Blockade of peanut allergy with a novel Ara h 2-Fcγ fusion protein in mice

Journal of Allergy and Clinical Immunology

Volumn 131, Issue 1, 2013, Pages

  Liu, Yu ^a   Sun, Yongtao ^b   Chang, Lee Jah ^a   Li, Newton ^a   Li, Huabin ^a   Yu, Yanni ^a   Bryce, Paul J ^a   Grammer, Leslie C ^a   Schleimer, Robert P ^a   Zhu, Daocheng ^a,b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

anaphylaxis; basophils; Food allergy; fusion protein; immunotherapy; mast cells; peanut

Indexed keywords

ANTIALLERGIC AGENT; ARA H 2 FC GAMMA 1 FUSION PROTEIN; FC RECEPTOR; FC RECEPTOR IIB; FOOD ALLERGEN; HISTAMINE; HYBRID PROTEIN; IMMUNOGLOBULIN E; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN BINDING; ANTIGEN EXPRESSION; ARTICLE; BASOPHIL DEGRANULATION; BODY TEMPERATURE; CONTROLLED STUDY; DISEASE MODEL; DRUG PROTEIN BINDING; FEMALE; HISTAMINE RELEASE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOMODULATION; MOUSE; NONHUMAN; PASSIVE SKIN ANAPHYLAXIS; PEANUT ALLERGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RESPIRATORY TRACT INFLAMMATION; SENSITIZATION; SKIN ALLERGY;

EID: 84871716197     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2012.10.018     Document Type: Article

References (30)

1. J.A. Boyce, A. Assa'ad, A.W. Burks, S.M. Jones, H.A. Sampson, and R.A. Wood Guidelines for the diagnosis and management of food allergy in the united states: summary of the NIAID-sponsored expert panel report J Allergy Clin Immunol 126 2010 1105 1118
2. D.Y. Leung, H.A. Sampson, J.W. Yunginger, A.W. Burks Jr., L.C. Schneider, and C.H. Wortel Effect of anti-IgE therapy in patients with peanut allergy N Engl J Med 348 2003 986 993
3. A.W. Burks Peanut allergy Lancet 371 2008 1538 1546
4. K. Blumchen, H. Ulbricht, U. Staden, K. Dobberstain, J. Beschorner, and L.C. de Oliveira Oral peanut immunotherapy in children with peanut anaphylaxis J Allergy Clin Immunol 126 2010 83 91
5. J.W. Yu, R. Kagan, N. Verreault, N. Nicolas, L. Joseph, and Y. St Pierre Accidental ingestions in children with peanut allergy J Allergy Clin Immunol 118 2006 466 472
6. J.M. Maloney, M.D. Chapman, and S.H. Sicherer Peanut allergen exposure through saliva: assessment and interventions to reduce exposure J Allergy Clin Immunol 118 2006 719 724
7. P. Varshney, S.M. Jones, A.M. Scurlock, T.T. Perry, A. Kemper, and P. Steele A randomized controlled study of peanut oral immunotherapy: clinical desensitization and modulation of the allergic response J Allergy Clin Immunol 127 2011 654 660
8. E.H. Kim, J.A. Bird, M. Kulis, S. Laubach, L. Pons, and W. Shreffler Sublingual immunotherapy for peanut allergy: clinical and immunologic evidence of desensitization J Allergy Clin Immunol 127 2011 640 646
9. M. Masilamani, J. Wei, S. Bhatt, M. Paul, S. Yakir, and H.A. Sampson Soybean isoflavones regulate dendritic cell function and suppress allergic sensitization to peanut J Allergy Clin Immunol 128 2011 1242 1250
10. S.P. Patil, J. Wang, Y. Song, S. Noone, N. Yang, and S. Wallenstain Clinical safety of Food Allergy Herbal Formula-2 (FAHF-2) and inhibitory effect on basophils from patients with food allergy: extended phase I study J Allergy Clin Immunol 128 2011 1259 1265
11. S.H. Sicherer, and D.Y. Leung Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2010 J Allergy Clin Immunol 127 2011 326 335
12. A. Thyagarajan, P. Varshney, S.M. Jones, S. Sicherer, R. Wood, and B.P. Vickery Peanut oral immunotherapy is not ready for clinical use J Allergy Clin Immunol 126 2010 31 32
13. S.J. Koppelman, M. Wensing, M. Ertmann, A.C. Knulst, and E.F. Knol Relevance of Ara h1, Ara h2 and Ara h3 in peanut-allergic patients, as determined by immunoglobulin E Western blotting, basophil-histamine release and intracutaneous testing: Ara h2 is the most important peanut allergen Clin Exp Allergy 34 2004 583 590
14. F.D. Finkelman Peanut allergy and anaphylaxis Curr Opin Immunol 22 2010 783 788
15. J. Kalesnikoff, and S.J. Galli New developments in mast cell biology Nat Immunol 9 2008 1215 1223
16. D.D. Metcalfe, R.D. Peavy, and A.M. Gilfillan Mechanisms of mast cell signaling in anaphylaxis J Allergy Clin Immunol 124 2009 639 646
17. M. Daeron, O. Malbec, S. Latour, M. Arock, and W.H. Fridman Regulation of high-affinity IgE receptor-mediated mast cell activation by murine low-affinity IgG receptors J Clin Invest 95 1995 577 585
18. J. Jackman, Y. Chen, A. Huang, B. Moffat, J.M. Scheer, and S.R. Leong Development of a two-part strategy to identify a therapeutic human bispecific antibody that inhibits IgE receptor signaling J Biol Chem 285 2010 20850 20859
19. D. Zhu, C.L. Kepley, M. Zhang, K. Zhang, and A. Saxon A novel human immunoglobulin Fc gamma Fc epsilon bifunctional fusion protein inhibits Fc epsilon RI-mediated degranulation Nat Med 8 2002 518 521
20. D. Zhu, C.L. Kepley, K. Zhang, T. Terada, T. Yamada, and A. Saxon A chimeric human-cat fusion protein blocks cat-induced allergy Nat Med 11 2005 446 449
21. T. Terada, K. Zhang, J. Belperio, V. Londhe, and A. Saxon A chimeric human-cat Fcgamma-Fel d1 fusion protein inhibits systemic, pulmonary, and cutaneous allergic reactivity to intratracheal challenge in mice sensitized to Fel d1, the major cat allergen Clin Immunol 120 2006 45 56
22. C.L. Kepley, J.C. Cambier, P.A. Morel, D. Lujan, E. Ortega, and B.S. Wilson Negative regulation of FcepsilonRI signaling by FcgammaRII costimulation in human blood basophils J Allergy Clin Immunol 106 2000 337 348
23. D. Dombrowicz, A.T. Brini, V. Flamand, E. Hicks, J.N. Snouwaert, and J.P. Kinet Anaphylaxis mediated through a humanized high affinity IgE receptor J Immunol 157 1996 1645 1651
24. J. Sun, K. Arias, D. Alvarez, R. Fattouh, T. Walker, and S. Goncharova Impact of CD40 ligand, B cells, and mast cells in peanut-induced anaphylactic responses J Immunol 179 2007 6696 6703
25. T. Takai, M. Ono, M. Hikida, H. Ohmori, and J.V. Ravetch Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice Nature 379 1996 346 349
26. F.D. Finkelman, M.E. Rothenberg, E.B. Brandt, S.C. Morris, and R.T. Strait Molecular mechanisms of anaphylaxis: lessons from studies with murine models J Allergy Clin Immunol 115 2005 449 457
27. C.A. Akdis, and M. Akdis Mechanisms of allergen-specific immunotherapy J Allergy Clin Immunol 127 2011 18 27
28. C. Uermosi, R.R. Beerli, M. Bauer, V. Manolova, K. Dietmeier, and R.B. Buser Mechanisms of allergen-specific desensitization J Allergy Clin Immunol 126 2010 375 383
29. K. Arias, D.K. Chu, K. Flader, F. Botelho, T. Walker, and N. Arias Distinct immune effector pathways contribute to the full expression of peanut-induced anaphylactic reactions in mice J Allergy Clin Immunol 127 2011 1552 1561
30. R.A. McDermott, H.S. Porterfield, R. El Mezayen, A.W. Burks, L. Pons, and D.G. Schlichting Contribution of Ara h 2 to peanut-specific, immunoglobulin E-mediated, cell activation Clin Exp Allergy 37 2007 752 763