Administration of a probiotic with peanut oral immunotherapy: A randomized trial

Journal of Allergy and Clinical Immunology

Volumn 135, Issue 3, 2015, Pages 737-744.e8

  Tang, Mimi L K ^a,b,c   Ponsonby, Anne Louise ^c   Orsini, Francesca ^c   Tey, Dean ^a,c   Robinson, Marnie ^a,c   Su, Ee Lyn ^a,c   Licciardi, Paul ^c   Burks, Wesley ^d   Donath, Susan ^b,c  

^a ROYAL CHILDREN'S HOSPITAL   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c MURDOCH CHILDREN'S RESEARCH INSTITUTE   (Australia)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

desensitization; immune modifying adjuvant; oral immunotherapy; Peanut allergy; peanut specific IgE; peanut specific IgG4; probiotic; sustained unresponsiveness; tolerance

Indexed keywords

PLACEBO; PROBIOTIC AGENT; ALLERGEN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G;

ARTICLE; BLOOD SAMPLING; CHILD; CONTROLLED STUDY; DESENSITIZATION; FEMALE; FOOD ALLERGY; HUMAN; IMMUNE RESPONSE; IMMUNOMODULATION; LACTOBACILLUS RHAMNOSUS; MAJOR CLINICAL STUDY; MALE; ORAL IMMUNOTHERAPY; OUTCOME ASSESSMENT; PEANUT ALLERGY; PRESCHOOL CHILD; PRICK TEST; PRIORITY JOURNAL; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; BLOOD; CHEMISTRY; DOUBLE BLIND PROCEDURE; IMMUNOLOGY; INFANT; ORAL DRUG ADMINISTRATION; PATHOPHYSIOLOGY; PEANUT; PEANUT HYPERSENSITIVITY; PROCEDURES; SKIN TEST; TREATMENT OUTCOME;

ADMINISTRATION, ORAL; ALLERGENS; ARACHIS HYPOGAEA; CHILD; CHILD, PRESCHOOL; DESENSITIZATION, IMMUNOLOGIC; DOUBLE-BLIND METHOD; FEMALE; HUMANS; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; INFANT; MALE; PEANUT HYPERSENSITIVITY; PROBIOTICS; SKIN TESTS; TREATMENT OUTCOME;

EID: 84924618612     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2014.11.034     Document Type: Article

References (41)

1. R. Gupta, A. Sheikh, D.P. Strachan, and H.R. Anderson Time trends in allergic disorders in the UK Thorax 62 2007 91 96
2. S.H. Sicherer, and H.A. Sampson 9. Food allergy J Allergy Clin Immunol 117 suppl 2006 S470 S475
3. W.K. Liew, E. Williamson, and M.L. Tang Anaphylaxis fatalities and admissions in Australia J Allergy Clin Immunol 123 2009 434 442
4. A.M. Branum, and S.L. Lukacs Food allergy among children in the United States Pediatrics 124 2009 1549 1555
5. J.J. Chafen, S.J. Newberry, M.A. Riedl, D.M. Bravata, M. Maglione, and M.J. Suttorp Diagnosing and managing common food allergies: a systematic review JAMA 303 2010 1848 1856
6. N.J. Osborne, J.J. Koplin, P.E. Martin, L.C. Gurrin, A.J. Lowe, and M.C. Matheson Prevalence of challenge-proven IgE-mediated food allergy using population-based sampling and predetermined challenge criteria in infants J Allergy Clin Immunol 127 2011 668 676 e1-2
7. S.A. Bock, A. Munoz-Furlong, and H.A. Sampson Further fatalities caused by anaphylactic reactions to food, 2001-2006 J Allergy Clin Immunol 119 2007 1016 1018
8. R.S. Pumphrey, and M.H. Gowland Further fatal allergic reactions to food in the United Kingdom, 1999-2006 J Allergy Clin Immunol 119 2007 1018 1019
9. M.L. Tang, and D.J. Martino Oral immunotherapy and tolerance induction in childhood Pediatr Allergy Immunol 24 2013 512 520
10. K. Anagnostou, S. Islam, Y. King, L. Foley, L. Pasea, and S. Bond Assessing the efficacy of oral immunotherapy for the desensitisation of peanut allergy in (STOP II): a phase 2 randomised controlled trial Lancet 383 2014 1297 1304
11. J.L. Brozek, L. Terracciano, J. Hsu, J. Kreis, E. Compalati, and N. Santesso Oral immunotherapy for IgE-mediated cow's milk allergy: a systematic review and meta-analysis Clin Exp Allergy 42 2012 363 374
12. M.C. Berin, and L. Mayer Can we produce true tolerance in patients with food allergy? J Allergy Clin Immunol 131 2013 14 22
13. E. Barbi, G. Longo, I. Berti, L. Matarazzo, L. Rubert, and A. Saccari Adverse effects during specific oral tolerance induction: in home phase Allergol Immunopathol (Madr) 40 2012 41 50
14. P. Varshney, P.H. Steele, B.P. Vickery, J.A. Bird, A. Thyagarajan, and A.M. Scurlock Adverse reactions during peanut oral immunotherapy home dosing J Allergy Clin Immunol 124 2009 1351 1352
15. K. Blumchen, H. Ulbricht, U. Staden, K. Dobberstein, J. Beschorner, and L.C. de Oliveira Oral peanut immunotherapy in children with peanut anaphylaxis J Allergy Clin Immunol 126 2010 83 91.e1
16. B.P. Vickery, A.M. Scurlock, M. Kulis, P.H. Steele, J. Kamilaris, and J.P. Berglund Sustained unresponsiveness to peanut in subjects who have completed peanut oral immunotherapy J Allergy Clin Immunol 133 2014 468 475
17. A.W. Burks, S.M. Jones, R.A. Wood, D.M. Fleischer, S.H. Sicherer, and R.W. Lindblad Oral immunotherapy for treatment of egg allergy in children N Engl J Med 367 2012 233 243
18. C.A. Keet, P.A. Frischmeyer-Guerrerio, A. Thyagarajan, J.T. Schroeder, R.G. Hamilton, and S. Boden The safety and efficacy of sublingual and oral immunotherapy for milk allergy J Allergy Clin Immunol 129 2012 448 455 e1-5
19. U. Staden, C. Rolinck-Werninghaus, F. Brewe, U. Wahn, B. Niggemann, and K. Beyer Specific oral tolerance induction in food allergy in children: efficacy and clinical patterns of reaction Allergy 62 2007 1261 1269
20. C.A. Keet, S. Seopaul, S. Knorr, S. Narisety, J. Skripak, and R.A. Wood Long-term follow-up of oral immunotherapy for cow's milk allergy J Allergy Clin Immunol 132 2013 737 739.e6
21. P.S. Creticos, J.T. Schroeder, R.G. Hamilton, S.L. Balcer-Whaley, A.P. Khattignavong, and R. Lindblad Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitis N Engl J Med 355 2006 1445 1455
22. K.J. Drachenberg, A.W. Wheeler, P. Stuebner, and F. Horak A well-tolerated grass pollen-specific allergy vaccine containing a novel adjuvant, monophosphoryl lipid A, reduces allergic symptoms after only four preseasonal injections Allergy 56 2001 498 505
23. F.E. Simons, Y. Shikishima, G. Van Nest, J.J. Eiden, and K.T. HayGlass Selective immune redirection in humans with ragweed allergy by injecting Amb a 1 linked to immunostimulatory DNA J Allergy Clin Immunol 113 2004 1144 1151
24. V. Lombardi, L. Van Overtvelt, S. Horiot, H. Moussu, H. Chabre, and A. Louise Toll-like receptor 2 agonist Pam3CSK4 enhances the induction of antigen-specific tolerance via the sublingual route Clin Exp Allergy 38 2008 1819 1829
25. L. Mascarell, L. Van Overtvelt, V. Lombardi, A. Razafindratsita, H. Moussu, and S. Horiot A synthetic triacylated pseudo-dipeptide molecule promotes Th1/TReg immune responses and enhances tolerance induction via the sublingual route Vaccine 26 2007 108 118
26. L. Van Overtvelt, H. Moussu, S. Horiot, S. Samson, V. Lombardi, and L. Mascarell Lactic acid bacteria as adjuvants for sublingual allergy vaccines Vaccine 28 2010 2986 2992
27. M. Miettinen, S. Matikainen, J. Vuopio-Varkila, J. Pirhonen, K. Varkila, and M. Kurimoto Lactobacilli and streptococci induce interleukin-12 (IL-12), IL-18, and gamma interferon production in human peripheral blood mononuclear cells Infect Immun 66 1998 6058 6062
28. S. Rautava, M. Kalliomaki, and E. Isolauri Probiotics during pregnancy and breast-feeding might confer immunomodulatory protection against atopic disease in the infant J Allergy Clin Immunol 109 2002 119 121
29. T. Pessi, Y. Sutas, M. Hurme, and E. Isolauri Interleukin-10 generation in atopic children following oral Lactobacillus rhamnosus GG Clin Exp Allergy 30 2000 1804 1808
30. E. Pohjavuori, M. Viljanen, R. Korpela, M. Kuitunen, M. Tiittanen, and O. Vaarala Lactobacillus GG effect in increasing IFN-γ production in infants with cow's milk allergy J Allergy Clin Immunol 114 2004 131 136
31. M.H. Ho, W.H. Wong, R.G. Heine, C.S. Hosking, D.J. Hill, and K.J. Allen Early clinical predictors of remission of peanut allergy in children J Allergy Clin Immunol 121 2008 731 736
32. M. Plaut, R.T. Sawyer, and M.J. Fenton Summary of the 2008 National Institute of Allergy and Infectious Diseases-US Food and Drug Administration Workshop on Food Allergy Clinical Trial Design J Allergy Clin Immunol 124 2009 671 678.e1
33. J.J. Koplin, M.L. Tang, P.E. Martin, N.J. Osborne, A.J. Lowe, and A.L. Ponsonby Predetermined challenge eligibility and cessation criteria for oral food challenges in the HealthNuts population-based study of infants J Allergy Clin Immunol 129 2012 1145 1147
34. H.S. Skolnick, M.K. Conover-Walker, C.B. Koerner, H.A. Sampson, W. Burks, and R.A. Wood The natural history of peanut allergy J Allergy Clin Immunol 107 2001 367 374
35. P. Varshney, S.M. Jones, A.M. Scurlock, T.T. Perry, A. Kemper, and P. Steele A randomized controlled study of peanut oral immunotherapy: clinical desensitization and modulation of the allergic response J Allergy Clin Immunol 127 2011 654 660
36. A.D. Buchanan, T.D. Green, S.M. Jones, A.M. Scurlock, L. Christie, and K.A. Althage Egg oral immunotherapy in nonanaphylactic children with egg allergy J Allergy Clin Immunol 119 2007 199 205
37. M. Vazquez-Ortiz, M. Alvaro-Lozano, L. Alsina, M.B. Garcia-Paba, M. Piquer-Gibert, and M.T. Giner-Munoz Safety and predictors of adverse events during oral immunotherapy for milk allergy: severity of reaction at oral challenge, specific IgE and prick test Clin Exp Allergy 43 2013 92 102
38. A.M. Hofmann, A.M. Scurlock, S.M. Jones, K.P. Palmer, Y. Lokhnygina, and P.H. Steele Safety of a peanut oral immunotherapy protocol in children with peanut allergy J Allergy Clin Immunol 124 2009 286 291 e1-6
39. J. Hol, E.H. van Leer, B.E. Elink Schuurman, L.F. de Ruiter, J.N. Samsom, and W. Hop The acquisition of tolerance toward cow's milk through probiotic supplementation: a randomized, controlled trial J Allergy Clin Immunol 121 2008 1448 1454
40. M.H. Ho, W.H. Wong, R.G. Heine, C.S. Hosking, D.J. Hill, and K.J. Allen Early clinical predictors of remission of peanut allergy in children J Allergy Clin Immunol 121 2008 731 736
41. M. Plaut, R.T. Sawyer, and M.J. Fenton Summary of the 2008 National Institute of Allergy and Infectious Diseases-US Food and Drug Administration Workshop on Food Allergy Clinical Trial Design J Allergy Clin Immunol 124 2009 671 678.e1