Highly efficient RNA-guided base editing in mouse embryos

Nature Biotechnology

Volumn 35, Issue 5, 2017, Pages 435-437

  Kim, Kyoungmi ^a   Ryu, Seuk Min ^a,b   Kim, Sang Tae ^a   Baek, Gayoung ^a   Kim, Daesik ^b   Lim, Kayeong ^a,b   Chung, Eugene ^a,b   Kim, Sunghyun ^a,b   Kim, Jin Soo ^a,b  

^a Institute for Basic Science   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEIC ACIDS;

ALLELIC FREQUENCY; CYTIDINE DEAMINASE; ELECTROPORATION; EUKARYOTIC CELLS; MICRO-INJECTION; MOUSE EMBRYOS; POINT MUTATIONS; RIBONUCLEOPROTEINS;

MAMMALS;

APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 1; CAS9 NICKASE; DYSTROPHIN; ENZYME INHIBITOR; GUIDE RNA; MESSENGER RNA; MONOPHENOL MONOOXYGENASE; RECOMBINANT ENZYME; RIBONUCLEOPROTEIN; UNCLASSIFIED DRUG; URACIL GLYCOSYLASE INHIBITOR; CASPASE 9; CRISPR ASSOCIATED PROTEIN; CYTIDINE DEAMINASE; HYBRID PROTEIN; RNA;

ARTICLE; CONTROLLED STUDY; CRISPR CAS SYSTEM; ELECTROPORATION; EMBRYO; FEMALE; GENE EDITING; GENE FREQUENCY; GENE TARGETING; MICROINJECTION; MOUSE; MOUSE EMBRYO; NEWBORN; NONHUMAN; NONSENSE MUTATION; NUCLEIC ACID BASE SUBSTITUTION; POINT MUTATION; PRIORITY JOURNAL; ZYGOTE; ANIMAL; BASE PAIRING; C57BL MOUSE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; EMBRYOLOGY; GENETICS; INSTITUTE FOR CANCER RESEARCH MOUSE; MAMMALIAN EMBRYO; PHYSIOLOGY; PROCEDURES; SITE DIRECTED MUTAGENESIS;

ANIMALS; BASE PAIRING; CASPASE 9; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; CRISPR-ASSOCIATED PROTEINS; CYTIDINE DEAMINASE; EMBRYO, MAMMALIAN; GENE EDITING; MICE; MICE, INBRED C57BL; MICE, INBRED ICR; MUTAGENESIS, SITE-DIRECTED; POINT MUTATION; RECOMBINANT FUSION PROTEINS; RNA;

EID: 85018918215     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.3816     Document Type: Article

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