Inhibition of myeloid cell differentiation in cancer: The role of reactive oxygen species

Journal of Leukocyte Biology

Volumn 74, Issue 2, 2003, Pages 186-196

  Kusmartsev, Sergei ^a   Gabrilovich, Dmitry I ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

Cell differentiation; Dendritic cells; Macrophages

Indexed keywords

CATALASE; GROWTH FACTOR; HYDROGEN PEROXIDE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL INFECTION; BIOACCUMULATION; BONE MARROW CELL; CANCER GROWTH; CANCER INHIBITION; CELL ACTIVITY; CELL DIFFERENTIATION; CELL ISOLATION; CELL MATURATION; CONTROLLED STUDY; DENDRITIC CELL; DISEASE COURSE; FEMALE; GRANULOCYTE; HOST; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CELL CULTURE; CELL DIVISION; COLON TUMOR; CYTOLOGY; METABOLISM; PATHOLOGY; PHYSIOLOGY; SARCOMA;

ANIMALIA; BACTERIA (MICROORGANISMS);

ANIMALS; CATALASE; CELL DIFFERENTIATION; CELL DIVISION; COLONIC NEOPLASMS; DENDRITIC CELLS; FEMALE; GRANULOCYTES; MACROPHAGES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; REACTIVE OXYGEN SPECIES; SARCOMA, EXPERIMENTAL; SUPEROXIDES; TUMOR CELLS, CULTURED;

EID: 0041850021     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0103010     Document Type: Article

References (30)

1. Bronte, V., Serafini, D., Appoloni, E., Zanovello, P. (2001) Tumor-induced immune dysfunctions caused by myeloid suppressor cells. J. Immunother. 24, 431-446.
2. Kusmartsev, S., Gahrilovich, D. I. (2002) Immature myeloid cells and cancer-associated immune suppression. Cancer Immunol. Immunother. 51, 293-298.
3. Almand, B., Resser, J., Lindman, B., Nadaf, S., Clark, J., Kwon, E., Carbone, D., Gabrilovich, D. (2000) Clinical significance of defective dendritic cell differentiation in cancer. Clin. Cancer Res. 6, 1755-1766.
4. Salvadori, S., Martinelli, G., Zier, K. (2000) Resection of solid tumors reverses T cell defects and restores protective immunity. J. Immunol. 164, 2214-2220.
5. Schmielau, J., Finn, O. J. (2001) Activated granulocytes and granulocyte-derived hydrogen peroxide are the underlying mechanism of suppression of T-cell function in advanced cancer patients. Cancer Res. 61, 4756-4760.
6. Almand, B., Clark, J. I., Nikitina, E., English, N. R., Knight, S. C., Carbone, D. P., Gabrilovich, D. I. (2001) Increased production of immature myeloid cells in cancer patients. A mechanism of immunosuppression in cancer. J. Immunol. 166, 678-689.
7. Bronte, V., Chappell, D. B., Apolloni, E., Cabrelle, A., Wang, M., Hwu, P., Restifo, N. P. (1999) Unopposed production of granulocyte-macrophage colony-stimulating factor by tumors inhibits CD8+ T cell responses by dysregulating antigen-presenting cell maturation. J. Immunol. 162, 5728-5737.
8. Bronte, V., Apolloni, E., Cabrelle, A., Ronca, R., Serafini, P., Zamboni, P., Restifo, N., Zanovello, P. (2000) Identification of a CD11b(+)/Gr-1(+)/CD31(+) myeloid progenitor capable of activating or suppressing CD8(+) T cells. Blood 96, 3838-3846.
9. Kusmartsev, S., Li, Y., Chen, S. (2000) Gr-1+ myeloid cells derived from tumor-bearing mice inhibit primary T cell activation induced through CD3/CD28 costimulation. J. Immunol. 165, 779-785.
10. Gabrilovich, D. I., Velders, M., Sotomayor, E., Kast, W. M. (2001) Mechanism of immune dysfunction in cancer mediated by immature Gr-1+ myeloid cells. J. Immunol. 166, 5398-5406.
11. Bronte, V., Wang, M., Overwijk, W., Surman, D., Pericle, F., Rosenberg, S. A., Restifo, N. P. (1998) Apoptotic death of CD8+ T lymphocytes after immunization: induction of a suppressive population of Mac-1+/Gr-1+ cells. J. Immunol. 161, 5313-5320.
12. Atochina, O., Daly-Angel, T., Piskorska, D., Harn, D. (2001) A shistosome-expressed immunomodulatory glycoconjugate expands peritoneal Gr1(+) macrophages that suppress naïve CD4(+) T cell proliferation via an IFN-gamma and nitric oxide-dependent mechanism. J. Immunol. 167, 4293-4302.
13. Cauley, L., Miller, E., Yen, M., Swain, S. (2000) Superantigen-induced CD4 T cell tolerance mediated by myeloid cells and IFN-gamma. J. Immunol. 165, 6056-6066.
14. Young, M. R. I., Newby, M., Wepsic, T. H. (1987) Hematopoiesis and suppressor bone marrow cells in mice bearing large metastatic Lewis lung carcinoma tumors. Cancer Res. 47, 100-106.
15. Jaffe, M., Arai, H., Nabel, G. (1996) Mechanisms of tumor-induced immunosuppression: evidence for contact-dependent T cell suppression by monocytes. Mol. Med. 2, 692-701.
16. Otsuji, M., Kimura, Y., Aoe, T., Okamoto, Y., Saito, T. (1996) Oxidative stress by tumor-derived macrophages suppresses the expression of CD3 zeta chain of T-cell receptor complex and antigen-specific T-cell responses. Proc. Natl. Acad. Sci. USA 93, 13119-13124.
17. Gabrilovich, D. I., Chen, H. L., Girgis, K. R., Cunningham, T., Meny, G. M., Nadaf, S., Kavanaugh, D., Carbone, D. P. (1996) Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells. Nat. Med. 2, 1096-1103.
18. Gabrilovich, D. I., Nadaf, S., Corak, J., Berzofsky, J. A., Carbone, D. P. (1996) Dendritic cells in anti-tumor immune responses. II. Dendritic cells grown from bone marrow precursors, but not mature DC from tumor-bearing mice are effective antigen carriers in the therapy of established tumors. Cell. Immunol. 170, 111-120.
19. Gabrilovich, D., Cheng, P., Fan, Y., Yu, B., Nikitina, E., Sirotkin, A., Shurin, M., Oyama, T., Adachi, Y., Nadaf, S., Carbone, D. P., Skoultchi, A. (2002) H1(0) histone and differentiation of dendritic cells. A molecular target for tumor-derived factors. J. Leukoc. Biol. 72, 285-296.
20. Shurin, G., Shurin, M., Bykovskaia, S., Shogan, J., Lotze, M., Barksdale, E. J. (2001) Neuroblastoma-derived gangliosides inhibit dendritic cell generation and function. Cancer Res. 61, 363-369.
21. Menetrier-Caux, C., Montmain, G., Dieu, M., Bain, C., Favrot, M., Caux, C., Blay, J. (1998) Inhibition of the differentiation of dendritic cells from CD34(+) progenitors by tumor cells: role of interleukin-6 and macrophage-colony-stimulating factor. Blood 92, 4778-4791.
22. Gabrilovich, D., Ishida, T., Oyama, T., Ran, S., Kravtsov, V., Nadaf, S., Carbone, D. P. (1998) Vascular endothelial growth factor inhibits the development of dendritic cells and dramatically affects the differentiation of multiple hematopoietic lineages in vivo. Blood 92, 4150-4166.
23. Sauer, H., Wartenberg, M., Hescheler, J. (2001) Reactive oxygen species as intracellular messengers during cell growth and differentiation. Cell. Physiol. Biochem. 11, 173-186.
24. Bladier, C., Wolvetang, E. J., Hutchison, P., de Haan, J. B., Kola, I. (1997) Response of a primary human fibroblast cell line to H2O2: senescence-like growth arrest or apoptosis. Cell Growth Differ. 8, 589-598.
25. Abe, J., Berk, B. C. (1999) Fyn and JAK2 mediate Ras activation by reactive oxygen species. J. Biol. Chem. 274, 21003-21010.
26. Sattler, M., Winkler, T., Verma, S., Byrne, C. H., Shrikhande, G., Salgia, R., Griffin, J. D. (1999) Hematopoietic growth factors signal through the formation of reactive oxygen species. Blood 93, 2928-2935.
27. Schreck, R., Albermann, K., Baeuerle, P. A. (1992) Nuclear factor kappa B: an oxidative stress-responsive transcription factor of eukaryotic cells (a review). Free Radic. Res. Commun. 17, 221-237.
28. Burkly, L., Hession, C., Ogata, L., Relly, C., Marconi, L. A., Olson, D., Tizard, R., Cate, R., Lo, D. (1995) Expression of relB is required for development of thymic medulla and dendritic cells. Nature 373, 531-536.
29. Wu, L., D'Amico, A., Winkel, K. D., Suter, M., Lo, D., Shortman, K. (1998) RelB is essential for the development of myeloid-related CD8 alpha (-) dendritic cells but not of lymphoid-related CD8 alpha(+) dendritic cells. Immunity 9, 839-847.
30. Oyama, T., Ran, S., Ishida, T., Nadaf, S., Kerr, L., Carbone, D., Gabrilovich, D. (1998) Vascular endothelial growth factor affects dendritic cell maturation through the inhibition of nuclear factor-kappaB activation in hemopoietic progenitor cells. J. Immunol. 160, 1224-1232.