Metformin activates AMP kinase through inhibition of AMP deaminase

Journal of Biological Chemistry

Volumn 286, Issue 1, 2011, Pages 1-11

  Ouyang, Jiangyong ^a   Parakhia, Rahulkumar A ^b   Ochs, Raymond S ^b  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ST JOHN'S UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE KINASE; AMP-ACTIVATED KINASE; FATTY ACID OXIDATION; GLUCOSE TRANSPORT; GLUCOSE UPTAKE; METABOLIC PATHWAYS; METABOLIC PROCESS; METFORMINS; MITOCHONDRIAL COMPLEX; MITOCHONDRIAL RESPIRATION; MITOCHONDRIAL RESPIRATORY CHAIN; NITROGEN SPECIES; OXIDE PRECURSORS; PEROXYNITRITES; SKELETAL MUSCLE;

AMINO ACIDS; GLUCOSE; IONIZATION OF GASES; METABOLISM; MITOCHONDRIA; NITRIC OXIDE; OXIDATION;

FATTY ACIDS;

ADENOSINE DIPHOSPHATE; ADENOSINE MONOPHOSPHATE DEAMINASE; ADENYLATE KINASE; AMMONIA; ARGININE; LINSIDOMINE; METFORMIN; PROTEIN KINASE LKB1; ROTENONE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; FATTY ACID OXIDATION; GLUCOSE TRANSPORT; MITOCHONDRIAL RESPIRATION; MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; RAT;

ADENYLATE KINASE; AMP DEAMINASE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BIOLOGICAL TRANSPORT; CATTLE; ENZYME ACTIVATION; ENZYME INHIBITORS; FATTY ACIDS; GLUCOSE; HYPOGLYCEMIC AGENTS; METFORMIN; MUSCLE, SKELETAL; OXIDATION-REDUCTION; RATS; REACTIVE OXYGEN SPECIES; ROTENONE;

EID: 78650931836     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.121806     Document Type: Article

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