE; MICE, INBRED C3H; NUT HYPERSENSITIVITY; PEPSIN A; PEPTIDE FRAGMENTS; PLANT PROTEINS; TH2 CELLS;

EID: 84865681346     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2012.05.044     Document Type: Article

References (33)

1. J.A. Boyce, A. Assa'ad, A.W. Burks, S.M. Jones, H.A. Sampson, and R.A. Wood Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel J Allergy Clin Immunol 126 suppl 2010 S1 S58
2. S. Clark, J.A. Espinola, S.A. Rudders, A. Banerji, and C.A. Camargo Jr. Frequency of US emergency department visits for food-related acute allergic reactions J Allergy Clin Immunol 127 2011 682 683
3. S.A. Bock, A. Munoz-Furlong, and H.A. Sampson Further fatalities caused by anaphylactic reactions to food, 2001-2006 J Allergy Clin Immunol 119 2007 1016 1018
4. S.H. Sicherer, A. Munoz-Furlong, J.H. Godbold, and H.A. Sampson US prevalence of self-reported peanut, tree nut, and sesame allergy: 11-year follow-up J Allergy Clin Immunol 125 2010 1322 1326
5. A.T. Clark, K. Anagnostou, and P.W. Ewan Cashew nut causes more severe reactions than peanut: case-matched comparison in 141 children Allergy 62 2007 913 916
6. J.J. Oppenheimer, H.S. Nelson, S.A. Bock, F. Christensen, and D.Y. Leung Treatment of peanut allergy with rush immunotherapy J Allergy Clin Immunol 90 1992 256 262
7. S.M. Jones, L. Pons, J.L. Roberts, A.M. Scurlock, T.T. Perry, and M. Kulis Clinical efficacy and immune regulation with peanut oral immunotherapy J Allergy Clin Immunol 124 2009 292 300 e291-7
8. K. Blumchen, H. Ulbricht, U. Staden, K. Dobberstein, J. Beschorner, and L.C. de Oliveria Oral peanut immunotherapy in children with peanut anaphylaxis J Allergy Clin Immunol 126 2010 83 91 e81
9. P. Varshney, S.M. Jones, A.M. Scurlock, T.T. Perry, A. Kemoer, and P. Steele A randomized controlled study of peanut oral immunotherapy: clinical desensitization and modulation of the allergic response J Allergy Clin Immunol 127 2011 654 660
10. E.H. Kim, J.A. Bird, M. Kulis, S. Laubach, L. Pons, and W. Shreffler Sublingual immunotherapy for peanut allergy: clinical and immunologic evidence of desensitization J Allergy Clin Immunol 127 2011 640 646 e641
11. H.A. Sampson, D.Y. Leung, A.W. Burks, G. Lack, S.L. Bahna, and S.M. Jones A phase II, randomized, doubleblind, parallelgroup, placebocontrolled oral food challenge trial of Xolair (omalizumab) in peanut allergy J Allergy Clin Immunol 127 2011 1309 1310 e1
12. Y. Song, C. Qu, K. Srivastava, N. Yang, P. Busse, and W. Zhao Food allergy herbal formula 2 protection against peanut anaphylactic reaction is via inhibition of mast cells and basophils J Allergy Clin Immunol 126 2010 1208 1217 e1203
13. J. Wang, S.P. Patil, N. Yang, J. Ko, J. Lee, and S. Noone Safety, tolerability, and immunologic effects of a food allergy herbal formula in food allergic individuals: a randomized, double-blinded, placebo-controlled, dose escalation, phase 1 study Ann Allergy Asthma Immunol 105 2010 75 84
14. X.M. Li, K. Srivastava, A. Grishin, C.K. Huang, B. Schofield, and W. Burks Persistent protective effect of heat-killed Escherichia coli producing "engineered," recombinant peanut proteins in a murine model of peanut allergy J Allergy Clin Immunol 112 2003 159 167
15. U. Muller, C.A. Akdis, M. Fricker, M. Akdis, T. Blesken, and F. Bettens Successful immunotherapy with T-cell epitope peptides of bee venom phospholipase A2 induces specific T-cell anergy in patients allergic to bee venom J Allergy Clin Immunol 101 1998 747 754
16. M. Larche Immunotherapy with allergen peptides Allergy Asthma Clin Immunol 3 2007 53 59
17. M. Worm, H.H. Lee, J. Kleine-Tebbe, R.P. Hafner, P. Laidier, and D. Healey Development and preliminary clinical evaluation of a peptide immunotherapy vaccine for cat allergy J Allergy Clin Immunol 127 2011 89 97 e81-14
18. M. Yang, C. Yang, and Y. Mine Multiple T cell epitope peptides suppress allergic responses in an egg allergy mouse model by the elicitation of forkhead box transcription factor 3- and transforming growth factor-beta-associated mechanisms Clin Exp Allergy 40 2010 668 678
19. S.J. Hong, J.G. Michael, A. Fehringer, and D.Y. Leung Pepsin-digested peanut contains T-cell epitopes but no IgE epitopes J Allergy Clin Immunol 104 1999 473 478
20. T. Eiwegger, N. Rigby, L. Mondoulet, H. Bernard, M.T. Krauth, and A. Boehm Gastro-duodenal digestion products of the major peanut allergen Ara h 1 retain an allergenic potential Clin Exp Allergy 36 2006 1281 1288
21. K.L. Bogh, S. Kroghsbo, L. Dahl, N.M. Rigby, V. Barkholt, and E.N. Mills Digested Ara h 1 has sensitizing capacity in Brown Norway rats Clin Exp Allergy 39 2009 1611 1621
22. M. Kulis, Y. Li, H. Lane, L. Pons, and W. Burks Single-tree nut immunotherapy attenuates allergic reactions in mice with hypersensitivity to multiple tree nuts J Allergy Clin Immunol 127 2011 81 88
23. M. Kulis, L. Pons, and A.W. Burks In vivo and T cell cross-reactivity between walnut, cashew and peanut Int Arch Allergy Immunol 148 2009 109 117
24. X.M. Li, D. Serebrisky, S.Y. Lee, C.K. Huang, L. Bardina, and B.H. Schofield A murine model of peanut anaphylaxis: T- and B-cell responses to a major peanut allergen mimic human responses J Allergy Clin Immunol 106 2000 150 158
25. N. King, R. Helm, J.S. Stanley, S. Vieths, D. Luttkopf, and L. Hatahet Allergenic characteristics of a modified peanut allergen Mol Nutr Food Res 49 2005 963 971
26. R. Campana, S. Vrtala, B. Maderegger, P. Jertschin, G. Stegfellner, and I. Swoboda Hypoallergenic derivatives of the major birch pollen allergen Bet v 1 obtained by rational sequence reassembly J Allergy Clin Immunol 126 2010 1024 1031 e1021-8
27. E.M. Schimek, B. Zwolfer, P. Briza, B. Jahn-Schmid, L. Vogel, and S. Vieths Gastrointestinal digestion of Bet v 1-homologous food allergens destroys their mediator-releasing, but not T cell-activating, capacity J Allergy Clin Immunol 116 2005 1327 1333
28. E. Untersmayr, H. Vestergaard, H.J. Malling, L.B. Jensen, M.H. Platzer, and G. Boltz-Nitulescu Incomplete digestion of codfish represents a risk factor for anaphylaxis in patients with allergy J Allergy Clin Immunol 119 2007 711 717
29. J. Sun, K. Arias, D. Alvarez, R. Fattouh, T. Walker, and S. Gonhcarova Impact of CD40 ligand, B cells, and mast cells in peanut-induced anaphylactic responses J Immunol 179 2007 6696 6703
30. W.G. Shreffler, K. Beyer, T.H. Chu, A.W. Burks, and H.A. Sampson Microarray immunoassay: association of clinical history, in vitro IgE function, and heterogeneity of allergenic peanut epitopes J Allergy Clin Immunol 113 2004 776 782
31. A.M. Ditto, C.V. Neilsen, S. Neerukonda, W.G. Shreffler, and P.J. Bryce Clinical reactivity to raw peanut correlates with IgE binding to conformational epitopes of Ara h 1: a case report Allergy 65 2010 1485 1486
32. M. Albrecht, Y. Kuhne, B.K. Ballmer-Weber, W.M. Becker, T. Holzhauser, and I. Lauer Relevance of IgE binding to short peptides for the allergenic activity of food allergens J Allergy Clin Immunol 124 2009 328 336 e321-6
33. J. Strid, J. Hourihane, I. Kimber, R. Callard, and S. Strobel Epicutaneous exposure to peanut protein prevents oral tolerance and enhances allergic sensitization Clin Exp Allergy 35 2005 757 766