Immunogenic cell death of human ovarian cancer cells induced by cytosolic poly(I:C) leads to myeloid cell maturation and activates NK cells

European Journal of Immunology

Volumn 41, Issue 10, 2011, Pages 3028-3039

  Kübler, Kirsten ^a   tho Pesch, Carola ^a   Gehrke, Nadine ^a   Riemann, Soheila ^a   Daßler, Juliane ^a   Coch, Christoph ^a   Landsberg, Jennifer ^a   Wimmenauer, Vera ^a   Pölcher, Martin ^a   Rudlowski, Christian ^a   Tüting, Thomas ^a   Kuhn, Walther ^a   Hartmann, Gunther ^a   Barchet, Winfried ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

Innate immunity; MDA 5; Ovarian cancer; Poly(I:C); Tumor immunogenicity

Indexed keywords

ALPHA INTERFERON; DOUBLE STRANDED RNA; DOXORUBICIN; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GENE PRODUCT; HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 2; INTERLEUKIN 6; MELANOMA DIFFERENTIATION ASSOCIATED GENE 5 PROTEIN; PACLITAXEL; POLYADENYLIC ACID; POLYINOSINIC POLYCYTIDYLIC ACID; TUMOR CELL VACCINE; UNCLASSIFIED DRUG; VIRUS RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; ASCITES; BONE MARROW CELL; CANCER IMMUNOTHERAPY; CANCER RELAPSE; CELL ACTIVATION; CELL MATURATION; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOLYSIS; CYTOSOL; DRUG DELIVERY SYSTEM; ELECTROPORATION; FEMALE; GENE ACTIVATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOGENICITY; IMMUNOSTIMULATION; INFLAMMATION; MONOCYTE; MOUSE; NATURAL KILLER CELL; NONHUMAN; OVARY CANCER; PRIORITY JOURNAL; SENSOR; SIGNAL TRANSDUCTION; SOMATIC CELL; TUMOR IMMUNITY; UPREGULATION;

ANIMALS; APOPTOSIS; ASCITES; CHEMOKINE CXCL10; DEAD-BOX RNA HELICASES; DENDRITIC CELLS; ELECTROPORATION; FEMALE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; INTERFERON TYPE I; INTERFERON-ALPHA; INTERLEUKIN-6; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; LYMPHOCYTE SUBSETS; LYMPHOCYTES, TUMOR-INFILTRATING; MICE; MICE, INBRED C57BL; MONOCYTES; MYELOID CELLS; OVARIAN NEOPLASMS; POLY I-C; TRANSFECTION;

EID: 80053152683     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201141555     Document Type: Article

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