AMPK/α-Ketoglutarate Axis Dynamically Mediates DNA Demethylation in the Prdm16 Promoter and Brown Adipogenesis

Cell Metabolism

Volumn 24, Issue 4, 2016, Pages 542-554

  Yang, Qiyuan ^a   Liang, Xingwei ^a   Sun, Xiaofei ^a   Zhang, Lupei ^a,c   Fu, Xing ^a   Rogers, Carl J ^a   Berim, Anna ^a   Zhang, Shuming ^a   Wang, Songbo ^a   Wang, Bo ^a   Foretz, Marc ^d,e   Viollet, Benoit ^d,e   Gang, David R ^a   Rodgers, Buel D ^a   Zhu, Mei Jun ^a   Du, Min ^a,b  

^a WASHINGTON STATE UNIVERSITY   (United States)

^b CHINA AGRICULTURAL UNIVERSITY   (China)

^c INSTITUTE OF PLANT PROTECTION   (China)

^d INSTITUT COCHIN   (France)

^e UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

brown adipogenesis; DNA demethylation; Prkaa1

Indexed keywords

2 OXOGLUTARIC ACID; 5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; DNA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; ISOCITRATE DEHYDROGENASE 2; METFORMIN; PEPTIDES AND PROTEINS; PR DOMAIN CONTAINING 16 PROTEIN; UNCLASSIFIED DRUG; ALPHA-KETOGLUTARIC ACID; DNA BINDING PROTEIN; PRDM16 PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

ADIPOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BROWN ADIPOCYTE; BROWN ADIPOSE TISSUE; CONTROLLED STUDY; DEMETHYLATION; ENERGY METABOLISM; ENZYME ACTIVATION; ENZYME ACTIVITY; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; THERMOGENESIS; ANIMAL; CELL LINE; DNA METHYLATION; GENE DELETION; GENETICS; KNOCKOUT MOUSE; METABOLISM; MOUSE MUTANT; STROMA CELL; ULTRASTRUCTURE; WEANING;

ADIPOGENESIS; ADIPOSE TISSUE, BROWN; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CELL LINE; DNA METHYLATION; DNA-BINDING PROTEINS; GENE DELETION; KETOGLUTARIC ACIDS; MICE, KNOCKOUT; MICE, OBESE; OBESITY; PROMOTER REGIONS, GENETIC; STROMAL CELLS; TRANSCRIPTION FACTORS; WEANING;

EID: 84992376572     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2016.08.010     Document Type: Article

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