The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue

Genes and Development

Volumn 30, Issue 22, 2016, Pages 2551-2564

  Wada, Shogo ^a   Neinast, Michael ^a   Jang, Cholsoon ^a,b   Ibrahim, Yasir H ^c   Lee, Gina ^c   Babu, Apoorva ^a   Li, Jian ^a   Hoshino, Atsushi ^a   Rowe, Glenn C ^d   Rhee, James ^e   Martina, José A ^f   Puertollano, Rosa ^f   Blenis, John ^c   Morley, Michael ^a   Baur, Joseph A ^a   Seale, Patrick ^a   Arany, Zoltan ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b PRINCETON UNIVERSITY   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d University of Alabama at Birmingham and Birmingham Veterans Affairs Medical Center   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

^f NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

Adipose tissue; Beige fat; FLCN; Mitochondria; MTOR; TFE3

Indexed keywords

AMINO ACID; ESTRONE; FAT; GROWTH FACTOR; MAMMALIAN TARGET OF RAPAMYCIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1BETA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR TFE3; TUBEROUS SCLEROSIS COMPLEX PROTEIN; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX LEUCINE ZIPPER TRANSCRIPTION FACTOR; BHD PROTEIN, MOUSE; MTOR PROTEIN, MOUSE; NUCLEAR PROTEIN; ONCOPROTEIN; PGC1B PROTEIN, MOUSE; S6 KINASE; TARGET OF RAPAMYCIN KINASE; TCFE3 PROTEIN, MOUSE; TUMOR SUPPRESSOR PROTEIN;

ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; CANONICAL ANALYSIS; CONTROLLED STUDY; FEMALE; IN VIVO STUDY; MITOCHONDRIAL BIOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; WHITE ADIPOSE TISSUE; ANIMAL; CELL RESPIRATION; CYTOPLASM; GENE DELETION; GENETICS; MALE; METABOLISM; MITOCHONDRION; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ADIPOSE TISSUE, BROWN; ADIPOSE TISSUE, WHITE; ANIMALS; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; CELL RESPIRATION; CYTOPLASM; GENE DELETION; MALE; MICE; MITOCHONDRIA; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS;

EID: 85006035893     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.287953.116     Document Type: Article

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