-
1
-
-
79958047295
-
Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype
-
Ahmadian, M., Abbott, M.J., Tang, T., Hudak, C.S.S., Kim, Y., Bruss, M., Hellerstein, M.K., Lee, H.-Y., Samuel, V.T., Shulman, G.I., et al. Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype. Cell Metab. 13 (2011), 739–748.
-
(2011)
Cell Metab.
, vol.13
, pp. 739-748
-
-
Ahmadian, M.1
Abbott, M.J.2
Tang, T.3
Hudak, C.S.S.4
Kim, Y.5
Bruss, M.6
Hellerstein, M.K.7
Lee, H.-Y.8
Samuel, V.T.9
Shulman, G.I.10
-
2
-
-
84937815403
-
AMPK Activation via Modulation of De Novo Purine Biosynthesis with an Inhibitor of ATIC Homodimerization
-
Asby, D.J., Cuda, F., Beyaert, M., Houghton, F.D., Cagampang, F.R., Tavassoli, A., AMPK Activation via Modulation of De Novo Purine Biosynthesis with an Inhibitor of ATIC Homodimerization. Chem. Biol. 22 (2015), 838–848.
-
(2015)
Chem. Biol.
, vol.22
, pp. 838-848
-
-
Asby, D.J.1
Cuda, F.2
Beyaert, M.3
Houghton, F.D.4
Cagampang, F.R.5
Tavassoli, A.6
-
3
-
-
84355161919
-
Chemical genetic screen for AMPKα2 substrates uncovers a network of proteins involved in mitosis
-
Banko, M.R., Allen, J.J., Schaffer, B.E., Wilker, E.W., Tsou, P., White, J.L., Villén, J., Wang, B., Kim, S.R., Sakamoto, K., et al. Chemical genetic screen for AMPKα2 substrates uncovers a network of proteins involved in mitosis. Mol. Cell 44 (2011), 878–892.
-
(2011)
Mol. Cell
, vol.44
, pp. 878-892
-
-
Banko, M.R.1
Allen, J.J.2
Schaffer, B.E.3
Wilker, E.W.4
Tsou, P.5
White, J.L.6
Villén, J.7
Wang, B.8
Kim, S.R.9
Sakamoto, K.10
-
4
-
-
84905719900
-
Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms
-
Calabrese, M.F., Rajamohan, F., Harris, M.S., Caspers, N.L., Magyar, R., Withka, J.M., Wang, H., Borzilleri, K.A., Sahasrabudhe, P.V., Hoth, L.R., et al. Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms. Structure 22 (2014), 1161–1172.
-
(2014)
Structure
, vol.22
, pp. 1161-1172
-
-
Calabrese, M.F.1
Rajamohan, F.2
Harris, M.S.3
Caspers, N.L.4
Magyar, R.5
Withka, J.M.6
Wang, H.7
Borzilleri, K.A.8
Sahasrabudhe, P.V.9
Hoth, L.R.10
-
5
-
-
67349276169
-
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
-
Cantó, C., Gerhart-Hines, Z., Feige, J.N., Lagouge, M., Noriega, L., Milne, J.C., Elliott, P.J., Puigserver, P., Auwerx, J., AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature 458 (2009), 1056–1060.
-
(2009)
Nature
, vol.458
, pp. 1056-1060
-
-
Cantó, C.1
Gerhart-Hines, Z.2
Feige, J.N.3
Lagouge, M.4
Noriega, L.5
Milne, J.C.6
Elliott, P.J.7
Puigserver, P.8
Auwerx, J.9
-
6
-
-
84905404389
-
Low concentrations of metformin suppress glucose production in hepatocytes through AMP-activated protein kinase (AMPK)
-
Cao, J., Meng, S., Chang, E., Beckwith-Fickas, K., Xiong, L., Cole, R.N., Radovick, S., Wondisford, F.E., He, L., Low concentrations of metformin suppress glucose production in hepatocytes through AMP-activated protein kinase (AMPK). J. Biol. Chem. 289 (2014), 20435–20446.
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 20435-20446
-
-
Cao, J.1
Meng, S.2
Chang, E.3
Beckwith-Fickas, K.4
Xiong, L.5
Cole, R.N.6
Radovick, S.7
Wondisford, F.E.8
He, L.9
-
7
-
-
84863719838
-
AMP-activated protein kinase undergoes nucleotide-dependent conformational changes
-
Chen, L., Wang, J., Zhang, Y.-Y., Yan, S.F., Neumann, D., Schlattner, U., Wang, Z.-X., Wu, J.-W., AMP-activated protein kinase undergoes nucleotide-dependent conformational changes. Nat. Struct. Mol. Biol. 19 (2012), 716–718.
-
(2012)
Nat. Struct. Mol. Biol.
, vol.19
, pp. 716-718
-
-
Chen, L.1
Wang, J.2
Zhang, Y.-Y.3
Yan, S.F.4
Neumann, D.5
Schlattner, U.6
Wang, Z.-X.7
Wu, J.-W.8
-
8
-
-
84878971103
-
Conserved regulatory elements in AMPK
-
Chen, L., Xin, F.-J., Wang, J., Hu, J., Zhang, Y.-Y., Wan, S., Cao, L.-S., Lu, C., Li, P., Yan, S.F., et al. Conserved regulatory elements in AMPK. Nature 498 (2013), E8–E10.
-
(2013)
Nature
, vol.498
, pp. E8-E10
-
-
Chen, L.1
Xin, F.-J.2
Wang, J.3
Hu, J.4
Zhang, Y.-Y.5
Wan, S.6
Cao, L.-S.7
Lu, C.8
Li, P.9
Yan, S.F.10
-
9
-
-
33744514139
-
Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome
-
Cool, B., Zinker, B., Chiou, W., Kifle, L., Cao, N., Perham, M., Dickinson, R., Adler, A., Gagne, G., Iyengar, R., et al. Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. Cell Metab. 3 (2006), 403–416.
-
(2006)
Cell Metab.
, vol.3
, pp. 403-416
-
-
Cool, B.1
Zinker, B.2
Chiou, W.3
Kifle, L.4
Cao, N.5
Perham, M.6
Dickinson, R.7
Adler, A.8
Gagne, G.9
Iyengar, R.10
-
10
-
-
84973389963
-
PKD1 Inhibits AMPKα2 through Phosphorylation of Serine 491 and Impairs Insulin Signaling in Skeletal Muscle Cells
-
Coughlan, K.A., Valentine, R.J., Sudit, B.S., Allen, K., Dagon, Y., Kahn, B.B., Ruderman, N.B., Saha, A.K., PKD1 Inhibits AMPKα2 through Phosphorylation of Serine 491 and Impairs Insulin Signaling in Skeletal Muscle Cells. J. Biol. Chem. 291 (2016), 5664–5675.
-
(2016)
J. Biol. Chem.
, vol.291
, pp. 5664-5675
-
-
Coughlan, K.A.1
Valentine, R.J.2
Sudit, B.S.3
Allen, K.4
Dagon, Y.5
Kahn, B.B.6
Ruderman, N.B.7
Saha, A.K.8
-
11
-
-
84863535512
-
p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake
-
Dagon, Y., Hur, E., Zheng, B., Wellenstein, K., Cantley, L.C., Kahn, B.B., p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake. Cell Metab. 16 (2012), 104–112.
-
(2012)
Cell Metab.
, vol.16
, pp. 104-112
-
-
Dagon, Y.1
Hur, E.2
Zheng, B.3
Wellenstein, K.4
Cantley, L.C.5
Kahn, B.B.6
-
12
-
-
84919595168
-
Energy stress regulates hippo-YAP signaling involving AMPK-mediated regulation of angiomotin-like 1 protein
-
DeRan, M., Yang, J., Shen, C.-H., Peters, E.C., Fitamant, J., Chan, P., Hsieh, M., Zhu, S., Asara, J.M., Zheng, B., et al. Energy stress regulates hippo-YAP signaling involving AMPK-mediated regulation of angiomotin-like 1 protein. Cell Rep. 9 (2014), 495–503.
-
(2014)
Cell Rep.
, vol.9
, pp. 495-503
-
-
DeRan, M.1
Yang, J.2
Shen, C.-H.3
Peters, E.C.4
Fitamant, J.5
Chan, P.6
Hsieh, M.7
Zhu, S.8
Asara, J.M.9
Zheng, B.10
-
13
-
-
84929177057
-
Metformin activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats
-
Duca, F.A., Côté, C.D., Rasmussen, B.A., Zadeh-Tahmasebi, M., Rutter, G.A., Filippi, B.M., Lam, T.K.T., Metformin activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats. Nat. Med. 21 (2015), 506–511.
-
(2015)
Nat. Med.
, vol.21
, pp. 506-511
-
-
Duca, F.A.1
Côté, C.D.2
Rasmussen, B.A.3
Zadeh-Tahmasebi, M.4
Rutter, G.A.5
Filippi, B.M.6
Lam, T.K.T.7
-
14
-
-
79251587803
-
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy
-
Egan, D.F., Shackelford, D.B., Mihaylova, M.M., Gelino, S., Kohnz, R.A., Mair, W., Vasquez, D.S., Joshi, A., Gwinn, D.M., Taylor, R., et al. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science 331 (2011), 456–461.
-
(2011)
Science
, vol.331
, pp. 456-461
-
-
Egan, D.F.1
Shackelford, D.B.2
Mihaylova, M.M.3
Gelino, S.4
Kohnz, R.A.5
Mair, W.6
Vasquez, D.S.7
Joshi, A.8
Gwinn, D.M.9
Taylor, R.10
-
15
-
-
84925491509
-
mTORC1-mediated translational elongation limits intestinal tumour initiation and growth
-
Faller, W.J., Jackson, T.J., Knight, J.R.P., Ridgway, R.A., Jamieson, T., Karim, S.A., Jones, C., Radulescu, S., Huels, D.J., Myant, K.B., et al. mTORC1-mediated translational elongation limits intestinal tumour initiation and growth. Nature 517 (2015), 497–500.
-
(2015)
Nature
, vol.517
, pp. 497-500
-
-
Faller, W.J.1
Jackson, T.J.2
Knight, J.R.P.3
Ridgway, R.A.4
Jamieson, T.5
Karim, S.A.6
Jones, C.7
Radulescu, S.8
Huels, D.J.9
Myant, K.B.10
-
16
-
-
84930606184
-
Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity
-
Ford, R.J., Fullerton, M.D., Pinkosky, S.L., Day, E.A., Scott, J.W., Oakhill, J.S., Bujak, A.L., Smith, B.K., Crane, J.D., Blümer, R.M., et al. Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity. Biochem. J. 468 (2015), 125–132.
-
(2015)
Biochem. J.
, vol.468
, pp. 125-132
-
-
Ford, R.J.1
Fullerton, M.D.2
Pinkosky, S.L.3
Day, E.A.4
Scott, J.W.5
Oakhill, J.S.6
Bujak, A.L.7
Smith, B.K.8
Crane, J.D.9
Blümer, R.M.10
-
17
-
-
84889887123
-
Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin
-
Fullerton, M.D., Galic, S., Marcinko, K., Sikkema, S., Pulinilkunnil, T., Chen, Z.-P., O'Neill, H.M., Ford, R.J., Palanivel, R., O'Brien, M., et al. Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin. Nat. Med. 19 (2013), 1649–1654.
-
(2013)
Nat. Med.
, vol.19
, pp. 1649-1654
-
-
Fullerton, M.D.1
Galic, S.2
Marcinko, K.3
Sikkema, S.4
Pulinilkunnil, T.5
Chen, Z.-P.6
O'Neill, H.M.7
Ford, R.J.8
Palanivel, R.9
O'Brien, M.10
-
18
-
-
84929469439
-
Salicylate improves macrophage cholesterol homeostasis via activation of Ampk
-
Fullerton, M.D., Ford, R.J., McGregor, C.P., LeBlond, N.D., Snider, S.A., Stypa, S.A., Day, E.A., Lhoták, Š., Schertzer, J.D., Austin, R.C., et al. Salicylate improves macrophage cholesterol homeostasis via activation of Ampk. J. Lipid Res. 56 (2015), 1025–1033.
-
(2015)
J. Lipid Res.
, vol.56
, pp. 1025-1033
-
-
Fullerton, M.D.1
Ford, R.J.2
McGregor, C.P.3
LeBlond, N.D.4
Snider, S.A.5
Stypa, S.A.6
Day, E.A.7
Lhoták, Š.8
Schertzer, J.D.9
Austin, R.C.10
-
19
-
-
79952114408
-
The PP1-R6 protein phosphatase holoenzyme is involved in the glucose-induced dephosphorylation and inactivation of AMP-activated protein kinase, a key regulator of insulin secretion, in MIN6 beta cells
-
Garcia-Haro, L., Garcia-Gimeno, M.A., Neumann, D., Beullens, M., Bollen, M., Sanz, P., The PP1-R6 protein phosphatase holoenzyme is involved in the glucose-induced dephosphorylation and inactivation of AMP-activated protein kinase, a key regulator of insulin secretion, in MIN6 beta cells. FASEB J. 24 (2010), 5080–5091.
-
(2010)
FASEB J.
, vol.24
, pp. 5080-5091
-
-
Garcia-Haro, L.1
Garcia-Gimeno, M.A.2
Neumann, D.3
Beullens, M.4
Bollen, M.5
Sanz, P.6
-
20
-
-
78650224772
-
A Potent and Selective AMPK Activator That Inhibits de Novo Lipogenesis
-
Gómez-Galeno, J.E., Dang, Q., Nguyen, T.H., Boyer, S.H., Grote, M.P., Sun, Z., Chen, M., Craigo, W.A., van Poelje, P.D., MacKenna, D.A., et al. A Potent and Selective AMPK Activator That Inhibits de Novo Lipogenesis. ACS Med. Chem. Lett. 1 (2010), 478–482.
-
(2010)
ACS Med. Chem. Lett.
, vol.1
, pp. 478-482
-
-
Gómez-Galeno, J.E.1
Dang, Q.2
Nguyen, T.H.3
Boyer, S.H.4
Grote, M.P.5
Sun, Z.6
Chen, M.7
Craigo, W.A.8
van Poelje, P.D.9
MacKenna, D.A.10
-
21
-
-
36348998521
-
Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase
-
Göransson, O., McBride, A., Hawley, S.A., Ross, F.A., Shpiro, N., Foretz, M., Viollet, B., Hardie, D.G., Sakamoto, K., Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase. J. Biol. Chem. 282 (2007), 32549–32560.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 32549-32560
-
-
Göransson, O.1
McBride, A.2
Hawley, S.A.3
Ross, F.A.4
Shpiro, N.5
Foretz, M.6
Viollet, B.7
Hardie, D.G.8
Sakamoto, K.9
-
22
-
-
84885168009
-
AMP is a true physiological regulator of AMP-activated protein kinase by both allosteric activation and enhancing net phosphorylation
-
Gowans, G.J., Hawley, S.A., Ross, F.A., Hardie, D.G., AMP is a true physiological regulator of AMP-activated protein kinase by both allosteric activation and enhancing net phosphorylation. Cell Metab. 18 (2013), 556–566.
-
(2013)
Cell Metab.
, vol.18
, pp. 556-566
-
-
Gowans, G.J.1
Hawley, S.A.2
Ross, F.A.3
Hardie, D.G.4
-
23
-
-
34848861463
-
The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor
-
Greer, E.L., Oskoui, P.R., Banko, M.R., Maniar, J.M., Gygi, M.P., Gygi, S.P., Brunet, A., The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor. J. Biol. Chem. 282 (2007), 30107–30119.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 30107-30119
-
-
Greer, E.L.1
Oskoui, P.R.2
Banko, M.R.3
Maniar, J.M.4
Gygi, M.P.5
Gygi, S.P.6
Brunet, A.7
-
24
-
-
42949139481
-
AMPK phosphorylation of raptor mediates a metabolic checkpoint
-
Gwinn, D.M., Shackelford, D.B., Egan, D.F., Mihaylova, M.M., Mery, A., Vasquez, D.S., Turk, B.E., Shaw, R.J., AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol. Cell 30 (2008), 214–226.
-
(2008)
Mol. Cell
, vol.30
, pp. 214-226
-
-
Gwinn, D.M.1
Shackelford, D.B.2
Egan, D.F.3
Mihaylova, M.M.4
Mery, A.5
Vasquez, D.S.6
Turk, B.E.7
Shaw, R.J.8
-
25
-
-
84883709817
-
AMPK: a target for drugs and natural products with effects on both diabetes and cancer
-
Hardie, D.G., AMPK: a target for drugs and natural products with effects on both diabetes and cancer. Diabetes 62 (2013), 2164–2172.
-
(2013)
Diabetes
, vol.62
, pp. 2164-2172
-
-
Hardie, D.G.1
-
26
-
-
84919621076
-
AMPK–sensing energy while talking to other signaling pathways
-
Hardie, D.G., AMPK–sensing energy while talking to other signaling pathways. Cell Metab. 20 (2014), 939–952.
-
(2014)
Cell Metab.
, vol.20
, pp. 939-952
-
-
Hardie, D.G.1
-
27
-
-
84958120581
-
AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs
-
Hardie, D.G., Schaffer, B.E., Brunet, A., AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs. Trends Cell Biol. 26 (2016), 190–201.
-
(2016)
Trends Cell Biol.
, vol.26
, pp. 190-201
-
-
Hardie, D.G.1
Schaffer, B.E.2
Brunet, A.3
-
28
-
-
0345107247
-
Complexes between the LKB1 tumor suppressor, STRAD α/β and MO25 α/β are upstream kinases in the AMP-activated protein kinase cascade
-
Hawley, S.A., Boudeau, J., Reid, J.L., Mustard, K.J., Udd, L., Mäkelä, T.P., Alessi, D.R., Hardie, D.G., Complexes between the LKB1 tumor suppressor, STRAD α/β and MO25 α/β are upstream kinases in the AMP-activated protein kinase cascade. J. Biol., 2, 2003, 28.
-
(2003)
J. Biol.
, vol.2
, pp. 28
-
-
Hawley, S.A.1
Boudeau, J.2
Reid, J.L.3
Mustard, K.J.4
Udd, L.5
Mäkelä, T.P.6
Alessi, D.R.7
Hardie, D.G.8
-
29
-
-
23044432463
-
Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase
-
Hawley, S.A., Pan, D.A., Mustard, K.J., Ross, L., Bain, J., Edelman, A.M., Frenguelli, B.G., Hardie, D.G., Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab. 2 (2005), 9–19.
-
(2005)
Cell Metab.
, vol.2
, pp. 9-19
-
-
Hawley, S.A.1
Pan, D.A.2
Mustard, K.J.3
Ross, L.4
Bain, J.5
Edelman, A.M.6
Frenguelli, B.G.7
Hardie, D.G.8
-
30
-
-
77956410464
-
Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation
-
Hawley, S.A., Ross, F.A., Chevtzoff, C., Green, K.A., Evans, A., Fogarty, S., Towler, M.C., Brown, L.J., Ogunbayo, O.A., Evans, A.M., Hardie, D.G., Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation. Cell Metab. 11 (2010), 554–565.
-
(2010)
Cell Metab.
, vol.11
, pp. 554-565
-
-
Hawley, S.A.1
Ross, F.A.2
Chevtzoff, C.3
Green, K.A.4
Evans, A.5
Fogarty, S.6
Towler, M.C.7
Brown, L.J.8
Ogunbayo, O.A.9
Evans, A.M.10
Hardie, D.G.11
-
31
-
-
84861222690
-
The ancient drug salicylate directly activates AMP-activated protein kinase
-
Hawley, S.A., Fullerton, M.D., Ross, F.A., Schertzer, J.D., Chevtzoff, C., Walker, K.J., Peggie, M.W., Zibrova, D., Green, K.A., Mustard, K.J., et al. The ancient drug salicylate directly activates AMP-activated protein kinase. Science 336 (2012), 918–922.
-
(2012)
Science
, vol.336
, pp. 918-922
-
-
Hawley, S.A.1
Fullerton, M.D.2
Ross, F.A.3
Schertzer, J.D.4
Chevtzoff, C.5
Walker, K.J.6
Peggie, M.W.7
Zibrova, D.8
Green, K.A.9
Mustard, K.J.10
-
32
-
-
84897534723
-
Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells
-
Hawley, S.A., Ross, F.A., Gowans, G.J., Tibarewal, P., Leslie, N.R., Hardie, D.G., Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells. Biochem. J. 459 (2014), 275–287.
-
(2014)
Biochem. J.
, vol.459
, pp. 275-287
-
-
Hawley, S.A.1
Ross, F.A.2
Gowans, G.J.3
Tibarewal, P.4
Leslie, N.R.5
Hardie, D.G.6
-
33
-
-
84922844480
-
Metformin action: concentrations matter
-
He, L., Wondisford, F.E., Metformin action: concentrations matter. Cell Metab. 21 (2015), 159–162.
-
(2015)
Cell Metab.
, vol.21
, pp. 159-162
-
-
He, L.1
Wondisford, F.E.2
-
34
-
-
84891382131
-
AMP-activated protein kinase induces p53 by phosphorylating MDMX and inhibiting its activity
-
He, G., Zhang, Y.-W., Lee, J.-H., Zeng, S.X., Wang, Y.V., Luo, Z., Dong, X.C., Viollet, B., Wahl, G.M., Lu, H., AMP-activated protein kinase induces p53 by phosphorylating MDMX and inhibiting its activity. Mol. Cell. Biol. 34 (2014), 148–157.
-
(2014)
Mol. Cell. Biol.
, vol.34
, pp. 148-157
-
-
He, G.1
Zhang, Y.-W.2
Lee, J.-H.3
Zeng, S.X.4
Wang, Y.V.5
Luo, Z.6
Dong, X.C.7
Viollet, B.8
Wahl, G.M.9
Lu, H.10
-
35
-
-
85009460365
-
Protein kinase C phosphorylates AMP-activated protein kinase α1 Ser487
-
Heathcote, H.R., Mancini, S.J., Strembitska, A., Jamal, K., Reihill, J.A., Palmer, T.M., Gould, G.W., Salt, I.P., Protein kinase C phosphorylates AMP-activated protein kinase α1 Ser487. Biochem. J. 473 (2016), 4681–4697.
-
(2016)
Biochem. J.
, vol.473
, pp. 4681-4697
-
-
Heathcote, H.R.1
Mancini, S.J.2
Strembitska, A.3
Jamal, K.4
Reihill, J.A.5
Palmer, T.M.6
Gould, G.W.7
Salt, I.P.8
-
36
-
-
84948412219
-
Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates
-
Hoffman, N.J., Parker, B.L., Chaudhuri, R., Fisher-Wellman, K.H., Kleinert, M., Humphrey, S.J., Yang, P., Holliday, M., Trefely, S., Fazakerley, D.J., et al. Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates. Cell Metab. 22 (2015), 922–935.
-
(2015)
Cell Metab.
, vol.22
, pp. 922-935
-
-
Hoffman, N.J.1
Parker, B.L.2
Chaudhuri, R.3
Fisher-Wellman, K.H.4
Kleinert, M.5
Humphrey, S.J.6
Yang, P.7
Holliday, M.8
Trefely, S.9
Fazakerley, D.J.10
-
37
-
-
0042847434
-
AMP-activated protein kinase regulates HNF4alpha transcriptional activity by inhibiting dimer formation and decreasing protein stability
-
Hong, Y.H., Varanasi, U.S., Yang, W., Leff, T., AMP-activated protein kinase regulates HNF4alpha transcriptional activity by inhibiting dimer formation and decreasing protein stability. J. Biol. Chem. 278 (2003), 27495–27501.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 27495-27501
-
-
Hong, Y.H.1
Varanasi, U.S.2
Yang, W.3
Leff, T.4
-
38
-
-
70449584566
-
AMP-activated protein kinase adapts rRNA synthesis to cellular energy supply
-
Hoppe, S., Bierhoff, H., Cado, I., Weber, A., Tiebe, M., Grummt, I., Voit, R., AMP-activated protein kinase adapts rRNA synthesis to cellular energy supply. Proc. Natl. Acad. Sci. USA 106 (2009), 17781–17786.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 17781-17786
-
-
Hoppe, S.1
Bierhoff, H.2
Cado, I.3
Weber, A.4
Tiebe, M.5
Grummt, I.6
Voit, R.7
-
39
-
-
49649085586
-
AMP-activated protein kinase phosphorylates and desensitizes smooth muscle myosin light chain kinase
-
Horman, S., Morel, N., Vertommen, D., Hussain, N., Neumann, D., Beauloye, C., El Najjar, N., Forcet, C., Viollet, B., Walsh, M.P., et al. AMP-activated protein kinase phosphorylates and desensitizes smooth muscle myosin light chain kinase. J. Biol. Chem. 283 (2008), 18505–18512.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 18505-18512
-
-
Horman, S.1
Morel, N.2
Vertommen, D.3
Hussain, N.4
Neumann, D.5
Beauloye, C.6
El Najjar, N.7
Forcet, C.8
Viollet, B.9
Walsh, M.P.10
-
40
-
-
84892933078
-
Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity
-
Houde, V.P., Ritorto, M.S., Gourlay, R., Varghese, J., Davies, P., Shpiro, N., Sakamoto, K., Alessi, D.R., Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity. Biochem. J. 458 (2014), 41–56.
-
(2014)
Biochem. J.
, vol.458
, pp. 41-56
-
-
Houde, V.P.1
Ritorto, M.S.2
Gourlay, R.3
Varghese, J.4
Davies, P.5
Shpiro, N.6
Sakamoto, K.7
Alessi, D.R.8
-
41
-
-
84904556335
-
Mechanism of action of compound-13: an α1-selective small molecule activator of AMPK
-
Hunter, R.W., Foretz, M., Bultot, L., Fullerton, M.D., Deak, M., Ross, F.A., Hawley, S.A., Shpiro, N., Viollet, B., Barron, D., et al. Mechanism of action of compound-13: an α1-selective small molecule activator of AMPK. Chem. Biol. 21 (2014), 866–879.
-
(2014)
Chem. Biol.
, vol.21
, pp. 866-879
-
-
Hunter, R.W.1
Foretz, M.2
Bultot, L.3
Fullerton, M.D.4
Deak, M.5
Ross, F.A.6
Hawley, S.A.7
Shpiro, N.8
Viollet, B.9
Barron, D.10
-
42
-
-
23844471263
-
The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases
-
Hurley, R.L., Anderson, K.A., Franzone, J.M., Kemp, B.E., Means, A.R., Witters, L.A., The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases. J. Biol. Chem. 280 (2005), 29060–29066.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 29060-29066
-
-
Hurley, R.L.1
Anderson, K.A.2
Franzone, J.M.3
Kemp, B.E.4
Means, A.R.5
Witters, L.A.6
-
43
-
-
33845972272
-
Regulation of AMP-activated protein kinase by multisite phosphorylation in response to agents that elevate cellular cAMP
-
Hurley, R.L., Barré, L.K., Wood, S.D., Anderson, K.A., Kemp, B.E., Means, A.R., Witters, L.A., Regulation of AMP-activated protein kinase by multisite phosphorylation in response to agents that elevate cellular cAMP. J. Biol. Chem. 281 (2006), 36662–36672.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 36662-36672
-
-
Hurley, R.L.1
Barré, L.K.2
Wood, S.D.3
Anderson, K.A.4
Kemp, B.E.5
Means, A.R.6
Witters, L.A.7
-
44
-
-
0345167800
-
TSC2 mediates cellular energy response to control cell growth and survival
-
Inoki, K., Zhu, T., Guan, K.L., TSC2 mediates cellular energy response to control cell growth and survival. Cell 115 (2003), 577–590.
-
(2003)
Cell
, vol.115
, pp. 577-590
-
-
Inoki, K.1
Zhu, T.2
Guan, K.L.3
-
45
-
-
34547545892
-
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha
-
Jäger, S., Handschin, C., St-Pierre, J., Spiegelman, B.M., AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proc. Natl. Acad. Sci. USA 104 (2007), 12017–12022.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 12017-12022
-
-
Jäger, S.1
Handschin, C.2
St-Pierre, J.3
Spiegelman, B.M.4
-
46
-
-
84863763440
-
AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress
-
Jeon, S.-M., Chandel, N.S., Hay, N., AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress. Nature 485 (2012), 661–665.
-
(2012)
Nature
, vol.485
, pp. 661-665
-
-
Jeon, S.-M.1
Chandel, N.S.2
Hay, N.3
-
47
-
-
84977609281
-
AMPK Facilitates Nuclear Accumulation of Nrf2 by Phosphorylating at Serine 550
-
Joo, M.S., Kim, W.D., Lee, K.Y., Kim, J.H., Koo, J.H., Kim, S.G., AMPK Facilitates Nuclear Accumulation of Nrf2 by Phosphorylating at Serine 550. Mol. Cell. Biol. 36 (2016), 1931–1942.
-
(2016)
Mol. Cell. Biol.
, vol.36
, pp. 1931-1942
-
-
Joo, M.S.1
Kim, W.D.2
Lee, K.Y.3
Kim, J.H.4
Koo, J.H.5
Kim, S.G.6
-
48
-
-
84872663835
-
AMPK at the crossroads of circadian clocks and metabolism
-
Jordan, S.D., Lamia, K.A., AMPK at the crossroads of circadian clocks and metabolism. Mol. Cell. Endocrinol. 366 (2013), 163–169.
-
(2013)
Mol. Cell. Endocrinol.
, vol.366
, pp. 163-169
-
-
Jordan, S.D.1
Lamia, K.A.2
-
49
-
-
84928406936
-
Inhibition of AMP Kinase by the Protein Phosphatase 2A Heterotrimer, PP2APpp2r2d
-
Joseph, B.K., Liu, H.-Y., Francisco, J., Pandya, D., Donigan, M., Gallo-Ebert, C., Giordano, C., Bata, A., Nickels, J.T. Jr., Inhibition of AMP Kinase by the Protein Phosphatase 2A Heterotrimer, PP2APpp2r2d. J. Biol. Chem. 290 (2015), 10588–10598.
-
(2015)
J. Biol. Chem.
, vol.290
, pp. 10588-10598
-
-
Joseph, B.K.1
Liu, H.-Y.2
Francisco, J.3
Pandya, D.4
Donigan, M.5
Gallo-Ebert, C.6
Giordano, C.7
Bata, A.8
Nickels, J.T.9
-
50
-
-
0037040185
-
Mechanism for fatty acid “sparing” effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase
-
Kawaguchi, T., Osatomi, K., Yamashita, H., Kabashima, T., Uyeda, K., Mechanism for fatty acid “sparing” effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase. J. Biol. Chem. 277 (2002), 3829–3835.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 3829-3835
-
-
Kawaguchi, T.1
Osatomi, K.2
Yamashita, H.3
Kabashima, T.4
Uyeda, K.5
-
51
-
-
79551598347
-
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
-
Kim, J., Kundu, M., Viollet, B., Guan, K.-L., AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat. Cell Biol. 13 (2011), 132–141.
-
(2011)
Nat. Cell Biol.
, vol.13
, pp. 132-141
-
-
Kim, J.1
Kundu, M.2
Viollet, B.3
Guan, K.-L.4
-
52
-
-
84872586081
-
Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy
-
Kim, J., Kim, Y.C., Fang, C., Russell, R.C., Kim, J.H., Fan, W., Liu, R., Zhong, Q., Guan, K.-L., Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell 152 (2013), 290–303.
-
(2013)
Cell
, vol.152
, pp. 290-303
-
-
Kim, J.1
Kim, Y.C.2
Fang, C.3
Russell, R.C.4
Kim, J.H.5
Fan, W.6
Liu, R.7
Zhong, Q.8
Guan, K.-L.9
-
53
-
-
84977666628
-
AMPK Phosphorylates Desnutrin/ATGL and Hormone-Sensitive Lipase To Regulate Lipolysis and Fatty Acid Oxidation within Adipose Tissue
-
Kim, S.-J., Tang, T., Abbott, M., Viscarra, J.A., Wang, Y., Sul, H.S., AMPK Phosphorylates Desnutrin/ATGL and Hormone-Sensitive Lipase To Regulate Lipolysis and Fatty Acid Oxidation within Adipose Tissue. Mol. Cell. Biol. 36 (2016), 1961–1976.
-
(2016)
Mol. Cell. Biol.
, vol.36
, pp. 1961-1976
-
-
Kim, S.-J.1
Tang, T.2
Abbott, M.3
Viscarra, J.A.4
Wang, Y.5
Sul, H.S.6
-
54
-
-
27144506185
-
The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism
-
Koo, S.-H., Flechner, L., Qi, L., Zhang, X., Screaton, R.A., Jeffries, S., Hedrick, S., Xu, W., Boussouar, F., Brindle, P., et al. The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature 437 (2005), 1109–1111.
-
(2005)
Nature
, vol.437
, pp. 1109-1111
-
-
Koo, S.-H.1
Flechner, L.2
Qi, L.3
Zhang, X.4
Screaton, R.A.5
Jeffries, S.6
Hedrick, S.7
Xu, W.8
Boussouar, F.9
Brindle, P.10
-
55
-
-
70350128135
-
AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation
-
Lamia, K.A., Sachdeva, U.M., DiTacchio, L., Williams, E.C., Alvarez, J.G., Egan, D.F., Vasquez, D.S., Juguilon, H., Panda, S., Shaw, R.J., et al. AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. Science 326 (2009), 437–440.
-
(2009)
Science
, vol.326
, pp. 437-440
-
-
Lamia, K.A.1
Sachdeva, U.M.2
DiTacchio, L.3
Williams, E.C.4
Alvarez, J.G.5
Egan, D.F.6
Vasquez, D.S.7
Juguilon, H.8
Panda, S.9
Shaw, R.J.10
-
56
-
-
84255206549
-
Cryptochromes mediate rhythmic repression of the glucocorticoid receptor
-
Lamia, K.A., Papp, S.J., Yu, R.T., Barish, G.D., Uhlenhaut, N.H., Jonker, J.W., Downes, M., Evans, R.M., Cryptochromes mediate rhythmic repression of the glucocorticoid receptor. Nature 480 (2011), 552–556.
-
(2011)
Nature
, vol.480
, pp. 552-556
-
-
Lamia, K.A.1
Papp, S.J.2
Yu, R.T.3
Barish, G.D.4
Uhlenhaut, N.H.5
Jonker, J.W.6
Downes, M.7
Evans, R.M.8
-
57
-
-
84874077399
-
E3 ubiquitin ligase, WWP1, interacts with AMPKα2 and down-regulates its expression in skeletal muscle C2C12 cells
-
Lee, J.O., Lee, S.K., Kim, N., Kim, J.H., You, G.Y., Moon, J.W., Jie, S., Kim, S.J., Lee, Y.W., Kang, H.J., et al. E3 ubiquitin ligase, WWP1, interacts with AMPKα2 and down-regulates its expression in skeletal muscle C2C12 cells. J. Biol. Chem. 288 (2013), 4673–4680.
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 4673-4680
-
-
Lee, J.O.1
Lee, S.K.2
Kim, N.3
Kim, J.H.4
You, G.Y.5
Moon, J.W.6
Jie, S.7
Kim, S.J.8
Lee, Y.W.9
Kang, H.J.10
-
58
-
-
84878271546
-
The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation
-
Leprivier, G., Remke, M., Rotblat, B., Dubuc, A., Mateo, A.-R.F., Kool, M., Agnihotri, S., El-Naggar, A., Yu, B., Somasekharan, S.P., et al. The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation. Cell 153 (2013), 1064–1079.
-
(2013)
Cell
, vol.153
, pp. 1064-1079
-
-
Leprivier, G.1
Remke, M.2
Rotblat, B.3
Dubuc, A.4
Mateo, A.-R.F.5
Kool, M.6
Agnihotri, S.7
El-Naggar, A.8
Yu, B.9
Somasekharan, S.P.10
-
59
-
-
79953755370
-
AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice
-
Li, Y., Xu, S., Mihaylova, M.M., Zheng, B., Hou, X., Jiang, B., Park, O., Luo, Z., Lefai, E., Shyy, J.Y.J., et al. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab. 13 (2011), 376–388.
-
(2011)
Cell Metab.
, vol.13
, pp. 376-388
-
-
Li, Y.1
Xu, S.2
Mihaylova, M.M.3
Zheng, B.4
Hou, X.5
Jiang, B.6
Park, O.7
Luo, Z.8
Lefai, E.9
Shyy, J.Y.J.10
-
60
-
-
84920276724
-
Structural basis of AMPK regulation by adenine nucleotides and glycogen
-
Li, X., Wang, L., Zhou, X.E., Ke, J., de Waal, P.W., Gu, X., Tan, M.H.E., Wang, D., Wu, D., Xu, H.E., Melcher, K., Structural basis of AMPK regulation by adenine nucleotides and glycogen. Cell Res. 25 (2015), 50–66.
-
(2015)
Cell Res.
, vol.25
, pp. 50-66
-
-
Li, X.1
Wang, L.2
Zhou, X.E.3
Ke, J.4
de Waal, P.W.5
Gu, X.6
Tan, M.H.E.7
Wang, D.8
Wu, D.9
Xu, H.E.10
Melcher, K.11
-
61
-
-
84947038316
-
AMP-Activated Protein Kinase Directly Phosphorylates and Destabilizes Hedgehog Pathway Transcription Factor GLI1 in Medulloblastoma
-
Li, Y.-H., Luo, J., Mosley, Y.-Y.C., Hedrick, V.E., Paul, L.N., Chang, J., Zhang, G., Wang, Y.-K., Banko, M.R., Brunet, A., et al. AMP-Activated Protein Kinase Directly Phosphorylates and Destabilizes Hedgehog Pathway Transcription Factor GLI1 in Medulloblastoma. Cell Rep. 12 (2015), 599–609.
-
(2015)
Cell Rep.
, vol.12
, pp. 599-609
-
-
Li, Y.-H.1
Luo, J.2
Mosley, Y.-Y.C.3
Hedrick, V.E.4
Paul, L.N.5
Chang, J.6
Zhang, G.7
Wang, Y.-K.8
Banko, M.R.9
Brunet, A.10
-
62
-
-
84939426946
-
Myristoylation confers noncanonical AMPK functions in autophagy selectivity and mitochondrial surveillance
-
Liang, J., Xu, Z.-X., Ding, Z., Lu, Y., Yu, Q., Werle, K.D., Zhou, G., Park, Y.-Y., Peng, G., Gambello, M.J., Mills, G.B., Myristoylation confers noncanonical AMPK functions in autophagy selectivity and mitochondrial surveillance. Nat. Commun., 6, 2015, 7926.
-
(2015)
Nat. Commun.
, vol.6
, pp. 7926
-
-
Liang, J.1
Xu, Z.-X.2
Ding, Z.3
Lu, Y.4
Yu, Q.5
Werle, K.D.6
Zhou, G.7
Park, Y.-Y.8
Peng, G.9
Gambello, M.J.10
Mills, G.B.11
-
63
-
-
84866061320
-
AMPK-dependent phosphorylation of ULK1 regulates ATG9 localization
-
Mack, H.I.D., Zheng, B., Asara, J.M., Thomas, S.M., AMPK-dependent phosphorylation of ULK1 regulates ATG9 localization. Autophagy 8 (2012), 1197–1214.
-
(2012)
Autophagy
, vol.8
, pp. 1197-1214
-
-
Mack, H.I.D.1
Zheng, B.2
Asara, J.M.3
Thomas, S.M.4
-
64
-
-
84903524608
-
Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
-
Madiraju, A.K., Erion, D.M., Rahimi, Y., Zhang, X.-M., Braddock, D.T., Albright, R.A., Prigaro, B.J., Wood, J.L., Bhanot, S., MacDonald, M.J., et al. Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase. Nature 510 (2014), 542–546.
-
(2014)
Nature
, vol.510
, pp. 542-546
-
-
Madiraju, A.K.1
Erion, D.M.2
Rahimi, Y.3
Zhang, X.-M.4
Braddock, D.T.5
Albright, R.A.6
Prigaro, B.J.7
Wood, J.L.8
Bhanot, S.9
MacDonald, M.J.10
-
65
-
-
85008145754
-
Transcription Factor EB Controls Metabolic Flexibility during Exercise
-
Mansueto, G., Armani, A., Viscomi, C., D'Orsi, L., De Cegli, R., Polishchuk, E.V., Lamperti, C., Di Meo, I., Romanello, V., Marchet, S., et al. Transcription Factor EB Controls Metabolic Flexibility during Exercise. Cell Metab. 25 (2017), 182–196.
-
(2017)
Cell Metab.
, vol.25
, pp. 182-196
-
-
Mansueto, G.1
Armani, A.2
Viscomi, C.3
D'Orsi, L.4
De Cegli, R.5
Polishchuk, E.V.6
Lamperti, C.7
Di Meo, I.8
Romanello, V.9
Marchet, S.10
-
66
-
-
57849090443
-
The glycogen-binding domain on the AMPK beta subunit allows the kinase to act as a glycogen sensor
-
McBride, A., Ghilagaber, S., Nikolaev, A., Hardie, D.G., The glycogen-binding domain on the AMPK beta subunit allows the kinase to act as a glycogen sensor. Cell Metab. 9 (2009), 23–34.
-
(2009)
Cell Metab.
, vol.9
, pp. 23-34
-
-
McBride, A.1
Ghilagaber, S.2
Nikolaev, A.3
Hardie, D.G.4
-
67
-
-
79955815135
-
Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis
-
Mihaylova, M.M., Vasquez, D.S., Ravnskjaer, K., Denechaud, P.-D., Yu, R.T., Alvarez, J.G., Downes, M., Evans, R.M., Montminy, M., Shaw, R.J., Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis. Cell 145 (2011), 607–621.
-
(2011)
Cell
, vol.145
, pp. 607-621
-
-
Mihaylova, M.M.1
Vasquez, D.S.2
Ravnskjaer, K.3
Denechaud, P.-D.4
Yu, R.T.5
Alvarez, J.G.6
Downes, M.7
Evans, R.M.8
Montminy, M.9
Shaw, R.J.10
-
68
-
-
84873707522
-
Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP
-
Miller, R.A., Chu, Q., Xie, J., Foretz, M., Viollet, B., Birnbaum, M.J., Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP. Nature 494 (2013), 256–260.
-
(2013)
Nature
, vol.494
, pp. 256-260
-
-
Miller, R.A.1
Chu, Q.2
Xie, J.3
Foretz, M.4
Viollet, B.5
Birnbaum, M.J.6
-
69
-
-
84928587895
-
Compartmentalized AMPK signaling illuminated by genetically encoded molecular sensors and actuators
-
Miyamoto, T., Rho, E., Sample, V., Akano, H., Magari, M., Ueno, T., Gorshkov, K., Chen, M., Tokumitsu, H., Zhang, J., Inoue, T., Compartmentalized AMPK signaling illuminated by genetically encoded molecular sensors and actuators. Cell Rep. 11 (2015), 657–670.
-
(2015)
Cell Rep.
, vol.11
, pp. 657-670
-
-
Miyamoto, T.1
Rho, E.2
Sample, V.3
Akano, H.4
Magari, M.5
Ueno, T.6
Gorshkov, K.7
Chen, M.8
Tokumitsu, H.9
Zhang, J.10
Inoue, T.11
-
70
-
-
84925970129
-
Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway
-
Mo, J.-S., Meng, Z., Kim, Y.C., Park, H.W., Hansen, C.G., Kim, S., Lim, D.-S., Guan, K.-L., Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway. Nat. Cell Biol. 17 (2015), 500–510.
-
(2015)
Nat. Cell Biol.
, vol.17
, pp. 500-510
-
-
Mo, J.-S.1
Meng, Z.2
Kim, Y.C.3
Park, H.W.4
Hansen, C.G.5
Kim, S.6
Lim, D.-S.7
Guan, K.-L.8
-
71
-
-
84904042103
-
Transcriptional coregulators: fine-tuning metabolism
-
Mouchiroud, L., Eichner, L.J., Shaw, R.J., Auwerx, J., Transcriptional coregulators: fine-tuning metabolism. Cell Metab. 20 (2014), 26–40.
-
(2014)
Cell Metab.
, vol.20
, pp. 26-40
-
-
Mouchiroud, L.1
Eichner, L.J.2
Shaw, R.J.3
Auwerx, J.4
-
72
-
-
78650606464
-
β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK)
-
Oakhill, J.S., Chen, Z.-P., Scott, J.W., Steel, R., Castelli, L.A., Ling, N., Macaulay, S.L., Kemp, B.E., β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK). Proc. Natl. Acad. Sci. USA 107 (2010), 19237–19241.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 19237-19241
-
-
Oakhill, J.S.1
Chen, Z.-P.2
Scott, J.W.3
Steel, R.4
Castelli, L.A.5
Ling, N.6
Macaulay, S.L.7
Kemp, B.E.8
-
73
-
-
79959338922
-
AMPK is a direct adenylate charge-regulated protein kinase
-
Oakhill, J.S., Steel, R., Chen, Z.P., Scott, J.W., Ling, N., Tam, S., Kemp, B.E., AMPK is a direct adenylate charge-regulated protein kinase. Science 332 (2011), 1433–1435.
-
(2011)
Science
, vol.332
, pp. 1433-1435
-
-
Oakhill, J.S.1
Steel, R.2
Chen, Z.P.3
Scott, J.W.4
Ling, N.5
Tam, S.6
Kemp, B.E.7
-
74
-
-
78650931836
-
Metformin activates AMP kinase through inhibition of AMP deaminase
-
Ouyang, J., Parakhia, R.A., Ochs, R.S., Metformin activates AMP kinase through inhibition of AMP deaminase. J. Biol. Chem. 286 (2011), 1–11.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 1-11
-
-
Ouyang, J.1
Parakhia, R.A.2
Ochs, R.S.3
-
75
-
-
84922689340
-
Degradation of AMPK by a cancer-specific ubiquitin ligase
-
Pineda, C.T., Ramanathan, S., Fon Tacer, K., Weon, J.L., Potts, M.B., Ou, Y.-H., White, M.A., Potts, P.R., Degradation of AMPK by a cancer-specific ubiquitin ligase. Cell 160 (2015), 715–728.
-
(2015)
Cell
, vol.160
, pp. 715-728
-
-
Pineda, C.T.1
Ramanathan, S.2
Fon Tacer, K.3
Weon, J.L.4
Potts, M.B.5
Ou, Y.-H.6
White, M.A.7
Potts, P.R.8
-
76
-
-
84921897035
-
Methotrexate promotes glucose uptake and lipid oxidation in skeletal muscle via AMPK activation
-
Pirkmajer, S., Kulkarni, S.S., Tom, R.Z., Ross, F.A., Hawley, S.A., Hardie, D.G., Zierath, J.R., Chibalin, A.V., Methotrexate promotes glucose uptake and lipid oxidation in skeletal muscle via AMPK activation. Diabetes 64 (2015), 360–369.
-
(2015)
Diabetes
, vol.64
, pp. 360-369
-
-
Pirkmajer, S.1
Kulkarni, S.S.2
Tom, R.Z.3
Ross, F.A.4
Hawley, S.A.5
Hardie, D.G.6
Zierath, J.R.7
Chibalin, A.V.8
-
77
-
-
84911500766
-
Effects of pharmacological AMP deaminase inhibition and Ampd1 deletion on nucleotide levels and AMPK activation in contracting skeletal muscle
-
Plaideau, C., Lai, Y.-C., Kviklyte, S., Zanou, N., Löfgren, L., Andersén, H., Vertommen, D., Gailly, P., Hue, L., Bohlooly-Y, M., et al. Effects of pharmacological AMP deaminase inhibition and Ampd1 deletion on nucleotide levels and AMPK activation in contracting skeletal muscle. Chem. Biol. 21 (2014), 1497–1510.
-
(2014)
Chem. Biol.
, vol.21
, pp. 1497-1510
-
-
Plaideau, C.1
Lai, Y.-C.2
Kviklyte, S.3
Zanou, N.4
Löfgren, L.5
Andersén, H.6
Vertommen, D.7
Gailly, P.8
Hue, L.9
Bohlooly-Y, M.10
-
78
-
-
67650456927
-
Therapeutics by cytotoxic metabolite accumulation: pemetrexed causes ZMP accumulation, AMPK activation, and mammalian target of rapamycin inhibition
-
Racanelli, A.C., Rothbart, S.B., Heyer, C.L., Moran, R.G., Therapeutics by cytotoxic metabolite accumulation: pemetrexed causes ZMP accumulation, AMPK activation, and mammalian target of rapamycin inhibition. Cancer Res. 69 (2009), 5467–5474.
-
(2009)
Cancer Res.
, vol.69
, pp. 5467-5474
-
-
Racanelli, A.C.1
Rothbart, S.B.2
Heyer, C.L.3
Moran, R.G.4
-
79
-
-
84983252357
-
AMP-activated protein kinase: a cellular energy sensor that comes in 12 flavours
-
Ross, F.A., MacKintosh, C., Hardie, D.G., AMP-activated protein kinase: a cellular energy sensor that comes in 12 flavours. FEBS J. 283 (2016), 2987–3001.
-
(2016)
FEBS J.
, vol.283
, pp. 2987-3001
-
-
Ross, F.A.1
MacKintosh, C.2
Hardie, D.G.3
-
80
-
-
36348978499
-
Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family
-
Sanders, M.J., Ali, Z.S., Hegarty, B.D., Heath, R., Snowden, M.A., Carling, D., Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family. J. Biol. Chem. 282 (2007), 32539–32548.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 32539-32548
-
-
Sanders, M.J.1
Ali, Z.S.2
Hegarty, B.D.3
Heath, R.4
Snowden, M.A.5
Carling, D.6
-
81
-
-
84948425160
-
Identification of AMPK Phosphorylation Sites Reveals a Network of Proteins Involved in Cell Invasion and Facilitates Large-Scale Substrate Prediction
-
Schaffer, B.E., Levin, R.S., Hertz, N.T., Maures, T.J., Schoof, M.L., Hollstein, P.E., Benayoun, B.A., Banko, M.R., Shaw, R.J., Shokat, K.M., Brunet, A., Identification of AMPK Phosphorylation Sites Reveals a Network of Proteins Involved in Cell Invasion and Facilitates Large-Scale Substrate Prediction. Cell Metab. 22 (2015), 907–921.
-
(2015)
Cell Metab.
, vol.22
, pp. 907-921
-
-
Schaffer, B.E.1
Levin, R.S.2
Hertz, N.T.3
Maures, T.J.4
Schoof, M.L.5
Hollstein, P.E.6
Benayoun, B.A.7
Banko, M.R.8
Shaw, R.J.9
Shokat, K.M.10
Brunet, A.11
-
82
-
-
84901329684
-
Small molecule drug A-769662 and AMP synergistically activate naive AMPK independent of upstream kinase signaling
-
Scott, J.W., Ling, N., Issa, S.M.A., Dite, T.A., O'Brien, M.T., Chen, Z.-P., Galic, S., Langendorf, C.G., Steinberg, G.R., Kemp, B.E., Oakhill, J.S., Small molecule drug A-769662 and AMP synergistically activate naive AMPK independent of upstream kinase signaling. Chem. Biol. 21 (2014), 619–627.
-
(2014)
Chem. Biol.
, vol.21
, pp. 619-627
-
-
Scott, J.W.1
Ling, N.2
Issa, S.M.A.3
Dite, T.A.4
O'Brien, M.T.5
Chen, Z.-P.6
Galic, S.7
Langendorf, C.G.8
Steinberg, G.R.9
Kemp, B.E.10
Oakhill, J.S.11
-
83
-
-
84893432818
-
A redox-dependent mechanism for regulation of AMPK activation by Thioredoxin1 during energy starvation
-
Shao, D., Oka, S., Liu, T., Zhai, P., Ago, T., Sciarretta, S., Li, H., Sadoshima, J., A redox-dependent mechanism for regulation of AMPK activation by Thioredoxin1 during energy starvation. Cell Metab. 19 (2014), 232–245.
-
(2014)
Cell Metab.
, vol.19
, pp. 232-245
-
-
Shao, D.1
Oka, S.2
Liu, T.3
Zhai, P.4
Ago, T.5
Sciarretta, S.6
Li, H.7
Sadoshima, J.8
-
84
-
-
1542618348
-
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
-
Shaw, R.J., Kosmatka, M., Bardeesy, N., Hurley, R.L., Witters, L.A., DePinho, R.A., Cantley, L.C., The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc. Natl. Acad. Sci. USA 101 (2004), 3329–3335.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 3329-3335
-
-
Shaw, R.J.1
Kosmatka, M.2
Bardeesy, N.3
Hurley, R.L.4
Witters, L.A.5
DePinho, R.A.6
Cantley, L.C.7
-
85
-
-
28844433635
-
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
-
Shaw, R.J., Lamia, K.A., Vasquez, D., Koo, S.-H., Bardeesy, N., Depinho, R.A., Montminy, M., Cantley, L.C., The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310 (2005), 1642–1646.
-
(2005)
Science
, vol.310
, pp. 1642-1646
-
-
Shaw, R.J.1
Lamia, K.A.2
Vasquez, D.3
Koo, S.-H.4
Bardeesy, N.5
Depinho, R.A.6
Montminy, M.7
Cantley, L.C.8
-
86
-
-
84975756856
-
AMPK-SKP2-CARM1 signalling cascade in transcriptional regulation of autophagy
-
Shin, H.-J.R., Kim, H., Oh, S., Lee, J.-G., Kee, M., Ko, H.-J., Kweon, M.-N., Won, K.-J., Baek, S.H., AMPK-SKP2-CARM1 signalling cascade in transcriptional regulation of autophagy. Nature 534 (2016), 553–557.
-
(2016)
Nature
, vol.534
, pp. 553-557
-
-
Shin, H.-J.R.1
Kim, H.2
Oh, S.3
Lee, J.-G.4
Kee, M.5
Ko, H.-J.6
Kweon, M.-N.7
Won, K.-J.8
Baek, S.H.9
-
87
-
-
84930762848
-
Co-activation of AMPK and mTORC1 Induces Cytotoxicity in Acute Myeloid Leukemia
-
Sujobert, P., Poulain, L., Paubelle, E., Zylbersztejn, F., Grenier, A., Lambert, M., Townsend, E.C., Brusq, J.-M., Nicodeme, E., Decrooqc, J., et al. Co-activation of AMPK and mTORC1 Induces Cytotoxicity in Acute Myeloid Leukemia. Cell Rep. 11 (2015), 1446–1457.
-
(2015)
Cell Rep.
, vol.11
, pp. 1446-1457
-
-
Sujobert, P.1
Poulain, L.2
Paubelle, E.3
Zylbersztejn, F.4
Grenier, A.5
Lambert, M.6
Townsend, E.C.7
Brusq, J.-M.8
Nicodeme, E.9
Decrooqc, J.10
-
88
-
-
33845949733
-
Dissecting the role of 5′-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase
-
Suter, M., Riek, U., Tuerk, R., Schlattner, U., Wallimann, T., Neumann, D., Dissecting the role of 5′-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase. J. Biol. Chem. 281 (2006), 32207–32216.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 32207-32216
-
-
Suter, M.1
Riek, U.2
Tuerk, R.3
Schlattner, U.4
Wallimann, T.5
Neumann, D.6
-
89
-
-
84887189624
-
Inhibition of AMPK catabolic action by GSK3
-
Suzuki, T., Bridges, D., Nakada, D., Skiniotis, G., Morrison, S.J., Lin, J.D., Saltiel, A.R., Inoki, K., Inhibition of AMPK catabolic action by GSK3. Mol. Cell 50 (2013), 407–419.
-
(2013)
Mol. Cell
, vol.50
, pp. 407-419
-
-
Suzuki, T.1
Bridges, D.2
Nakada, D.3
Skiniotis, G.4
Morrison, S.J.5
Lin, J.D.6
Saltiel, A.R.7
Inoki, K.8
-
90
-
-
84954318420
-
Metabolism. AMP-activated protein kinase mediates mitochondrial fission in response to energy stress
-
Toyama, E.Q., Herzig, S., Courchet, J., Lewis, T.L. Jr., Losón, O.C., Hellberg, K., Young, N.P., Chen, H., Polleux, F., Chan, D.C., Shaw, R.J., Metabolism. AMP-activated protein kinase mediates mitochondrial fission in response to energy stress. Science 351 (2016), 275–281.
-
(2016)
Science
, vol.351
, pp. 275-281
-
-
Toyama, E.Q.1
Herzig, S.2
Courchet, J.3
Lewis, T.L.4
Losón, O.C.5
Hellberg, K.6
Young, N.P.7
Chen, H.8
Polleux, F.9
Chan, D.C.10
Shaw, R.J.11
-
91
-
-
34547127625
-
Activation of 5′-AMP-activated kinase with diabetes drug metformin induces casein kinase Iepsilon (CKIepsilon)-dependent degradation of clock protein mPer2
-
Um, J.H., Yang, S., Yamazaki, S., Kang, H., Viollet, B., Foretz, M., Chung, J.H., Activation of 5′-AMP-activated kinase with diabetes drug metformin induces casein kinase Iepsilon (CKIepsilon)-dependent degradation of clock protein mPer2. J. Biol. Chem. 282 (2007), 20794–20798.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 20794-20798
-
-
Um, J.H.1
Yang, S.2
Yamazaki, S.3
Kang, H.4
Viollet, B.5
Foretz, M.6
Chung, J.H.7
-
92
-
-
85011269383
-
A UBE2O-AMPKα2 Axis that Promotes Tumor Initiation and Progression Offers Opportunities for Therapy
-
Vila, I.K., Yao, Y., Kim, G., Xia, W., Kim, H., Kim, S.-J., Park, M.-K., Hwang, J.P., González-Billalabeitia, E., Hung, M.-C., et al. A UBE2O-AMPKα2 Axis that Promotes Tumor Initiation and Progression Offers Opportunities for Therapy. Cancer Cell 31 (2017), 208–224.
-
(2017)
Cancer Cell
, vol.31
, pp. 208-224
-
-
Vila, I.K.1
Yao, Y.2
Kim, G.3
Xia, W.4
Kim, H.5
Kim, S.-J.6
Park, M.-K.7
Hwang, J.P.8
González-Billalabeitia, E.9
Hung, M.-C.10
-
93
-
-
85006035893
-
The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue
-
Wada, S., Neinast, M., Jang, C., Ibrahim, Y.H., Lee, G., Babu, A., Li, J., Hoshino, A., Rowe, G.C., Rhee, J., et al. The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue. Genes Dev. 30 (2016), 2551–2564.
-
(2016)
Genes Dev.
, vol.30
, pp. 2551-2564
-
-
Wada, S.1
Neinast, M.2
Jang, C.3
Ibrahim, Y.H.4
Lee, G.5
Babu, A.6
Li, J.7
Hoshino, A.8
Rowe, G.C.9
Rhee, J.10
-
94
-
-
84925941268
-
AMPK modulates Hippo pathway activity to regulate energy homeostasis
-
Wang, W., Xiao, Z.-D., Li, X., Aziz, K.E., Gan, B., Johnson, R.L., Chen, J., AMPK modulates Hippo pathway activity to regulate energy homeostasis. Nat. Cell Biol. 17 (2015), 490–499.
-
(2015)
Nat. Cell Biol.
, vol.17
, pp. 490-499
-
-
Wang, W.1
Xiao, Z.-D.2
Li, X.3
Aziz, K.E.4
Gan, B.5
Johnson, R.L.6
Chen, J.7
-
95
-
-
84918805701
-
Metabolic-stress-induced rearrangement of the 14-3-3ζ interactome promotes autophagy via a ULK1- and AMPK-regulated 14-3-3ζ interaction with phosphorylated Atg9
-
Weerasekara, V.K., Panek, D.J., Broadbent, D.G., Mortenson, J.B., Mathis, A.D., Logan, G.N., Prince, J.T., Thomson, D.M., Thompson, J.W., Andersen, J.L., Metabolic-stress-induced rearrangement of the 14-3-3ζ interactome promotes autophagy via a ULK1- and AMPK-regulated 14-3-3ζ interaction with phosphorylated Atg9. Mol. Cell. Biol. 34 (2014), 4379–4388.
-
(2014)
Mol. Cell. Biol.
, vol.34
, pp. 4379-4388
-
-
Weerasekara, V.K.1
Panek, D.J.2
Broadbent, D.G.3
Mortenson, J.B.4
Mathis, A.D.5
Logan, G.N.6
Prince, J.T.7
Thomson, D.M.8
Thompson, J.W.9
Andersen, J.L.10
-
96
-
-
10744230065
-
LKB1 is the upstream kinase in the AMP-activated protein kinase cascade
-
Woods, A., Johnstone, S.R., Dickerson, K., Leiper, F.C., Fryer, L.G.D., Neumann, D., Schlattner, U., Wallimann, T., Carlson, M., Carling, D., LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr. Biol. 13 (2003), 2004–2008.
-
(2003)
Curr. Biol.
, vol.13
, pp. 2004-2008
-
-
Woods, A.1
Johnstone, S.R.2
Dickerson, K.3
Leiper, F.C.4
Fryer, L.G.D.5
Neumann, D.6
Schlattner, U.7
Wallimann, T.8
Carlson, M.9
Carling, D.10
-
97
-
-
23044437445
-
Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells
-
Woods, A., Dickerson, K., Heath, R., Hong, S.-P., Momcilovic, M., Johnstone, S.R., Carlson, M., Carling, D., Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells. Cell Metab. 2 (2005), 21–33.
-
(2005)
Cell Metab.
, vol.2
, pp. 21-33
-
-
Woods, A.1
Dickerson, K.2
Heath, R.3
Hong, S.-P.4
Momcilovic, M.5
Johnstone, S.R.6
Carlson, M.7
Carling, D.8
-
98
-
-
84875813063
-
AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1
-
Wu, N., Zheng, B., Shaywitz, A., Dagon, Y., Tower, C., Bellinger, G., Shen, C.-H., Wen, J., Asara, J., McGraw, T.E., et al. AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1. Mol. Cell 49 (2013), 1167–1175.
-
(2013)
Mol. Cell
, vol.49
, pp. 1167-1175
-
-
Wu, N.1
Zheng, B.2
Shaywitz, A.3
Dagon, Y.4
Tower, C.5
Bellinger, G.6
Shen, C.-H.7
Wen, J.8
Asara, J.9
McGraw, T.E.10
-
99
-
-
79954517977
-
Structure of mammalian AMPK and its regulation by ADP
-
Xiao, B., Sanders, M.J., Underwood, E., Heath, R., Mayer, F.V., Carmena, D., Jing, C., Walker, P.A., Eccleston, J.F., Haire, L.F., et al. Structure of mammalian AMPK and its regulation by ADP. Nature 472 (2011), 230–233.
-
(2011)
Nature
, vol.472
, pp. 230-233
-
-
Xiao, B.1
Sanders, M.J.2
Underwood, E.3
Heath, R.4
Mayer, F.V.5
Carmena, D.6
Jing, C.7
Walker, P.A.8
Eccleston, J.F.9
Haire, L.F.10
-
100
-
-
84890963021
-
Structural basis of AMPK regulation by small molecule activators
-
Xiao, B., Sanders, M.J., Carmena, D., Bright, N.J., Haire, L.F., Underwood, E., Patel, B.R., Heath, R.B., Walker, P.A., Hallen, S., et al. Structural basis of AMPK regulation by small molecule activators. Nat. Commun., 4, 2013, 3017.
-
(2013)
Nat. Commun.
, vol.4
, pp. 3017
-
-
Xiao, B.1
Sanders, M.J.2
Carmena, D.3
Bright, N.J.4
Haire, L.F.5
Underwood, E.6
Patel, B.R.7
Heath, R.B.8
Walker, P.A.9
Hallen, S.10
-
101
-
-
84885187278
-
Coordinated regulation of AMPK activity by multiple elements in the α-subunit
-
Xin, F.-J., Wang, J., Zhao, R.-Q., Wang, Z.-X., Wu, J.-W., Coordinated regulation of AMPK activity by multiple elements in the α-subunit. Cell Res. 23 (2013), 1237–1240.
-
(2013)
Cell Res.
, vol.23
, pp. 1237-1240
-
-
Xin, F.-J.1
Wang, J.2
Zhao, R.-Q.3
Wang, Z.-X.4
Wu, J.-W.5
-
102
-
-
84992376572
-
AMPK/α-Ketoglutarate Axis Dynamically Mediates DNA Demethylation in the Prdm16 Promoter and Brown Adipogenesis
-
Yang, Q., Liang, X., Sun, X., Zhang, L., Fu, X., Rogers, C.J., Berim, A., Zhang, S., Wang, S., Wang, B., et al. AMPK/α-Ketoglutarate Axis Dynamically Mediates DNA Demethylation in the Prdm16 Promoter and Brown Adipogenesis. Cell Metab. 24 (2016), 542–554.
-
(2016)
Cell Metab.
, vol.24
, pp. 542-554
-
-
Yang, Q.1
Liang, X.2
Sun, X.3
Zhang, L.4
Fu, X.5
Rogers, C.J.6
Berim, A.7
Zhang, S.8
Wang, S.9
Wang, B.10
-
103
-
-
84959487667
-
AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes
-
Young, N.P., Kamireddy, A., Van Nostrand, J.L., Eichner, L.J., Shokhirev, M.N., Dayn, Y., Shaw, R.J., AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes. Genes Dev. 30 (2016), 535–552.
-
(2016)
Genes Dev.
, vol.30
, pp. 535-552
-
-
Young, N.P.1
Kamireddy, A.2
Van Nostrand, J.L.3
Eichner, L.J.4
Shokhirev, M.N.5
Dayn, Y.6
Shaw, R.J.7
-
104
-
-
84885142437
-
AMP as a low-energy charge signal autonomously initiates assembly of AXIN-AMPK-LKB1 complex for AMPK activation
-
Zhang, Y.-L., Guo, H., Zhang, C.-S., Lin, S.-Y., Yin, Z., Peng, Y., Luo, H., Shi, Y., Lian, G., Zhang, C., et al. AMP as a low-energy charge signal autonomously initiates assembly of AXIN-AMPK-LKB1 complex for AMPK activation. Cell Metab. 18 (2013), 546–555.
-
(2013)
Cell Metab.
, vol.18
, pp. 546-555
-
-
Zhang, Y.-L.1
Guo, H.2
Zhang, C.-S.3
Lin, S.-Y.4
Yin, Z.5
Peng, Y.6
Luo, H.7
Shi, Y.8
Lian, G.9
Zhang, C.10
-
105
-
-
84907519033
-
The lysosomal v-ATPase-Ragulator complex is a common activator for AMPK and mTORC1, acting as a switch between catabolism and anabolism
-
Zhang, C.-S., Jiang, B., Li, M., Zhu, M., Peng, Y., Zhang, Y.-L., Wu, Y.-Q., Li, T.Y., Liang, Y., Lu, Z., et al. The lysosomal v-ATPase-Ragulator complex is a common activator for AMPK and mTORC1, acting as a switch between catabolism and anabolism. Cell Metab. 20 (2014), 526–540.
-
(2014)
Cell Metab.
, vol.20
, pp. 526-540
-
-
Zhang, C.-S.1
Jiang, B.2
Li, M.3
Zhu, M.4
Peng, Y.5
Zhang, Y.-L.6
Wu, Y.-Q.7
Li, T.Y.8
Liang, Y.9
Lu, Z.10
-
106
-
-
85003955407
-
Regulation of mATG9 trafficking by Src- and ULK1-mediated phosphorylation in basal and starvation-induced autophagy
-
Zhou, C., Ma, K., Gao, R., Mu, C., Chen, L., Liu, Q., Luo, Q., Feng, D., Zhu, Y., Chen, Q., Regulation of mATG9 trafficking by Src- and ULK1-mediated phosphorylation in basal and starvation-induced autophagy. Cell Res. 27 (2017), 184–201.
-
(2017)
Cell Res.
, vol.27
, pp. 184-201
-
-
Zhou, C.1
Ma, K.2
Gao, R.3
Mu, C.4
Chen, L.5
Liu, Q.6
Luo, Q.7
Feng, D.8
Zhu, Y.9
Chen, Q.10
-
107
-
-
77958501463
-
Exposure to hydrogen peroxide induces oxidation and activation of AMP-activated protein kinase
-
Zmijewski, J.W., Banerjee, S., Bae, H., Friggeri, A., Lazarowski, E.R., Abraham, E., Exposure to hydrogen peroxide induces oxidation and activation of AMP-activated protein kinase. J. Biol. Chem. 285 (2010), 33154–33164.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 33154-33164
-
-
Zmijewski, J.W.1
Banerjee, S.2
Bae, H.3
Friggeri, A.4
Lazarowski, E.R.5
Abraham, E.6
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