RAGE is the major receptor for the proinflammatory activity of HMGB1 in rodent macrophages

Scandinavian Journal of Immunology

Volumn 61, Issue 1, 2005, Pages 1-9

  Kokkola, R ^a   Andersson, A ^b   Mullins, G ^b   Ostberg T ^a   Treutiger, C J ^b   Arnold, B ^c   Nawroth, P ^c   Andersson, U ^b   Harris, R A ^b   Harris, H E ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; CD86 ANTIGEN; CYTOKINE; HIGH MOBILITY GROUP B1 PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1BETA; INTERLEUKIN 6; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ARTICLE; CYTOKINE PRODUCTION; ENZYME ACTIVATION; FEMALE; IN VITRO STUDY; MACROPHAGE; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT; RAT STRAIN;

ANIMALS; ANTIGENS, NEOPLASM; CYTOKINES; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; HIGH MOBILITY GROUP PROTEINS; HISTOCOMPATIBILITY ANTIGENS CLASS II; HMGB1 PROTEIN; INFLAMMATION MEDIATORS; MACROPHAGE ACTIVATION; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; NITRIC OXIDE; PHOSPHORYLATION; RATS; RECEPTORS, CELL SURFACE; RECEPTORS, IMMUNOLOGIC; RECEPTORS, INTERLEUKIN-1; RECEPTORS, INTERLEUKIN-1 TYPE I; RECOMBINANT PROTEINS; REPRESSOR PROTEINS; TOLL-LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR-ALPHA;

EID: 19944431800     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0300-9475.2005.01534.x     Document Type: Article

References (32)

1. Bustin M. Revised nomenclature for high mobility group (HMG) chromosomal proteins. Trends Biochem Sci 2001;26 (3):152-3.
2. Bustin M, Lehn DA, Landsman D. Structural features of the HMG chromosomal proteins and their genes. Biochim Biophys Acta 1990;1049 (3):231-43.
3. Mosevitsky MI, Novitskaya VA, Iogannsen MG, Zaberhinsky MA. Tissue specificity of nucleo-cytoplasmic distribution of HMG1 and HMG2 proteins and their probable functions. Eur J Biochem 1989;185 (2):303-10.
4. Vaccari T, Beltrame M, Ferrari S, Bianchi ME. Hmg4, a new member of the Hmg1/2 gene family. Genomics 1998;49 (2): 247-52.
5. Bustin M, Reeves R. High-mobility-group chromosomal proteins: architectural components that facilitate chromatin function. Prog Nucleic Acid Res Mol Biol 1996;54:35-100.
6. Bustin M. Regulation of DNA-dependent activities by the functional motifs of the high-mobility-group chromosomal proteins. Mol Cell Biol 1999;19 (8):5237-46.
7. Bianchi ME, Beltrame M. Upwardly mobile proteins. Workshop: the role of HMG proteins in chromatin structure, gene expression and neoplasia. EMBO Rep 2000;1 (2):109-14.
8. Wang H, Vishnubhakar JM, Bloom O et al. Proinflammatory cytokines (tumor necrosis factor and interleukin 1) stimulate release of high mobility group protein-1 by pituicytes. Surgery 1999;126 (2):389-92.
9. Gardella S, Andrei C, Ferrera D et al. The nuclear protein HMGB1 is secreted by monocytes via a non-classical, vesicle-mediated secretory pathway. EMBO Rep 2002;3 (10):995-1001.
10. Andersson U, Wang H, Palmblad K et al. High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes. J Exp Med 2000;192 (4):565-70.
11. Muller S, Scaffidi P, Degryse B et al. New EMBO members' review: the double life of HMGB1 chromatin protein: architectural factor and extracellular signal. Embo J 2001;20 (16):4337-40.
12. Scaffidi P, Misteli T, Bianchi ME. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 2002;418 (6894):191-5.
13. Czura CJ, Tracey KJ. Targeting high mobility group box 1 as a late-acting mediator of inflammation. Crit Care Med 2003;31 (1):S46-50.
14. Wang H, Bloom O, Zhang M et al. HMG-1 as a late mediator of endotoxin lethality in mice. Science 1999;285 (5425):248-51.
15. Wang H, Yang H, Czura CJ, Sama AE, Tracey KJ. HMGB1 as a late mediator of lethal systemic inflammation. Am J Respir Crit Care Med 2001;164 (10 Part 1):1768-73.
16. Abraham E, Arcaroli J, Carmody A, Wang H, Tracey KJ. Cutting edge: HMG-1 as a mediator of acute lung inflammation. J Immunol 2000;165 (6):2950-4.
17. Ombrellino M, Wang H, Ajemian MS et al. Increased serum concentrations of high-mobility-group protein 1 in haemorrhagic shock. Lancet 1999;354 (9188):1446-7.
18. Kokkola R, Sundberg E, Ulfgren AK et al. High mobility group box chromosomal protein 1: a novel proinflammatory mediator in synovitis. Arthritis Rheum 2002;46 (10):2598-603.
19. Degryse B, Bonaldi T, Scaffidi P et al. The high mobility group (HMG) boxes of the nuclear protein HMG1 induce chemotaxis and cytoskeleton reorganization in rat smooth muscle cells. J Cell Biol 2001;152 (6):1197-206.
20. Huttunen HJ, Fages C, Rauvala H. Receptor for advanced glycation end products (RAGE)-mediated neurite outgrowth and activation of NF-kappaB require the cytoplasmic domain of the receptor but different downstream signaling pathways. J Biol Chem 1999;274 (28):19919-24.
21. Treutiger CJ, Mullins GE, Johansson AS et al. High mobility group 1 B-box mediates activation of human endothelium. J Intern Med 2003;254 (4):375-85.
22. Fiuza C, Bustin M, Talwar S et al. Inflammatory promoting activity of HMGB1 on human microvascular endothelial cells. Blood 2002;27:27.
23. Hori O, Brett J, Slattery T et al. The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. Mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous system. J Biol Chem 1995;270 (43):25752-61.
24. Taguchi A, Blood DC, del Toro G et al. Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases. Nature 2000;405 (6784):354-60.
25. Brickman JM, Adam M, Prashne M. Interactions between an HMG-1 protein and members of the Rel family. Proc Natl Acad Sci USA 1999;96 (19):10679-83.
26. Zetterstrom CK, Carlsson-Skwirut C, Andersson U, Soder O. High mobility group box chromosomal protein 1 (HMGB1) activates T lymphocytes by interaction with interleukin-1 receptor type I. PhD Thesis. Karolinska Institutet, 2001.
27. Park JS, Svetkauskaite D, He Q, et al. Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein. J Biol Chem 2004;279:7370-7.
28. Li J, Kokkola R, Tabibzadeh S et al. Structural basis for the proinflammatory cytokine activity of high mobility group box 1. Mol Med 2003;9 (1-2):37-45.
29. Czura CJ, Wang H, Tracey KJ. Dual roles for HMGB1: DNA binding and cytokine. J Endotoxin Res 2001;7 (4):315-21.
30. Yang H, Wang H, Tracey KJ. HMG-1 rediscovered as a cytokine. Shock 2001;15 (4):247.
31. Sass G, Koetber K, Bang R, Guehring H, Tiegs G. Inducible nitric oxide synthase is critical for immune-mediated liver injury in mice. J Clin Invest 2001;107 (4):439-47.
32. Menezes JM, Hietholzer C, Watkins SC, Billiat TR, Peitzman AB, Harbtecht BG. The modulation of hepatic injury and heat shock expression by inhibition of inducible nitric oxide synthase after hemorrhagic shock. Shock 2002;17 (1):13-8.