Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

Nature

Volumn 510, Issue 7506, 2014, Pages 542-546

  Madiraju, Anila K ^a   Erion, Derek M ^a   Rahimi, Yasmeen ^a   Zhang, Xian Man ^a   Braddock, Demetrios T ^a   Albright, Ronald A ^a   Prigaro, Brett J ^b   Wood, John L ^c   Bhanot, Sanjay ^d   MacDonald, Michael J ^e   Jurczak, Michael J ^a   Camporez, Joao Paulo ^a   Lee, Hui Young ^a   Cline, Gary W ^a   Samuel, Varman T ^a   Kibbey, Richard G ^a   Shulman, Gerald I ^a,f  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Department of Ecosystem Science and Sustainability   (United States)

^c BAYLOR UNIVERSITY   (United States)

^d ISIS PHARMACEUTICALS   (United States)

^e UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^f University of Copenhagen   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; GLUCOSE; GLYCEROL; GLYCEROL 3 PHOSPHATE DEHYDROGENASE; LACTIC ACID; METFORMIN; SODIUM CHLORIDE;

BLOOD; DIABETES; DISEASE CONTROL; ENZYME ACTIVITY; GLUCOSE; MITOCHONDRION; REDOX CONDITIONS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOSOLIC FRACTION; EMBRYO; ENZYME INHIBITION; GENE SILENCING; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLYCEROL BLOOD LEVEL; HEK293 CELL LINE; HUMAN; HUMAN CELL; LIVER CELL; LIVER METABOLISM; LIVER MITOCHONDRION; LONG TERM CARE; MALE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATION REDUCTION STATE; PHENOTYPE; PRIORITY JOURNAL; RAT; REDUCTION;

MUS; RATTUS;

ANIMALS; BLOOD GLUCOSE; CELLS, CULTURED; DIABETES MELLITUS, TYPE 2; GLUCONEOGENESIS; GLYCEROLPHOSPHATE DEHYDROGENASE; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; LACTIC ACID; LIVER; MALE; METFORMIN; MICE, KNOCKOUT; MITOCHONDRIA; OXIDATION-REDUCTION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84903524608     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature13270     Document Type: Article

References (33)

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