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Volumn 75, Issue 2, 2018, Pages 225-240

Mechanisms regulating immune surveillance of cellular stress in cancer

Author keywords

Cancer immune surveillance; Cancer immunity; Cancer inflammation; Cancer associated stress; Chromosome instability (CIN); Danger associated molecular patterns (DAMPs); DNA damage response (DDR); ER stress; Hyperploidy; Immunogenic cell death; Mitochondrial stress; Oncometabolites; Senescence associated secretory phenotype (SASP); Tumor microenvironment; Unfolded protein response

Indexed keywords

ANIMAL; BIOLOGICAL MODEL; DNA DAMAGE; ENDOPLASMIC RETICULUM STRESS; GENETICS; HUMAN; IMMUNOLOGY; IMMUNOSURVEILLANCE; METABOLISM; MITOSIS; NEOPLASM; OXIDATIVE STRESS; SIGNAL TRANSDUCTION;

EID: 85025805336     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-017-2597-7     Document Type: Review
Times cited : (23)

References (203)
  • 2
    • 84943663898 scopus 로고    scopus 로고
    • Diverse roles of STING-dependent signaling on the development of cancer
    • COI: 1:CAS:528:DC%2BC2MXitlSgsb8%3D, PID: 25639870
    • Ahn J, Konno H, Barber GN (2015) Diverse roles of STING-dependent signaling on the development of cancer. Oncogene 34:5302–5308
    • (2015) Oncogene , vol.34 , pp. 5302-5308
    • Ahn, J.1    Konno, H.2    Barber, G.N.3
  • 7
    • 0000730374 scopus 로고
    • Cytoplasmic components in hepatic cell lysosomes
    • COI: 1:STN:280:DyaF38%2FgsVSqsQ%3D%3D, PID: 13862833
    • Ashford TP, Porter KR (1962) Cytoplasmic components in hepatic cell lysosomes. J Cell Biol 12:198–202
    • (1962) J Cell Biol , vol.12 , pp. 198-202
    • Ashford, T.P.1    Porter, K.R.2
  • 8
    • 84921409248 scopus 로고    scopus 로고
    • Lactate dehydrogenase 5: an old friend and a new hope in the war on cancer
    • COI: 1:CAS:528:DC%2BC2MXislKjtQ%3D%3D, PID: 25528630
    • Augoff K, Hryniewicz-Jankowska A, Tabola R (2015) Lactate dehydrogenase 5: an old friend and a new hope in the war on cancer. Cancer Lett 358:1–7
    • (2015) Cancer Lett , vol.358 , pp. 1-7
    • Augoff, K.1    Hryniewicz-Jankowska, A.2    Tabola, R.3
  • 9
  • 10
    • 84893872087 scopus 로고    scopus 로고
    • A mechanism of hypoxia-mediated escape from adaptive immunity in cancer cells
    • COI: 1:CAS:528:DC%2BC2cXhvVSmsr4%3D, PID: 24336068
    • Barsoum IB, Smallwood CA, Siemens DR, Graham CH (2014) A mechanism of hypoxia-mediated escape from adaptive immunity in cancer cells. Cancer Res 74:665–674
    • (2014) Cancer Res , vol.74 , pp. 665-674
    • Barsoum, I.B.1    Smallwood, C.A.2    Siemens, D.R.3    Graham, C.H.4
  • 11
    • 0035070198 scopus 로고    scopus 로고
    • CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin
    • COI: 1:CAS:528:DC%2BD3MXis1ehurc%3D, PID: 11290339
    • Basu S, Binder RJ, Ramalingam T, Srivastava PK (2001) CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin. Immunity 14:303–313
    • (2001) Immunity , vol.14 , pp. 303-313
    • Basu, S.1    Binder, R.J.2    Ramalingam, T.3    Srivastava, P.K.4
  • 13
    • 0033532619 scopus 로고    scopus 로고
    • Thioredoxin, a redox enzyme released in infection and inflammation, is a unique chemoattractant for neutrophils, monocytes, and T cells
    • COI: 1:CAS:528:DyaK1MXjvVSnu7w%3D, PID: 10359582
    • Bertini R, Howard OM, Dong HF, Oppenheim JJ, Bizzarri C, Sergi R, Caselli G, Pagliei S, Romines B, Wilshire JA et al (1999) Thioredoxin, a redox enzyme released in infection and inflammation, is a unique chemoattractant for neutrophils, monocytes, and T cells. J Exp Med 189:1783–1789
    • (1999) J Exp Med , vol.189 , pp. 1783-1789
    • Bertini, R.1    Howard, O.M.2    Dong, H.F.3    Oppenheim, J.J.4    Bizzarri, C.5    Sergi, R.6    Caselli, G.7    Pagliei, S.8    Romines, B.9    Wilshire, J.A.10
  • 14
    • 33846423166 scopus 로고    scopus 로고
    • Tumor-induced oxidative stress perturbs nuclear factor-kappaB activity-augmenting tumor necrosis factor-alpha-mediated T-cell death: protection by curcumin
    • COI: 1:CAS:528:DC%2BD2sXisFSqsQ%3D%3D, PID: 17210719
    • Bhattacharyya S, Mandal D, Sen GS, Pal S, Banerjee S, Lahiry L, Finke JH, Tannenbaum CS, Das T, Sa G (2007) Tumor-induced oxidative stress perturbs nuclear factor-kappaB activity-augmenting tumor necrosis factor-alpha-mediated T-cell death: protection by curcumin. Cancer Res 67:362–370
    • (2007) Cancer Res , vol.67 , pp. 362-370
    • Bhattacharyya, S.1    Mandal, D.2    Sen, G.S.3    Pal, S.4    Banerjee, S.5    Lahiry, L.6    Finke, J.H.7    Tannenbaum, C.S.8    Das, T.9    Sa, G.10
  • 16
    • 79959481888 scopus 로고    scopus 로고
    • Protein folding and modification in the mammalian endoplasmic reticulum
    • COI: 1:CAS:528:DC%2BC3MXptVCns78%3D, PID: 21495850
    • Braakman I, Bulleid NJ (2011) Protein folding and modification in the mammalian endoplasmic reticulum. Annu Rev Biochem 80:71–99
    • (2011) Annu Rev Biochem , vol.80 , pp. 71-99
    • Braakman, I.1    Bulleid, N.J.2
  • 17
    • 0038519365 scopus 로고    scopus 로고
    • l-Arginine metabolism in myeloid cells controls T-lymphocyte functions
    • COI: 1:CAS:528:DC%2BD3sXks1amsrc%3D, PID: 12810105
    • Bronte V, Serafini P, Mazzoni A, Segal DM, Zanovello P (2003) l-Arginine metabolism in myeloid cells controls T-lymphocyte functions. Trends Immunol 24:302–306
    • (2003) Trends Immunol , vol.24 , pp. 302-306
    • Bronte, V.1    Serafini, P.2    Mazzoni, A.3    Segal, D.M.4    Zanovello, P.5
  • 18
    • 81455154853 scopus 로고    scopus 로고
    • The DNA damage response induces IFN
    • COI: 1:CAS:528:DC%2BC3MXhsVSitbzK, PID: 22013119
    • Brzostek-Racine S, Gordon C, Van Scoy S, Reich NC (2011) The DNA damage response induces IFN. J Immunol 187:5336–5345
    • (2011) J Immunol , vol.187 , pp. 5336-5345
    • Brzostek-Racine, S.1    Gordon, C.2    Van Scoy, S.3    Reich, N.C.4
  • 19
    • 79251517382 scopus 로고    scopus 로고
    • Regulation of cancer cell metabolism
    • COI: 1:CAS:528:DC%2BC3MXps1ahuw%3D%3D, PID: 21258394
    • Cairns RA, Harris IS, Mak TW (2011) Regulation of cancer cell metabolism. Nat Rev Cancer 11:85–95
    • (2011) Nat Rev Cancer , vol.11 , pp. 85-95
    • Cairns, R.A.1    Harris, I.S.2    Mak, T.W.3
  • 21
    • 84987776130 scopus 로고    scopus 로고
    • The DNA damage response: a common pathway in the regulation of NKG2D and DNAM-1 ligand expression in normal, infected, and cancer cells
    • PID: 24432022
    • Cerboni C, Fionda C, Soriani A, Zingoni A, Doria M, Cippitelli M, Santoni A (2014) The DNA damage response: a common pathway in the regulation of NKG2D and DNAM-1 ligand expression in normal, infected, and cancer cells. Front Immunol 4:508
    • (2014) Front Immunol , vol.4 , pp. 508
    • Cerboni, C.1    Fionda, C.2    Soriani, A.3    Zingoni, A.4    Doria, M.5    Cippitelli, M.6    Santoni, A.7
  • 22
    • 84890042092 scopus 로고    scopus 로고
    • Molecular mechanisms of natural killer cell activation in response to cellular stress
    • COI: 1:CAS:528:DC%2BC3sXhvFCqtr7M, PID: 23579243
    • Chan CJ, Smyth MJ, Martinet L (2014) Molecular mechanisms of natural killer cell activation in response to cellular stress. Cell Death Differ 21:5–14
    • (2014) Cell Death Differ , vol.21 , pp. 5-14
    • Chan, C.J.1    Smyth, M.J.2    Martinet, L.3
  • 24
    • 0022978272 scopus 로고
    • Effect of antioxidants on primary alloantigen-induced T cell activation and proliferation
    • COI: 1:CAS:528:DyaL2sXjs1yj, PID: 2944959
    • Chaudhri G, Clark IA, Hunt NH, Cowden WB, Ceredig R (1986) Effect of antioxidants on primary alloantigen-induced T cell activation and proliferation. J Immunol 137:2646–2652
    • (1986) J Immunol , vol.137 , pp. 2646-2652
    • Chaudhri, G.1    Clark, I.A.2    Hunt, N.H.3    Cowden, W.B.4    Ceredig, R.5
  • 25
    • 0023740171 scopus 로고
    • Antioxidants inhibit proliferation and cell surface expression of receptors for interleukin-2 and transferrin in T lymphocytes stimulated with phorbol myristate acetate and ionomycin
    • COI: 1:CAS:528:DyaL1cXkslWrt7c%3D, PID: 3135944
    • Chaudhri G, Hunt NH, Clark IA, Ceredig R (1988) Antioxidants inhibit proliferation and cell surface expression of receptors for interleukin-2 and transferrin in T lymphocytes stimulated with phorbol myristate acetate and ionomycin. Cell Immunol 115:204–213
    • (1988) Cell Immunol , vol.115 , pp. 204-213
    • Chaudhri, G.1    Hunt, N.H.2    Clark, I.A.3    Ceredig, R.4
  • 26
    • 51049094007 scopus 로고    scopus 로고
    • Oxidation of ovarian epithelial cancer cells by hypochlorous acid enhances immunogenicity and stimulates T cells that recognize autologous primary tumor
    • COI: 1:CAS:528:DC%2BD1cXpt1eisr4%3D, PID: 18676764
    • Chiang CL, Ledermann JA, Aitkens E, Benjamin E, Katz DR, Chain BM (2008) Oxidation of ovarian epithelial cancer cells by hypochlorous acid enhances immunogenicity and stimulates T cells that recognize autologous primary tumor. Clin Cancer Res 14:4898–4907
    • (2008) Clin Cancer Res , vol.14 , pp. 4898-4907
    • Chiang, C.L.1    Ledermann, J.A.2    Aitkens, E.3    Benjamin, E.4    Katz, D.R.5    Chain, B.M.6
  • 27
    • 77950787070 scopus 로고    scopus 로고
    • Toll-like receptor 3-mediated suppression of TRAMP prostate cancer shows the critical role of type I interferons in tumor immune surveillance
    • COI: 1:CAS:528:DC%2BC3cXktFynsLk%3D, PID: 20233880
    • Chin AI, Miyahira AK, Covarrubias A, Teague J, Guo B, Dempsey PW, Cheng G (2010) Toll-like receptor 3-mediated suppression of TRAMP prostate cancer shows the critical role of type I interferons in tumor immune surveillance. Cancer Res 70:2595–2603
    • (2010) Cancer Res , vol.70 , pp. 2595-2603
    • Chin, A.I.1    Miyahira, A.K.2    Covarrubias, A.3    Teague, J.4    Guo, B.5    Dempsey, P.W.6    Cheng, G.7
  • 29
    • 77949881221 scopus 로고    scopus 로고
    • The senescence-associated secretory phenotype: the dark side of tumor suppression
    • COI: 1:CAS:528:DC%2BC3cXivFekt70%3D, PID: 20078217
    • Coppe JP, Desprez PY, Krtolica A, Campisi J (2010) The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol 5:99–118
    • (2010) Annu Rev Pathol , vol.5 , pp. 99-118
    • Coppe, J.P.1    Desprez, P.Y.2    Krtolica, A.3    Campisi, J.4
  • 30
    • 84891713034 scopus 로고    scopus 로고
    • Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
    • COI: 1:CAS:528:DC%2BD1MXlsFGhsQ%3D%3D, PID: 19053174
    • Coppe JP, Patil CK, Rodier F, Sun Y, Munoz DP, Goldstein J, Nelson PS, Desprez PY, Campisi J (2008) Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol 6:2853–2868
    • (2008) PLoS Biol , vol.6 , pp. 2853-2868
    • Coppe, J.P.1    Patil, C.K.2    Rodier, F.3    Sun, Y.4    Munoz, D.P.5    Goldstein, J.6    Nelson, P.S.7    Desprez, P.Y.8    Campisi, J.9
  • 31
    • 84979944251 scopus 로고    scopus 로고
    • Changing perspective on oncometabolites: from metabolic signature of cancer to tumorigenic and immunosuppressive agents
    • PID: 27083002
    • Corrado M, Scorrano L, Campello S (2016) Changing perspective on oncometabolites: from metabolic signature of cancer to tumorigenic and immunosuppressive agents. Oncotarget 7:46692–46706
    • (2016) Oncotarget , vol.7 , pp. 46692-46706
    • Corrado, M.1    Scorrano, L.2    Campello, S.3
  • 32
    • 42949129074 scopus 로고    scopus 로고
    • Many roads lead to oncogene-induced senescence
    • COI: 1:CAS:528:DC%2BD1cXltlSgs7w%3D, PID: 18193093
    • Courtois-Cox S, Jones SL, Cichowski K (2008) Many roads lead to oncogene-induced senescence. Oncogene 27:2801–2809
    • (2008) Oncogene , vol.27 , pp. 2801-2809
    • Courtois-Cox, S.1    Jones, S.L.2    Cichowski, K.3
  • 33
    • 84890814629 scopus 로고    scopus 로고
    • Breakthrough of the year 2013. Cancer immunotherapy
    • COI: 1:CAS:528:DC%2BC2cXotF2qsg%3D%3D, PID: 24357284
    • Couzin-Frankel J (2013) Breakthrough of the year 2013. Cancer immunotherapy. Science 342:1432–1433
    • (2013) Science , vol.342 , pp. 1432-1433
    • Couzin-Frankel, J.1
  • 35
    • 85012100204 scopus 로고    scopus 로고
    • Tumorigenic and immunosuppressive effects of endoplasmic reticulum stress in cancer
    • COI: 1:CAS:528:DC%2BC2sXis1ygtL4%3D, PID: 28187289
    • Cubillos-Ruiz JR, Bettigole SE, Glimcher LH (2017) Tumorigenic and immunosuppressive effects of endoplasmic reticulum stress in cancer. Cell 168:692–706
    • (2017) Cell , vol.168 , pp. 692-706
    • Cubillos-Ruiz, J.R.1    Bettigole, S.E.2    Glimcher, L.H.3
  • 36
    • 84922450037 scopus 로고    scopus 로고
    • Breast tumor cells primed by endoplasmic reticulum stress remodel macrophage phenotype
    • COI: 1:CAS:528:DC%2BC3sXntFars7Y%3D, PID: 23593541
    • Cullen SJ, Fatemie S, Ladiges W (2013) Breast tumor cells primed by endoplasmic reticulum stress remodel macrophage phenotype. Am J Cancer Res 3:196–210
    • (2013) Am J Cancer Res , vol.3 , pp. 196-210
    • Cullen, S.J.1    Fatemie, S.2    Ladiges, W.3
  • 38
    • 84866278132 scopus 로고    scopus 로고
    • Physiological concentrations of interleukin-6 directly promote insulin secretion, signal transduction, nitric oxide release, and redox status in a clonal pancreatic beta-cell line and mouse islets
    • PID: 22761278
    • da Silva Krause M, Bittencourt A, de Bittencourt PIH, Jr McClenaghan NH, Flatt PR, Murphy C, Newsholme P (2012) Physiological concentrations of interleukin-6 directly promote insulin secretion, signal transduction, nitric oxide release, and redox status in a clonal pancreatic beta-cell line and mouse islets. J Endocrinol 214:301–311
    • (2012) J Endocrinol , vol.214 , pp. 301-311
    • da Silva Krause, M.1    Bittencourt, A.2    de Bittencourt, P.I.H.3    McClenaghan, M.C.4    Flatt, P.R.5    Murphy, C.6    Newsholme, P.7
  • 40
    • 8644282751 scopus 로고    scopus 로고
    • Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2
    • COI: 1:CAS:528:DC%2BD2cXhtVart7zJ, PID: 15542827
    • Deng J, Lu PD, Zhang Y, Scheuner D, Kaufman RJ, Sonenberg N, Harding HP, Ron D (2004) Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2. Mol Cell Biol 24:10161–10168
    • (2004) Mol Cell Biol , vol.24 , pp. 10161-10168
    • Deng, J.1    Lu, P.D.2    Zhang, Y.3    Scheuner, D.4    Kaufman, R.J.5    Sonenberg, N.6    Harding, H.P.7    Ron, D.8
  • 41
    • 84912128872 scopus 로고    scopus 로고
    • STING-dependent cytosolic DNA sensing promotes radiation-induced type I interferon-dependent antitumor immunity in immunogenic tumors
    • COI: 1:CAS:528:DC%2BC2cXhvFOitrbM, PID: 25517616
    • Deng L, Liang H, Xu M, Yang X, Burnette B, Arina A, Li XD, Mauceri H, Beckett M, Darga T et al (2014) STING-dependent cytosolic DNA sensing promotes radiation-induced type I interferon-dependent antitumor immunity in immunogenic tumors. Immunity 41:843–852
    • (2014) Immunity , vol.41 , pp. 843-852
    • Deng, L.1    Liang, H.2    Xu, M.3    Yang, X.4    Burnette, B.5    Arina, A.6    Li, X.D.7    Mauceri, H.8    Beckett, M.9    Darga, T.10
  • 42
    • 0037033433 scopus 로고    scopus 로고
    • Discrete generation of superoxide and hydrogen peroxide by T cell receptor stimulation: selective regulation of mitogen-activated protein kinase activation and fas ligand expression
    • COI: 1:CAS:528:DC%2BD38XjslOjsA%3D%3D, PID: 11781366
    • Devadas S, Zaritskaya L, Rhee SG, Oberley L, Williams MS (2002) Discrete generation of superoxide and hydrogen peroxide by T cell receptor stimulation: selective regulation of mitogen-activated protein kinase activation and fas ligand expression. J Exp Med 195:59–70
    • (2002) J Exp Med , vol.195 , pp. 59-70
    • Devadas, S.1    Zaritskaya, L.2    Rhee, S.G.3    Oberley, L.4    Williams, M.S.5
  • 43
    • 0030775488 scopus 로고    scopus 로고
    • Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma
    • COI: 1:CAS:528:DyaK2sXlt1Squr0%3D, PID: 9242382
    • DeYoung KL, Ray ME, Su YA, Anzick SL, Johnstone RW, Trapani JA, Meltzer PS, Trent JM (1997) Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma. Oncogene 15:453–457
    • (1997) Oncogene , vol.15 , pp. 453-457
    • DeYoung, K.L.1    Ray, M.E.2    Su, Y.A.3    Anzick, S.L.4    Johnstone, R.W.5    Trapani, J.A.6    Meltzer, P.S.7    Trent, J.M.8
  • 45
    • 84909945799 scopus 로고    scopus 로고
    • Lack of Absent in Melanoma 2 (AIM2) expression in tumor cells is closely associated with poor survival in colorectal cancer patients
    • COI: 1:CAS:528:DC%2BC2cXmvV2ktbw%3D, PID: 24729378
    • Dihlmann S, Tao S, Echterdiek F, Herpel E, Jansen L, Chang-Claude J, Brenner H, Hoffmeister M, Kloor M (2014) Lack of Absent in Melanoma 2 (AIM2) expression in tumor cells is closely associated with poor survival in colorectal cancer patients. Int J Cancer 135:2387–2396
    • (2014) Int J Cancer , vol.135 , pp. 2387-2396
    • Dihlmann, S.1    Tao, S.2    Echterdiek, F.3    Herpel, E.4    Jansen, L.5    Chang-Claude, J.6    Brenner, H.7    Hoffmeister, M.8    Kloor, M.9
  • 46
    • 84940794527 scopus 로고    scopus 로고
    • Mitotic stress is an integral part of the oncogene-induced senescence program that promotes multinucleation and cell cycle arrest
    • COI: 1:CAS:528:DC%2BC2MXhtlOmtbnM, PID: 26299965
    • Dikovskaya D, Cole JJ, Mason SM, Nixon C, Karim SA, McGarry L, Clark W, Hewitt RN, Sammons MA, Zhu J et al (2015) Mitotic stress is an integral part of the oncogene-induced senescence program that promotes multinucleation and cell cycle arrest. Cell Rep 12:1483–1496
    • (2015) Cell Rep , vol.12 , pp. 1483-1496
    • Dikovskaya, D.1    Cole, J.J.2    Mason, S.M.3    Nixon, C.4    Karim, S.A.5    McGarry, L.6    Clark, W.7    Hewitt, R.N.8    Sammons, M.A.9    Zhu, J.10
  • 47
    • 85027949213 scopus 로고    scopus 로고
    • RIG-I-like helicases induce immunogenic cell death of pancreatic cancer cells and sensitize tumors toward killing by CD8(+) T cells
    • COI: 1:CAS:528:DC%2BC2cXhtFCktL7N, PID: 25012502
    • Duewell P, Steger A, Lohr H, Bourhis H, Hoelz H, Kirchleitner SV, Stieg MR, Grassmann S, Kobold S, Siveke JT et al (2014) RIG-I-like helicases induce immunogenic cell death of pancreatic cancer cells and sensitize tumors toward killing by CD8(+) T cells. Cell Death Differ 21:1825–1837
    • (2014) Cell Death Differ , vol.21 , pp. 1825-1837
    • Duewell, P.1    Steger, A.2    Lohr, H.3    Bourhis, H.4    Hoelz, H.5    Kirchleitner, S.V.6    Stieg, M.R.7    Grassmann, S.8    Kobold, S.9    Siveke, J.T.10
  • 48
    • 84885158978 scopus 로고    scopus 로고
    • The cancer biology of whole-chromosome instability
    • COI: 1:CAS:528:DC%2BC3sXntFagtw%3D%3D, PID: 23318433
    • Duijf PH, Benezra R (2013) The cancer biology of whole-chromosome instability. Oncogene 32:4727–4736
    • (2013) Oncogene , vol.32 , pp. 4727-4736
    • Duijf, P.H.1    Benezra, R.2
  • 49
    • 0021263604 scopus 로고
    • Involvement of hydroxyl free radical, but not superoxide, in the cytolytic pathway of natural killer cells. Revision of an earlier hypothesis
    • COI: 1:CAS:528:DyaL2cXlsV2gtbk%3D, PID: 6088913
    • Duwe AK, Roder JC (1984) Involvement of hydroxyl free radical, but not superoxide, in the cytolytic pathway of natural killer cells. Revision of an earlier hypothesis. Med Biol 62:95–100
    • (1984) Med Biol , vol.62 , pp. 95-100
    • Duwe, A.K.1    Roder, J.C.2
  • 50
    • 0021925790 scopus 로고
    • Natural killer cell-mediated lysis involves an hydroxyl radical-dependent step
    • COI: 1:CAS:528:DyaL2MXhs1Gisbs%3D, PID: 2982948
    • Duwe AK, Werkmeister J, Roder JC, Lauzon R, Payne U (1985) Natural killer cell-mediated lysis involves an hydroxyl radical-dependent step. J Immunol 134:2637–2644
    • (1985) J Immunol , vol.134 , pp. 2637-2644
    • Duwe, A.K.1    Werkmeister, J.2    Roder, J.C.3    Lauzon, R.4    Payne, U.5
  • 51
    • 79251539881 scopus 로고    scopus 로고
    • Ncf1 (p47phox) is essential for direct regulatory T cell mediated suppression of CD4+ effector T cells
    • COI: 1:CAS:528:DC%2BC3MXosVymtw%3D%3D, PID: 21253614
    • Efimova O, Szankasi P, Kelley TW (2011) Ncf1 (p47phox) is essential for direct regulatory T cell mediated suppression of CD4+ effector T cells. PLoS One 6:e16013
    • (2011) PLoS One , vol.6
    • Efimova, O.1    Szankasi, P.2    Kelley, T.W.3
  • 52
    • 84875464528 scopus 로고    scopus 로고
    • Therapeutic efficacy of bifunctional siRNA combining TGF-beta1 silencing with RIG-I activation in pancreatic cancer
    • COI: 1:CAS:528:DC%2BC3sXktVGju7o%3D, PID: 23338611
    • Ellermeier J, Wei J, Duewell P, Hoves S, Stieg MR, Adunka T, Noerenberg D, Anders HJ, Mayr D, Poeck H et al (2013) Therapeutic efficacy of bifunctional siRNA combining TGF-beta1 silencing with RIG-I activation in pancreatic cancer. Cancer Res 73:1709–1720
    • (2013) Cancer Res , vol.73 , pp. 1709-1720
    • Ellermeier, J.1    Wei, J.2    Duewell, P.3    Hoves, S.4    Stieg, M.R.5    Adunka, T.6    Noerenberg, D.7    Anders, H.J.8    Mayr, D.9    Poeck, H.10
  • 55
    • 0023258794 scopus 로고
    • Modulation of intracellular glutathione concentrations alters lymphocyte activation and proliferation
    • COI: 1:CAS:528:DyaL2sXltFCisb8%3D, PID: 3595735
    • Fidelus RK, Ginouves P, Lawrence D, Tsan MF (1987) Modulation of intracellular glutathione concentrations alters lymphocyte activation and proliferation. Exp Cell Res 170:269–275
    • (1987) Exp Cell Res , vol.170 , pp. 269-275
    • Fidelus, R.K.1    Ginouves, P.2    Lawrence, D.3    Tsan, M.F.4
  • 57
    • 84862059630 scopus 로고    scopus 로고
    • Polyinosinic-polycytidylic acid limits tumor outgrowth in a mouse model of metastatic lung cancer
    • COI: 1:CAS:528:DC%2BC38Xnt1ais7s%3D, PID: 22516955
    • Forte G, Rega A, Morello S, Luciano A, Arra C, Pinto A, Sorrentino R (2012) Polyinosinic-polycytidylic acid limits tumor outgrowth in a mouse model of metastatic lung cancer. J Immunol 188:5357–5364
    • (2012) J Immunol , vol.188 , pp. 5357-5364
    • Forte, G.1    Rega, A.2    Morello, S.3    Luciano, A.4    Arra, C.5    Pinto, A.6    Sorrentino, R.7
  • 58
    • 10244279184 scopus 로고    scopus 로고
    • Mechanisms and functional significance of tumour-induced dendritic-cell defects
    • COI: 1:CAS:528:DC%2BD2cXhtVarsb7P, PID: 15573129
    • Gabrilovich D (2004) Mechanisms and functional significance of tumour-induced dendritic-cell defects. Nat Rev Immunol 4:941–952
    • (2004) Nat Rev Immunol , vol.4 , pp. 941-952
    • Gabrilovich, D.1
  • 59
    • 61349100687 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells as regulators of the immune system
    • COI: 1:CAS:528:DC%2BD1MXhsFeqsbw%3D, PID: 19197294
    • Gabrilovich DI, Nagaraj S (2009) Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol 9:162–174
    • (2009) Nat Rev Immunol , vol.9 , pp. 162-174
    • Gabrilovich, D.I.1    Nagaraj, S.2
  • 62
    • 24144443517 scopus 로고    scopus 로고
    • The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor
    • COI: 1:CAS:528:DC%2BD2MXovVOgtr4%3D, PID: 15995699
    • Gasser S, Orsulic S, Brown EJ, Raulet DH (2005) The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor. Nature 436:1186–1190
    • (2005) Nature , vol.436 , pp. 1186-1190
    • Gasser, S.1    Orsulic, S.2    Brown, E.J.3    Raulet, D.H.4
  • 63
    • 33646239388 scopus 로고    scopus 로고
    • The DNA damage response arouses the immune system
    • COI: 1:CAS:528:DC%2BD28XjsFSlsLg%3D
    • Gasser S, Raulet DH (2006) The DNA damage response arouses the immune system. Can Res 66:3959–3962
    • (2006) Can Res , vol.66 , pp. 3959-3962
    • Gasser, S.1    Raulet, D.H.2
  • 64
    • 70350569295 scopus 로고    scopus 로고
    • Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors
    • COI: 1:CAS:528:DC%2BD1MXhtFGjt7rK, PID: 19767732
    • Ghiringhelli F, Apetoh L, Tesniere A, Aymeric L, Ma Y, Ortiz C, Vermaelen K, Panaretakis T, Mignot G, Ullrich E et al (2009) Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors. Nat Med 15:1170–1178
    • (2009) Nat Med , vol.15 , pp. 1170-1178
    • Ghiringhelli, F.1    Apetoh, L.2    Tesniere, A.3    Aymeric, L.4    Ma, Y.5    Ortiz, C.6    Vermaelen, K.7    Panaretakis, T.8    Mignot, G.9    Ullrich, E.10
  • 65
    • 0035213138 scopus 로고    scopus 로고
    • The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathway
    • COI: 1:CAS:528:DC%2BD38XhslShsw%3D%3D, PID: 11605159
    • Gimenez-Roqueplo AP, Favier J, Rustin P, Mourad JJ, Plouin PF, Corvol P, Rotig A, Jeunemaitre X (2001) The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathway. Am J Hum Genet 69:1186–1197
    • (2001) Am J Hum Genet , vol.69 , pp. 1186-1197
    • Gimenez-Roqueplo, A.P.1    Favier, J.2    Rustin, P.3    Mourad, J.J.4    Plouin, P.F.5    Corvol, P.6    Rotig, A.7    Jeunemaitre, X.8
  • 66
    • 62349138124 scopus 로고    scopus 로고
    • The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment
    • COI: 1:CAS:528:DC%2BD1MXivFSiuro%3D, PID: 19136477
    • Greenhough A, Smartt HJ, Moore AE, Roberts HR, Williams AC, Paraskeva C, Kaidi A (2009) The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment. Carcinogenesis 30:377–386
    • (2009) Carcinogenesis , vol.30 , pp. 377-386
    • Greenhough, A.1    Smartt, H.J.2    Moore, A.E.3    Roberts, H.R.4    Williams, A.C.5    Paraskeva, C.6    Kaidi, A.7
  • 67
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • COI: 1:CAS:528:DC%2BD3cXks1CktA%3D%3D, PID: 10647931
    • Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100:57–70
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 68
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • COI: 1:CAS:528:DC%2BC3MXjsFeqtrk%3D, PID: 21376230
    • Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646–674
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 69
    • 0030039450 scopus 로고    scopus 로고
    • Induction of apoptosis in NK cells by monocyte-derived reactive oxygen metabolites
    • COI: 1:CAS:528:DyaK28XlsVGl, PID: 8598491
    • Hansson M, Asea A, Ersson U, Hermodsson S, Hellstrand K (1996) Induction of apoptosis in NK cells by monocyte-derived reactive oxygen metabolites. J Immunol 156:42–47
    • (1996) J Immunol , vol.156 , pp. 42-47
    • Hansson, M.1    Asea, A.2    Ersson, U.3    Hermodsson, S.4    Hellstrand, K.5
  • 70
  • 71
    • 2442649129 scopus 로고    scopus 로고
    • Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors
    • COI: 1:CAS:528:DC%2BD2cXjvVKgsLs%3D, PID: 15141213
    • He W, Miao FJ, Lin DC, Schwandner RT, Wang Z, Gao J, Chen JL, Tian H, Ling L (2004) Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors. Nature 429:188–193
    • (2004) Nature , vol.429 , pp. 188-193
    • He, W.1    Miao, F.J.2    Lin, D.C.3    Schwandner, R.T.4    Wang, Z.5    Gao, J.6    Chen, J.L.7    Tian, H.8    Ling, L.9
  • 72
    • 0028113354 scopus 로고
    • Histaminergic regulation of NK cells. Role of monocyte-derived reactive oxygen metabolites
    • COI: 1:CAS:528:DyaK2MXit1Gjsrg%3D, PID: 7963557
    • Hellstrand K, Asea A, Dahlgren C, Hermodsson S (1994) Histaminergic regulation of NK cells. Role of monocyte-derived reactive oxygen metabolites. J Immunol 153:4940–4947
    • (1994) J Immunol , vol.153 , pp. 4940-4947
    • Hellstrand, K.1    Asea, A.2    Dahlgren, C.3    Hermodsson, S.4
  • 73
    • 84994507182 scopus 로고    scopus 로고
    • The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury
    • COI: 1:CAS:528:DC%2BC28XhvVSnsLvI, PID: 27846608
    • Hu B, Jin C, Li HB, Tong J, Ouyang X, Cetinbas NM, Zhu S, Strowig T, Lam FC, Zhao C et al (2016) The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury. Science 354:765–768
    • (2016) Science , vol.354 , pp. 765-768
    • Hu, B.1    Jin, C.2    Li, H.B.3    Tong, J.4    Ouyang, X.5    Cetinbas, N.M.6    Zhu, S.7    Strowig, T.8    Lam, F.C.9    Zhao, C.10
  • 74
    • 78650643194 scopus 로고    scopus 로고
    • Macroautophagy regulates energy metabolism during effector T cell activation
    • COI: 1:CAS:528:DC%2BC3cXhsFSltLjI, PID: 21059894
    • Hubbard VM, Valdor R, Patel B, Singh R, Cuervo AM, Macian F (2010) Macroautophagy regulates energy metabolism during effector T cell activation. J Immunol 185:7349–7357
    • (2010) J Immunol , vol.185 , pp. 7349-7357
    • Hubbard, V.M.1    Valdor, R.2    Patel, B.3    Singh, R.4    Cuervo, A.M.5    Macian, F.6
  • 75
    • 84880648196 scopus 로고    scopus 로고
    • Tumor-derived lactate modifies antitumor immune response: effect on myeloid-derived suppressor cells and NK cells
    • COI: 1:CAS:528:DC%2BC3sXhtFequ7rF, PID: 23817426
    • Husain Z, Huang Y, Seth P, Sukhatme VP (2013) Tumor-derived lactate modifies antitumor immune response: effect on myeloid-derived suppressor cells and NK cells. J Immunol 191:1486–1495
    • (2013) J Immunol , vol.191 , pp. 1486-1495
    • Husain, Z.1    Huang, Y.2    Seth, P.3    Sukhatme, V.P.4
  • 76
    • 84885458655 scopus 로고    scopus 로고
    • p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells
    • COI: 1:CAS:528:DC%2BC3sXhsFelsLnF, PID: 24043758
    • Iannello A, Thompson TW, Ardolino M, Lowe SW, Raulet DH (2013) p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells. J Exp Med 210:2057–2069
    • (2013) J Exp Med , vol.210 , pp. 2057-2069
    • Iannello, A.1    Thompson, T.W.2    Ardolino, M.3    Lowe, S.W.4    Raulet, D.H.5
  • 77
    • 0000520727 scopus 로고
    • Virus interference. I. The interferon
    • COI: 1:STN:280:DyaG1c%2FgvVekuw%3D%3D, PID: 13465720
    • Isaacs A, Lindenmann J (1957) Virus interference. I. The interferon. Proc R Soc Lond B Biol Sci 147:258–267
    • (1957) Proc R Soc Lond B Biol Sci , vol.147 , pp. 258-267
    • Isaacs, A.1    Lindenmann, J.2
  • 78
    • 53349178089 scopus 로고    scopus 로고
    • STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
    • COI: 1:CAS:528:DC%2BD1cXhtF2hsbzL, PID: 18724357
    • Ishikawa H, Barber GN (2008) STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature 455:674–678
    • (2008) Nature , vol.455 , pp. 674-678
    • Ishikawa, H.1    Barber, G.N.2
  • 79
    • 70349943834 scopus 로고    scopus 로고
    • STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
    • COI: 1:CAS:528:DC%2BD1MXhtFGqtbvI, PID: 19776740
    • Ishikawa H, Ma Z, Barber GN (2009) STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature 461:788–792
    • (2009) Nature , vol.461 , pp. 788-792
    • Ishikawa, H.1    Ma, Z.2    Barber, G.N.3
  • 80
    • 82355173358 scopus 로고    scopus 로고
    • H(2)O(2) production within tumor microenvironment inversely correlated with infiltration of CD56(dim) NK cells in gastric and esophageal cancer: possible mechanisms of NK cell dysfunction
    • COI: 1:CAS:528:DC%2BC3MXhsFantrrO, PID: 21811786
    • Izawa S, Kono K, Mimura K, Kawaguchi Y, Watanabe M, Maruyama T, Fujii H (2011) H(2)O(2) production within tumor microenvironment inversely correlated with infiltration of CD56(dim) NK cells in gastric and esophageal cancer: possible mechanisms of NK cell dysfunction. Cancer Immunol Immunother 60:1801–1810
    • (2011) Cancer Immunol Immunother , vol.60 , pp. 1801-1810
    • Izawa, S.1    Kono, K.2    Mimura, K.3    Kawaguchi, Y.4    Watanabe, M.5    Maruyama, T.6    Fujii, H.7
  • 82
    • 77953859606 scopus 로고    scopus 로고
    • NF-kappaB as a critical link between inflammation and cancer
    • PID: 20066113
    • Karin M (2009) NF-kappaB as a critical link between inflammation and cancer. Cold Spring Harb Perspect Biol 1:a000141
    • (2009) Cold Spring Harb Perspect Biol , vol.1 , pp. a000141
    • Karin, M.1
  • 83
    • 77951260924 scopus 로고    scopus 로고
    • The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
    • COI: 1:CAS:528:DC%2BC3cXkvFSjsrc%3D, PID: 20404851
    • Kawai T, Akira S (2010) The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 11:373–384
    • (2010) Nat Immunol , vol.11 , pp. 373-384
    • Kawai, T.1    Akira, S.2
  • 84
    • 84884252997 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells in cancer: recent progress and prospects
    • COI: 1:CAS:528:DC%2BC3sXhsVCms7vF, PID: 23797066
    • Khaled YS, Ammori BJ, Elkord E (2013) Myeloid-derived suppressor cells in cancer: recent progress and prospects. Immunol Cell Biol 91:493–502
    • (2013) Immunol Cell Biol , vol.91 , pp. 493-502
    • Khaled, Y.S.1    Ammori, B.J.2    Elkord, E.3
  • 85
    • 33644542104 scopus 로고    scopus 로고
    • Oxidative stress promotes polarization of human T cell differentiation toward a T helper 2 phenotype
    • COI: 1:CAS:528:DC%2BD28Xhs1ert70%3D, PID: 16493032
    • King MR, Ismail AS, Davis LS, Karp DR (2006) Oxidative stress promotes polarization of human T cell differentiation toward a T helper 2 phenotype. J Immunol 176:2765–2772
    • (2006) J Immunol , vol.176 , pp. 2765-2772
    • King, M.R.1    Ismail, A.S.2    Davis, L.S.3    Karp, D.R.4
  • 86
    • 18244390487 scopus 로고    scopus 로고
    • Myeloperoxidase: friend and foe
    • COI: 1:CAS:528:DC%2BD2MXktFentLw%3D, PID: 15689384
    • Klebanoff SJ (2005) Myeloperoxidase: friend and foe. J Leukoc Biol 77:598–625
    • (2005) J Leukoc Biol , vol.77 , pp. 598-625
    • Klebanoff, S.J.1
  • 88
    • 0030048536 scopus 로고    scopus 로고
    • Hydrogen peroxide secreted by tumor-derived macrophages down-modulates signal-transducing zeta molecules and inhibits tumor-specific T cell-and natural killer cell-mediated cytotoxicity
    • COI: 1:CAS:528:DyaK28Xks1egtr0%3D, PID: 8647210
    • Kono K, Salazar-Onfray F, Petersson M, Hansson J, Masucci G, Wasserman K, Nakazawa T, Anderson P, Kiessling R (1996) Hydrogen peroxide secreted by tumor-derived macrophages down-modulates signal-transducing zeta molecules and inhibits tumor-specific T cell-and natural killer cell-mediated cytotoxicity. Eur J Immunol 26:1308–1313
    • (1996) Eur J Immunol , vol.26 , pp. 1308-1313
    • Kono, K.1    Salazar-Onfray, F.2    Petersson, M.3    Hansson, J.4    Masucci, G.5    Wasserman, K.6    Nakazawa, T.7    Anderson, P.8    Kiessling, R.9
  • 89
    • 25844475838 scopus 로고    scopus 로고
    • On the road to cancer: aneuploidy and the mitotic checkpoint
    • COI: 1:CAS:528:DC%2BD2MXhtVGjs7bL, PID: 16195750
    • Kops GJ, Weaver BA, Cleveland DW (2005) On the road to cancer: aneuploidy and the mitotic checkpoint. Nat Rev Cancer 5:773–785
    • (2005) Nat Rev Cancer , vol.5 , pp. 773-785
    • Kops, G.J.1    Weaver, B.A.2    Cleveland, D.W.3
  • 91
    • 37849002321 scopus 로고    scopus 로고
    • Toll-like receptor 9 (TLR9) agonists in the treatment of cancer
    • COI: 1:CAS:528:DC%2BD1cXitl2hsg%3D%3D, PID: 18176597
    • Krieg AM (2008) Toll-like receptor 9 (TLR9) agonists in the treatment of cancer. Oncogene 27:161–167
    • (2008) Oncogene , vol.27 , pp. 161-167
    • Krieg, A.M.1
  • 92
    • 84875552922 scopus 로고    scopus 로고
    • Immunogenic cell death in cancer therapy
    • COI: 1:CAS:528:DC%2BC3sXnsFClsL8%3D, PID: 23157435
    • Kroemer G, Galluzzi L, Kepp O, Zitvogel L (2013) Immunogenic cell death in cancer therapy. Annu Rev Immunol 31:51–72
    • (2013) Annu Rev Immunol , vol.31 , pp. 51-72
    • Kroemer, G.1    Galluzzi, L.2    Kepp, O.3    Zitvogel, L.4
  • 94
    • 0041850021 scopus 로고    scopus 로고
    • Inhibition of myeloid cell differentiation in cancer: the role of reactive oxygen species
    • COI: 1:CAS:528:DC%2BD3sXmt1Ggtbc%3D, PID: 12885935
    • Kusmartsev S, Gabrilovich DI (2003) Inhibition of myeloid cell differentiation in cancer: the role of reactive oxygen species. J Leukoc Biol 74:186–196
    • (2003) J Leukoc Biol , vol.74 , pp. 186-196
    • Kusmartsev, S.1    Gabrilovich, D.I.2
  • 95
    • 0031936187 scopus 로고    scopus 로고
    • Pre-exposure to oxidative stress decreases the nuclear factor-kappa B-dependent transcription in T lymphocytes
    • COI: 1:CAS:528:DyaK1cXnslWltg%3D%3D, PID: 9570554
    • Lahdenpohja N, Savinainen K, Hurme M (1998) Pre-exposure to oxidative stress decreases the nuclear factor-kappa B-dependent transcription in T lymphocytes. J Immunol 160:1354–1358
    • (1998) J Immunol , vol.160 , pp. 1354-1358
    • Lahdenpohja, N.1    Savinainen, K.2    Hurme, M.3
  • 96
    • 84926523961 scopus 로고    scopus 로고
    • Senescence-associated inflammatory responses: aging and cancer perspectives
    • COI: 1:CAS:528:DC%2BC2MXktVCltbo%3D, PID: 25801910
    • Lasry A, Ben-Neriah Y (2015) Senescence-associated inflammatory responses: aging and cancer perspectives. Trends Immunol 36:217–228
    • (2015) Trends Immunol , vol.36 , pp. 217-228
    • Lasry, A.1    Ben-Neriah, Y.2
  • 97
    • 84954405682 scopus 로고    scopus 로고
    • Antitumor activity of cGAMP via stimulation of cGAS-cGAMP-STING-IRF3 mediated innate immune response
    • COI: 1:CAS:528:DC%2BC28Xns1Wqtg%3D%3D, PID: 26754564
    • Li T, Cheng H, Yuan H, Xu Q, Shu C, Zhang Y, Xu P, Tan J, Rui Y, Li P, Tan X (2016) Antitumor activity of cGAMP via stimulation of cGAS-cGAMP-STING-IRF3 mediated innate immune response. Sci Rep 6:19049
    • (2016) Sci Rep , vol.6 , pp. 19049
    • Li, T.1    Cheng, H.2    Yuan, H.3    Xu, Q.4    Shu, C.5    Zhang, Y.6    Xu, P.7    Tan, J.8    Rui, Y.9    Li, P.10    Tan, X.11
  • 98
    • 85006217731 scopus 로고    scopus 로고
    • DNA damage, tumor mutational load and their impact on immune responses against cancer
    • PID: 27563651
    • Liontos M, Anastasiou I, Bamias A, Dimopoulos MA (2016) DNA damage, tumor mutational load and their impact on immune responses against cancer. Ann Transl Med 4:264
    • (2016) Ann Transl Med , vol.4 , pp. 264
    • Liontos, M.1    Anastasiou, I.2    Bamias, A.3    Dimopoulos, M.A.4
  • 99
    • 84948808349 scopus 로고    scopus 로고
    • Chromosomal instability triggers cell death via local signalling through the innate immune receptor Toll
    • PID: 26462024
    • Liu D, Shaukat Z, Saint RB, Gregory SL (2015) Chromosomal instability triggers cell death via local signalling through the innate immune receptor Toll. Oncotarget 6:38552–38565
    • (2015) Oncotarget , vol.6 , pp. 38552-38565
    • Liu, D.1    Shaukat, Z.2    Saint, R.B.3    Gregory, S.L.4
  • 101
    • 61449182121 scopus 로고    scopus 로고
    • Principles of cancer therapy: oncogene and non-oncogene addiction
    • COI: 1:CAS:528:DC%2BD1MXltFSnsLw%3D, PID: 19269363
    • Luo J, Solimini NL, Elledge SJ (2009) Principles of cancer therapy: oncogene and non-oncogene addiction. Cell 136:823–837
    • (2009) Cell , vol.136 , pp. 823-837
    • Luo, J.1    Solimini, N.L.2    Elledge, S.J.3
  • 102
    • 84871265006 scopus 로고    scopus 로고
    • Cell-extrinsic effects of tumor ER stress imprint myeloid dendritic cells and impair CD8(+) T cell priming
    • COI: 1:CAS:528:DC%2BC3sXktVSisQ%3D%3D, PID: 23272178
    • Mahadevan NR, Anufreichik V, Rodvold JJ, Chiu KT, Sepulveda H, Zanetti M (2012) Cell-extrinsic effects of tumor ER stress imprint myeloid dendritic cells and impair CD8(+) T cell priming. PLoS One 7:e51845
    • (2012) PLoS One , vol.7
    • Mahadevan, N.R.1    Anufreichik, V.2    Rodvold, J.J.3    Chiu, K.T.4    Sepulveda, H.5    Zanetti, M.6
  • 103
    • 79955632933 scopus 로고    scopus 로고
    • Transmission of endoplasmic reticulum stress and pro-inflammation from tumor cells to myeloid cells
    • COI: 1:CAS:528:DC%2BC3MXlt1emtro%3D, PID: 21464300
    • Mahadevan NR, Rodvold J, Sepulveda H, Rossi S, Drew AF, Zanetti M (2011) Transmission of endoplasmic reticulum stress and pro-inflammation from tumor cells to myeloid cells. Proc Natl Acad Sci USA 108:6561–6566
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 6561-6566
    • Mahadevan, N.R.1    Rodvold, J.2    Sepulveda, H.3    Rossi, S.4    Drew, A.F.5    Zanetti, M.6
  • 105
  • 107
    • 73949135474 scopus 로고    scopus 로고
    • Distinct and complementary functions of MDA5 and TLR3 in poly(I:C)-mediated activation of mouse NK cells
    • COI: 1:CAS:528:DC%2BD1MXhs1Wlsb3F, PID: 19995959
    • McCartney S, Vermi W, Gilfillan S, Cella M, Murphy TL, Schreiber RD, Murphy KM, Colonna M (2009) Distinct and complementary functions of MDA5 and TLR3 in poly(I:C)-mediated activation of mouse NK cells. J Exp Med 206:2967–2976
    • (2009) J Exp Med , vol.206 , pp. 2967-2976
    • McCartney, S.1    Vermi, W.2    Gilfillan, S.3    Cella, M.4    Murphy, T.L.5    Schreiber, R.D.6    Murphy, K.M.7    Colonna, M.8
  • 108
    • 0034284333 scopus 로고    scopus 로고
    • Natural killer cell dysfunction and apoptosis induced by chronic myelogenous leukemia cells: role of reactive oxygen species and regulation by histamine
    • COI: 1:CAS:528:DC%2BD3cXmt1Omu7c%3D, PID: 10961901
    • Mellqvist UH, Hansson M, Brune M, Dahlgren C, Hermodsson S, Hellstrand K (2000) Natural killer cell dysfunction and apoptosis induced by chronic myelogenous leukemia cells: role of reactive oxygen species and regulation by histamine. Blood 96:1961–1968
    • (2000) Blood , vol.96 , pp. 1961-1968
    • Mellqvist, U.H.1    Hansson, M.2    Brune, M.3    Dahlgren, C.4    Hermodsson, S.5    Hellstrand, K.6
  • 110
    • 0014028832 scopus 로고
    • Immunization of normal mouse spleen cell suspensions in vitro
    • COI: 1:STN:280:DyaF2s%2FhsVWmsg%3D%3D, PID: 5917547
    • Mishell RI, Dutton RW (1966) Immunization of normal mouse spleen cell suspensions in vitro. Science 153:1004–1006
    • (1966) Science , vol.153 , pp. 1004-1006
    • Mishell, R.I.1    Dutton, R.W.2
  • 111
    • 85040148236 scopus 로고    scopus 로고
    • Mertens F (eds, Mitelman database of chromosome aberrations and gene fusions in cancer
    • Mitelman F, Johansson B, Mertens F (eds) (2017) Mitelman database of chromosome aberrations and gene fusions in cancer. http://cgap.nci.nih.gov/Chromosomes/Mitelman
    • (2017) Johansson B
    • Mitelman, F.1
  • 112
    • 78751700887 scopus 로고    scopus 로고
    • Increased thioredoxin-1 production in human naturally occurring regulatory T cells confers enhanced tolerance to oxidative stress
    • COI: 1:CAS:528:DC%2BC3MXhslKks7o%3D, PID: 21030559
    • Mougiakakos D, Johansson CC, Jitschin R, Bottcher M, Kiessling R (2011) Increased thioredoxin-1 production in human naturally occurring regulatory T cells confers enhanced tolerance to oxidative stress. Blood 117:857–861
    • (2011) Blood , vol.117 , pp. 857-861
    • Mougiakakos, D.1    Johansson, C.C.2    Jitschin, R.3    Bottcher, M.4    Kiessling, R.5
  • 114
    • 84895832850 scopus 로고    scopus 로고
    • Combinatorial immunotherapy of polyinosinic-polycytidylic acid and blockade of programmed death-ligand 1 induce effective CD8 T-cell responses against established tumors
    • COI: 1:CAS:528:DC%2BC2cXks1Ohurs%3D, PID: 24389326
    • Nagato T, Lee YR, Harabuchi Y, Celis E (2014) Combinatorial immunotherapy of polyinosinic-polycytidylic acid and blockade of programmed death-ligand 1 induce effective CD8 T-cell responses against established tumors. Clin Cancer Res 20:1223–1234
    • (2014) Clin Cancer Res , vol.20 , pp. 1223-1234
    • Nagato, T.1    Lee, Y.R.2    Harabuchi, Y.3    Celis, E.4
  • 115
    • 79951642032 scopus 로고    scopus 로고
    • Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
    • COI: 1:CAS:528:DC%2BC3cXhsFGgtrzE, PID: 21151103
    • Nakahira K, Haspel JA, Rathinam VA, Lee SJ, Dolinay T, Lam HC, Englert JA, Rabinovitch M, Cernadas M, Kim HP et al (2011) Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol 12:222–230
    • (2011) Nat Immunol , vol.12 , pp. 222-230
    • Nakahira, K.1    Haspel, J.A.2    Rathinam, V.A.3    Lee, S.J.4    Dolinay, T.5    Lam, H.C.6    Englert, J.A.7    Rabinovitch, M.8    Cernadas, M.9    Kim, H.P.10
  • 116
    • 0018854239 scopus 로고
    • Role of oxygen-dependent mechanisms in antibody-induced lysis of tumor cells by activated macrophages
    • COI: 1:CAS:528:DyaL3cXkvFegu7c%3D, PID: 6995553
    • Nathan C, Cohn Z (1980) Role of oxygen-dependent mechanisms in antibody-induced lysis of tumor cells by activated macrophages. J Exp Med 152:198–208
    • (1980) J Exp Med , vol.152 , pp. 198-208
    • Nathan, C.1    Cohn, Z.2
  • 117
    • 0019470352 scopus 로고
    • Tumor cell anti-oxidant defenses. Inhibition of the glutathione redox cycle enhances macrophage-mediated cytolysis
    • COI: 1:CAS:528:DyaL3MXhsFCksL4%3D, PID: 7252413
    • Nathan CF, Arrick BA, Murray HW, DeSantis NM, Cohn ZA (1981) Tumor cell anti-oxidant defenses. Inhibition of the glutathione redox cycle enhances macrophage-mediated cytolysis. J Exp Med 153:766–782
    • (1981) J Exp Med , vol.153 , pp. 766-782
    • Nathan, C.F.1    Arrick, B.A.2    Murray, H.W.3    DeSantis, N.M.4    Cohn, Z.A.5
  • 118
    • 0020029343 scopus 로고
    • Augmentation of spontaneous macrophage-mediated cytolysis by eosinophil peroxidase
    • COI: 1:CAS:528:DyaL38XitFGrur0%3D, PID: 6802924
    • Nathan CF, Klebanoff SJ (1982) Augmentation of spontaneous macrophage-mediated cytolysis by eosinophil peroxidase. J Exp Med 155:1291–1308
    • (1982) J Exp Med , vol.155 , pp. 1291-1308
    • Nathan, C.F.1    Klebanoff, S.J.2
  • 119
    • 0018343415 scopus 로고
    • Extracellular cytolysis by activated macrophages and granulocytes. II. Hydrogen peroxide as a mediator of cytotoxicity
    • COI: 1:STN:280:DyaE1M7htV2mtA%3D%3D, PID: 216763
    • Nathan CF, Silverstein SC, Brukner LH, Cohn ZA (1979) Extracellular cytolysis by activated macrophages and granulocytes. II. Hydrogen peroxide as a mediator of cytotoxicity. J Exp Med 149:100–113
    • (1979) J Exp Med , vol.149 , pp. 100-113
    • Nathan, C.F.1    Silverstein, S.C.2    Brukner, L.H.3    Cohn, Z.A.4
  • 120
    • 0016765108 scopus 로고
    • Differential stimulation of murine lymphoma growth in vitro by normal and BCG-activated macrophages
    • COI: 1:STN:280:DyaE28%2Fis1equw%3D%3D, PID: 170358
    • Nathan CF, Terry WD (1975) Differential stimulation of murine lymphoma growth in vitro by normal and BCG-activated macrophages. J Exp Med 142:887–902
    • (1975) J Exp Med , vol.142 , pp. 887-902
    • Nathan, C.F.1    Terry, W.D.2
  • 121
    • 85007576245 scopus 로고    scopus 로고
    • Clinical Implications of high-mobility group box-1 (HMGB1) and the receptor for advanced glycation end-products (RAGE) in cutaneous malignancy: a systematic review
    • PID: 28011467
    • Nguyen AH, Detty SQ, Agrawal DK (2017) Clinical Implications of high-mobility group box-1 (HMGB1) and the receptor for advanced glycation end-products (RAGE) in cutaneous malignancy: a systematic review. Anticancer Res 37:1–7
    • (2017) Anticancer Res , vol.37 , pp. 1-7
    • Nguyen, A.H.1    Detty, S.Q.2    Agrawal, D.K.3
  • 122
    • 67649255876 scopus 로고    scopus 로고
    • A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish
    • COI: 1:CAS:528:DC%2BD1MXmslCmtL0%3D, PID: 19494811
    • Niethammer P, Grabher C, Look AT, Mitchison TJ (2009) A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish. Nature 459:996–999
    • (2009) Nature , vol.459 , pp. 996-999
    • Niethammer, P.1    Grabher, C.2    Look, A.T.3    Mitchison, T.J.4
  • 123
    • 0011855455 scopus 로고
    • Hydroxyl radical scavengers inhibit lymphocyte mitogenesis
    • COI: 1:CAS:528:DyaL38Xhs1SlsbY%3D, PID: 6122209
    • Novogrodsky A, Ravid A, Rubin AL, Stenzel KH (1982) Hydroxyl radical scavengers inhibit lymphocyte mitogenesis. Proc Natl Acad Sci USA 79:1171–1174
    • (1982) Proc Natl Acad Sci USA , vol.79 , pp. 1171-1174
    • Novogrodsky, A.1    Ravid, A.2    Rubin, A.L.3    Stenzel, K.H.4
  • 125
    • 84964698449 scopus 로고    scopus 로고
    • STING contributes to antiglioma immunity via triggering type I IFN signals in the tumor microenvironment
    • COI: 1:CAS:528:DC%2BC2cXitVCjtr3K, PID: 25300859
    • Ohkuri T, Ghosh A, Kosaka A, Zhu J, Ikeura M, David M, Watkins SC, Sarkar SN, Okada H (2014) STING contributes to antiglioma immunity via triggering type I IFN signals in the tumor microenvironment. Cancer Immunol Res 2:1199–1208
    • (2014) Cancer Immunol Res , vol.2 , pp. 1199-1208
    • Ohkuri, T.1    Ghosh, A.2    Kosaka, A.3    Zhu, J.4    Ikeura, M.5    David, M.6    Watkins, S.C.7    Sarkar, S.N.8    Okada, H.9
  • 126
    • 0030603101 scopus 로고    scopus 로고
    • + and reactive oxygen intermediates as messengers
    • COI: 1:CAS:528:DyaK28Xlt1KisLg%3D, PID: 8772190
    • + and reactive oxygen intermediates as messengers. FEBS Lett 392:129–136
    • (1996) FEBS Lett , vol.392 , pp. 129-136
    • Pahl, H.L.1    Baeuerle, P.A.2
  • 127
    • 0037038696 scopus 로고    scopus 로고
    • Regulation of the IRF-1 tumour modifier during the response to genotoxic stress involves an ATM-dependent signalling pathway
    • COI: 1:CAS:528:DC%2BD38XosVektLg%3D, PID: 12420214
    • Pamment J, Ramsay E, Kelleher M, Dornan D, Ball KL (2002) Regulation of the IRF-1 tumour modifier during the response to genotoxic stress involves an ATM-dependent signalling pathway. Oncogene 21:7776–7785
    • (2002) Oncogene , vol.21 , pp. 7776-7785
    • Pamment, J.1    Ramsay, E.2    Kelleher, M.3    Dornan, D.4    Ball, K.L.5
  • 129
    • 84982817526 scopus 로고    scopus 로고
    • ROS homeostasis and metabolism: a dangerous liason in cancer cells
    • COI: 1:CAS:528:DC%2BC28XmvFChsLo%3D, PID: 27277675
    • Panieri E, Santoro MM (2016) ROS homeostasis and metabolism: a dangerous liason in cancer cells. Cell Death Dis 7:e2253
    • (2016) Cell Death Dis , vol.7
    • Panieri, E.1    Santoro, M.M.2
  • 131
    • 26444570010 scopus 로고    scopus 로고
    • Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations
    • COI: 1:CAS:528:DC%2BD2MXmt1ert78%3D, PID: 15987702
    • Pollard PJ, Briere JJ, Alam NA, Barwell J, Barclay E, Wortham NC, Hunt T, Mitchell M, Olpin S, Moat SJ et al (2005) Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations. Hum Mol Genet 14:2231–2239
    • (2005) Hum Mol Genet , vol.14 , pp. 2231-2239
    • Pollard, P.J.1    Briere, J.J.2    Alam, N.A.3    Barwell, J.4    Barclay, E.5    Wortham, N.C.6    Hunt, T.7    Mitchell, M.8    Olpin, S.9    Moat, S.J.10
  • 132
    • 84886384437 scopus 로고    scopus 로고
    • AIM2, an IFN-inducible cytosolic DNA sensor, in the development of benign prostate hyperplasia and prostate cancer
    • COI: 1:CAS:528:DC%2BC3sXhs1elurvM, PID: 23864729
    • Ponomareva L, Liu H, Duan X, Dickerson E, Shen H, Panchanathan R, Choubey D (2013) AIM2, an IFN-inducible cytosolic DNA sensor, in the development of benign prostate hyperplasia and prostate cancer. Mol Cancer Res 11:1193–1202
    • (2013) Mol Cancer Res , vol.11 , pp. 1193-1202
    • Ponomareva, L.1    Liu, H.2    Duan, X.3    Dickerson, E.4    Shen, H.5    Panchanathan, R.6    Choubey, D.7
  • 133
    • 33846461678 scopus 로고    scopus 로고
    • A critical role for the autophagy gene Atg5 in T cell survival and proliferation
    • COI: 1:CAS:528:DC%2BD2sXhtFGjsbs%3D, PID: 17190837
    • Pua HH, Dzhagalov I, Chuck M, Mizushima N, He YW (2007) A critical role for the autophagy gene Atg5 in T cell survival and proliferation. J Exp Med 204:25–31
    • (2007) J Exp Med , vol.204 , pp. 25-31
    • Pua, H.H.1    Dzhagalov, I.2    Chuck, M.3    Mizushima, N.4    He, Y.W.5
  • 135
    • 84992176811 scopus 로고    scopus 로고
    • Emerging links among chromosome instability (CIN), cancer, and aging
    • COI: 1:CAS:528:DC%2BC28XhtlGmt7rM, PID: 27533343
    • Rao CV, Asch AS, Yamada HY (2017) Emerging links among chromosome instability (CIN), cancer, and aging. Mol Carcinog 56:791–803
    • (2017) Mol Carcinog , vol.56 , pp. 791-803
    • Rao, C.V.1    Asch, A.S.2    Yamada, H.Y.3
  • 136
    • 0019985050 scopus 로고
    • Oxygen intermediates are triggered early in the cytolytic pathway of human NK cells
    • COI: 1:CAS:528:DyaL3sXjsVer, PID: 6178976
    • Roder JC, Helfand SL, Werkmeister J, McGarry R, Beaumont TJ, Duwe A (1982) Oxygen intermediates are triggered early in the cytolytic pathway of human NK cells. Nature 298:569–572
    • (1982) Nature , vol.298 , pp. 569-572
    • Roder, J.C.1    Helfand, S.L.2    Werkmeister, J.3    McGarry, R.4    Beaumont, T.J.5    Duwe, A.6
  • 138
    • 33644797314 scopus 로고    scopus 로고
    • NKp46 and NKG2D receptor expression in NK cells with CD56dim and CD56bright phenotype: regulation by histamine and reactive oxygen species
    • COI: 1:CAS:528:DC%2BD28Xkt1GrsA%3D%3D, PID: 16371024
    • Romero AI, Thoren FB, Brune M, Hellstrand K (2006) NKp46 and NKG2D receptor expression in NK cells with CD56dim and CD56bright phenotype: regulation by histamine and reactive oxygen species. Br J Haematol 132:91–98
    • (2006) Br J Haematol , vol.132 , pp. 91-98
    • Romero, A.I.1    Thoren, F.B.2    Brune, M.3    Hellstrand, K.4
  • 140
    • 0345435976 scopus 로고    scopus 로고
    • Reactive oxygen species activate human peripheral blood dendritic cells
    • COI: 1:CAS:528:DyaK1MXhsF2n, PID: 9890657
    • Rutault K, Alderman C, Chain BM, Katz DR (1999) Reactive oxygen species activate human peripheral blood dendritic cells. Free Radic Biol Med 26:232–238
    • (1999) Free Radic Biol Med , vol.26 , pp. 232-238
    • Rutault, K.1    Alderman, C.2    Chain, B.M.3    Katz, D.R.4
  • 142
    • 84905650695 scopus 로고    scopus 로고
    • Toll-like receptor 9 in breast cancer
    • PID: 25101078
    • Sandholm J, Selander KS (2014) Toll-like receptor 9 in breast cancer. Front Immunol 5:330
    • (2014) Front Immunol , vol.5 , pp. 330
    • Sandholm, J.1    Selander, K.S.2
  • 143
    • 84878404499 scopus 로고    scopus 로고
    • Hypoxia induced impairment of NK cell cytotoxicity against multiple myeloma can be overcome by IL-2 activation of the NK cells
    • COI: 1:CAS:528:DC%2BC3sXpsVKrsbk%3D, PID: 23724099
    • Sarkar S, Germeraad WT, Rouschop KM, Steeghs EM, van Gelder M, Bos GM, Wieten L (2013) Hypoxia induced impairment of NK cell cytotoxicity against multiple myeloma can be overcome by IL-2 activation of the NK cells. PLoS One 8:e64835
    • (2013) PLoS One , vol.8
    • Sarkar, S.1    Germeraad, W.T.2    Rouschop, K.M.3    Steeghs, E.M.4    van Gelder, M.5    Bos, G.M.6    Wieten, L.7
  • 144
    • 0035874990 scopus 로고    scopus 로고
    • Activated granulocytes and granulocyte-derived hydrogen peroxide are the underlying mechanism of suppression of t-cell function in advanced cancer patients
    • COI: 1:CAS:528:DC%2BD3MXks1Grtbg%3D, PID: 11406548
    • Schmielau J, Finn OJ (2001) Activated granulocytes and granulocyte-derived hydrogen peroxide are the underlying mechanism of suppression of t-cell function in advanced cancer patients. Cancer Res 61:4756–4760
    • (2001) Cancer Res , vol.61 , pp. 4756-4760
    • Schmielau, J.1    Finn, O.J.2
  • 145
    • 84886943543 scopus 로고    scopus 로고
    • Breaking tumor-induced immunosuppression with 5′-triphosphate siRNA silencing TGFbeta and activating RIG-I
    • PID: 23762798
    • Schnurr M, Duewell P (2013) Breaking tumor-induced immunosuppression with 5′-triphosphate siRNA silencing TGFbeta and activating RIG-I. Oncoimmunology 2:e24170
    • (2013) Oncoimmunology , vol.2
    • Schnurr, M.1    Duewell, P.2
  • 146
    • 37848999304 scopus 로고    scopus 로고
    • TLR7 and TLR8 as targets in cancer therapy
    • COI: 1:STN:280:DC%2BD1c%2FhtFWjsQ%3D%3D, PID: 18176600
    • Schon MP, Schon M (2008) TLR7 and TLR8 as targets in cancer therapy. Oncogene 27:190–199
    • (2008) Oncogene , vol.27 , pp. 190-199
    • Schon, M.P.1    Schon, M.2
  • 147
    • 10444226462 scopus 로고    scopus 로고
    • ER stress and the unfolded protein response
    • PID: 15603751
    • Schroder M, Kaufman RJ (2005) ER stress and the unfolded protein response. Mutat Res 569:29–63
    • (2005) Mutat Res , vol.569 , pp. 29-63
    • Schroder, M.1    Kaufman, R.J.2
  • 148
    • 33748165596 scopus 로고    scopus 로고
    • Reactive oxygen species in cancer cells: live by the sword, die by the sword
    • COI: 1:CAS:528:DC%2BD28XhtVSlu73M, PID: 16959608
    • Schumacker PT (2006) Reactive oxygen species in cancer cells: live by the sword, die by the sword. Cancer Cell 10:175–176
    • (2006) Cancer Cell , vol.10 , pp. 175-176
    • Schumacker, P.T.1
  • 149
    • 84922763809 scopus 로고    scopus 로고
    • Reactive oxygen species in cancer: a dance with the devil
    • COI: 1:CAS:528:DC%2BC2MXisFertbw%3D, PID: 25670075
    • Schumacker PT (2015) Reactive oxygen species in cancer: a dance with the devil. Cancer Cell 27:156–157
    • (2015) Cancer Cell , vol.27 , pp. 156-157
    • Schumacker, P.T.1
  • 150
    • 0020045971 scopus 로고
    • Suppression of natural killing in vitro by monocytes and polymorphonuclear leukocytes: requirement for reactive metabolites of oxygen
    • COI: 1:CAS:528:DyaL38XitFGrt7k%3D, PID: 7076851
    • Seaman WE, Gindhart TD, Blackman MA, Dalal B, Talal N, Werb Z (1982) Suppression of natural killing in vitro by monocytes and polymorphonuclear leukocytes: requirement for reactive metabolites of oxygen. J Clin Invest 69:876–888
    • (1982) J Clin Invest , vol.69 , pp. 876-888
    • Seaman, W.E.1    Gindhart, T.D.2    Blackman, M.A.3    Dalal, B.4    Talal, N.5    Werb, Z.6
  • 152
    • 84928473926 scopus 로고    scopus 로고
    • Sterile inflammation in Drosophila
    • Shaukat Z, Liu D, Gregory S (2015) Sterile inflammation in Drosophila. Mediat Inflamm 2015:369286
    • (2015) Mediat Inflamm , vol.2015 , pp. 369286
    • Shaukat, Z.1    Liu, D.2    Gregory, S.3
  • 155
    • 49649105571 scopus 로고    scopus 로고
    • Hypoxia increases tumor cell shedding of MHC class I chain-related molecule: role of nitric oxide
    • COI: 1:CAS:528:DC%2BD1cXnt1ejsro%3D, PID: 18559521
    • Siemens DR, Hu N, Sheikhi AK, Chung E, Frederiksen LJ, Pross H, Graham CH (2008) Hypoxia increases tumor cell shedding of MHC class I chain-related molecule: role of nitric oxide. Cancer Res 68:4746–4753
    • (2008) Cancer Res , vol.68 , pp. 4746-4753
    • Siemens, D.R.1    Hu, N.2    Sheikhi, A.K.3    Chung, E.4    Frederiksen, L.J.5    Pross, H.6    Graham, C.H.7
  • 156
    • 0038171416 scopus 로고    scopus 로고
    • Neutrophil apoptosis pathways and their modifications in inflammation
    • COI: 1:CAS:528:DC%2BD3sXkslemsLs%3D, PID: 12752675
    • Simon HU (2003) Neutrophil apoptosis pathways and their modifications in inflammation. Immunol Rev 193:101–110
    • (2003) Immunol Rev , vol.193 , pp. 101-110
    • Simon, H.U.1
  • 159
    • 34249300128 scopus 로고    scopus 로고
    • Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cells
    • COI: 1:CAS:528:DC%2BD2sXltVyrtrY%3D, PID: 17483367
    • Sinha P, Clements VK, Fulton AM, Ostrand-Rosenberg S (2007) Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cells. Cancer Res 67:4507–4513
    • (2007) Cancer Res , vol.67 , pp. 4507-4513
    • Sinha, P.1    Clements, V.K.2    Fulton, A.M.3    Ostrand-Rosenberg, S.4
  • 161
    • 24344479617 scopus 로고    scopus 로고
    • NKG2D function protects the host from tumor initiation
    • COI: 1:CAS:528:DC%2BD2MXhtVSjs7%2FF, PID: 16129707
    • Smyth MJ, Swann J, Cretney E, Zerafa N, Yokoyama WM, Hayakawa Y (2005) NKG2D function protects the host from tumor initiation. J Exp Med 202:583–588
    • (2005) J Exp Med , vol.202 , pp. 583-588
    • Smyth, M.J.1    Swann, J.2    Cretney, E.3    Zerafa, N.4    Yokoyama, W.M.5    Hayakawa, Y.6
  • 162
    • 84896692416 scopus 로고    scopus 로고
    • Chemotherapy-elicited upregulation of NKG2D and DNAM-1 ligands as a therapeutic target in multiple myeloma
    • PID: 24498552
    • Soriani A, Fionda C, Ricci B, Iannitto ML, Cippitelli M, Santoni A (2013) Chemotherapy-elicited upregulation of NKG2D and DNAM-1 ligands as a therapeutic target in multiple myeloma. Oncoimmunology 2:e26663
    • (2013) Oncoimmunology , vol.2
    • Soriani, A.1    Fionda, C.2    Ricci, B.3    Iannitto, M.L.4    Cippitelli, M.5    Santoni, A.6
  • 163
    • 65349131915 scopus 로고    scopus 로고
    • ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype
    • COI: 1:CAS:528:DC%2BD1MXkslCku7o%3D, PID: 19098271
    • Soriani A, Zingoni A, Cerboni C, Iannitto ML, Ricciardi MR, Di Gialleonardo V, Cippitelli M, Fionda C, Petrucci MT, Guarini A et al (2009) ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype. Blood 113:3503–3511
    • (2009) Blood , vol.113 , pp. 3503-3511
    • Soriani, A.1    Zingoni, A.2    Cerboni, C.3    Iannitto, M.L.4    Ricciardi, M.R.5    Di Gialleonardo, V.6    Cippitelli, M.7    Fionda, C.8    Petrucci, M.T.9    Guarini, A.10
  • 164
    • 75149123468 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells inhibit T-cell activation by depleting cystine and cysteine
    • COI: 1:CAS:528:DC%2BC3cXltVaj, PID: 20028852
    • Srivastava MK, Sinha P, Clements VK, Rodriguez P, Ostrand-Rosenberg S (2010) Myeloid-derived suppressor cells inhibit T-cell activation by depleting cystine and cysteine. Cancer Res 70:68–77
    • (2010) Cancer Res , vol.70 , pp. 68-77
    • Srivastava, M.K.1    Sinha, P.2    Clements, V.K.3    Rodriguez, P.4    Ostrand-Rosenberg, S.5
  • 165
  • 166
    • 75949098378 scopus 로고    scopus 로고
    • Hypoxia induces T-cell apoptosis by inhibiting chemokine C receptor 7 expression: the role of adenosine receptor A(2)
    • COI: 1:CAS:528:DC%2BC3cXht1KksbY%3D, PID: 20029460
    • Sun J, Zhang Y, Yang M, Zhang Y, Xie Q, Li Z, Dong Z, Yang Y, Deng B, Feng A et al (2010) Hypoxia induces T-cell apoptosis by inhibiting chemokine C receptor 7 expression: the role of adenosine receptor A(2). Cell Mol Immunol 7:77–82
    • (2010) Cell Mol Immunol , vol.7 , pp. 77-82
    • Sun, J.1    Zhang, Y.2    Yang, M.3    Zhang, Y.4    Xie, Q.5    Li, Z.6    Dong, Z.7    Yang, Y.8    Deng, B.9    Feng, A.10
  • 168
    • 84886945068 scopus 로고    scopus 로고
    • ATM activation mediates anticancer immunosurveillance by natural killer and T cells
    • PID: 23894700
    • Tang ML, Gasser S (2013) ATM activation mediates anticancer immunosurveillance by natural killer and T cells. Oncoimmunology 2:e24438
    • (2013) Oncoimmunology , vol.2
    • Tang, M.L.1    Gasser, S.2
  • 169
    • 84897969175 scopus 로고    scopus 로고
    • The DNA damage response induces antigen presenting cell-like functions in fibroblasts
    • COI: 1:CAS:528:DC%2BC2cXisFOhs7w%3D, PID: 24375454
    • Tang ML, Khan MK, Croxford JL, Tan KW, Angeli V, Gasser S (2014) The DNA damage response induces antigen presenting cell-like functions in fibroblasts. Eur J Immunol 44:1108–1118
    • (2014) Eur J Immunol , vol.44 , pp. 1108-1118
    • Tang, M.L.1    Khan, M.K.2    Croxford, J.L.3    Tan, K.W.4    Angeli, V.5    Gasser, S.6
  • 172
    • 4344594217 scopus 로고    scopus 로고
    • Sensitization of T cells to apoptosis—a role for ROS?
    • COI: 1:CAS:528:DC%2BD2cXms12isLc%3D, PID: 15314279
    • Tripathi P, Hildeman D (2004) Sensitization of T cells to apoptosis—a role for ROS? Apoptosis 9:515–523
    • (2004) Apoptosis , vol.9 , pp. 515-523
    • Tripathi, P.1    Hildeman, D.2
  • 173
    • 0034723235 scopus 로고    scopus 로고
    • Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
    • COI: 1:CAS:528:DC%2BD3cXovVyhuw%3D%3D, PID: 10650002
    • Urano F, Wang X, Bertolotti A, Zhang Y, Chung P, Harding HP, Ron D (2000) Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 287:664–666
    • (2000) Science , vol.287 , pp. 664-666
    • Urano, F.1    Wang, X.2    Bertolotti, A.3    Zhang, Y.4    Chung, P.5    Harding, H.P.6    Ron, D.7
  • 174
    • 84901288438 scopus 로고    scopus 로고
    • The role of senescent cells in ageing
    • PID: 24848057
    • van Deursen JM (2014) The role of senescent cells in ageing. Nature 509:439–446
    • (2014) Nature , vol.509 , pp. 439-446
    • van Deursen, J.M.1
  • 175
    • 84938215240 scopus 로고    scopus 로고
    • The PERKs of damage-associated molecular patterns mediating cancer immunogenicity: from sensor to the plasma membrane and beyond
    • PID: 25882379
    • van Vliet AR, Martin S, Garg AD, Agostinis P (2015) The PERKs of damage-associated molecular patterns mediating cancer immunogenicity: from sensor to the plasma membrane and beyond. Semin Cancer Biol 33:74–85
    • (2015) Semin Cancer Biol , vol.33 , pp. 74-85
    • van Vliet, A.R.1    Martin, S.2    Garg, A.D.3    Agostinis, P.4
  • 176
    • 84876098009 scopus 로고    scopus 로고
    • Targeting ER stress induced apoptosis and inflammation in cancer
    • COI: 1:CAS:528:DC%2BC3sXlvVWitLk%3D, PID: 20732741
    • Verfaillie T, Garg AD, Agostinis P (2013) Targeting ER stress induced apoptosis and inflammation in cancer. Cancer Lett 332:249–264
    • (2013) Cancer Lett , vol.332 , pp. 249-264
    • Verfaillie, T.1    Garg, A.D.2    Agostinis, P.3
  • 177
  • 178
    • 0026624980 scopus 로고
    • Diseases of the mitochondrial DNA
    • COI: 1:CAS:528:DyaK3sXkslCn, PID: 1497308
    • Wallace DC (1992) Diseases of the mitochondrial DNA. Annu Rev Biochem 61:1175–1212
    • (1992) Annu Rev Biochem , vol.61 , pp. 1175-1212
    • Wallace, D.C.1
  • 179
    • 82255173966 scopus 로고    scopus 로고
    • The unfolded protein response: from stress pathway to homeostatic regulation
    • COI: 1:CAS:528:DC%2BC3MXhsV2mu7jL, PID: 22116877
    • Walter P, Ron D (2011) The unfolded protein response: from stress pathway to homeostatic regulation. Science 334:1081–1086
    • (2011) Science , vol.334 , pp. 1081-1086
    • Walter, P.1    Ron, D.2
  • 180
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • COI: 1:STN:280:DyaG28%2FltV2ktQ%3D%3D, PID: 13298683
    • Warburg O (1956) On the origin of cancer cells. Science 123:309–314
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 181
    • 84961288748 scopus 로고    scopus 로고
    • Cationic nanocarriers induce cell necrosis through impairment of Na(+)/K(+)-ATPase and cause subsequent inflammatory response
    • COI: 1:CAS:528:DC%2BC2MXhs1SgtLo%3D, PID: 25613571
    • Wei X, Shao B, He Z, Ye T, Luo M, Sang Y, Liang X, Wang W, Luo S, Yang S et al (2015) Cationic nanocarriers induce cell necrosis through impairment of Na(+)/K(+)-ATPase and cause subsequent inflammatory response. Cell Res 25:237–253
    • (2015) Cell Res , vol.25 , pp. 237-253
    • Wei, X.1    Shao, B.2    He, Z.3    Ye, T.4    Luo, M.5    Sang, Y.6    Liang, X.7    Wang, W.8    Luo, S.9    Yang, S.10
  • 184
    • 82255161799 scopus 로고    scopus 로고
    • The role of the adenosinergic pathway in immunosuppression mediated by human regulatory T cells (Treg)
    • COI: 1:CAS:528:DC%2BC3MXhs1Shtr3N, PID: 22087822
    • Whiteside TL, Mandapathil M, Schuler P (2011) The role of the adenosinergic pathway in immunosuppression mediated by human regulatory T cells (Treg). Curr Med Chem 18:5217–5223
    • (2011) Curr Med Chem , vol.18 , pp. 5217-5223
    • Whiteside, T.L.1    Mandapathil, M.2    Schuler, P.3
  • 187
    • 84896806608 scopus 로고    scopus 로고
    • JNK signaling is needed to tolerate chromosomal instability
    • COI: 1:CAS:528:DC%2BC2cXhtFWgs7vL, PID: 24335260
    • Wong HW, Shaukat Z, Wang J, Saint R, Gregory SL (2014) JNK signaling is needed to tolerate chromosomal instability. Cell Cycle 13:622–631
    • (2014) Cell Cycle , vol.13 , pp. 622-631
    • Wong, H.W.1    Shaukat, Z.2    Wang, J.3    Saint, R.4    Gregory, S.L.5
  • 189
    • 34848857434 scopus 로고    scopus 로고
    • Transforming growth factor-beta and the immune response: implications for anticancer therapy
    • COI: 1:CAS:528:DC%2BD2sXhtVCitL7K, PID: 17875754
    • Wrzesinski SH, Wan YY, Flavell RA (2007) Transforming growth factor-beta and the immune response: implications for anticancer therapy. Clin Cancer Res 13:5262–5270
    • (2007) Clin Cancer Res , vol.13 , pp. 5262-5270
    • Wrzesinski, S.H.1    Wan, Y.Y.2    Flavell, R.A.3
  • 190
    • 84955365022 scopus 로고    scopus 로고
    • Deregulation of STING signaling in colorectal carcinoma constrains DNA damage responses and correlates with tumorigenesis
    • COI: 1:CAS:528:DC%2BC28XhvFaqtA%3D%3D, PID: 26748708
    • Xia T, Konno H, Ahn J, Barber GN (2016) Deregulation of STING signaling in colorectal carcinoma constrains DNA damage responses and correlates with tumorigenesis. Cell Rep 14:282–297
    • (2016) Cell Rep , vol.14 , pp. 282-297
    • Xia, T.1    Konno, H.2    Ahn, J.3    Barber, G.N.4
  • 191
    • 84863172276 scopus 로고    scopus 로고
    • Haploinsufficiency of SGO1 results in deregulated centrosome dynamics, enhanced chromosomal instability and colon tumorigenesis
    • COI: 1:CAS:528:DC%2BC38Xjs1Krt7s%3D, PID: 22262168
    • Yamada HY, Yao Y, Wang X, Zhang Y, Huang Y, Dai W, Rao CV (2012) Haploinsufficiency of SGO1 results in deregulated centrosome dynamics, enhanced chromosomal instability and colon tumorigenesis. Cell Cycle 11:479–488
    • (2012) Cell Cycle , vol.11 , pp. 479-488
    • Yamada, H.Y.1    Yao, Y.2    Wang, X.3    Zhang, Y.4    Huang, Y.5    Dai, W.6    Rao, C.V.7
  • 193
    • 70349314830 scopus 로고    scopus 로고
    • Extracellular redox modulation by regulatory T cells
    • COI: 1:CAS:528:DC%2BD1MXhtFyisb7K, PID: 19718041
    • Yan Z, Garg SK, Kipnis J, Banerjee R (2009) Extracellular redox modulation by regulatory T cells. Nat Chem Biol 5:721–723
    • (2009) Nat Chem Biol , vol.5 , pp. 721-723
    • Yan, Z.1    Garg, S.K.2    Kipnis, J.3    Banerjee, R.4
  • 194
    • 34948822892 scopus 로고    scopus 로고
    • Pro-inflammatory cytokines increase reactive oxygen species through mitochondria and NADPH oxidase in cultured RPE cells
    • COI: 1:CAS:528:DC%2BD2sXhtFGrsrjO, PID: 17765224
    • Yang D, Elner SG, Bian ZM, Till GO, Petty HR, Elner VM (2007) Pro-inflammatory cytokines increase reactive oxygen species through mitochondria and NADPH oxidase in cultured RPE cells. Exp Eye Res 85:462–472
    • (2007) Exp Eye Res , vol.85 , pp. 462-472
    • Yang, D.1    Elner, S.G.2    Bian, Z.M.3    Till, G.O.4    Petty, H.R.5    Elner, V.M.6
  • 196
    • 84892416698 scopus 로고    scopus 로고
    • Targeting the tumor microenvironment with interferon-beta bridges innate and adaptive immune responses
    • PID: 24434209
    • Yang X, Zhang X, Fu ML, Weichselbaum RR, Gajewski TF, Guo Y, Fu YX (2014) Targeting the tumor microenvironment with interferon-beta bridges innate and adaptive immune responses. Cancer Cell 25:37–48
    • (2014) Cancer Cell , vol.25 , pp. 37-48
    • Yang, X.1    Zhang, X.2    Fu, M.L.3    Weichselbaum, R.R.4    Gajewski, T.F.5    Guo, Y.6    Fu, Y.X.7
  • 197
    • 84971015088 scopus 로고    scopus 로고
    • Activation of the MDA-5-IPS-1 viral sensing pathway induces cancer cell death and type I IFN-dependent antitumor immunity
    • COI: 1:CAS:528:DC%2BC28XmtVahuro%3D, PID: 26893477
    • Yu X, Wang H, Li X, Guo C, Yuan F, Fisher PB, Wang XY (2016) Activation of the MDA-5-IPS-1 viral sensing pathway induces cancer cell death and type I IFN-dependent antitumor immunity. Cancer Res 76:2166–2176
    • (2016) Cancer Res , vol.76 , pp. 2166-2176
    • Yu, X.1    Wang, H.2    Li, X.3    Guo, C.4    Yuan, F.5    Fisher, P.B.6    Wang, X.Y.7
  • 198
    • 84955724289 scopus 로고    scopus 로고
    • The evolving paradigm of cell-nonautonomous UPR-based regulation of immunity by cancer cells
    • COI: 1:CAS:528:DC%2BC28XhtFWhsb8%3D, PID: 25893303
    • Zanetti M, Rodvold JJ, Mahadevan NR (2016) The evolving paradigm of cell-nonautonomous UPR-based regulation of immunity by cancer cells. Oncogene 35:269–278
    • (2016) Oncogene , vol.35 , pp. 269-278
    • Zanetti, M.1    Rodvold, J.J.2    Mahadevan, N.R.3
  • 200
  • 202
    • 84910131670 scopus 로고    scopus 로고
    • Cutting edge: STING mediates protection against colorectal tumorigenesis by governing the magnitude of intestinal inflammation
    • COI: 1:CAS:528:DC%2BC2cXhvVyjtbfJ, PID: 25320273
    • Zhu Q, Man SM, Gurung P, Liu Z, Vogel P, Lamkanfi M, Kanneganti TD (2014) Cutting edge: STING mediates protection against colorectal tumorigenesis by governing the magnitude of intestinal inflammation. J Immunol 193:4779–4782
    • (2014) J Immunol , vol.193 , pp. 4779-4782
    • Zhu, Q.1    Man, S.M.2    Gurung, P.3    Liu, Z.4    Vogel, P.5    Lamkanfi, M.6    Kanneganti, T.D.7
  • 203
    • 0028123367 scopus 로고
    • Effects of hypoxia on interleukin-2 mRNA expression by T lymphocytes
    • COI: 1:STN:280:DyaK2c7jvFehug%3D%3D, PID: 8306676
    • Zuckerberg AL, Goldberg LI, Lederman HM (1994) Effects of hypoxia on interleukin-2 mRNA expression by T lymphocytes. Crit Care Med 22:197–203
    • (1994) Crit Care Med , vol.22 , pp. 197-203
    • Zuckerberg, A.L.1    Goldberg, L.I.2    Lederman, H.M.3


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