메뉴 건너뛰기




Volumn 358, Issue 1, 2015, Pages 1-7

Lactate dehydrogenase 5: An old friend and a new hope in the war on cancer

Author keywords

Aerobic glycolysis; Cancer metabolism; Lactate dehydrogenase 5 (LDH 5)

Indexed keywords

1 HYDROXY 6 PHENYL 4 (TRIFLUOROMETHYL) 1H INDOL 2 CARBOXYLIC ACID; 3 DIHYDROXY 6 METHYL 7 (PHENYLMETHYL)4 PROPYLNAPHTHALENE 1 CARBOXYLIC ACID; 3 [[3 CARBAMOYL 7 (3,5 DIMETHYLISOXAZOL 4 YL) 6 METHOXYQUINOLIN 4 YL]AMINO]BENZOIC ACID; CHINESE GALL EXTRACT; ENZYME INHIBITOR; LACTATE DEHYDROGENASE; LACTATE DEHYDROGENASE 5; LACTATE DEHYDROGENASE 5 INHIBITOR; LACTATE DEHYDROGENASE ISOENZYME; METHYL 1 HYDROXY 6 PHENYL 4 (TRIFLUOROMETHYL) 1H INDOL 2 CARBOXYLATE; PLANT EXTRACT; SPATHOLOBUS SUBERECTUS EXTRACT; TUMOR MARKER; UNCLASSIFIED DRUG; ISOENZYME;

EID: 84921409248     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2014.12.035     Document Type: Review
Times cited : (195)

References (96)
  • 1
    • 84860512005 scopus 로고    scopus 로고
    • Links between metabolism and cancer
    • Dang C.V. Links between metabolism and cancer. Genes Dev 2012, 26(9):877-890.
    • (2012) Genes Dev , vol.26 , Issue.9 , pp. 877-890
    • Dang, C.V.1
  • 2
    • 8144228566 scopus 로고    scopus 로고
    • Why do cancers have high aerobic glycolysis?
    • Gatenby R.A., Gillies R.J. Why do cancers have high aerobic glycolysis?. Nat. Rev. Cancer 2004, 4:891-899.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 891-899
    • Gatenby, R.A.1    Gillies, R.J.2
  • 3
    • 0030460724 scopus 로고    scopus 로고
    • Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1
    • Semenza G.L., Jiang B.H., Leung S.W., Passantino R., et al. Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. J. Biol. Chem 1996, 271(51):32529-32537.
    • (1996) J. Biol. Chem , vol.271 , Issue.51 , pp. 32529-32537
    • Semenza, G.L.1    Jiang, B.H.2    Leung, S.W.3    Passantino, R.4
  • 4
    • 0030921103 scopus 로고    scopus 로고
    • C-Myc transactivation of LDH-A: implications for tumor metabolism and growth
    • Shim H., Dolde C., Lewis B.C., Wu C.S., et al. c-Myc transactivation of LDH-A: implications for tumor metabolism and growth. Proc. Natl. Acad. Sci. U.S.A. 1997, 94(13):6658-6663.
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , Issue.13 , pp. 6658-6663
    • Shim, H.1    Dolde, C.2    Lewis, B.C.3    Wu, C.S.4
  • 5
    • 84867097473 scopus 로고    scopus 로고
    • Knockdown of lactate dehydrogenase A suppresses tumor growth and metastasis of human hepatocellular carcinoma
    • Sheng S.L., Liu J.J., Dai Y.H., Sun X.G., et al. Knockdown of lactate dehydrogenase A suppresses tumor growth and metastasis of human hepatocellular carcinoma. FEBS J. 2012, 279(20):3898-3910.
    • (2012) FEBS J. , vol.279 , Issue.20 , pp. 3898-3910
    • Sheng, S.L.1    Liu, J.J.2    Dai, Y.H.3    Sun, X.G.4
  • 6
    • 0014060889 scopus 로고
    • Lactate dehydrogenase isoenzymes a comparison of pyruvate-to-lactate and lactate-to-pyruvate assays
    • Krieg A.F., Rosenblum L.J., Henry J.B. Lactate dehydrogenase isoenzymes a comparison of pyruvate-to-lactate and lactate-to-pyruvate assays. Clin. Chem 1967, 13(3):196-203.
    • (1967) Clin. Chem , vol.13 , Issue.3 , pp. 196-203
    • Krieg, A.F.1    Rosenblum, L.J.2    Henry, J.B.3
  • 7
    • 0015009623 scopus 로고
    • Immunochemical specificity of lactate dehydrogenase-X
    • Goldberg E. Immunochemical specificity of lactate dehydrogenase-X. Proc. Natl. Acad. Sci. U.S.A. 1971, 68(2):349-352.
    • (1971) Proc. Natl. Acad. Sci. U.S.A. , vol.68 , Issue.2 , pp. 349-352
    • Goldberg, E.1
  • 8
    • 0030594816 scopus 로고    scopus 로고
    • Methods for the separation of lactate dehydrogenases and clinical significance of the enzyme
    • Kopperschläger G., Kirchberger J. Methods for the separation of lactate dehydrogenases and clinical significance of the enzyme. J. Chromatogr. B. Biomed Appl 1996, 684(1-2):25-49.
    • (1996) J. Chromatogr. B. Biomed Appl , vol.684 , Issue.1-2 , pp. 25-49
    • Kopperschläger, G.1    Kirchberger, J.2
  • 9
    • 0022894808 scopus 로고
    • Lactate dehydrogenase and glyceraldehyde-phosphate dehydrogenase are single-stranded DNA-binding proteins that affect the DNA-polymerase-alpha-primase complex
    • Grosse F., Nasheuer H.P., Scholtissek S., Schomburg U. Lactate dehydrogenase and glyceraldehyde-phosphate dehydrogenase are single-stranded DNA-binding proteins that affect the DNA-polymerase-alpha-primase complex. Eur. J. Biochem 1986, 160(3):459-467.
    • (1986) Eur. J. Biochem , vol.160 , Issue.3 , pp. 459-467
    • Grosse, F.1    Nasheuer, H.P.2    Scholtissek, S.3    Schomburg, U.4
  • 10
    • 0021254544 scopus 로고
    • Phosphorylation sites in enolase and lactate dehydrogenase utilized by tyrosine protein kinases in vivo and in vitro
    • Cooper J.A., Esch F.S., Taylor S.S., Hunter T. Phosphorylation sites in enolase and lactate dehydrogenase utilized by tyrosine protein kinases in vivo and in vitro. J. Biol. Chem 1984, 259(12):7835-7841.
    • (1984) J. Biol. Chem , vol.259 , Issue.12 , pp. 7835-7841
    • Cooper, J.A.1    Esch, F.S.2    Taylor, S.S.3    Hunter, T.4
  • 11
    • 83255171153 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of lactate dehydrogenase A is important for NADH/NAD(+) redox homeostasis in cancer cells
    • Fan J., Hitosugi T., Chung T.W., Xie J., et al. Tyrosine phosphorylation of lactate dehydrogenase A is important for NADH/NAD(+) redox homeostasis in cancer cells. Mol. Cell. Biol 2011, 31(24):4938-4950.
    • (2011) Mol. Cell. Biol , vol.31 , Issue.24 , pp. 4938-4950
    • Fan, J.1    Hitosugi, T.2    Chung, T.W.3    Xie, J.4
  • 12
    • 84880788592 scopus 로고    scopus 로고
    • LDH-A acetylation: implication in cancer
    • Zhao D., Xiong Y., Lei Q.Y., Guan K.L. LDH-A acetylation: implication in cancer. Oncotarget 2013, 4(6):802-803.
    • (2013) Oncotarget , vol.4 , Issue.6 , pp. 802-803
    • Zhao, D.1    Xiong, Y.2    Lei, Q.Y.3    Guan, K.L.4
  • 13
    • 84876417170 scopus 로고    scopus 로고
    • Lysine-5 acetylation negatively regulates lactate dehydrogenase A and is decreased in pancreatic cancer
    • Zhao D., Zou S.W., Liu Y., Zhou X., et al. Lysine-5 acetylation negatively regulates lactate dehydrogenase A and is decreased in pancreatic cancer. Cancer Cell 2013, 23(4):464-476.
    • (2013) Cancer Cell , vol.23 , Issue.4 , pp. 464-476
    • Zhao, D.1    Zou, S.W.2    Liu, Y.3    Zhou, X.4
  • 14
    • 0022423138 scopus 로고
    • Epidermal growth factor or serum stimulation of rat fibroblasts induces an elevation in mRNA levels for lactate dehydrogenase and other glycolytic enzymes
    • Matrisian L.M., Rautmann G., Magun B.E., Breathnach R. Epidermal growth factor or serum stimulation of rat fibroblasts induces an elevation in mRNA levels for lactate dehydrogenase and other glycolytic enzymes. Nucleic Acids Res 1985, 13(3):711-726.
    • (1985) Nucleic Acids Res , vol.13 , Issue.3 , pp. 711-726
    • Matrisian, L.M.1    Rautmann, G.2    Magun, B.E.3    Breathnach, R.4
  • 15
    • 0032851247 scopus 로고    scopus 로고
    • Epidermal growth factor regulates glucose metabolism through lactate dehydrogenase A messenger ribonucleic acid expression in cultured porcine Sertoli cells
    • Boussouar F., Benahmed M. Epidermal growth factor regulates glucose metabolism through lactate dehydrogenase A messenger ribonucleic acid expression in cultured porcine Sertoli cells. Biol. Reprod 1999, 61(4):1139-1145.
    • (1999) Biol. Reprod , vol.61 , Issue.4 , pp. 1139-1145
    • Boussouar, F.1    Benahmed, M.2
  • 16
    • 0033304798 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha stimulates lactate dehydrogenase A expression in porcine cultured sertoli cells: mechanisms of action
    • Boussouar F., Grataroli R., Ji J., Benahmed M. Tumor necrosis factor-alpha stimulates lactate dehydrogenase A expression in porcine cultured sertoli cells: mechanisms of action. Endocrinology 1999, 140(7):3054-3062.
    • (1999) Endocrinology , vol.140 , Issue.7 , pp. 3054-3062
    • Boussouar, F.1    Grataroli, R.2    Ji, J.3    Benahmed, M.4
  • 17
    • 0032561344 scopus 로고    scopus 로고
    • Protein kinase A stimulates binding of multiple proteins to a U-rich domain in the 3'-untranslated region of lactate dehydrogenase A mRNA that is required for the regulation of mRNA stability
    • Tian D., Huang D., Brown R.C., Jungmann R.A. Protein kinase A stimulates binding of multiple proteins to a U-rich domain in the 3'-untranslated region of lactate dehydrogenase A mRNA that is required for the regulation of mRNA stability. J. Biol. Chem 1998, 273(43):28454-28460.
    • (1998) J. Biol. Chem , vol.273 , Issue.43 , pp. 28454-28460
    • Tian, D.1    Huang, D.2    Brown, R.C.3    Jungmann, R.A.4
  • 18
    • 0028929573 scopus 로고
    • Transcriptional regulation of the lactate dehydrogenase A subunit gene by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate
    • Huang D., Jungmann R.A. Transcriptional regulation of the lactate dehydrogenase A subunit gene by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate. Mol. Cell. Endocrinol 1995, 108(1-2):87-94.
    • (1995) Mol. Cell. Endocrinol , vol.108 , Issue.1-2 , pp. 87-94
    • Huang, D.1    Jungmann, R.A.2
  • 19
    • 0028099552 scopus 로고
    • Analysis of the rat lactate dehydrogenase A subunit gene promoter/regulatory region
    • Short M.L., Huang D., Milkowski D.M., Short S., et al. Analysis of the rat lactate dehydrogenase A subunit gene promoter/regulatory region. Biochem. J. 1994, 304(Pt 2):391-398.
    • (1994) Biochem. J. , vol.304 , pp. 391-398
    • Short, M.L.1    Huang, D.2    Milkowski, D.M.3    Short, S.4
  • 20
    • 0033571682 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases
    • Zhong H., De Marzo A.M., Laughner E., Lim M., et al. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res 1999, 59(22):5830-5835.
    • (1999) Cancer Res , vol.59 , Issue.22 , pp. 5830-5835
    • Zhong, H.1    De Marzo, A.M.2    Laughner, E.3    Lim, M.4
  • 21
    • 0141730410 scopus 로고    scopus 로고
    • Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis
    • Tumour and Angiogenesis Research Group
    • Koukourakis M.I., Giatromanolaki A., Sivridis E., Bougioukas G., et al. Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis. Br. J. Cancer 2003, 89(5):877-885. Tumour and Angiogenesis Research Group.
    • (2003) Br. J. Cancer , vol.89 , Issue.5 , pp. 877-885
    • Koukourakis, M.I.1    Giatromanolaki, A.2    Sivridis, E.3    Bougioukas, G.4
  • 22
    • 48149091757 scopus 로고    scopus 로고
    • Lactate dehydrogenase-5 (LDH-5) expression in human gastric cancer: association with hypoxia-inducible factor (HIF-1alpha) pathway, angiogenic factors production and poor prognosis
    • Kolev Y., Uetake H., Takagi Y., Sugihara K. Lactate dehydrogenase-5 (LDH-5) expression in human gastric cancer: association with hypoxia-inducible factor (HIF-1alpha) pathway, angiogenic factors production and poor prognosis. Ann. Surg. Oncol 2008, 15(8):2336-2344.
    • (2008) Ann. Surg. Oncol , vol.15 , Issue.8 , pp. 2336-2344
    • Kolev, Y.1    Uetake, H.2    Takagi, Y.3    Sugihara, K.4
  • 24
    • 84871712505 scopus 로고    scopus 로고
    • Regulation of angiogenesis by hypoxia: the role of microRNA
    • Madanecki P., Kapoor N., Bebok Z., Ochocka R., et al. Regulation of angiogenesis by hypoxia: the role of microRNA. Cell. Mol. Biol. Lett 2013, 18(1):47-57.
    • (2013) Cell. Mol. Biol. Lett , vol.18 , Issue.1 , pp. 47-57
    • Madanecki, P.1    Kapoor, N.2    Bebok, Z.3    Ochocka, R.4
  • 25
    • 79960040020 scopus 로고    scopus 로고
    • MicroRNA in cancer: the involvement of aberrant MicroRNA biogenesis regulatory pathways
    • Davis-Dusenbery B.N., Hata A. MicroRNA in cancer: the involvement of aberrant MicroRNA biogenesis regulatory pathways. Genes Cancer 2010, 1(11):1100-1114.
    • (2010) Genes Cancer , vol.1 , Issue.11 , pp. 1100-1114
    • Davis-Dusenbery, B.N.1    Hata, A.2
  • 26
    • 84869159093 scopus 로고    scopus 로고
    • Roles of microRNA on cancer cell metabolism
    • Chen B., Li H., Zeng X., Yang P., Liu X., et al. Roles of microRNA on cancer cell metabolism. J. Transl. Med 2012, 10:2-28.
    • (2012) J. Transl. Med , vol.10 , pp. 2-28
    • Chen, B.1    Li, H.2    Zeng, X.3    Yang, P.4    Liu, X.5
  • 27
    • 84455163058 scopus 로고    scopus 로고
    • Tumor suppressive microRNA-375 regulates lactate dehydrogenase B in maxillary sinus squamous cell carcinoma
    • Kinoshita T., Nohata N., Yoshino H., Hanazawa T., et al. Tumor suppressive microRNA-375 regulates lactate dehydrogenase B in maxillary sinus squamous cell carcinoma. Int. J. Oncol 2012, 40(1):85-93.
    • (2012) Int. J. Oncol , vol.40 , Issue.1 , pp. 85-93
    • Kinoshita, T.1    Nohata, N.2    Yoshino, H.3    Hanazawa, T.4
  • 28
    • 80051613002 scopus 로고    scopus 로고
    • Genome-wide characterization of miR-34a induced changes in protein and mRNA expression by a combined pulsed SILAC and microarray analysis
    • M111.010462
    • Kaller M., Liffers S.T., Oeljeklaus S., Kuhlmann K., et al. Genome-wide characterization of miR-34a induced changes in protein and mRNA expression by a combined pulsed SILAC and microarray analysis. Mol. Cell. Proteomics 2011, 10(8). M111.010462.
    • (2011) Mol. Cell. Proteomics , vol.10 , Issue.8
    • Kaller, M.1    Liffers, S.T.2    Oeljeklaus, S.3    Kuhlmann, K.4
  • 29
    • 49749126791 scopus 로고    scopus 로고
    • Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer
    • Lodygin D., Tarasov V., Epanchintsev A., Berking C., et al. Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer. Cell Cycle 2008, 7(16):2591-2600.
    • (2008) Cell Cycle , vol.7 , Issue.16 , pp. 2591-2600
    • Lodygin, D.1    Tarasov, V.2    Epanchintsev, A.3    Berking, C.4
  • 30
    • 84921346624 scopus 로고    scopus 로고
    • Metabolic myopathies; clinical, biochemical, genetic and histopathological basis of diagnosis
    • Srivastava N.K., Yadav R., Pradhan S. Metabolic myopathies; clinical, biochemical, genetic and histopathological basis of diagnosis. Ann. Neurosci 2005, 12(4):87-98.
    • (2005) Ann. Neurosci , vol.12 , Issue.4 , pp. 87-98
    • Srivastava, N.K.1    Yadav, R.2    Pradhan, S.3
  • 31
    • 0026638649 scopus 로고
    • Hereditary lactate dehydrogenase A-subunit deficiency as cause of early postimplantation death of homozygotes in Mus musculus
    • Merkle S., Favor J., Graw J., Hornhardt S., Pretsch W. Hereditary lactate dehydrogenase A-subunit deficiency as cause of early postimplantation death of homozygotes in Mus musculus. Genetics 1992, 131(2):413-421.
    • (1992) Genetics , vol.131 , Issue.2 , pp. 413-421
    • Merkle, S.1    Favor, J.2    Graw, J.3    Hornhardt, S.4    Pretsch, W.5
  • 32
    • 0029318475 scopus 로고
    • Characterization of the oxidative metabolism in lactate dehydrogenase A deficiency
    • Miyajima H., Takahashi Y., Kaneko E. Characterization of the oxidative metabolism in lactate dehydrogenase A deficiency. Intern. Med 1995, 34(6):502-506.
    • (1995) Intern. Med , vol.34 , Issue.6 , pp. 502-506
    • Miyajima, H.1    Takahashi, Y.2    Kaneko, E.3
  • 33
    • 0031748828 scopus 로고    scopus 로고
    • The contribution of lactic acid to acidification of tumours: studies of variant cells lacking lactate dehydrogenase
    • Yamagata M., Hasuda K., Stamato T., Tannock I.F. The contribution of lactic acid to acidification of tumours: studies of variant cells lacking lactate dehydrogenase. Br. J. Cancer 1998, 77(11):1726-1731.
    • (1998) Br. J. Cancer , vol.77 , Issue.11 , pp. 1726-1731
    • Yamagata, M.1    Hasuda, K.2    Stamato, T.3    Tannock, I.F.4
  • 34
    • 0018730143 scopus 로고
    • Serum lactic dehydrogenase as a prognostic tool for non-Hodgkin lymphomas
    • Ferraris A.M., Giuntini P., Gaetani G.F. Serum lactic dehydrogenase as a prognostic tool for non-Hodgkin lymphomas. Blood 1979, 54(4):928-932.
    • (1979) Blood , vol.54 , Issue.4 , pp. 928-932
    • Ferraris, A.M.1    Giuntini, P.2    Gaetani, G.F.3
  • 35
    • 0027374105 scopus 로고
    • Serum lactate dehydrogenase level as a prognostic factor in Hodgkin's disease
    • García R., Hernández J.M., Caballero M.D., González M., et al. Serum lactate dehydrogenase level as a prognostic factor in Hodgkin's disease. Br. J. Cancer 1993, 68(6):1227-1231.
    • (1993) Br. J. Cancer , vol.68 , Issue.6 , pp. 1227-1231
    • García, R.1    Hernández, J.M.2    Caballero, M.D.3    González, M.4
  • 36
    • 16544386245 scopus 로고    scopus 로고
    • Profiles and prognostic values of serum LDH isoenzymes in patients with haematopoietic malignancies
    • Bouafia F., Drai J., Bienvenu J., Thieblemont C., et al. Profiles and prognostic values of serum LDH isoenzymes in patients with haematopoietic malignancies. Bull. Cancer 2004, 91(7-8):E229-E240.
    • (2004) Bull. Cancer , vol.91 , Issue.7-8 , pp. E229-E240
    • Bouafia, F.1    Drai, J.2    Bienvenu, J.3    Thieblemont, C.4
  • 37
    • 84856138810 scopus 로고    scopus 로고
    • Increased serum lactate dehydrongenase should be included among the variables that define very-high-risk multiple myeloma
    • Gkotzamanidou M., Kastritis E., Gavriatopoulou M.R., Nikitas N., et al. Increased serum lactate dehydrongenase should be included among the variables that define very-high-risk multiple myeloma. Clin. Lymphoma Myeloma Leuk 2011, 11(5):409-413.
    • (2011) Clin. Lymphoma Myeloma Leuk , vol.11 , Issue.5 , pp. 409-413
    • Gkotzamanidou, M.1    Kastritis, E.2    Gavriatopoulou, M.R.3    Nikitas, N.4
  • 38
    • 84884516363 scopus 로고    scopus 로고
    • Lactate dehydrogenase 5 expression in non-Hodgkin lymphoma is associated with the induced hypoxia regulated protein and poor prognosis
    • Lu R., Jiang M., Chen Z., Xu X., et al. Lactate dehydrogenase 5 expression in non-Hodgkin lymphoma is associated with the induced hypoxia regulated protein and poor prognosis. PLoS ONE 2013, 8(9):e74853.
    • (2013) PLoS ONE , vol.8 , Issue.9 , pp. e74853
    • Lu, R.1    Jiang, M.2    Chen, Z.3    Xu, X.4
  • 39
    • 78649986923 scopus 로고    scopus 로고
    • Lactate dehydrogenase as prognostic factor in limited and extensive disease stage small cell lung cancer - a retrospective single institution analysis
    • Hermes A., Gatzemeier U., Waschki B., Reck M. Lactate dehydrogenase as prognostic factor in limited and extensive disease stage small cell lung cancer - a retrospective single institution analysis. Respir. Med 2010, 104(12):1937-1942.
    • (2010) Respir. Med , vol.104 , Issue.12 , pp. 1937-1942
    • Hermes, A.1    Gatzemeier, U.2    Waschki, B.3    Reck, M.4
  • 40
    • 77954696788 scopus 로고    scopus 로고
    • High serum lactate dehydrogenase adds prognostic value to the international myeloma staging system even in the era of novel agents
    • Terpos E., Katodritou E., Roussou M., Pouli A., et al. High serum lactate dehydrogenase adds prognostic value to the international myeloma staging system even in the era of novel agents. Eur. J. Haematol 2010, 85(2):114-119.
    • (2010) Eur. J. Haematol , vol.85 , Issue.2 , pp. 114-119
    • Terpos, E.1    Katodritou, E.2    Roussou, M.3    Pouli, A.4
  • 41
    • 84857790397 scopus 로고    scopus 로고
    • Pre-treatment lactate dehydrogenase levels as predictor of efficacy of first-line bevacizumab-based therapy in metastatic colorectal cancer patients
    • Scartozzi M., Giampieri R., Maccaroni E., Del Prete M., et al. Pre-treatment lactate dehydrogenase levels as predictor of efficacy of first-line bevacizumab-based therapy in metastatic colorectal cancer patients. Br. J. Cancer 2012, 106(5):799-804.
    • (2012) Br. J. Cancer , vol.106 , Issue.5 , pp. 799-804
    • Scartozzi, M.1    Giampieri, R.2    Maccaroni, E.3    Del Prete, M.4
  • 42
    • 84876134099 scopus 로고    scopus 로고
    • Serum lactic dehydrogenase strongly predicts survival in metastatic nasopharyngeal carcinoma treated with palliative chemotherapy
    • Jin Y., Ye X., Shao L., Lin B.C., et al. Serum lactic dehydrogenase strongly predicts survival in metastatic nasopharyngeal carcinoma treated with palliative chemotherapy. Eur. J. Cancer 2013, 49(7):1619-1626.
    • (2013) Eur. J. Cancer , vol.49 , Issue.7 , pp. 1619-1626
    • Jin, Y.1    Ye, X.2    Shao, L.3    Lin, B.C.4
  • 43
    • 84878390914 scopus 로고    scopus 로고
    • High pretreatment serum lactate dehydrogenase level correlates with disease relapse and predicts an inferior outcome in locally advanced nasopharyngeal carcinoma
    • Wan X.B., Wei L., Li H., Dong M., et al. High pretreatment serum lactate dehydrogenase level correlates with disease relapse and predicts an inferior outcome in locally advanced nasopharyngeal carcinoma. Eur. J. Cancer 2013, 49(10):2356-2364.
    • (2013) Eur. J. Cancer , vol.49 , Issue.10 , pp. 2356-2364
    • Wan, X.B.1    Wei, L.2    Li, H.3    Dong, M.4
  • 44
    • 84907376447 scopus 로고    scopus 로고
    • Initial LDH level can predict the survival benefit from bevacizumab in the first-line setting in Chinese patients with metastatic colorectal cancer
    • Yin C., Jiang C., Liao F., Rong Y., et al. Initial LDH level can predict the survival benefit from bevacizumab in the first-line setting in Chinese patients with metastatic colorectal cancer. Onco Targets Ther 2014, 7:1415-1422.
    • (2014) Onco Targets Ther , vol.7 , pp. 1415-1422
    • Yin, C.1    Jiang, C.2    Liao, F.3    Rong, Y.4
  • 45
    • 84858855476 scopus 로고    scopus 로고
    • The role of LDH serum levels in predicting global outcome in HCC patients undergoing TACE: implications for clinical management
    • Scartozzi M., Faloppi L., Bianconi M., Giampieri R., et al. The role of LDH serum levels in predicting global outcome in HCC patients undergoing TACE: implications for clinical management. PLoS ONE 2012, 7(3):e32653.
    • (2012) PLoS ONE , vol.7 , Issue.3 , pp. e32653
    • Scartozzi, M.1    Faloppi, L.2    Bianconi, M.3    Giampieri, R.4
  • 46
    • 84894320606 scopus 로고    scopus 로고
    • The role of LDH serum levels in predicting global outcome in HCC patients treated with sorafenib: implications for clinical management
    • Faloppi L., Scartozzi M., Bianconi M., Svegliati Baroni G., et al. The role of LDH serum levels in predicting global outcome in HCC patients treated with sorafenib: implications for clinical management. BMC Cancer 2014, 14(110):2-8.
    • (2014) BMC Cancer , vol.14 , Issue.110 , pp. 2-8
    • Faloppi, L.1    Scartozzi, M.2    Bianconi, M.3    Svegliati Baroni, G.4
  • 47
    • 0017202011 scopus 로고
    • Prognostic usefulness of serum lactic dehydrogenase and its fifth isoenzyme levels in carcinoma of the prostate
    • Ishibe T. Prognostic usefulness of serum lactic dehydrogenase and its fifth isoenzyme levels in carcinoma of the prostate. Int. Urol. Nephrol 1976, 8(3):221-225.
    • (1976) Int. Urol. Nephrol , vol.8 , Issue.3 , pp. 221-225
    • Ishibe, T.1
  • 48
    • 84866761624 scopus 로고    scopus 로고
    • Serum lactate dehydrogenase predicts for overall survival benefit in patients with metastatic renal cell carcinoma treated with inhibition of mammalian target of rapamycin
    • Armstrong A.J., George D.J., Halabi S. Serum lactate dehydrogenase predicts for overall survival benefit in patients with metastatic renal cell carcinoma treated with inhibition of mammalian target of rapamycin. J. Clin. Oncol 2012, 30(27):3402-3407.
    • (2012) J. Clin. Oncol , vol.30 , Issue.27 , pp. 3402-3407
    • Armstrong, A.J.1    George, D.J.2    Halabi, S.3
  • 49
    • 0032896712 scopus 로고    scopus 로고
    • Lactate dehydrogenase isoenzyme analysis for the diagnosis of pleural effusion in haemato-oncological patients
    • Lossos I.S., Intrator O., Berkman N., Breuer R. Lactate dehydrogenase isoenzyme analysis for the diagnosis of pleural effusion in haemato-oncological patients. Respir. Med 1999, 93(5):338-341.
    • (1999) Respir. Med , vol.93 , Issue.5 , pp. 338-341
    • Lossos, I.S.1    Intrator, O.2    Berkman, N.3    Breuer, R.4
  • 50
    • 12344274314 scopus 로고    scopus 로고
    • The utility of lactate dehydrogenase isoenzyme pattern in the diagnostic evaluation of malignant and nonmalignant ascites
    • Sevinc A., Sari R., Fadillioglu E. The utility of lactate dehydrogenase isoenzyme pattern in the diagnostic evaluation of malignant and nonmalignant ascites. J. Natl Med. Assoc 2005, 97(1):79-84.
    • (2005) J. Natl Med. Assoc , vol.97 , Issue.1 , pp. 79-84
    • Sevinc, A.1    Sari, R.2    Fadillioglu, E.3
  • 51
    • 0025906355 scopus 로고
    • The diagnostic significance of lactate dehydrogenase isoenzymes in urinary cytology
    • Nishikawa A., Tanaka T., Takeuchi T., Fujihiro S., Mori H. The diagnostic significance of lactate dehydrogenase isoenzymes in urinary cytology. Br. J. Cancer 1991, 63(5):819-821.
    • (1991) Br. J. Cancer , vol.63 , Issue.5 , pp. 819-821
    • Nishikawa, A.1    Tanaka, T.2    Takeuchi, T.3    Fujihiro, S.4    Mori, H.5
  • 52
    • 0025237070 scopus 로고
    • Lactate dehydrogenase isoenzyme 1 activity in sera of patients with ovarian cancer
    • Buamah P.K., Skillen A.W. Lactate dehydrogenase isoenzyme 1 activity in sera of patients with ovarian cancer. Clin. Chem 1990, 36(4):707-708.
    • (1990) Clin. Chem , vol.36 , Issue.4 , pp. 707-708
    • Buamah, P.K.1    Skillen, A.W.2
  • 53
    • 0034773023 scopus 로고    scopus 로고
    • A systematic review of lactate dehydrogenase isoenzyme 1 and germ cell tumors
    • von Eyben F.E. A systematic review of lactate dehydrogenase isoenzyme 1 and germ cell tumors. Clin. Biochem 2001, 34(6):441-454.
    • (2001) Clin. Biochem , vol.34 , Issue.6 , pp. 441-454
    • von Eyben, F.E.1
  • 54
    • 0015175253 scopus 로고
    • Lactate dehydrogenase isoenzymes in tumours of the nervous system
    • Timperley W.R. Lactate dehydrogenase isoenzymes in tumours of the nervous system. Acta Neuropathol 1971, 19(1):20-24.
    • (1971) Acta Neuropathol , vol.19 , Issue.1 , pp. 20-24
    • Timperley, W.R.1
  • 55
    • 0016769923 scopus 로고
    • Changes in lactate dehydrogenase enzyme pattern in Chinese hamster cells infected and transformed with Simian virus 40
    • Caltrider N.C., Lehman J.M. Changes in lactate dehydrogenase enzyme pattern in Chinese hamster cells infected and transformed with Simian virus 40. Cancer Res 1975, 35(8):1944-1949.
    • (1975) Cancer Res , vol.35 , Issue.8 , pp. 1944-1949
    • Caltrider, N.C.1    Lehman, J.M.2
  • 56
    • 84856213516 scopus 로고    scopus 로고
    • LDH-A silencing suppresses breast cancer tumorigenicity through induction of oxidative stress mediated mitochondrial pathway apoptosis
    • Wang Z.Y., Loo T.Y., Shen J.G., Wang N., et al. LDH-A silencing suppresses breast cancer tumorigenicity through induction of oxidative stress mediated mitochondrial pathway apoptosis. Breast Cancer Res. Treat 2012, 131(3):791-800.
    • (2012) Breast Cancer Res. Treat , vol.131 , Issue.3 , pp. 791-800
    • Wang, Z.Y.1    Loo, T.Y.2    Shen, J.G.3    Wang, N.4
  • 57
    • 0019854673 scopus 로고
    • Lactate dehydrogenase isozyme patterns of normal human fibroblasts and their in vitro-transformed counterparts obtained by treatment with CO-60 gamma-rays, SV40 or 4-nitroquinoline 1-oxide
    • Nishitani K., Namba M., Kimoto T. Lactate dehydrogenase isozyme patterns of normal human fibroblasts and their in vitro-transformed counterparts obtained by treatment with CO-60 gamma-rays, SV40 or 4-nitroquinoline 1-oxide. Gann 1981, 72(2):300-304.
    • (1981) Gann , vol.72 , Issue.2 , pp. 300-304
    • Nishitani, K.1    Namba, M.2    Kimoto, T.3
  • 58
    • 0016785803 scopus 로고
    • Prediction of local recurrence in colorectal carcinoma: an LDH isoenzymatic assay
    • Langvad E., Jemec B. Prediction of local recurrence in colorectal carcinoma: an LDH isoenzymatic assay. Br. J. Cancer 1975, 31(6):661-664.
    • (1975) Br. J. Cancer , vol.31 , Issue.6 , pp. 661-664
    • Langvad, E.1    Jemec, B.2
  • 60
    • 77950672300 scopus 로고    scopus 로고
    • Lactate-dehydrogenase 5 is overexpressed in non-small cell lung cancer and correlates with the expression of the transketolase-like protein 1
    • Kayser G., Kassem A., Sienel W., Schulte-Uentrop L., et al. Lactate-dehydrogenase 5 is overexpressed in non-small cell lung cancer and correlates with the expression of the transketolase-like protein 1. Diagn. Pathol 2010, 5:22.
    • (2010) Diagn. Pathol , vol.5 , pp. 22
    • Kayser, G.1    Kassem, A.2    Sienel, W.3    Schulte-Uentrop, L.4
  • 61
    • 84896737770 scopus 로고    scopus 로고
    • High lactate dehydrogenase 5 expression correlates with high tumoral and stromal vascular endothelial growth factor expression in gastric cancer
    • Kim H.S., Lee H.E., Yang H.K., Kim W.H. High lactate dehydrogenase 5 expression correlates with high tumoral and stromal vascular endothelial growth factor expression in gastric cancer. Pathobiology 2013, 81(2):78-85.
    • (2013) Pathobiology , vol.81 , Issue.2 , pp. 78-85
    • Kim, H.S.1    Lee, H.E.2    Yang, H.K.3    Kim, W.H.4
  • 62
    • 84876500210 scopus 로고    scopus 로고
    • Increased LDH5 expression is associated with lymph node metastasis and outcome in oral squamous cell carcinoma
    • Grimm M., Alexander D., Munz A., Hoffmann J., Reinert S. Increased LDH5 expression is associated with lymph node metastasis and outcome in oral squamous cell carcinoma. Clin. Exp. Metastasis 2013, 30(4):529-540.
    • (2013) Clin. Exp. Metastasis , vol.30 , Issue.4 , pp. 529-540
    • Grimm, M.1    Alexander, D.2    Munz, A.3    Hoffmann, J.4    Reinert, S.5
  • 63
    • 84872790592 scopus 로고    scopus 로고
    • LDHA is necessary for the tumorigenicity of esophageal squamous cell carcinoma
    • Yao F., Zhao T., Zhong C., Zhu J., Zhao H. LDHA is necessary for the tumorigenicity of esophageal squamous cell carcinoma. Tumour Biol 2013, 34(1):25-31.
    • (2013) Tumour Biol , vol.34 , Issue.1 , pp. 25-31
    • Yao, F.1    Zhao, T.2    Zhong, C.3    Zhu, J.4    Zhao, H.5
  • 64
    • 84878678600 scopus 로고    scopus 로고
    • Lactate dehydrogenase A is overexpressed in pancreatic cancer and promotes the growth of pancreatic cancer cells
    • Rong Y., Wu W., Ni X., Kuang T., Jin D., et al. Lactate dehydrogenase A is overexpressed in pancreatic cancer and promotes the growth of pancreatic cancer cells. Tumour Biol 2013, 34(3):1523-1530.
    • (2013) Tumour Biol , vol.34 , Issue.3 , pp. 1523-1530
    • Rong, Y.1    Wu, W.2    Ni, X.3    Kuang, T.4    Jin, D.5
  • 65
    • 84884560281 scopus 로고    scopus 로고
    • Relationships between LDH-A, lactate, and metastases in 4T1 breast tumors
    • Rizwan A., Serganova I., Khanin R., Karabeber H., et al. Relationships between LDH-A, lactate, and metastases in 4T1 breast tumors. Clin. Cancer Res 2013, 19(18):5158-5169.
    • (2013) Clin. Cancer Res , vol.19 , Issue.18 , pp. 5158-5169
    • Rizwan, A.1    Serganova, I.2    Khanin, R.3    Karabeber, H.4
  • 66
    • 84898010739 scopus 로고    scopus 로고
    • Overexpression of lactate dehydrogenase-A in human intrahepatic cholangiocarcinoma: its implication for treatment
    • Yu Y., Liao M., Liu R., Chen J., et al. Overexpression of lactate dehydrogenase-A in human intrahepatic cholangiocarcinoma: its implication for treatment. World J. Surg. Oncol 2014, 12(78):1-7.
    • (2014) World J. Surg. Oncol , vol.12 , Issue.78 , pp. 1-7
    • Yu, Y.1    Liao, M.2    Liu, R.3    Chen, J.4
  • 67
    • 0014975476 scopus 로고
    • Abnormal lactic dehydrogenase isoenzyme patterns in ulcerative colitis with precancerous change
    • Lewis B., Morson B.C., February A.W., Jones J.H., Misiewicz J.J. Abnormal lactic dehydrogenase isoenzyme patterns in ulcerative colitis with precancerous change. Gut 1971, 12(1):16-19.
    • (1971) Gut , vol.12 , Issue.1 , pp. 16-19
    • Lewis, B.1    Morson, B.C.2    February, A.W.3    Jones, J.H.4    Misiewicz, J.J.5
  • 68
    • 0014018527 scopus 로고
    • Enzyme and isoenzyme studies in preinvasive carcinoma of the cervix
    • Latner A.L., Turner D.M., Way S.A. Enzyme and isoenzyme studies in preinvasive carcinoma of the cervix. Lancet 1966, 2(7468):814-816.
    • (1966) Lancet , vol.2 , Issue.7468 , pp. 814-816
    • Latner, A.L.1    Turner, D.M.2    Way, S.A.3
  • 69
    • 0014266426 scopus 로고
    • Lactate dehydrogenase isoenzyme patterns in bronchogenic carcinoma
    • Langvad E. Lactate dehydrogenase isoenzyme patterns in bronchogenic carcinoma. Eur. J. Cancer 1968, 4(1):107-115.
    • (1968) Eur. J. Cancer , vol.4 , Issue.1 , pp. 107-115
    • Langvad, E.1
  • 70
    • 0017124851 scopus 로고
    • LDH isoenzyme pattern of uninvolved gastric mucosa of patients with gastric carcinoma and benign gastric disease
    • Woollams R., Barratt P.J., Orwell R.L., Piper D.W. LDH isoenzyme pattern of uninvolved gastric mucosa of patients with gastric carcinoma and benign gastric disease. Digestion 1976, 14(1):20-28.
    • (1976) Digestion , vol.14 , Issue.1 , pp. 20-28
    • Woollams, R.1    Barratt, P.J.2    Orwell, R.L.3    Piper, D.W.4
  • 71
    • 0018096692 scopus 로고
    • Abnormal lactic dehydrogenase patterns in carcinoma of stomach and in peritumoral tissues
    • Mate J., Pajares J.M., Moreno-Otero R., Perez-Cuadrado S. Abnormal lactic dehydrogenase patterns in carcinoma of stomach and in peritumoral tissues. Digestion 1978, 17(5):377-382.
    • (1978) Digestion , vol.17 , Issue.5 , pp. 377-382
    • Mate, J.1    Pajares, J.M.2    Moreno-Otero, R.3    Perez-Cuadrado, S.4
  • 72
    • 33749027749 scopus 로고    scopus 로고
    • Lactate dehydrogenase 5 expression in operable colorectal cancer: strong association with survival and activated vascular endothelial growth factor pathway - a report of the Tumour Angiogenesis Research Group
    • Tumour Angiogenesis Research Group
    • Koukourakis M.I., Giatromanolaki A., Sivridis E., Gatter K.C., Harris A.L. Lactate dehydrogenase 5 expression in operable colorectal cancer: strong association with survival and activated vascular endothelial growth factor pathway - a report of the Tumour Angiogenesis Research Group. J. Clin. Oncol 2006, 24(26):4301-4308. Tumour Angiogenesis Research Group.
    • (2006) J. Clin. Oncol , vol.24 , Issue.26 , pp. 4301-4308
    • Koukourakis, M.I.1    Giatromanolaki, A.2    Sivridis, E.3    Gatter, K.C.4    Harris, A.L.5
  • 73
    • 73349132626 scopus 로고    scopus 로고
    • Field effect in cancer-an update
    • Chai H., Brown R.E. Field effect in cancer-an update. Ann. Clin. Lab. Sci 2009, 39(4):331-337.
    • (2009) Ann. Clin. Lab. Sci , vol.39 , Issue.4 , pp. 331-337
    • Chai, H.1    Brown, R.E.2
  • 74
    • 84921346929 scopus 로고    scopus 로고
    • The A/B ratio of lactate dehydrogenase (LDH) subunits in combination with Ki-67 labelling index (LI Ki-67) in relation to clinicopathological variables and prognosis in gastric cancer
    • Augoff K., Grabowski K., Wozniak Z., Taboła R., Chrzanowska T. The A/B ratio of lactate dehydrogenase (LDH) subunits in combination with Ki-67 labelling index (LI Ki-67) in relation to clinicopathological variables and prognosis in gastric cancer. Case Rep. Clin. Pract. Rev 2004, 5:108-113.
    • (2004) Case Rep. Clin. Pract. Rev , vol.5 , pp. 108-113
    • Augoff, K.1    Grabowski, K.2    Wozniak, Z.3    Taboła, R.4    Chrzanowska, T.5
  • 75
    • 74549186565 scopus 로고    scopus 로고
    • Glycolytic metabolism and tumour response to fractionated irradiation
    • Sattler U.S., Meyer S.S., Quennet V., Hoerner C., et al. Glycolytic metabolism and tumour response to fractionated irradiation. Radiother. Oncol 2010, 94(1):102-109.
    • (2010) Radiother. Oncol , vol.94 , Issue.1 , pp. 102-109
    • Sattler, U.S.1    Meyer, S.S.2    Quennet, V.3    Hoerner, C.4
  • 76
    • 84857716739 scopus 로고    scopus 로고
    • Multiple biological activities of lactic acid in cancer: influences on tumor growth, angiogenesis and metastasis
    • Dhup S., Dadhich R.K., Porporato P.E., Sonveaux P. Multiple biological activities of lactic acid in cancer: influences on tumor growth, angiogenesis and metastasis. Curr. Pharm. Des 2012, 18(10):1319-1330.
    • (2012) Curr. Pharm. Des , vol.18 , Issue.10 , pp. 1319-1330
    • Dhup, S.1    Dadhich, R.K.2    Porporato, P.E.3    Sonveaux, P.4
  • 77
    • 33744783432 scopus 로고    scopus 로고
    • Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
    • Fantin V.R., St-Pierre J., Leder P. Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell 2006, 9(6):425-434.
    • (2006) Cancer Cell , vol.9 , Issue.6 , pp. 425-434
    • Fantin, V.R.1    St-Pierre, J.2    Leder, P.3
  • 78
    • 76649126249 scopus 로고    scopus 로고
    • Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
    • Le A., Cooper C.R., Gouw A.M., Dinavahi R., Maitra A., et al. Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. Proc. Natl. Acad. Sci. U.S.A. 2010, 107(5):2037-2042.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , Issue.5 , pp. 2037-2042
    • Le, A.1    Cooper, C.R.2    Gouw, A.M.3    Dinavahi, R.4    Maitra, A.5
  • 79
    • 81355138825 scopus 로고    scopus 로고
    • LDH-A influences hypoxia-inducible factor 1α (HIF1 α) and is critical for growth of HT29 colon carcinoma cells in vivo
    • Langhammer S., Najjar M., Hess-Stumpp H., Thierauch K.H. LDH-A influences hypoxia-inducible factor 1α (HIF1 α) and is critical for growth of HT29 colon carcinoma cells in vivo. Target Oncol 2011, 6(3):155-162.
    • (2011) Target Oncol , vol.6 , Issue.3 , pp. 155-162
    • Langhammer, S.1    Najjar, M.2    Hess-Stumpp, H.3    Thierauch, K.H.4
  • 80
    • 84900296103 scopus 로고    scopus 로고
    • Targeting lactate dehydrogenase-a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells
    • Xie H., Hanai J., Ren J.G., Kats L., et al. Targeting lactate dehydrogenase-a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells. Cell Metab 2014, 19(5):795-809.
    • (2014) Cell Metab , vol.19 , Issue.5 , pp. 795-809
    • Xie, H.1    Hanai, J.2    Ren, J.G.3    Kats, L.4
  • 81
    • 84884174877 scopus 로고    scopus 로고
    • Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds
    • Granchi C., Calvaresi E.C., Tuccinardi T., Paterni I., et al. Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds. Org. Biomol. Chem 2013, 11(38):6588-6596.
    • (2013) Org. Biomol. Chem , vol.11 , Issue.38 , pp. 6588-6596
    • Granchi, C.1    Calvaresi, E.C.2    Tuccinardi, T.3    Paterni, I.4
  • 82
    • 84866480001 scopus 로고    scopus 로고
    • Galloflavin, a new lactate dehydrogenase inhibitor, induces the death of human breast cancer cells with different glycolytic attitude by affecting distinct signaling pathways
    • Farabegoli F., Vettraino M., Manerba M., Fiume L., et al. Galloflavin, a new lactate dehydrogenase inhibitor, induces the death of human breast cancer cells with different glycolytic attitude by affecting distinct signaling pathways. Eur. J. Pharm. Sci 2012, 47(4):729-738.
    • (2012) Eur. J. Pharm. Sci , vol.47 , Issue.4 , pp. 729-738
    • Farabegoli, F.1    Vettraino, M.2    Manerba, M.3    Fiume, L.4
  • 83
    • 77649094375 scopus 로고    scopus 로고
    • Warburg effect in chemosensitivity: targeting lactate dehydrogenase-A re-sensitizes taxol-resistant cancer cells to taxol
    • Zhou M., Zhao Y., Ding Y., Liu H., et al. Warburg effect in chemosensitivity: targeting lactate dehydrogenase-A re-sensitizes taxol-resistant cancer cells to taxol. Mol. Cancer 2010, 9:33.
    • (2010) Mol. Cancer , vol.9 , pp. 33
    • Zhou, M.1    Zhao, Y.2    Ding, Y.3    Liu, H.4
  • 84
    • 84892411852 scopus 로고    scopus 로고
    • Inhibition of LDH-A by oxamate induces G2/M arrest, apoptosis and increases radiosensitivity in nasopharyngeal carcinoma cells
    • Zhai X., Yang Y., Wan J., Zhu R., Wu Y. Inhibition of LDH-A by oxamate induces G2/M arrest, apoptosis and increases radiosensitivity in nasopharyngeal carcinoma cells. Oncol. Rep 2013, 6:2983-2991.
    • (2013) Oncol. Rep , vol.6 , pp. 2983-2991
    • Zhai, X.1    Yang, Y.2    Wan, J.3    Zhu, R.4    Wu, Y.5
  • 85
    • 84920006718 scopus 로고    scopus 로고
    • Different effects of LDH-A inhibition by oxamate in non-small cell lung cancer cells
    • 2620 [pii]
    • Yang Y., Su D., Zhao L., Zhang D., et al. Different effects of LDH-A inhibition by oxamate in non-small cell lung cancer cells. Oncotarget 2014, 2620 [pii].
    • (2014) Oncotarget
    • Yang, Y.1    Su, D.2    Zhao, L.3    Zhang, D.4
  • 86
    • 84872362914 scopus 로고    scopus 로고
    • Galloflavin prevents the binding of lactate dehydrogenase A to single stranded DNA and inhibits RNA synthesis in cultured cells
    • Fiume L., Vettraino M., Carnicelli D., Arfilli V., et al. Galloflavin prevents the binding of lactate dehydrogenase A to single stranded DNA and inhibits RNA synthesis in cultured cells. Biochem. Biophys. Res. Commun 2013, 430(2):466-469.
    • (2013) Biochem. Biophys. Res. Commun , vol.430 , Issue.2 , pp. 466-469
    • Fiume, L.1    Vettraino, M.2    Carnicelli, D.3    Arfilli, V.4
  • 87
    • 84891855687 scopus 로고    scopus 로고
    • Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcitabine against pancreatic cancer cells in hypoxia
    • Maftouh M., Avan A., Sciarrillo R., Granchi C., et al. Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcitabine against pancreatic cancer cells in hypoxia. Br. J. Cancer 2014, 110(1):172-182.
    • (2014) Br. J. Cancer , vol.110 , Issue.1 , pp. 172-182
    • Maftouh, M.1    Avan, A.2    Sciarrillo, R.3    Granchi, C.4
  • 88
    • 84900399656 scopus 로고    scopus 로고
    • Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53-independent pathways
    • Allison S.J., Knight J.R., Granchi C., Rani R., et al. Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53-independent pathways. Oncogenesis 2014, 3:e102.
    • (2014) Oncogenesis , vol.3 , pp. e102
    • Allison, S.J.1    Knight, J.R.2    Granchi, C.3    Rani, R.4
  • 89
    • 84899851570 scopus 로고    scopus 로고
    • Synergistic anti-cancer effect of phenformin and oxamate
    • Miskimins W.K., Ahn H.J., Kim J.Y., Ryu S., et al. Synergistic anti-cancer effect of phenformin and oxamate. PLoS ONE 2014, 9(1):e85576.
    • (2014) PLoS ONE , vol.9 , Issue.1 , pp. e85576
    • Miskimins, W.K.1    Ahn, H.J.2    Kim, J.Y.3    Ryu, S.4
  • 90
    • 84921398278 scopus 로고    scopus 로고
    • Abstract 964: inhibiting glycolysis with an LDHA inhibitor: a new solution to an old problem
    • April 5-9, 2014; San Diego, CA.
    • T. O'Brien, H. Purkey, A. Hitz, D. Peterson, etal., Abstract 964: inhibiting glycolysis with an LDHA inhibitor: a new solution to an old problem, Proceedings: AACR Annual Meeting, April 5-9, 2014; San Diego, CA, 2014.
    • (2014) Proceedings: AACR Annual Meeting
    • O'Brien, T.1    Purkey, H.2    Hitz, A.3    Peterson, D.4
  • 91
    • 84905914054 scopus 로고    scopus 로고
    • Identification of substituted 3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase
    • Dragovich P.S., Fauber B.P., Boggs J., Chen J., et al. Identification of substituted 3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase. Bioorg. Med. Chem. Lett 2014, 24(16):3764-3771.
    • (2014) Bioorg. Med. Chem. Lett , vol.24 , Issue.16 , pp. 3764-3771
    • Dragovich, P.S.1    Fauber, B.P.2    Boggs, J.3    Chen, J.4
  • 92
    • 84907989938 scopus 로고    scopus 로고
    • High-throughput screening to identify plant derived human LDH-A inhibitors
    • Deiab S., Mazzio E., Messeha S., Mack N., Soliman K.F.A. High-throughput screening to identify plant derived human LDH-A inhibitors. Eur. J. Med. Plants 2013, 3(4):603-615.
    • (2013) Eur. J. Med. Plants , vol.3 , Issue.4 , pp. 603-615
    • Deiab, S.1    Mazzio, E.2    Messeha, S.3    Mack, N.4    Soliman, K.F.A.5
  • 93
    • 84874002588 scopus 로고    scopus 로고
    • Bioactivity-guided identification and cell signaling technology to delineate the lactate dehydrogenase A inhibition effects of Spatholobus suberectus on breast cancer
    • Wang Z., Wang D., Han S., Wang N., et al. Bioactivity-guided identification and cell signaling technology to delineate the lactate dehydrogenase A inhibition effects of Spatholobus suberectus on breast cancer. PLoS ONE 2013, 8(2):e56631.
    • (2013) PLoS ONE , vol.8 , Issue.2 , pp. e56631
    • Wang, Z.1    Wang, D.2    Han, S.3    Wang, N.4
  • 94
    • 84859790465 scopus 로고    scopus 로고
    • Design and synthesis of novel lactate dehydrogenase A inhibitors by fragment-based lead generation
    • Ward R.A., Brassington C., Breeze A.L., Caputo A., et al. Design and synthesis of novel lactate dehydrogenase A inhibitors by fragment-based lead generation. J. Med. Chem 2012, 55(7):3285-3306.
    • (2012) J. Med. Chem , vol.55 , Issue.7 , pp. 3285-3306
    • Ward, R.A.1    Brassington, C.2    Breeze, A.L.3    Caputo, A.4
  • 95
    • 84873908263 scopus 로고    scopus 로고
    • Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors
    • Kohlmann A., Zech S.G., Li F., Zhou T., et al. Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors. J. Med. Chem 2013, 56(3):1023-1040.
    • (2013) J. Med. Chem , vol.56 , Issue.3 , pp. 1023-1040
    • Kohlmann, A.1    Zech, S.G.2    Li, F.3    Zhou, T.4
  • 96
    • 84898407135 scopus 로고    scopus 로고
    • Human lactate dehydrogenase a inhibitors: a molecular dynamics investigation
    • Shi Y., Pinto B.M. Human lactate dehydrogenase a inhibitors: a molecular dynamics investigation. PLoS ONE 2014, 9(1):e86365.
    • (2014) PLoS ONE , vol.9 , Issue.1 , pp. e86365
    • Shi, Y.1    Pinto, B.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.