Low concentrations of metformin suppress glucose production in hepatocytes through AMP-activated protein kinase (AMPK)

Journal of Biological Chemistry

Volumn 289, Issue 30, 2014, Pages 20435-20446

  Cao, Jia ^a   Meng, Shumei ^a   Chang, Evan ^a   Beckwith Fickas, Katherine ^a   Xiong, Lishou ^a   Cole, Robert N ^a   Radovick, Sally ^a   Wondisford, Fredric E ^a   He, Ling ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE EXPRESSION; LIVER; PHOSPHORYLATION;

AMP-ACTIVATED PROTEIN KINASE; ANTIDIABETIC AGENTS; DIABETIC PATIENT; GLUCONEOGENIC GENES; GLUCOSE PRODUCTION; LOW CONCENTRATIONS; PRIMARY HEPATOCYTES; THERAPEUTIC TARGETS;

GLUCOSE;

ANTIDIABETIC AGENT; CYCLIC AMP DEPENDENT PROTEIN KINASE; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; METFORMIN;

ANIMAL; BIOSYNTHESIS; CELL CULTURE; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GLUCONEOGENESIS; LIVER CELL; METABOLISM; MOUSE;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CELLS, CULTURED; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; GLUCONEOGENESIS; GLUCOSE; HEPATOCYTES; HYPOGLYCEMIC AGENTS; METFORMIN; MICE;

EID: 84905404389     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.567271     Document Type: Article

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