Randomized controlled trial of early regular egg intake to prevent egg allergy

Journal of Allergy and Clinical Immunology

Volumn 139, Issue 5, 2017, Pages 1600-1607.e2

  Palmer, Debra J ^a,b   Sullivan, Thomas R ^c   Gold, Michael S ^c   Prescott, Susan L ^a,d   Makrides, Maria ^b,c,e  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b Women's and Children's Health Research Institute   (Australia)

^c UNIVERSITY OF ADELAIDE   (Australia)

^d UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^e SOUTH AUSTRALIAN HEALTH AND MEDICAL RESEARCH INSTITUTE   (Australia)

Author keywords

Allergy prevention; complementary feeding; egg; food allergy; hereditary risk; oral tolerance; randomized controlled trial

Indexed keywords

IMMUNOGLOBULIN E; IMMUNOGLOBULIN G4; LYSOZYME; OVALBUMIN; OVOMUCOID; OVOTRANSFERRIN; EGG PROTEIN;

ALLERGIC REACTION; ARTICLE; CLINICAL OUTCOME; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; EGG ALLERGY; FEMALE; HUMAN; INFANT; MAJOR CLINICAL STUDY; OUTCOME ASSESSMENT; PHYSICIAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; SAMPLE SIZE; ADVERSE EFFECTS; BLOOD; CLINICAL TRIAL; EGG; EGG HYPERSENSITIVITY; IMMUNOLOGY; MALE; MULTICENTER STUDY;

DOUBLE-BLIND METHOD; EGG HYPERSENSITIVITY; EGG PROTEINS; EGGS; FEMALE; HUMANS; IMMUNOGLOBULIN E; INFANT; MALE; RISK FACTORS;

EID: 85011028290     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2016.06.052     Document Type: Article

References (17)

1. 1 American Academy of Pediatrics. Committee on Nutrition. Hypoallergenic infant formulas. Pediatrics 106 (2000), 346–349.
2. 2 Prescott, S.L., Smith, P., Tang, M., Palmer, D.J., Sinn, J., Huntley, S.J., et al. The importance of early complementary feeding in the development of oral tolerance: concerns and controversies. Pediatr Allergy Immunol 19 (2008), 375–380.
3. 3 Smith, K.M., Eaton, A.D., Finlayson, L.M., Garside, P., Oral tolerance. Am J Respir Crit Care Med 162 (2000), S175–S178.
4. 4 Kull, I., Bergstrom, A., Lilja, G., Pershagen, G., Wickman, M., Fish consumption during the first year of life and development of allergic diseases during childhood. Allergy 61 (2006), 1009–1015.
5. 5 Poole, J.A., Barriga, K., Leung, D.Y., Hoffman, M., Eisenbarth, G.S., Rewers, M., et al. Timing of initial exposure to cereal grains and the risk of wheat allergy. Pediatrics 117 (2006), 2175–2182.
6. 6 Zutavern, A., von Mutius, E., Harris, J., Mills, P., Moffatt, S., White, C., et al. The introduction of solids in relation to asthma and eczema. Arch Dis Child 89 (2004), 303–308.
7. 7 Agostoni, C., Decsi, T., Fewtrell, M., Goulet, O., Kolacek, S., Koletzko, B., et al. Complementary feeding: a commentary by the ESPGHAN Committee on Nutrition. J Pediatr Gastrenterol Nutr 46 (2008), 99–110.
8. 8 Greer, F.R., Sicherer, S.H., Burks, A.W., Effects of early nutritional interventions on the development of atopic disease in infants and children: the role of maternal dietary restriction, breastfeeding, timing of introduction of complementary foods, and hydrolyzed formulas. Pediatrics 121 (2008), 183–191.
9. 9 Host, A., Halken, S., Muraro, A., Dreborg, S., Niggemann, B., Aalberse, R., et al. Dietary prevention of allergic diseases in infants and small children. Pediatr Allergy Immunol 19 (2008), 1–4.
10. 10 Osborne, N.J., Koplin, J.J., Martin, P.E., Gurrin, L.C., Lowe, A.J., Matheson, M.C., et al. Prevalence of challenge-proven IgE-mediated food allergy using population-based sampling and predetermined challenge criteria in infants. J Allergy Clin Immunol 127 (2011), 668–676 e1-2.
11. 11 Koplin, J.J., Osborne, N.J., Wake, M., Martin, P.E., Gurrin, L.C., Robinson, M.N., et al. Can early introduction of egg prevent egg allergy in infants? A population-based study. J Allergy Clin Immunol 126 (2010), 807–813.
12. 12 Palmer, D.J., Metcalfe, J., Makrides, M., Gold, M.S., Quinn, P., West, C.E., et al. Early regular egg exposure in infants with eczema: a randomized controlled trial. J Allergy Clin Immunol 132 (2013), 387–392.e1.
13. 13 Du Toit, G., Roberts, G., Sayre, P.H., Bahnson, H.T., Radulovic, S., Santos, A.F., et al. Randomized trial of peanut consumption in infants at risk for peanut allergy. N Engl J Med 372 (2015), 803–813.
14. 14 Perkin, M.R., Logan, K., Tseng, A., Raji, B., Ayis, S., Peacock, J., et al. Randomized trial of introduction of allergenic foods in breast-fed infants. N Engl J Med 374 (2016), 1733–1743.
15. 15 Metcalfe, J.R., D'Vaz, N., Makrides, M., Gold, M.S., Quinn, P., West, C.E., et al. Elevated IL-5 and IL-13 responses to egg proteins predate the introduction of egg in solid foods in infants with eczema. Clin Exp Allergy 46 (2016), 308–316.
16. van Buuren, S., Multiple imputation of discrete and continuous data by fully conditional specification. Stat Methods Med Res 16 (2007), 219–242.
17. Rubin, D.B., Multiple imputation for nonresponse in surveys. 1987, John Wiley & Sons, New York.