Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells

Biochemical Journal

Volumn 459, Issue 2, 2014, Pages 275-287

  Hawley, Simon A ^a   Ross, Fiona A ^a   Gowans, Graeme J ^a   Tibarewal, Priyanka ^a,b   Leslie, Nicholas R ^a,b   Hardie, D Grahame ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b HERIOT WATT UNIVERSITY   (United Kingdom)

Author keywords

Akt; AMP activated protein kinase (AMPK); Cancer; Cross talk; Tumour suppressor

Indexed keywords

6,7 DIHYDRO 4 HYDROXY 3 (2' HYDROXY 1,1' BIPHENYL 4 YL) 6 OXOTHIENO[2,3 B]PYRIDINE 5 CARBONITRILE; 8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; CALCIMYCIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE ALPHA 1; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE ALPHA 2; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; SERINE; THREONINE; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHOSPHORYLATION; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN HEK293; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SERINE THREONINE RICH LOOP; STOICHIOMETRY; TUMOR CELL;

AMINO ACID SEQUENCE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HEK293 CELLS; HUMANS; MODELS, MOLECULAR; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE;

EID: 84897534723     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20131344     Document Type: Article

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