Randomized placebo-controlled trial of hen's egg consumption for primary prevention in infants

Journal of Allergy and Clinical Immunology

Volumn 139, Issue 5, 2017, Pages 1591-1599.e2

  Bellach, Johanna ^a   Schwarz, Veronika ^a   Ahrens, Birgit ^a   Trendelenburg, Valérie ^a   Aksünger, Özlem ^a   Kalb, Birgit ^a   Niggemann, Bodo ^a   Keil, Thomas ^a   Beyer, Kirsten ^a,b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

allergy prevention; atopic eczema; complementary feeding; Food allergy; hen's egg allergy; oral tolerance; randomized controlled trial

Indexed keywords

EGG PROTEIN; IMMUNOGLOBULIN E; PLACEBO; EGG WHITE;

ADVERSE OUTCOME; ANAPHYLAXIS; ARTICLE; CARDIOVASCULAR DISEASE; CLINICAL OUTCOME; COMPLEMENTARY FEEDING; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; EGG; EGG ALLERGY; ENTEROCOLITIS; FEMALE; HEN; HUMAN; IMMEDIATE TYPE HYPERSENSITIVITY; IMMUNOGLOBULIN BLOOD LEVEL; INFANT; MAJOR CLINICAL STUDY; MALE; MEDICATION COMPLIANCE; PRIMARY PREVENTION; PRIORITY JOURNAL; PROVOCATION TEST; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT DISEASE; SENSITIZATION; SEROCONVERSION; ANIMAL; BLOOD; CHICKEN; EGG HYPERSENSITIVITY; IMMUNOLOGY;

ANAPHYLAXIS; ANIMALS; CHICKENS; DOUBLE-BLIND METHOD; EGG HYPERSENSITIVITY; EGG PROTEINS; EGG WHITE; FEMALE; HUMANS; IMMUNOGLOBULIN E; INFANT; MALE; PRIMARY PREVENTION;

EID: 84995685525     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2016.06.045     Document Type: Article

References (27)

1. 1 Prescott, S.L., Pawankar, R., Allen, K.J., Campbell, D.E., Sinn, J., Fiocchi, A., et al. A global survey of changing patterns of food allergy burden in children. World Allergy Org J, 6, 2013, 21.
2. 2 Rudders, S.A., Arias, S.A., Camargo, C.A. Jr., Trends in hospitalizations for food-induced anaphylaxis in US children, 2000-2009. J Allergy Clin Immunol 134 (2014), 960–962.e3.
3. 3 Mullins, R.J., Dear, K.B., Tang, M.L., Time trends in Australian hospital anaphylaxis admissions in 1998-1999 to 2011-2012. J Allergy Clin Immunol 136 (2015), 367–375.
4. 4 Xepapadaki, P., Fiocchi, A., Grabenhenrich, L., Roberts, G., Grimshaw, K.E., Fiandor, A., et al. Incidence and natural history of hen's egg allergy in the first 2 years of life—the EuroPrevall birth cohort study. Allergy 71 (2016), 350–357.
5. 5 Muraro, A., Halken, S., Arshad, S.H., Beyer, K., Dubois, A.E., Du Toit, G., et al. EAACI food allergy and anaphylaxis guidelines. Primary prevention of food allergy. Allergy 69 (2014), 590–601.
6. 6 Du Toit, G., Roberts, G., Sayre, P.H., Bahnson, H.T., Radulovic, S., Santos, A.F., et al. Randomized trial of peanut consumption in infants at risk for peanut allergy. N Engl J Med 372 (2015), 803–813.
7. 7 Fleischer, D.M., Sicherer, S., Greenhawt, M., Campbell, D., Chan, E., Muraro, A., et al. Consensus communication on early peanut introduction and the prevention of peanut allergy in high-risk infants. Allergy 70 (2015), 1193–1195.
8. 8 Koplin, J.J., Osborne, N.J., Wake, M., Martin, P.E., Gurrin, L.C., Robinson, M.N., et al. Can early introduction of egg prevent egg allergy in infants? A population-based study. J Allergy Clin Immunol 126 (2010), 807–813.
9. 9 Palmer, D.J., Metcalfe, J., Makrides, M., Gold, M.S., Quinn, P., West, C.E., et al. Early regular egg exposure in infants with eczema: A randomized controlled trial. J Allergy Clin Immunol 132 (2013), 387–392.e1.
10. 10 Keil, T., McBride, D., Grimshaw, K., Niggemann, B., Xepapadaki, P., Zannikos, K., et al. The multinational birth cohort of EuroPrevall: background, aims and methods. Allergy 65 (2010), 482–490.
11. 11 Schafer, T., Bauer, C.P., Beyer, K., Bufe, A., Friedrichs, F., Gieler, U., et al. S3-guideline on allergy prevention: 2014 update: guideline of the German Society for Allergology and Clinical Immunology (DGAKI) and the German Society for Pediatric and Adolescent Medicine (DGKJ). Allergo J Int 23 (2014), 186–199.
12. 12 Sampson, H.A., Gerth van Wijk, R., Bindslev-Jensen, C., Sicherer, S., Teuber, S.S., Burks, A.W., et al. Standardizing double-blind, placebo-controlled oral food challenges: American Academy of Allergy, Asthma & Immunology-European Academy of Allergy and Clinical Immunology PRACTALL consensus report. J Allergy Clin Immunol 130 (2012), 1260–1274.
13. 13 Niggemann, B., When is an oral food challenge positive?. Allergy 65 (2010), 2–6.
14. 14 Niggemann, B., Lange, L., Finger, A., Ziegert, M., Muller, V., Beyer, K., Accurate oral food challenge requires a cumulative dose on a subsequent day. J Allergy Clin Immunol 130 (2012), 261–263.
15. 15 Escudero, C., Sanchez-Garcia, S., Rodriguez del Rio, P., Pastor-Vargas, C., Garcia-Fernandez, C., Perez-Rangel, I., et al. Dehydrated egg white: an allergen source for improving efficacy and safety in the diagnosis and treatment for egg allergy. Pediatr Allergy Immunol 24 (2013), 263–269.
16. 16 Netting, M., Donato, A., Makrides, M., Gold, M., Quinn, P., Penttila, I., Allergenicity of pasteurized whole raw Hen's egg compared with fresh whole raw Hen's egg. Pediatr Allergy Immunol 26 (2015), 234–238.
17. 17 Altman, D.G., Moher, D., Schulz, K.F., Improving the reporting of randomised trials: the CONSORT Statement and beyond. Stat Med 31 (2012), 2985–2997.
18. 18 Altman, D.G., Schulz, K.F., Moher, D., Egger, M., Davidoff, F., Elbourne, D., et al. The revised CONSORT statement for reporting randomized trials: explanation and elaboration. Ann Intern Med 134 (2001), 663–694.
19. 19 Hill, D.J., Hosking, C.S., de Benedictis, F.M., Oranje, A.P., Diepgen, T.L., Bauchau, V., Confirmation of the association between high levels of immunoglobulin E food sensitization and eczema in infancy: an international study. Clin Exp Allergy 38 (2008), 161–168.
20. 20 Prescott, S.L., Smith, P., Tang, M., Palmer, D.J., Sinn, J., Huntley, S.J., et al. The importance of early complementary feeding in the development of oral tolerance: concerns and controversies. Pediatr Allergy Immunol 19 (2008), 375–380.
21. 21 Lack, G., Update on risk factors for food allergy. J Allergy Clin Immunol 129 (2012), 1187–1197.
22. 22 Katz, Y., Rajuan, N., Goldberg, M.R., Eisenberg, E., Heyman, E., Cohen, A., et al. Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy. J Allergy Clin Immunol 126 (2010), 77–82.e1.
23. 23 Saarinen, K.M., Juntunen-Backman, K., Jarvenpaa, A.L., Kuitunen, P., Lope, L., Renlund, M., et al. Supplementary feeding in maternity hospitals and the risk of cow's milk allergy: a prospective study of 6209 infants. J Allergy Clin Immunol 104 (1999), 457–461.
24. 24 Shin, M., Han, Y., Ahn, K., The influence of the time and temperature of heat treatment on the allergenicity of egg white proteins. Allergy Asthma Immunol Res 5 (2013), 96–101.
25. 25 Perkin, M.R., Logan, K., Tseng, A., Raji, B., Ayis, S., Peacock, J., et al. Randomized trial of introduction of allergenic foods in breast-fed infants. N Engl J Med 374 (2016), 1733–1743.
26. 26 Jitlal, M., Khan, I., Lee, S.M., Hackshaw, A., Stopping clinical trials early for futility: retrospective analysis of several randomised clinical studies. Br J Cancer 107 (2012), 910–917.
27. 27 Perkin, M.R., Logan, K., Marrs, T., Radulovic, S., Craven, J., Flohr, C., et al. Enquiring About Tolerance (EAT) study: feasibility of an early allergenic food introduction regimen. J Allergy Clin Immunol 137 (2016), 1477–1486.e8.