메뉴 건너뛰기




Volumn 52, Issue , 2017, Pages 4-13

Basics of genome editing technology and its application in livestock species

Author keywords

CRISPR CAS9; gene targeting; genome editing; TALEN; transgenic animals; ZFN

Indexed keywords

DEOXYRIBONUCLEASE; ENDONUCLEASE; TRANSCRIPTION ACTIVATOR LIKE EFFECTOR NUCLEASE; ZINC FINGER NUCLEASE;

EID: 85027575283     PISSN: 09366768     EISSN: 14390531     Source Type: Journal    
DOI: 10.1111/rda.13012     Document Type: Review
Times cited : (73)

References (93)
  • 2
    • 80755187812 scopus 로고    scopus 로고
    • CRISPR-Cas systems in bacteria and archaea: Versatile small RNAs for adaptive defense and regulation
    • Bhaya, D., Davison, M., & Barrangou, R. (2011). CRISPR-Cas systems in bacteria and archaea: Versatile small RNAs for adaptive defense and regulation. Annual Review of Genetics, 45, 273–297.
    • (2011) Annual Review of Genetics , vol.45 , pp. 273-297
    • Bhaya, D.1    Davison, M.2    Barrangou, R.3
  • 3
    • 84982099230 scopus 로고    scopus 로고
    • Isozygous and selectable marker-free MSTN knockout cloned pigs generated by the combined use of CRISPR/Cas9 and Cre/LoxP
    • Bi, Y., Hua, Z., Liu, X., Hua, W., Ren, H., Xiao, H., … Zheng, X. (2016). Isozygous and selectable marker-free MSTN knockout cloned pigs generated by the combined use of CRISPR/Cas9 and Cre/LoxP. Scientific Reports, 6, 31729.
    • (2016) Scientific Reports , vol.6 , pp. 31729
    • Bi, Y.1    Hua, Z.2    Liu, X.3    Hua, W.4    Ren, H.5    Xiao, H.6    Zheng, X.7
  • 4
    • 77956126894 scopus 로고    scopus 로고
    • Xanthomonas AvrBs3 family-type III effectors: Discovery and function
    • Boch, J., & Bonas, U. (2010). Xanthomonas AvrBs3 family-type III effectors: Discovery and function. Annual Review of Phytopathology, 48, 419–436.
    • (2010) Annual Review of Phytopathology , vol.48 , pp. 419-436
    • Boch, J.1    Bonas, U.2
  • 5
    • 72149110399 scopus 로고    scopus 로고
    • Breaking the Code of DNA Binding Specificity of TAL-Type III Effectors
    • Boch, J., Scholze, H., Schornack, S., Landgraf, A., Hahn, S., Kay, S., … Bonas, U. (2009). Breaking the Code of DNA Binding Specificity of TAL-Type III Effectors. Science, 326, 1509–1512.
    • (2009) Science , vol.326 , pp. 1509-1512
    • Boch, J.1    Scholze, H.2    Schornack, S.3    Landgraf, A.4    Hahn, S.5    Kay, S.6    Bonas, U.7
  • 6
    • 85014070672 scopus 로고    scopus 로고
    • Precision engineering for PRRSV resistance in pigs: Macrophages from genome edited pigs lacking CD163 SRCR5 domain are fully resistant to both PRRSV genotypes while maintaining biological function
    • Burkard, C., Lillico, S. G., Reid, E., Jackson, B., Mileham, A. J., Ait-Ali, T., … Archibald, A. L. (2017). Precision engineering for PRRSV resistance in pigs: Macrophages from genome edited pigs lacking CD163 SRCR5 domain are fully resistant to both PRRSV genotypes while maintaining biological function. PLoS Pathogens, 13, e1006206.
    • (2017) PLoS Pathogens , vol.13
    • Burkard, C.1    Lillico, S.G.2    Reid, E.3    Jackson, B.4    Mileham, A.J.5    Ait-Ali, T.6    Archibald, A.L.7
  • 7
    • 84964378099 scopus 로고    scopus 로고
    • Silencing porcine genes significantly reduces human-anti-pig cytotoxicity profiles: An alternative to direct complement regulation
    • Butler, J. R., Martens, G. R., Estrada, J. L., Reyes, L. M., Ladowski, J. M., Galli, C., … Joseph Tector, A. (2016). Silencing porcine genes significantly reduces human-anti-pig cytotoxicity profiles: An alternative to direct complement regulation. Transgenic Research, 25, 751–759.
    • (2016) Transgenic Research , vol.25 , pp. 751-759
    • Butler, J.R.1    Martens, G.R.2    Estrada, J.L.3    Reyes, L.M.4    Ladowski, J.M.5    Galli, C.6    Joseph Tector, A.7
  • 8
    • 0029967424 scopus 로고    scopus 로고
    • Sheep cloned by nuclear transfer from a cultured cell line
    • Campbell, K. H., McWhir, J., Ritchie, W. A., & Wilmut, I. (1996). Sheep cloned by nuclear transfer from a cultured cell line. Nature, 380, 64–66.
    • (1996) Nature , vol.380 , pp. 64-66
    • Campbell, K.H.1    McWhir, J.2    Ritchie, W.A.3    Wilmut, I.4
  • 11
    • 45749145124 scopus 로고    scopus 로고
    • Zinc-finger nucleases: The next generation emerges
    • Cathomen, T., & Joung, J. K. (2008). Zinc-finger nucleases: The next generation emerges. Molecular Therapy, 16, 1200–1207.
    • (2008) Molecular Therapy , vol.16 , pp. 1200-1207
    • Cathomen, T.1    Joung, J.K.2
  • 13
    • 0028919608 scopus 로고
    • Induction of homologous recombination in mammalian chromosomes by using the I-SceI system of Saccharomyces cerevisiae
    • Choulika, A., Perrin, A., Dujon, B., & Nicolas, J. F. (1995). Induction of homologous recombination in mammalian chromosomes by using the I-SceI system of Saccharomyces cerevisiae. Molecular and Cellular Biology, 15, 1968–1973.
    • (1995) Molecular and Cellular Biology , vol.15 , pp. 1968-1973
    • Choulika, A.1    Perrin, A.2    Dujon, B.3    Nicolas, J.F.4
  • 15
  • 16
    • 84930216593 scopus 로고    scopus 로고
    • Gene targeting by TALEN-induced homologous recombination in goats directs production of beta-lactoglobulin-free, high-human lactoferrin milk
    • Cui, C., Song, Y., Liu, J., Ge, H., Li, Q., Huang, H., … Zhang, Y. (2015). Gene targeting by TALEN-induced homologous recombination in goats directs production of beta-lactoglobulin-free, high-human lactoferrin milk. Scientific Reports, 5, 10482.
    • (2015) Scientific Reports , vol.5 , pp. 10482
    • Cui, C.1    Song, Y.2    Liu, J.3    Ge, H.4    Li, Q.5    Huang, H.6    Zhang, Y.7
  • 18
    • 0031863007 scopus 로고    scopus 로고
    • Analysis of gene targeting and intrachromosomal homologous recombination stimulated by genomic double-strand breaks in mouse embryonic stem cells
    • Donoho, G., Jasin, M., & Berg, P. (1998). Analysis of gene targeting and intrachromosomal homologous recombination stimulated by genomic double-strand breaks in mouse embryonic stem cells. Molecular and Cellular Biology, 18, 4070–4078.
    • (1998) Molecular and Cellular Biology , vol.18 , pp. 4070-4078
    • Donoho, G.1    Jasin, M.2    Berg, P.3
  • 19
  • 23
    • 84964862130 scopus 로고    scopus 로고
    • The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA
    • Fonfara, I., Richter, H., Bratovic, M., Le Rhun, A., & Charpentier, E. (2016). The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA. Nature, 532, 517–521.
    • (2016) Nature , vol.532 , pp. 517-521
    • Fonfara, I.1    Richter, H.2    Bratovic, M.3    Le Rhun, A.4    Charpentier, E.5
  • 24
    • 84896929630 scopus 로고    scopus 로고
    • Improving CRISPR-Cas nuclease specificity using truncated guide RNAs
    • Fu, Y., Sander, J. D., Reyon, D., Cascio, V. M., & Joung, J. K. (2014). Improving CRISPR-Cas nuclease specificity using truncated guide RNAs. Nature Biotechnology, 32, 279–284.
    • (2014) Nature Biotechnology , vol.32 , pp. 279-284
    • Fu, Y.1    Sander, J.D.2    Reyon, D.3    Cascio, V.M.4    Joung, J.K.5
  • 25
    • 84879264708 scopus 로고    scopus 로고
    • ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering
    • Gaj, T., Gersbach, C. A., & Barbas, C. F. 3rd (2013). ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering. Trends in Biotechnology, 31, 397–405.
    • (2013) Trends in Biotechnology , vol.31 , pp. 397-405
    • Gaj, T.1    Gersbach, C.A.2    Barbas, C.F.3
  • 26
    • 85011279013 scopus 로고    scopus 로고
    • Single Cas9 nickase induced generation of NRAMP1 knockin cattle with reduced off-target effects
    • Gao, Y., Wu, H., Wang, Y., Liu, X., Chen, L., Li, Q., … Zhang, Y. (2017). Single Cas9 nickase induced generation of NRAMP1 knockin cattle with reduced off-target effects. Genome Biology, 18, 13.
    • (2017) Genome Biology , vol.18 , pp. 13
    • Gao, Y.1    Wu, H.2    Wang, Y.3    Liu, X.4    Chen, L.5    Li, Q.6    Zhang, Y.7
  • 27
    • 84902210542 scopus 로고    scopus 로고
    • Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification
    • Guilinger, J. P., Thompson, D. B., & Liu, D. R. (2014). Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification. Nature Biotechnology, 32, 577–582.
    • (2014) Nature Biotechnology , vol.32 , pp. 577-582
    • Guilinger, J.P.1    Thompson, D.B.2    Liu, D.R.3
  • 28
    • 84978716213 scopus 로고    scopus 로고
    • Generation and evaluation of Myostatin knock-out rabbits and goats using CRISPR/Cas9 system
    • Guo, R. H., Wan, Y. J., Xu, D., Cui, L. B., Deng, M. T., Zhang, G. M., … Zhang, Y. L. (2016). Generation and evaluation of Myostatin knock-out rabbits and goats using CRISPR/Cas9 system. Scientific Reports, 6, 29855.
    • (2016) Scientific Reports , vol.6 , pp. 29855
    • Guo, R.H.1    Wan, Y.J.2    Xu, D.3    Cui, L.B.4    Deng, M.T.5    Zhang, G.M.6    Zhang, Y.L.7
  • 29
    • 57849128497 scopus 로고    scopus 로고
    • Nuclear reprogramming in cells
    • Gurdon, J. B., & Melton, D. A. (2008). Nuclear reprogramming in cells. Science, 322, 1811–1815.
    • (2008) Science , vol.322 , pp. 1811-1815
    • Gurdon, J.B.1    Melton, D.A.2
  • 30
    • 84897594300 scopus 로고    scopus 로고
    • One-step generation of knockout pigs by zygote injection of CRISPR/Cas system
    • Hai, T., Teng, F., Guo, R., Li, W., & Zhou, Q. (2014). One-step generation of knockout pigs by zygote injection of CRISPR/Cas system. Cell Research, 24, 372–375.
    • (2014) Cell Research , vol.24 , pp. 372-375
    • Hai, T.1    Teng, F.2    Guo, R.3    Li, W.4    Zhou, Q.5
  • 33
    • 79961185942 scopus 로고    scopus 로고
    • Heritable gene targeting in zebrafish using customized TALENs
    • Huang, P., Xiao, A., Zhou, M., Zhu, Z., Lin, S., & Zhang, B. (2011). Heritable gene targeting in zebrafish using customized TALENs. Nature Biotechnology, 29, 699–700.
    • (2011) Nature Biotechnology , vol.29 , pp. 699-700
    • Huang, P.1    Xiao, A.2    Zhou, M.3    Zhu, Z.4    Lin, S.5    Zhang, B.6
  • 38
    • 0038947196 scopus 로고    scopus 로고
    • Site-specific cleavage of DNA-RNA hybrids by zinc finger/FokI cleavage domain fusions
    • Kim, Y. G., Shi, Y., Berg, J. M., & Chandrasegaran, S. (1997). Site-specific cleavage of DNA-RNA hybrids by zinc finger/FokI cleavage domain fusions. Gene, 203, 43–49.
    • (1997) Gene , vol.203 , pp. 43-49
    • Kim, Y.G.1    Shi, Y.2    Berg, J.M.3    Chandrasegaran, S.4
  • 39
    • 84963941043 scopus 로고    scopus 로고
    • High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects
    • Kleinstiver, B. P., Pattanayak, V., Prew, M. S., Tsai, S. Q., Nguyen, N. T., & Zheng, Z. (2016). High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects. Nature, 529, 490–495.
    • (2016) Nature , vol.529 , pp. 490-495
    • Kleinstiver, B.P.1    Pattanayak, V.2    Prew, M.S.3    Tsai, S.Q.4    Nguyen, N.T.5    Zheng, Z.6
  • 40
    • 84963941043 scopus 로고    scopus 로고
    • High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects
    • Kleinstiver, B. P., Pattanayak, V., Prew, M. S., Tsai, S. Q., Nguyen, N. T., Zheng, Z., & Joung, J. K. (2016). High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects. Nature, 529, 490–495.
    • (2016) Nature , vol.529 , pp. 490-495
    • Kleinstiver, B.P.1    Pattanayak, V.2    Prew, M.S.3    Tsai, S.Q.4    Nguyen, N.T.5    Zheng, Z.6    Joung, J.K.7
  • 42
    • 84885723361 scopus 로고    scopus 로고
    • Dystrophin-deficient pigs provide new insights into the hierarchy of physiological derangements of dystrophic muscle
    • Klymiuk, N., Blutke, A., Graf, A., Krause, S., Burkhardt, K., Wuensch, A., … Wolf, E. (2013). Dystrophin-deficient pigs provide new insights into the hierarchy of physiological derangements of dystrophic muscle. Human Molecular Genetics, 22, 4368–4382.
    • (2013) Human Molecular Genetics , vol.22 , pp. 4368-4382
    • Klymiuk, N.1    Blutke, A.2    Graf, A.3    Krause, S.4    Burkhardt, K.5    Wuensch, A.6    Wolf, E.7
  • 43
    • 84971006562 scopus 로고    scopus 로고
    • Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
    • Komor, A. C., Kim, Y. B., Packer, M. S., Zuris, J. A., & Liu, D. R. (2016). Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage. Nature, 533, 420–424.
    • (2016) Nature , vol.533 , pp. 420-424
    • Komor, A.C.1    Kim, Y.B.2    Packer, M.S.3    Zuris, J.A.4    Liu, D.R.5
  • 44
    • 78651270582 scopus 로고    scopus 로고
    • TAL nucleases (TALNs): Hybrid proteins composed of TAL effectors and FokI DNA-cleavage domain
    • Li, T., Huang, S., Jiang, W. Z., Wright, D., Spalding, M. H., Weeks, D. P., & Yang, B. (2011). TAL nucleases (TALNs): Hybrid proteins composed of TAL effectors and FokI DNA-cleavage domain. Nucleic Acids Research, 39, 359–372.
    • (2011) Nucleic Acids Research , vol.39 , pp. 359-372
    • Li, T.1    Huang, S.2    Jiang, W.Z.3    Wright, D.4    Spalding, M.H.5    Weeks, D.P.6    Yang, B.7
  • 45
    • 79960034141 scopus 로고    scopus 로고
    • Modularly assembled designer TAL effector nucleases for targeted gene knockout and gene replacement in eukaryotes
    • Li, T., Huang, S., Zhao, X., Wright, D. A., Carpenter, S., Spalding, M. H., … Yang, B. (2011). Modularly assembled designer TAL effector nucleases for targeted gene knockout and gene replacement in eukaryotes. Nucleic Acids Research, 39, 6315–6325.
    • (2011) Nucleic Acids Research , vol.39 , pp. 6315-6325
    • Li, T.1    Huang, S.2    Zhao, X.3    Wright, D.A.4    Carpenter, S.5    Spalding, M.H.6    Yang, B.7
  • 46
    • 84899683227 scopus 로고    scopus 로고
    • Efficient generation of myostatin (MSTN) biallelic mutations in cattle using zinc finger nucleases
    • Luo, J., Song, Z., Yu, S., Cui, D., Wang, B., Ding, F., … Li, N. (2014). Efficient generation of myostatin (MSTN) biallelic mutations in cattle using zinc finger nucleases. PLoS One, 9, e95225.
    • (2014) PLoS One , vol.9
    • Luo, J.1    Song, Z.2    Yu, S.3    Cui, D.4    Wang, B.5    Ding, F.6    Li, N.7
  • 47
    • 79952302385 scopus 로고    scopus 로고
    • De novo-engineered transcription activator-like effector (TALE) hybrid nuclease with novel DNA binding specificity creates double-strand breaks
    • Mahfouz, M. M., Li, L., Shamimuzzaman, M., Wibowo, A., Fang, X., & Zhu, J. K. (2011). De novo-engineered transcription activator-like effector (TALE) hybrid nuclease with novel DNA binding specificity creates double-strand breaks. Proceedings of the National Academy of Sciences, 108, 2623–2628.
    • (2011) Proceedings of the National Academy of Sciences , vol.108 , pp. 2623-2628
    • Mahfouz, M.M.1    Li, L.2    Shamimuzzaman, M.3    Wibowo, A.4    Fang, X.5    Zhu, J.K.6
  • 49
    • 0040215628 scopus 로고
    • Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes
    • Miller, J., McLachlan, A. D., & Klug, A. (1985). Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes. EMBO Journal, 4, 1609–1614.
    • (1985) EMBO Journal , vol.4 , pp. 1609-1614
    • Miller, J.1    McLachlan, A.D.2    Klug, A.3
  • 51
    • 72149090954 scopus 로고    scopus 로고
    • A simple cipher governs DNA recognition by TAL effectors
    • Moscou, M. J., & Bogdanove, A. J. (2009). A simple cipher governs DNA recognition by TAL effectors. Science, 326, 1501–1501.
    • (2009) Science , vol.326 , pp. 1501
    • Moscou, M.J.1    Bogdanove, A.J.2
  • 52
  • 54
    • 0034923498 scopus 로고    scopus 로고
    • Design and selection of novel Cys2His2 zinc finger proteins
    • Pabo, C. O., Peisach, E., & Grant, R. A. (2001). Design and selection of novel Cys2His2 zinc finger proteins. Annual Review of Biochemistry, 70, 313–340.
    • (2001) Annual Review of Biochemistry , vol.70 , pp. 313-340
    • Pabo, C.O.1    Peisach, E.2    Grant, R.A.3
  • 56
    • 0025773296 scopus 로고
    • Zinc finger-DNA recognition: Crystal structure of a Zif268-DNA complex at 2.1 A
    • Pavletich, N. P., & Pabo, C. O. (1991). Zinc finger-DNA recognition: Crystal structure of a Zif268-DNA complex at 2.1 A. Science, 252, 809–817.
    • (1991) Science , vol.252 , pp. 809-817
    • Pavletich, N.P.1    Pabo, C.O.2
  • 57
    • 84988470736 scopus 로고    scopus 로고
    • Efficient production of biallelic GGTA1 knockout pigs by cytoplasmic microinjection of CRISPR/Cas9 into zygotes
    • Petersen, B., Frenzel, A., Lucas-Hahn, A., Herrmann, D., Hassel, P., Klein, S., … Niemann, H. (2016). Efficient production of biallelic GGTA1 knockout pigs by cytoplasmic microinjection of CRISPR/Cas9 into zygotes. Xenotransplantation, 23, 338–346.
    • (2016) Xenotransplantation , vol.23 , pp. 338-346
    • Petersen, B.1    Frenzel, A.2    Lucas-Hahn, A.3    Herrmann, D.4    Hassel, P.5    Klein, S.6    Niemann, H.7
  • 58
    • 51349092848 scopus 로고    scopus 로고
    • Development and validation of a highly efficient protocol of porcine somatic cloning using preovulatory embryo transfer in peripubertal gilts
    • Petersen, B., Lucas-Hahn, A., Oropeza, M., Hornen, N., Lemme, E., Hassel, P., … Niemann, H. (2008). Development and validation of a highly efficient protocol of porcine somatic cloning using preovulatory embryo transfer in peripubertal gilts. Cloning and Stem Cells, 10, 355–362.
    • (2008) Cloning and Stem Cells , vol.10 , pp. 355-362
    • Petersen, B.1    Lucas-Hahn, A.2    Oropeza, M.3    Hornen, N.4    Lemme, E.5    Hassel, P.6    Niemann, H.7
  • 60
    • 84942134094 scopus 로고    scopus 로고
    • Targeted mutations in myostatin by zinc-finger nucleases result in double-muscled phenotype in Meishan pigs
    • Qian, L., Tang, M., Yang, J., Wang, Q., Cai, C., Jiang, S., … Cui, W. (2015). Targeted mutations in myostatin by zinc-finger nucleases result in double-muscled phenotype in Meishan pigs. Scientific Reports, 5, 14435.
    • (2015) Scientific Reports , vol.5 , pp. 14435
    • Qian, L.1    Tang, M.2    Yang, J.3    Wang, Q.4    Cai, C.5    Jiang, S.6    Cui, W.7
  • 62
    • 0028237305 scopus 로고
    • Expression of a site-specific endonuclease stimulates homologous recombination in mammalian cells
    • Rouet, P., Smih, F., & Jasin, M. (1994a). Expression of a site-specific endonuclease stimulates homologous recombination in mammalian cells. Proceedings of the National Academy of Sciences, 91, 6064–6068.
    • (1994) Proceedings of the National Academy of Sciences , vol.91 , pp. 6064-6068
    • Rouet, P.1    Smih, F.2    Jasin, M.3
  • 63
    • 0028061666 scopus 로고
    • Introduction of double-strand breaks into the genome of mouse cells by expression of a rare-cutting endonuclease
    • Rouet, P., Smih, F., & Jasin, M. (1994b). Introduction of double-strand breaks into the genome of mouse cells by expression of a rare-cutting endonuclease. Molecular and Cellular Biology, 14, 8096–8106.
    • (1994) Molecular and Cellular Biology , vol.14 , pp. 8096-8106
    • Rouet, P.1    Smih, F.2    Jasin, M.3
  • 65
    • 84897954175 scopus 로고    scopus 로고
    • Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects
    • Shen, B., Zhang, W., Zhang, J., Zhou, J., Wang, J., Chen, L., … Skarnes, W. C. (2014). Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects. Nature Methods, 11, 399–402.
    • (2014) Nature Methods , vol.11 , pp. 399-402
    • Shen, B.1    Zhang, W.2    Zhang, J.3    Zhou, J.4    Wang, J.5    Chen, L.6    Skarnes, W.C.7
  • 67
    • 84952943845 scopus 로고    scopus 로고
    • Rationally engineered Cas9 nucleases with improved specificity
    • Slaymaker, I. M., Gao, L., Zetsche, B., Scott, D. A., Yan, W. X., & Zhang, F. (2016). Rationally engineered Cas9 nucleases with improved specificity. Science, 351, 84–88.
    • (2016) Science , vol.351 , pp. 84-88
    • Slaymaker, I.M.1    Gao, L.2    Zetsche, B.3    Scott, D.A.4    Yan, W.X.5    Zhang, F.6
  • 68
    • 0034283804 scopus 로고    scopus 로고
    • Requirements for double-strand cleavage by chimeric restriction enzymes with zinc finger DNA-recognition domains
    • Smith, J., Bibikova, M., Whitby, F. G., Reddy, A. R., Chandrasegaran, S., & Carroll, D. (2000). Requirements for double-strand cleavage by chimeric restriction enzymes with zinc finger DNA-recognition domains. Nucleic Acids Research, 28, 3361–3369.
    • (2000) Nucleic Acids Research , vol.28 , pp. 3361-3369
    • Smith, J.1    Bibikova, M.2    Whitby, F.G.3    Reddy, A.R.4    Chandrasegaran, S.5    Carroll, D.6
  • 69
    • 84928397982 scopus 로고    scopus 로고
    • Expression, purification and characterization of zinc-finger nuclease to knockout the goat beta-lactoglobulin gene
    • Song, Y., Cui, C., Zhu, H., Li, Q., Zhao, F., & Jin, Y. (2015). Expression, purification and characterization of zinc-finger nuclease to knockout the goat beta-lactoglobulin gene. Protein Expression and Purification, 112, 1–7.
    • (2015) Protein Expression and Purification , vol.112 , pp. 1-7
    • Song, Y.1    Cui, C.2    Zhu, H.3    Li, Q.4    Zhao, F.5    Jin, Y.6
  • 70
    • 34447323568 scopus 로고    scopus 로고
    • Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases
    • Szczepek, M., Brondani, V., Buchel, J., Serrano, L., Segal, D. J., & Cathomen, T. (2007). Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases. Nature Biotechnology, 25, 786–793.
    • (2007) Nature Biotechnology , vol.25 , pp. 786-793
    • Szczepek, M.1    Brondani, V.2    Buchel, J.3    Serrano, L.4    Segal, D.J.5    Cathomen, T.6
  • 77
    • 72149111192 scopus 로고    scopus 로고
    • Plant scienc. DNA binding made easy
    • Voytas, D. F., & Joung, J. K. (2009). Plant scienc. DNA binding made easy. Science, 326, 1491–1492.
    • (2009) Science , vol.326 , pp. 1491-1492
    • Voytas, D.F.1    Joung, J.K.2
  • 78
    • 85006373186 scopus 로고    scopus 로고
    • Efficient generation of B2 m-null pigs via injection of zygote with TALENs
    • Wang, Y., Du, Y., Zhou, X., Wang, L., Li, J., Wang, F., … Wei, H. (2016). Efficient generation of B2 m-null pigs via injection of zygote with TALENs. Scientific Reports, 6, 38854.
    • (2016) Scientific Reports , vol.6 , pp. 38854
    • Wang, Y.1    Du, Y.2    Zhou, X.3    Wang, L.4    Li, J.5    Wang, F.6    Wei, H.7
  • 79
    • 84941206117 scopus 로고    scopus 로고
    • Generation of gene-modified goats targeting MSTN and FGF5 via zygote injection of CRISPR/Cas9 system
    • Wang, X., Yu, H., Lei, A., Zhou, J., Zeng, W., Zhu, H., … Chen, Y. (2015). Generation of gene-modified goats targeting MSTN and FGF5 via zygote injection of CRISPR/Cas9 system. Scientific Reports, 5, 13878.
    • (2015) Scientific Reports , vol.5 , pp. 13878
    • Wang, X.1    Yu, H.2    Lei, A.3    Zhou, J.4    Zeng, W.5    Zhu, H.6    Chen, Y.7
  • 81
    • 85020285841 scopus 로고    scopus 로고
    • Genome-editing technologies to improve research, reproduction, and production in pigs
    • Wells, K. D., & Prather, R. S. (2017). Genome-editing technologies to improve research, reproduction, and production in pigs. Molecular Reproduction and Development, doi: https://doi.org/10.1002/mrd.22812.
    • (2017) Molecular Reproduction and Development
    • Wells, K.D.1    Prather, R.S.2
  • 84
    • 84857097177 scopus 로고    scopus 로고
    • RNA-guided genetic silencing systems in bacteria and archaea
    • Wiedenheft, B., Sternberg, S. H., & Doudna, J. A. (2012). RNA-guided genetic silencing systems in bacteria and archaea. Nature, 482, 331–338.
    • (2012) Nature , vol.482 , pp. 331-338
    • Wiedenheft, B.1    Sternberg, S.H.2    Doudna, J.A.3
  • 87
    • 84879419797 scopus 로고    scopus 로고
    • Targeted editing of goat genome with modular-assembly zinc finger nucleases based on activity prediction by computational molecular modeling
    • Xiong, K., Li, S., Zhang, H., Cui, Y., Yu, D., Li, Y., … Chen, J. (2013). Targeted editing of goat genome with modular-assembly zinc finger nucleases based on activity prediction by computational molecular modeling. Molecular Biology Reports, 40, 4251–4256.
    • (2013) Molecular Biology Reports , vol.40 , pp. 4251-4256
    • Xiong, K.1    Li, S.2    Zhang, H.3    Cui, Y.4    Yu, D.5    Li, Y.6    Chen, J.7
  • 88
    • 84948447883 scopus 로고    scopus 로고
    • Genome-wide inactivation of porcine endogenous retroviruses (PERVs)
    • Yang, L., Guell, M., Niu, D., George, H., Lesha, E., Grishin, D., … Church, G. (2015). Genome-wide inactivation of porcine endogenous retroviruses (PERVs). Science, 350, 1101–1104.
    • (2015) Science , vol.350 , pp. 1101-1104
    • Yang, L.1    Guell, M.2    Niu, D.3    George, H.4    Lesha, E.5    Grishin, D.6    Church, G.7
  • 89
    • 33847275530 scopus 로고    scopus 로고
    • Nuclear reprogramming of cloned embryos and its implications for therapeutic cloning
    • Yang, X., Smith, S. L., Tian, X. C., Lewin, H. A., Renard, J. P., & Wakayama, T. (2007). Nuclear reprogramming of cloned embryos and its implications for therapeutic cloning. Nature Genetics, 39, 295–302.
    • (2007) Nature Genetics , vol.39 , pp. 295-302
    • Yang, X.1    Smith, S.L.2    Tian, X.C.3    Lewin, H.A.4    Renard, J.P.5    Wakayama, T.6
  • 90
    • 85027921901 scopus 로고    scopus 로고
    • Generation of PPARgamma mono-allelic knockout pigs via zinc-finger nucleases and nuclear transfer cloning
    • Yang, D., Yang, H., Li, W., Zhao, B., Ouyang, Z., Liu, Z., … Lai, L. (2011). Generation of PPARgamma mono-allelic knockout pigs via zinc-finger nucleases and nuclear transfer cloning. Cell Research, 21, 979–982.
    • (2011) Cell Research , vol.21 , pp. 979-982
    • Yang, D.1    Yang, H.2    Li, W.3    Zhao, B.4    Ouyang, Z.5    Liu, Z.6    Lai, L.7
  • 92
    • 80555150663 scopus 로고    scopus 로고
    • Highly efficient modification of beta-lactoglobulin (BLG) gene via zinc-finger nucleases in cattle
    • Yu, S., Luo, J., Song, Z., Ding, F., Dai, Y., & Li, N. (2011). Highly efficient modification of beta-lactoglobulin (BLG) gene via zinc-finger nucleases in cattle. Cell Research, 21, 1638–1640.
    • (2011) Cell Research , vol.21 , pp. 1638-1640
    • Yu, S.1    Luo, J.2    Song, Z.3    Ding, F.4    Dai, Y.5    Li, N.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.