Small molecule drug A-769662 and AMP synergistically activate naive AMPK independent of upstream kinase signaling

Chemistry and Biology

Volumn 21, Issue 5, 2014, Pages 619-627

  Scott, John W ^a   Ling, Naomi ^a   Issa, Samah M A ^a   Dite, Toby A ^a   O'Brien, Matthew T ^a   Chen, Zhi Ping ^a   Galic, Sandra ^a   Langendorf, Christopher G ^a   Steinberg, Gregory R ^b   Kemp, Bruce E ^a   Oakhill, Jonathan S ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

6,7 DIHYDRO 4 HYDROXY 3 (2' HYDROXY 1,1' BIPHENYL 4 YL) 6 OXOTHIENO[2,3 B]PYRIDINE 5 CARBONITRILE; ADENOSINE PHOSPHATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; SERINE; PYRONE DERIVATIVE; THIOPHENE DERIVATIVE;

ALLOSTERISM; ARTICLE; DRUG MECHANISM; DRUG PROTEIN BINDING; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; NUCLEOTIDE BINDING SITE; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; CHEMISTRY; CHLOROCEBUS AETHIOPS; COS 1 CELL LINE; DOSE RESPONSE; DRUG EFFECTS; DRUG POTENTIATION; METABOLISM; MOLECULAR WEIGHT; PHOSPHORYLATION; STRUCTURE ACTIVITY RELATION;

ADENOSINE MONOPHOSPHATE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; ENZYME ACTIVATION; MOLECULAR WEIGHT; PHOSPHORYLATION; PYRONES; SERINE; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 84901329684     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2014.03.006     Document Type: Article

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