Activation of the MDA-5-IPS-1 viral sensing pathway induces cancer cell death and type I IFN-dependent antitumor immunity

Cancer Research

Volumn 76, Issue 8, 2016, Pages 2166-2176

  Yu, Xiaofei ^a   Wang, Hongxia ^a   Li, Xia ^a   Guo, Chunqing ^a   Yuan, Fang ^a   Fisher, Paul B ^a,b,c   Wang, Xiang Yang ^a,b,c  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; ALPHA INTERFERON RECEPTOR; ANTINEOPLASTIC AGENT; BETA INTERFERON RECEPTOR; CASPASE; CYTOSOL RECEPTOR; INTERFERON; INTERFERON BETA PROMOTER STIMULATOR 1 PROTEIN; MELANOMA DIFFERENTIATION ASSOCIATED GENE 5 PROTEIN; MUTANT PROTEIN; UNCLASSIFIED DRUG; IFIH1 PROTEIN, HUMAN; INTERFERON INDUCED HELICASE C DOMAIN CONTAINING PROTEIN 1; SIGNAL TRANSDUCING ADAPTOR PROTEIN; VISA PROTEIN, HUMAN;

ADENOVIRIDAE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER GENE THERAPY; CANCER REGRESSION; CANCER RESISTANCE; CELL DEATH; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; DRUG MECHANISM; GENETIC CONSERVATION; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; MDA 5 GENE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TUMOR IMMUNITY; VIRAL GENE DELIVERY SYSTEM; VIRUS REPLICATION; ANIMAL; APOPTOSIS; C57BL MOUSE; IMMUNOLOGY; MALE; PATHOLOGY; PHYSIOLOGY; PROSTATE TUMOR; SATELLITE VIRUS; XENOGRAFT;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADENOVIRIDAE; ANIMALS; APOPTOSIS; DEFECTIVE VIRUSES; HETEROGRAFTS; HUMANS; INTERFERON TYPE I; INTERFERON-INDUCED HELICASE, IFIH1; MALE; MICE; MICE, INBRED C57BL; PROSTATIC NEOPLASMS;

EID: 84971015088     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-15-2142     Document Type: Article

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