Creating class I MHC-null pigs using guide RNA and the Cas9 endonuclease

Journal of Immunology

Volumn 193, Issue 11, 2014, Pages 5751-5757

  Reyes, Luz M ^a   Estrada, Jose L ^a   Wang, Zheng Yu ^a   Blosser, Rachel J ^a   Smith, Rashod F ^a   Sidner, Richard A ^a   Paris, Leela L ^a   Blankenship, Ross L ^a   Ray, Caitlin N ^a   Miner, Aaron C ^a   Tector, Matthew ^b   Joseph Tector, A ^a,b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INDIANA UNIVERSITY HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDONUCLEASE; ENDONUCLEASE CAS9; GUIDE RNA; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; UNCLASSIFIED DRUG; HLA ANTIGEN CLASS 1;

ANIMAL CELL; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL SURFACE; CELLULAR IMMUNITY; CONTROLLED STUDY; EXPRESSION VECTOR; FETUS; FIBROBLAST; GENE AMPLIFICATION; GENE DISRUPTION; GENETIC ENGINEERING; GENETIC POLYMORPHISM; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; SEQUENCE ALIGNMENT; SWINE; XENOTRANSPLANTATION; ANIMAL; ANIMAL MODEL; CELL CULTURE; CELL NUCLEUS TRANSPLANTATION; GENE SILENCING; GENETICS; GRAFT REJECTION; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; PROCEDURES; T LYMPHOCYTE; VIRUS INFECTION; XENOGRAFT;

ANIMALS; CELLS, CULTURED; ENDONUCLEASES; FIBROBLASTS; GENE KNOCKDOWN TECHNIQUES; GENETIC ENGINEERING; GRAFT REJECTION; HISTOCOMPATIBILITY ANTIGENS CLASS I; MODELS, ANIMAL; NUCLEAR TRANSFER TECHNIQUES; RNA, GUIDE; SWINE; T-LYMPHOCYTES; TRANSPLANTATION, HETEROLOGOUS; VIRUS DISEASES;

EID: 84912569481     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1402059     Document Type: Article

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