Investigation of LKB1 Ser431 phosphorylation and Cys 433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity

Biochemical Journal

Volumn 458, Issue 1, 2014, Pages 41-56

  Houde, Vanessa P ^a   Ritorto, Maria Stella ^a   Gourlay, Robert ^a   Varghese, Joby ^a   Davies, Paul ^a   Shpiro, Natalia ^a   Sakamoto, Kei ^a   Alessi, Dario R ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

5 amino 4 imidazolecarboxamide riboside (AICAR); AMP activated protein kinase related kinase (AMPK related kinase); Monoclonal antibody; Phenformin; SAD A SAD B kinase; Signal transduction

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ADENYLATE KINASE; BR SERINE THREONINE KINASE 1 PROTEIN; BR SERINE THREONINE KINASE 2 PROTEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYSTINE; FARNESYL DIPHOSPHATE; MAP MICROTUBULE AFFINITY REGULATING KINASE 4 PROTEIN; MONOCLONAL ANTIBODY; NUAK FAMILY SNF1 LIKE KINASE 1 PROTEIN; PHENFORMIN; PROTEIN KINASE LKB1; S6 KINASE; SALT INDUCIBLE KINASE 3 PROTEIN; SERINE; UNCLASSIFIED DRUG; CYSTEINE; PROTEIN SERINE THREONINE KINASE; STK11 PROTEIN, MOUSE;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL MODEL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FIBROBLAST; HOMOZYGOTE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LIPOGENESIS; LIVER CELL; LIVER MEMBRANE; MOUSE; MUSCLE CONTRACTION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PRENYLATION; PROTEIN PROCESSING; WILD TYPE; ANIMAL; CELL STRAIN HEK293; GENETICS; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION;

ADENYLATE KINASE; AMINO ACID SEQUENCE; ANIMALS; CYSTEINE; HEK293 CELLS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN PRENYLATION; PROTEIN-SERINE-THREONINE KINASES; SERINE;

EID: 84892933078     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20131324     Document Type: Article

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