Mechanism of action of compound-13: An α1-selective small molecule activator of AMPK

Chemistry and Biology

Volumn 21, Issue 7, 2014, Pages 866-879

  Hunter, Roger W ^a,b   Foretz, Marc ^c,d   Bultot, Laurent ^b   Fullerton, Morgan D ^e   Deak, Maria ^b   Ross, Fiona A ^a   Hawley, Simon A ^a   Shpiro, Natalia ^a   Viollet, Benoit ^c,d   Barron, Denis ^b   Kemp, Bruce E ^f   Steinberg, Gregory R ^e   Hardie, D Grahame ^a   Sakamoto, Kei ^a,b  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b NESTLÉ RESEARCH CENTER   (Switzerland)

^c INSTITUT COCHIN   (France)

^d UNIVERSITÉ PARIS DESCARTES   (France)

^e MCMASTER UNIVERSITY   (Canada)

^f UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

5 (5 HYDROXYL ISOXAZOL 3 YL) FURAN 2 PHOSPHONIC ACID; 5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; 6,7 DIHYDRO 4 HYDROXY 3 (2' HYDROXY 1,1' BIPHENYL 4 YL) 6 OXOTHIENO[2,3 B]PYRIDINE 5 CARBONITRILE; ADENOSINE PHOSPHATE; ADENYLATE KINASE; ADENYLATE KINASE ALPHA2; ADENYLATE KINASE BETA1; ADENYLATE KINASE BETA2; BETA TUBULIN; COMPOUND 13; ENZYME ACTIVATOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; PRODRUG; SALICYLIC ACID; UNCLASSIFIED DRUG; FATTY ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MOLECULAR LIBRARY; PROTEIN SUBUNIT; RECOMBINANT PROTEIN;

ALLOSTERISM; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; ESTERIFICATION; IN VITRO STUDY; LIPOGENESIS; LIVER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; WILD TYPE; AGONISTS; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; ENZYME ACTIVATION; ENZYME SPECIFICITY; METABOLISM; MOLECULAR GENETICS; MOLECULAR LIBRARY; PHARMACOLOGY; PROTEIN SUBUNIT; SIGNAL TRANSDUCTION;

ADENOSINE MONOPHOSPHATE; AMINO ACID SEQUENCE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ENZYME ACTIVATION; ENZYME ACTIVATORS; ESTERIFICATION; FATTY ACIDS; HEPATOCYTES; LIPOGENESIS; MICE; MOLECULAR SEQUENCE DATA; PRODRUGS; PROTEIN SUBUNITS; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES; SUBSTRATE SPECIFICITY;

EID: 84904556335     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2014.05.014     Document Type: Article

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