-
1
-
-
0346102907
-
Intrasteric control of AMPK via the gamma1 subunit AMP allosteric regulatory site
-
Adams, J., Chen, Z.P., Van Denderen, B.J., Morton, C.J., Parker, M.W., Witters, L.A., Stapleton, D., and Kemp, B.E. (2004). Intrasteric control of AMPK via the gamma1 subunit AMP allosteric regulatory site. Protein Sci. 13, 155-165.
-
(2004)
Protein Sci.
, vol.13
, pp. 155-165
-
-
Adams, J.1
Chen, Z.P.2
Van Denderen, B.J.3
Morton, C.J.4
Parker, M.W.5
Witters, L.A.6
Stapleton, D.7
Kemp, B.E.8
-
2
-
-
27144483324
-
AMP-activated protein kinase and coordination of hepatic fatty acid metabolism of starved/carbohydrate-refed rats
-
Assifi, M.M., Suchankova, G., Constant, S., Prentki, M., Saha, A.K., and Ruderman, N.B. (2005). AMP-activated protein kinase and coordination of hepatic fatty acid metabolism of starved/carbohydrate-refed rats. Am. J. Physiol. Endocrinol. Metab. 289, E794-E800.
-
(2005)
Am. J. Physiol. Endocrinol. Metab.
, vol.289
-
-
Assifi, M.M.1
Suchankova, G.2
Constant, S.3
Prentki, M.4
Saha, A.K.5
Ruderman, N.B.6
-
3
-
-
0038614742
-
Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD
-
Baas, A.F., Boudeau, J., Sapkota, G.P., Smit, L., Medema, R., Morrice, N.A., Alessi, D.R., and Clevers, H.C. (2003). Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD. EMBO J. 22, 3062-3072.
-
(2003)
EMBO J.
, vol.22
, pp. 3062-3072
-
-
Baas, A.F.1
Boudeau, J.2
Sapkota, G.P.3
Smit, L.4
Medema, R.5
Morrice, N.A.6
Alessi, D.R.7
Clevers, H.C.8
-
4
-
-
0031016272
-
The structure of a domain common to archaebacteria and the homocystinuria disease protein
-
Bateman, A. (1997). The structure of a domain common to archaebacteria and the homocystinuria disease protein. Trends Biochem. Sci. 22, 12-13.
-
(1997)
Trends Biochem. Sci.
, vol.22
, pp. 12-13
-
-
Bateman, A.1
-
5
-
-
0141753981
-
MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm
-
Boudeau, J., Baas, A.F., Deak, M., Morrice, N.A., Kieloch, A., Schutkowski, M., Prescott, A.R., Clevers, H.C., and Alessi, D.R. (2003). MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. EMBO J. 22, 5102-5114.
-
(2003)
EMBO J.
, vol.22
, pp. 5102-5114
-
-
Boudeau, J.1
Baas, A.F.2
Deak, M.3
Morrice, N.A.4
Kieloch, A.5
Schutkowski, M.6
Prescott, A.R.7
Clevers, H.C.8
Alessi, D.R.9
-
6
-
-
84862493914
-
AMP-activated protein kinase: New regulation, new roles?
-
Carling, D., Thornton, C., Woods, A., and Sanders, M.J. (2012). AMP-activated protein kinase: new regulation, new roles? Biochem. J. 445, 11-27.
-
(2012)
Biochem. J.
, vol.445
, pp. 11-27
-
-
Carling, D.1
Thornton, C.2
Woods, A.3
Sanders, M.J.4
-
7
-
-
67649484365
-
Structural insight into the autoinhibition mechanism of AMP-activated protein kinase
-
Chen, L., Jiao, Z.H., Zheng, L.S., Zhang, Y.Y., Xie, S.T., Wang, Z.X., and Wu, J.W. (2009). Structural insight into the autoinhibition mechanism of AMP-activated protein kinase. Nature 459, 1146-1149.
-
(2009)
Nature
, vol.459
, pp. 1146-1149
-
-
Chen, L.1
Jiao, Z.H.2
Zheng, L.S.3
Zhang, Y.Y.4
Xie, S.T.5
Wang, Z.X.6
Wu, J.W.7
-
8
-
-
84863719838
-
AMP-activated protein kinase undergoes nucleotide-dependent conformational changes
-
Chen, L., Wang, J., Zhang, Y.Y., Yan, S.F., Neumann, D., Schlattner, U., Wang, Z.X., and Wu, J.W. (2012). AMP-activated protein kinase undergoes nucleotide-dependent conformational changes. Nat. Struct. Mol. Biol. 19, 716-718.
-
(2012)
Nat. Struct. Mol. Biol.
, vol.19
, pp. 716-718
-
-
Chen, L.1
Wang, J.2
Zhang, Y.Y.3
Yan, S.F.4
Neumann, D.5
Schlattner, U.6
Wang, Z.X.7
Wu, J.W.8
-
9
-
-
0032567252
-
Functional domains of the alpha1 catalytic subunit of the AMP-activated protein kinase
-
Crute, B.E., Seefeld, K., Gamble, J., Kemp, B.E., and Witters, L.A. (1998). Functional domains of the alpha1 catalytic subunit of the AMP-activated protein kinase. J. Biol. Chem. 273, 35347-35354.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 35347-35354
-
-
Crute, B.E.1
Seefeld, K.2
Gamble, J.3
Kemp, B.E.4
Witters, L.A.5
-
10
-
-
0025192341
-
Location and function of three sites phosphorylated on rat acetyl-CoA carboxylase by the AMP-activated protein kinase
-
Davies, S.P., Sim, A.T., and Hardie, D.G. (1990). Location and function of three sites phosphorylated on rat acetyl-CoA carboxylase by the AMP-activated protein kinase. Eur. J. Biochem. 187, 183-190.
-
(1990)
Eur. J. Biochem.
, vol.187
, pp. 183-190
-
-
Davies, S.P.1
Sim, A.T.2
Hardie, D.G.3
-
11
-
-
0029561919
-
50-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2C alpha and native bovine protein phosphatase-2AC
-
Davies, S.P., Helps, N.R., Cohen, P.T., and Hardie, D.G. (1995). 50-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2C alpha and native bovine protein phosphatase-2AC. FEBS Lett. 377, 421-425.
-
(1995)
FEBS Lett.
, vol.377
, pp. 421-425
-
-
Davies, S.P.1
Helps, N.R.2
Cohen, P.T.3
Hardie, D.G.4
-
12
-
-
84864975933
-
The Axin/TNKS complex interacts with KIF3A and is required for insulin-stimulated GLUT4 translocation
-
Guo, H.L., Zhang, C., Liu, Q., Li, Q., Lian, G., Wu, D., Li, X., Zhang, W., Shen, Y., Ye, Z., et al. (2012). The Axin/TNKS complex interacts with KIF3A and is required for insulin-stimulated GLUT4 translocation. Cell Res. 22, 1246-1257.
-
(2012)
Cell Res.
, vol.22
, pp. 1246-1257
-
-
Guo, H.L.1
Zhang, C.2
Liu, Q.3
Li, Q.4
Lian, G.5
Wu, D.6
Li, X.7
Zhang, W.8
Shen, Y.9
Ye, Z.10
-
13
-
-
84876320551
-
LKB1 and AMPK and the cancer-metabolism link-ten years after
-
Hardie, D.G., and Alessi, D.R. (2013). LKB1 and AMPK and the cancer-metabolism link-ten years after. BMC Biol. 11, 36.
-
(2013)
BMC Biol.
, vol.11
, pp. 36
-
-
Hardie, D.G.1
Alessi, D.R.2
-
14
-
-
84868005485
-
AMP-activated protein kinase: A target for drugs both ancient and modern
-
Hardie, D.G., Ross, F.A., and Hawley, S.A. (2012a). AMP-activated protein kinase: a target for drugs both ancient and modern. Chem. Biol. 19, 1222-1236.
-
(2012)
Chem. Biol.
, vol.19
, pp. 1222-1236
-
-
Hardie, D.G.1
Ross, F.A.2
Hawley, S.A.3
-
15
-
-
84858782079
-
AMPK: A nutrient and energy sensor that maintains energy homeostasis
-
Hardie, D.G., Ross, F.A., and Hawley, S.A. (2012b). AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat. Rev. Mol. Cell Biol. 13, 251-262.
-
(2012)
Nat. Rev. Mol. Cell Biol.
, vol.13
, pp. 251-262
-
-
Hardie, D.G.1
Ross, F.A.2
Hawley, S.A.3
-
16
-
-
0028845251
-
50-AMP activates the AMP-activated protein kinase cascade, and Ca2+/calmodulin activates the calmodulin-dependent protein kinase i cascade, via three independent mechanisms
-
Hawley, S.A., Selbert, M.A., Goldstein, E.G., Edelman, A.M., Carling, D., and Hardie, D.G. (1995). 50-AMP activates the AMP-activated protein kinase cascade, and Ca2+/calmodulin activates the calmodulin-dependent protein kinase I cascade, via three independent mechanisms. J. Biol. Chem. 270, 27186-27191.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 27186-27191
-
-
Hawley, S.A.1
Selbert, M.A.2
Goldstein, E.G.3
Edelman, A.M.4
Carling, D.5
Hardie, D.G.6
-
17
-
-
0029910018
-
Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase
-
Hawley, S.A., Davison, M., Woods, A., Davies, S.P., Beri, R.K., Carling, D., and Hardie, D.G. (1996). Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase. J. Biol. Chem. 271, 27879-27887.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 27879-27887
-
-
Hawley, S.A.1
Davison, M.2
Woods, A.3
Davies, S.P.4
Beri, R.K.5
Carling, D.6
Hardie, D.G.7
-
18
-
-
0345107247
-
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade
-
Hawley, S.A., Boudeau, J., Reid, J.L., Mustard, K.J., Udd, L., Mäkelä, T.P., Alessi, D.R., and Hardie, D.G. (2003). Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J. Biol. 2, 28.
-
(2003)
J. Biol.
, vol.2
, pp. 28
-
-
Hawley, S.A.1
Boudeau, J.2
Reid, J.L.3
Mustard, K.J.4
Udd, L.5
Mäkelä, T.P.6
Alessi, D.R.7
Hardie, D.G.8
-
19
-
-
23044432463
-
Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase
-
Hawley, S.A., Pan, D.A., Mustard, K.J., Ross, L., Bain, J., Edelman, A.M., Frenguelli, B.G., and Hardie, D.G. (2005). Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab. 2, 9-19.
-
(2005)
Cell Metab.
, vol.2
, pp. 9-19
-
-
Hawley, S.A.1
Pan, D.A.2
Mustard, K.J.3
Ross, L.4
Bain, J.5
Edelman, A.M.6
Frenguelli, B.G.7
Hardie, D.G.8
-
20
-
-
0041305909
-
Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases
-
Hong, S.P., Leiper, F.C., Woods, A., Carling, D., and Carlson, M. (2003). Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases. Proc. Natl. Acad. Sci. USA 100, 8839-8843.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 8839-8843
-
-
Hong, S.P.1
Leiper, F.C.2
Woods, A.3
Carling, D.4
Carlson, M.5
-
21
-
-
0038814313
-
A novel domain in AMP-activated protein kinase causes glycogen storage bodies similar to those seen in hereditary cardiac arrhythmias
-
Hudson, E.R., Pan, D.A., James, J., Lucocq, J.M., Hawley, S.A., Green, K.A., Baba, O., Terashima, T., and Hardie, D.G. (2003). A novel domain in AMP-activated protein kinase causes glycogen storage bodies similar to those seen in hereditary cardiac arrhythmias. Curr. Biol. 13, 861-866.
-
(2003)
Curr. Biol.
, vol.13
, pp. 861-866
-
-
Hudson, E.R.1
Pan, D.A.2
James, J.3
Lucocq, J.M.4
Hawley, S.A.5
Green, K.A.6
Baba, O.7
Terashima, T.8
Hardie, D.G.9
-
22
-
-
23844471263
-
The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases
-
Hurley, R.L., Anderson, K.A., Franzone, J.M., Kemp, B.E., Means, A.R., and Witters, L.A. (2005). The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases. J. Biol. Chem. 280, 29060-29066.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 29060-29066
-
-
Hurley, R.L.1
Anderson, K.A.2
Franzone, J.M.3
Kemp, B.E.4
Means, A.R.5
Witters, L.A.6
-
23
-
-
33748153690
-
TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth
-
Inoki, K., Ouyang, H., Zhu, T., Lindvall, C., Wang, Y., Zhang, X., Yang, Q., Bennett, C., Harada, Y., Stankunas, K., et al. (2006). TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell 126, 955-968.
-
(2006)
Cell
, vol.126
, pp. 955-968
-
-
Inoki, K.1
Ouyang, H.2
Zhu, T.3
Lindvall, C.4
Wang, Y.5
Zhang, X.6
Yang, Q.7
Bennett, C.8
Harada, Y.9
Stankunas, K.10
-
24
-
-
17144362480
-
AMP-activated protein kinase beta subunit tethers alpha and gamma subunits via its C-terminal sequence (186-270)
-
Iseli, T.J., Walter, M., van Denderen, B.J., Katsis, F., Witters, L.A., Kemp, B.E., Michell, B.J., and Stapleton, D. (2005). AMP-activated protein kinase beta subunit tethers alpha and gamma subunits via its C-terminal sequence (186-270). J. Biol. Chem. 280, 13395-13400.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 13395-13400
-
-
Iseli, T.J.1
Walter, M.2
Van Denderen, B.J.3
Katsis, F.4
Witters, L.A.5
Kemp, B.E.6
Michell, B.J.7
Stapleton, D.8
-
25
-
-
1342332128
-
Bateman domains and adenosine derivatives form a binding contract
-
Kemp, B.E. (2004). Bateman domains and adenosine derivatives form a binding contract. J. Clin. Invest. 113, 182-184.
-
(2004)
J. Clin. Invest.
, vol.113
, pp. 182-184
-
-
Kemp, B.E.1
-
26
-
-
84860504360
-
Secondary causes of nonalcoholic fatty liver disease
-
Kneeman, J.M., Misdraji, J., and Corey, K.E. (2012). Secondary causes of nonalcoholic fatty liver disease. Therap. Adv. Gastroenterol. 5, 199-207.
-
(2012)
Therap. Adv. Gastroenterol.
, vol.5
, pp. 199-207
-
-
Kneeman, J.M.1
Misdraji, J.2
Corey, K.E.3
-
27
-
-
78649711427
-
The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes
-
Levine, A.J., and Puzio-Kuter, A.M. (2010). The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes. Science 330, 1340-1344.
-
(2010)
Science
, vol.330
, pp. 1340-1344
-
-
Levine, A.J.1
Puzio-Kuter, A.M.2
-
28
-
-
69949171963
-
Axin determines cell fate by controlling the p53 activation threshold after DNA damage
-
Li, Q., Lin, S., Wang, X., Lian, G., Lu, Z., Guo, H., Ruan, K., Wang, Y., Ye, Z., Han, J., and Lin, S.C. (2009). Axin determines cell fate by controlling the p53 activation threshold after DNA damage. Nat. Cell Biol. 11, 1128-1134.
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 1128-1134
-
-
Li, Q.1
Lin, S.2
Wang, X.3
Lian, G.4
Lu, Z.5
Guo, H.6
Ruan, K.7
Wang, Y.8
Ye, Z.9
Han, J.10
Lin, S.C.11
-
29
-
-
79953755370
-
AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice
-
Li, Y., Xu, S., Mihaylova, M.M., Zheng, B., Hou, X., Jiang, B., Park, O., Luo, Z., Lefai, E., Shyy, J.Y., et al. (2011). AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab. 13, 376-388.
-
(2011)
Cell Metab.
, vol.13
, pp. 376-388
-
-
Li, Y.1
Xu, S.2
Mihaylova, M.M.3
Zheng, B.4
Hou, X.5
Jiang, B.6
Park, O.7
Luo, Z.8
Lefai, E.9
Shyy, J.Y.10
-
30
-
-
84863012559
-
Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK
-
Lin, Y.Y., Kiihl, S., Suhail, Y., Liu, S.Y., Chou, Y.H., Kuang, Z., Lu, J.Y., Khor, C.N., Lin, C.L., Bader, J.S., et al. (2012). Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK. Nature 482, 251-255.
-
(2012)
Nature
, vol.482
, pp. 251-255
-
-
Lin, Y.Y.1
Kiihl, S.2
Suhail, Y.3
Liu, S.Y.4
Chou, Y.H.5
Kuang, Z.6
Lu, J.Y.7
Khor, C.N.8
Lin, C.L.9
Bader, J.S.10
-
31
-
-
33646132747
-
Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia
-
Liu, W., Rui, H., Wang, J., Lin, S., He, Y., Chen, M., Li, Q., Ye, Z., Zhang, S., Chan, S.C., et al. (2006). Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia. EMBO J. 25, 1646-1658.
-
(2006)
EMBO J.
, vol.25
, pp. 1646-1658
-
-
Liu, W.1
Rui, H.2
Wang, J.3
Lin, S.4
He, Y.5
Chen, M.6
Li, Q.7
Ye, Z.8
Zhang, S.9
Chan, S.C.10
-
32
-
-
0025915269
-
Evidence that AMP triggers phosphorylation as well as direct allosteric activation of rat liver AMP-activated protein kinase. A sensitive mechanism to protect the cell against ATP depletion
-
Moore, F., Weekes, J., and Hardie, D.G. (1991). Evidence that AMP triggers phosphorylation as well as direct allosteric activation of rat liver AMP-activated protein kinase. A sensitive mechanism to protect the cell against ATP depletion. Eur. J. Biochem. 199, 691-697.
-
(1991)
Eur. J. Biochem.
, vol.199
, pp. 691-697
-
-
Moore, F.1
Weekes, J.2
Hardie, D.G.3
-
33
-
-
33745213627
-
AMPK and cell proliferation-AMPK as a therapeutic target for atherosclerosis and cancer
-
Motoshima, H., Goldstein, B.J., Igata, M., and Araki, E. (2006). AMPK and cell proliferation-AMPK as a therapeutic target for atherosclerosis and cancer. J. Physiol. 574, 63-71.
-
(2006)
J. Physiol.
, vol.574
, pp. 63-71
-
-
Motoshima, H.1
Goldstein, B.J.2
Igata, M.3
Araki, E.4
-
34
-
-
0043071497
-
Mammalian AMP-activated protein kinase: Functional, heterotrimeric complexes by co-expression of subunits in Escherichia coli
-
Neumann, D., Woods, A., Carling, D., Wallimann, T., and Schlattner, U. (2003). Mammalian AMP-activated protein kinase: functional, heterotrimeric complexes by co-expression of subunits in Escherichia coli. Protein Expr. Purif. 30, 230-237.
-
(2003)
Protein Expr. Purif.
, vol.30
, pp. 230-237
-
-
Neumann, D.1
Woods, A.2
Carling, D.3
Wallimann, T.4
Schlattner, U.5
-
35
-
-
78650606464
-
B-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK)
-
Oakhill, J.S., Chen, Z.P., Scott, J.W., Steel, R., Castelli, L.A., Ling, N., Macaulay, S.L., and Kemp, B.E. (2010). b-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK). Proc. Natl. Acad. Sci. USA 107, 19237-19241.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 19237-19241
-
-
Oakhill, J.S.1
Chen, Z.P.2
Scott, J.W.3
Steel, R.4
Castelli, L.A.5
Ling, N.6
Macaulay, S.L.7
Kemp, B.E.8
-
36
-
-
79959338922
-
AMPK is a direct adenylate charge-regulated protein kinase
-
Oakhill, J.S., Steel, R., Chen, Z.P., Scott, J.W., Ling, N., Tam, S., and Kemp, B.E. (2011). AMPK is a direct adenylate charge-regulated protein kinase. Science 332, 1433-1435.
-
(2011)
Science
, vol.332
, pp. 1433-1435
-
-
Oakhill, J.S.1
Steel, R.2
Chen, Z.P.3
Scott, J.W.4
Ling, N.5
Tam, S.6
Kemp, B.E.7
-
37
-
-
33846945033
-
Conserved alpha-helix acts as autoinhibitory sequence in AMP-activated protein kinase alpha subunits
-
Pang, T., Xiong, B., Li, J.Y., Qiu, B.Y., Jin, G.Z., Shen, J.K., and Li, J. (2007). Conserved alpha-helix acts as autoinhibitory sequence in AMP-activated protein kinase alpha subunits. J. Biol. Chem. 282, 495-506.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 495-506
-
-
Pang, T.1
Xiong, B.2
Li, J.Y.3
Qiu, B.Y.4
Jin, G.Z.5
Shen, J.K.6
Li, J.7
-
38
-
-
10644290911
-
Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation
-
Rui, Y., Xu, Z., Lin, S., Li, Q., Rui, H., Luo, W., Zhou, H.M., Cheung, P.Y.,Wu, Z., Ye, Z., et al. (2004). Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation. EMBO J. 23, 4583-4594.
-
(2004)
EMBO J.
, vol.23
, pp. 4583-4594
-
-
Rui, Y.1
Xu, Z.2
Lin, S.3
Li, Q.4
Rui, H.5
Luo, W.6
Zhou, H.M.7
Cheung, P.Y.8
Wu, Z.9
Ye, Z.10
-
39
-
-
34147152841
-
Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade
-
Sanders, M.J., Grondin, P.O., Hegarty, B.D., Snowden, M.A., and Carling, D. (2007). Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade. Biochem. J. 403, 139-148.
-
(2007)
Biochem. J.
, vol.403
, pp. 139-148
-
-
Sanders, M.J.1
Grondin, P.O.2
Hegarty, B.D.3
Snowden, M.A.4
Carling, D.5
-
40
-
-
85047691317
-
CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations
-
Scott, J.W., Hawley, S.A., Green, K.A., Anis, M., Stewart, G., Scullion, G.A., Norman, D.G., and Hardie, D.G. (2004). CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations. J. Clin. Invest. 113, 274-284.
-
(2004)
J. Clin. Invest.
, vol.113
, pp. 274-284
-
-
Scott, J.W.1
Hawley, S.A.2
Green, K.A.3
Anis, M.4
Stewart, G.5
Scullion, G.A.6
Norman, D.G.7
Hardie, D.G.8
-
41
-
-
1542618348
-
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
-
Shaw, R.J., Kosmatka, M., Bardeesy, N., Hurley, R.L., Witters, L.A., DePinho, R.A., and Cantley, L.C. (2004). The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc. Natl. Acad. Sci. USA 101, 3329-3335.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 3329-3335
-
-
Shaw, R.J.1
Kosmatka, M.2
Bardeesy, N.3
Hurley, R.L.4
Witters, L.A.5
Depinho, R.A.6
Cantley, L.C.7
-
42
-
-
28844433635
-
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
-
Shaw, R.J., Lamia, K.A., Vasquez, D., Koo, S.H., Bardeesy, N., Depinho, R.A., Montminy, M., and Cantley, L.C. (2005). The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310, 1642-1646.
-
(2005)
Science
, vol.310
, pp. 1642-1646
-
-
Shaw, R.J.1
Lamia, K.A.2
Vasquez, D.3
Koo, S.H.4
Bardeesy, N.5
Depinho, R.A.6
Montminy, M.7
Cantley, L.C.8
-
44
-
-
67650914230
-
AMPK in health and disease
-
Steinberg, G.R., and Kemp, B.E. (2009). AMPK in Health and Disease. Physiol. Rev. 89, 1025-1078.
-
(2009)
Physiol. Rev.
, vol.89
, pp. 1025-1078
-
-
Steinberg, G.R.1
Kemp, B.E.2
-
45
-
-
0034723073
-
Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription
-
Strovel, E.T., Wu, D., and Sussman, D.J. (2000). Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription. J. Biol. Chem. 275, 2399-2403.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 2399-2403
-
-
Strovel, E.T.1
Wu, D.2
Sussman, D.J.3
-
46
-
-
33845949733
-
Dissecting the role of 50-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase
-
Suter, M., Riek, U., Tuerk, R., Schlattner, U., Wallimann, T., and Neumann, D. (2006). Dissecting the role of 50-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase. J. Biol. Chem. 281, 32207-32216.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 32207-32216
-
-
Suter, M.1
Riek, U.2
Tuerk, R.3
Schlattner, U.4
Wallimann, T.5
Neumann, D.6
-
47
-
-
84887189624
-
Inhibition of AMPK catabolic action by GSK3
-
Suzuki, T., Bridges, D., Nakada, D., Skiniotis, G., Morrison, S.J., Lin, J.D., Saltiel, A.R., and Inoki, K. (2013). Inhibition of AMPK catabolic action by GSK3. Mol. Cell 50, 407-419.
-
(2013)
Mol. Cell
, vol.50
, pp. 407-419
-
-
Suzuki, T.1
Bridges, D.2
Nakada, D.3
Skiniotis, G.4
Morrison, S.J.5
Lin, J.D.6
Saltiel, A.R.7
Inoki, K.8
-
48
-
-
34848857902
-
Metabolomics (liver and blood profiling) in a mouse model in response to fasting: A study of hepatic steatosis
-
van Ginneken, V., Verhey, E., Poelmann, R., Ramakers, R., van Dijk, K.W., Ham, L., Voshol, P., Havekes, L., Van Eck, M., and van der Greef, J. (2007). Metabolomics (liver and blood profiling) in a mouse model in response to fasting: a study of hepatic steatosis. Biochim. Biophys. Acta 1771, 1263-1270.
-
(2007)
Biochim. Biophys. Acta
, vol.1771
, pp. 1263-1270
-
-
Van Ginneken, V.1
Verhey, E.2
Poelmann, R.3
Ramakers, R.4
Van Dijk, K.W.5
Ham, L.6
Voshol, P.7
Havekes, L.8
Van Eck, M.9
Van Der Greef, J.10
-
49
-
-
77952200593
-
Alternative fuel-another role for p53 in the regulation of metabolism
-
Vousden, K.H. (2010). Alternative fuel-another role for p53 in the regulation of metabolism. Proc. Natl. Acad. Sci. USA 107, 7117-7118.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 7117-7118
-
-
Vousden, K.H.1
-
50
-
-
11144283125
-
Role of PP2C in cardiac lipid accumulation in obese rodents and its prevention by troglitazone
-
Wang, M.Y., and Unger, R.H. (2005). Role of PP2C in cardiac lipid accumulation in obese rodents and its prevention by troglitazone. Am. J. Physiol. Endocrinol. Metab. 288, E216-E221.
-
(2005)
Am. J. Physiol. Endocrinol. Metab.
, vol.288
-
-
Wang, M.Y.1
Unger, R.H.2
-
51
-
-
10744230065
-
LKB1 is the upstream kinase in the AMP-activated protein kinase cascade
-
Woods, A., Johnstone, S.R., Dickerson, K., Leiper, F.C., Fryer, L.G., Neumann, D., Schlattner, U., Wallimann, T., Carlson, M., and Carling, D. (2003). LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr. Biol. 13, 2004-2008.
-
(2003)
Curr. Biol.
, vol.13
, pp. 2004-2008
-
-
Woods, A.1
Johnstone, S.R.2
Dickerson, K.3
Leiper, F.C.4
Fryer, L.G.5
Neumann, D.6
Schlattner, U.7
Wallimann, T.8
Carlson, M.9
Carling, D.10
-
52
-
-
23044437445
-
Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells
-
Woods, A., Dickerson, K., Heath, R., Hong, S.P., Momcilovic, M., Johnstone, S.R., Carlson, M., and Carling, D. (2005). Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells. Cell Metab. 2, 21-33.
-
(2005)
Cell Metab.
, vol.2
, pp. 21-33
-
-
Woods, A.1
Dickerson, K.2
Heath, R.3
Hong, S.P.4
Momcilovic, M.5
Johnstone, S.R.6
Carlson, M.7
Carling, D.8
-
53
-
-
34248199965
-
Activation of protein phosphatase 2A by palmitate inhibits AMP-activated protein kinase
-
Wu, Y., Song, P., Xu, J., Zhang, M., and Zou, M.H. (2007). Activation of protein phosphatase 2A by palmitate inhibits AMP-activated protein kinase. J. Biol. Chem. 282, 9777-9788.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 9777-9788
-
-
Wu, Y.1
Song, P.2
Xu, J.3
Zhang, M.4
Zou, M.H.5
-
54
-
-
34848840368
-
Structural basis for AMP binding to mammalian AMP-activated protein kinase
-
Xiao, B., Heath, R., Saiu, P., Leiper, F.C., Leone, P., Jing, C., Walker, P.A., Haire, L., Eccleston, J.F., Davis, C.T., et al. (2007). Structural basis for AMP binding to mammalian AMP-activated protein kinase. Nature 449, 496-500.
-
(2007)
Nature
, vol.449
, pp. 496-500
-
-
Xiao, B.1
Heath, R.2
Saiu, P.3
Leiper, F.C.4
Leone, P.5
Jing, C.6
Walker, P.A.7
Haire, L.8
Eccleston, J.F.9
Davis, C.T.10
-
55
-
-
0031457978
-
The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation
-
Zeng, L., Fagotto, F., Zhang, T., Hsu, W., Vasicek, T.J., Perry, W.L., 3rd, Lee, J.J., Tilghman, S.M., Gumbiner, B.M., and Costantini, F. (1997). The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation. Cell 90, 181-192.
-
(1997)
Cell
, vol.90
, pp. 181-192
-
-
Zeng, L.1
Fagotto, F.2
Zhang, T.3
Hsu, W.4
Vasicek, T.J.5
Perry III, W.L.6
Lee, J.J.7
Tilghman, S.M.8
Gumbiner, B.M.9
Costantini, F.10
-
56
-
-
72949115493
-
Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation
-
Zeqiraj, E., Filippi, B.M., Deak, M., Alessi, D.R., and van Aalten, D.M. (2009). Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation. Science 326, 1707-1711.
-
(2009)
Science
, vol.326
, pp. 1707-1711
-
-
Zeqiraj, E.1
Filippi, B.M.2
Deak, M.3
Alessi, D.R.4
Van Aalten, D.M.5
-
57
-
-
79953843867
-
Structural insights into the architecture and allostery of full-length AMP-activated protein kinase
-
Zhu, L., Chen, L., Zhou, X.M., Zhang, Y.Y., Zhang, Y.J., Zhao, J., Ji, S.R., Wu, J.W., and Wu, Y. (2011). Structural insights into the architecture and allostery of full-length AMP-activated protein kinase. Structure 19, 515-522.
-
(2011)
Structure
, vol.19
, pp. 515-522
-
-
Zhu, L.1
Chen, L.2
Zhou, X.M.3
Zhang, Y.Y.4
Zhang, Y.J.5
Zhao, J.6
Ji, S.R.7
Wu, J.W.8
Wu, Y.9
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