AMP-activated protein kinase regulates HNF4α transcriptional activity by inhibiting dimer formation and decreasing protein stability

Journal of Biological Chemistry

Volumn 278, Issue 30, 2003, Pages 27495-27501

  Hong, Yu Holly ^b,c   Varanasi, Usha S ^a   Yang, Wenbo ^b   Leff, Todd ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PFIZER INC   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEGRADATION; DNA; ENZYMES; PROTEINS;

INTRACELLULAR ENERGY LEVELS;

BIOCHEMISTRY;

CELL NUCLEUS RECEPTOR; DIMER; ENZYME; HEPATIC NUCLEAR FACTOR ALPHA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PROTEIN KINASE; SERINE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ENERGY; CONTROLLED STUDY; DIABETES MELLITUS; DIMERIZATION; ENERGY METABOLISM; GENE EXPRESSION; GENETIC TRANSCRIPTION; INTESTINE; LIVER; NONHUMAN; NUCLEOTIDE SEQUENCE; NULL ALLELE; PANCREAS ISLET; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DNA BINDING; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; SIGNAL TRANSDUCTION;

ALLELES; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BLOTTING, WESTERN; CHO CELLS; CRICETINAE; DIMERIZATION; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES, REPORTER; GENETIC VECTORS; HEPATOCYTE NUCLEAR FACTOR 4; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; MUTATION; PHOSPHOPROTEINS; PHOSPHORYLATION; PLASMIDS; PROMOTER REGIONS (GENETICS); PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; SEQUENCE HOMOLOGY, AMINO ACID; SERINE; TIME FACTORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

ANIMALIA;

EID: 0042847434     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M304112200     Document Type: Article

References (53)

1. Sladek, R., and Giguere, V. (2000) Adv. Pharmacol. 47, 23-87
2. Ryffel, G. U. (2001) J. Mol. Endocrinol. 27, 11-29
3. Yamagata, K., Furuta, H., Oda, N., Kaisaki, P. J., Menzel, S., Cox, N. J., Fajans, S. S., Signorini, S., Stoffel, M., and Bell, G. I. (1996) Nature 384, 458-460
4. Herman, W. H., Fajans, S. S., Smith, M. J., Polonsky, K. S., Bell, G. I., and Halter, J. B. (1997) Diabetes 46, 1749-1754
5. Lindner, T., Gragnoli, C., Furuta, H., Cockburn, B. N., Petzold, C., Rietzsch, H., Weiss, U., Schulze, J., and Bell, G. I. (1997) J. Clin. Invest. 100, 1400-1405
6. Stoffel, M., and Duncan, S. A. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 13209-13214
7. Duncan, S. A., Navas, M. A., Dufort, D., Rossant, J., and Stoffel, M. (1998) Science 281, 692-695
8. Wang, H., Maechler, P., Antinozzi, P. A., Hagenfeldt, K. A., and Wollheim, C. B. (2000) J. Biol. Chem. 275, 35953-35959
9. Sladek, F. M., Dallas-Yang, Q., and Nepomuceno, L. (1998) Diabetes 47, 985-990
10. Yoon, J. C., Puigserver, P., Chen, G., Donovan, J., Wu, Z., Rhee, J., Adelmant, G., Stafford, J., Kahn, C. R., Granner, D. K., Newgard, C. B., and Spiegelman, B. M. (2001) Nature 413, 131-138
11. Woods, A., Munday, M. R., Scott, J., Yang, X., Carlson, M., and Carling, D. (1994) J. Biol. Chem. 269, 19509-19515
12. Woods, A., Azzout-Marniche, D., Foretz, M., Stein, S. C., Lemarchand, P., Ferre, P., Foufelle, F., and Carling, D. (2000) Mol. Cell. Biol. 20, 6704-6711
13. Hardie, D. G., Carling, D., and Carlson, M. (1998) Annu. Rev. Biochem. 67, 821-855
14. da Silva Xavier, G., Leclerc, I., Salt, I. P., Doiron, B., Hardie, D. G., Kahn, A., and Rutter, G. A. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 4023-4028
15. Marsin, A. S., Bertrand, L., Rider, M. H., Deprez, J., Beauloye, C., Vincent, M. F., Van den Berghe, G., Carling, D., and Hue, L. (2000) Curr. Biol. 10, 1247-1255
16. Corton, J. M., Gillespie, J. G., and Hardie, D. G. (1994) Curr. Biol. 4, 315-324
17. Hayashi, T., Hirshman, M. F., Xurth, E. J., Winder, W. W., and Goodyear, L. J. (1998) Diabetes 47, 1369-1373
18. Mu, J., Brozinick, J. T., Jr., Valladares, O., Bucan, M., and Birnbaum, M. J. (2001) Mol. Cell 7, 1085-1094
19. Musi, N., Fujii, N., Hirshman, M. F., Ekberg, I., Froberg, S., Ljungqvist, O., Thorell, A., and Goodyear, L. J. (2001) Diabetes 50, 921-927
20. Merrill, G. F., Kurth, E. J., Hardie, D. G., and Winder, W. W. (1997) Am. J. Physiol. 273, E1107-E1112
21. Bergeron, R., Russell, R. R., III, Young, L. H., Ren, J. M., Marcucci, M., Lee, A., and Shulman, G. I. (1999) Am. J. Physiol. 276, E938-E944
22. Foretz, M., Carling, D., Guichard, C., Ferre, P., and Foufelle, F. (1998) J. Biol. Chem. 273, 14767-14771
23. Henin, N., Vincent, M. F., Gruber, H. E., and Van den Berghe, G. (1995) FASEB J. 9, 541-546
24. Hubert, A., Husson, A., Chedeville, A., and Lavoinne, A. (2000) FEBS Lett. 481, 209-212
25. Salt, I. P., Johnson, G., Ashcroft, S. J., and Hardie, D. G. (1998) Biochem. J. 335, 533-539
26. Woods, A., Cheung, P. C., Smith, F. C., Davison, M. D., Scott, J., Beri, R. K., and Carling, D. (1996) J. Biol. Chem. 271, 10282-10290
27. Gao, G., Fernandez, C. S., Stapleton, D., Auster, A. S., Widmer, J., Dyck, J. R., Kemp, B. E., and Witters, L. A. (1996) J. Biol. Chem. 271, 8675-8681
28. Woods, A., Salt, I., Scott, J., Hardie, D. G., and Carling, D. (1996) FEBS Lett. 397, 347-351
29. Thornton, C., Snowden, M. A., and Carling, D. (1998) J. Biol. Chem. 273, 12443-12450
30. Stapleton, D., Woollatt, E., Mitchelhill, K. I., Nicholl, J. K., Fernandez, C. S., Michell, B. J., Witters, L. A., Power, D. A., Sutherland, G. R., and Kemp, B. E. (1997) FEBS Lett. 409, 452-456
31. Salt, I., Celler, J. W., Hawley, S. A., Prescott, A., Woods, A., Carling, D., and Hardie, D. G. (1998) Biochem. J. 334, 177-187
32. Yang, W., Hong, Y. H., Shen, X. Q., Frankowski, C., Camp, H. S., and Leff, T. (2001) J. Biol. Chem. 276, 38341-38344
33. Leclerc, I., Lenzner, C., Gourdon, L., Vaulont, S., Kahn, A., and Viollet, B. (2001) Diabetes 50, 1515-1521
34. Dignam, J. D., Lebovitz, R. M., and Roeder, R. G. (1983) Nucleic Acids Res. 11, 1475-1489
35. Reddy, S., Yang, W., Taylor, D. G., Shen, X., Oxender, D., Kust, G., and Leff, T. (1999) J. Biol. Chem. 274, 33050-33056
36. Jiang, G., Nepomuceno, L., Yang, Q., and Sladek, F. M. (1997) Arch. Biochem. Biophys. 340, 1-9
37. Viollet, B., Kahn, A., and Raymondjean, M. (1997) Mol. Cell. Biol. 17, 4208-4219
38. Sullivan, J. E., Brocklehurst, K. J., Marley, A. E., Carey, F., Carling, D., and Beri, R. K. (1994) FEBS Lett. 353, 33-36
39. Ktistaki, E., Ktistakis, N. T., Papadogeorgaki, E., and Talianidis, I. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 9876-9880
40. Turnley, A. M., Stapleton, D., Mann, R. J., Witters, L. A., Kemp, B. E., and Bartlett, P. F. (1999) J. Neurochem. 72, 1707-1716
41. Kawaguchi, T., Osatomi, K., Yamashita, H., Kabashima, T., and Uyeda, K. (2002) J. Biol. Chem. 277, 3829-3835
42. Lo, W. S., Duggan, L., Tolga, N. C., Emre, Belotserkovskya, R., Lane, W. S., Shiekhattar, R., and Berger, S. L. (2001) Science 293, 1142-1146
43. Ilag, L. L., Tabaei, B. P., Herman, W. H., Zawacki, C. M., D'Souza, E., Bell, G. I., and Fajans, S. S. (2000) Diabetes 49, 961-968
44. Ishihara, H., and Wollheim, C. B. (2000) IUBMB Life 49, 391-395
45. Hayhurst, G. P., Lee, Y. H., Lambert, G., Ward, J. M., and Gonzalez, F. J. (2001) Mol. Cell. Biol. 21, 1393-1403
46. Inoue, Y., Hayhurst, G. P., Inoue, J., Mori, M., and Gonzalez, F. J. (2002) J. Biol. Chem. 277, 25257-25265
47. Nitsch, D., Boshart, M., and Schutz, G. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 5479-5483
48. Diaz Guerra, M. J., Bergot, M. O., Martinez, A., Cuif, M. H., Kahn, A., and Raymondjean, M. (1993) Mol. Cell. Biol. 13, 7725-7733
49. Hall, R. K., Sladek, F. M., and Granner, D. K. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 412-416
50. Figueiredo, M. S. and Brownlee, G. G. (1995) J. Biol. Chem. 270, 11828-11838
51. Iwasaki, N., Ogata, M., Tomonaga, O., Kuroki, H., Kasahara, T., Yano, N., and Iwamoto, Y. (1998) Diabetes Care 21, 2144-2148
52. Shih, D. Q., Dansky, H. M., Fleisher, M., Assmann, G., Fajans, S. S., and Stoffel, M. (2000) Diabetes 49, 832-837
53. Hardie, D. G., and Carling, D. (1997) Eur. J. Biochem. 246, 259-273