A UBE2O-AMPKα2 Axis that Promotes Tumor Initiation and Progression Offers Opportunities for Therapy

Cancer Cell

Volumn 31, Issue 2, 2017, Pages 208-224

  Vila, Isabelle K ^a   Yao, Yixin ^a   Kim, Goeun ^b   Xia, Weiya ^a   Kim, Hyejin ^a   Kim, Sun Joong ^a   Park, Mi Kyung ^a   Hwang, James P ^a   González Billalabeitia, Enrique ^c   Hung, Mien Chie ^a,d,e   Song, Su Jung ^b   Song, Min Sup ^a,d  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b Soonchunhyang University   (South Korea)

^c HOSPITAL MORALES MESEGUER   (Spain)

^d UNIVERSITY OF TEXAS   (United States)

^e CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

AMPK; AMPK 2; arsenite; breast cancer; cancer metabolism; HIF1 ; mTOR; prostate cancer; UBE2O; ubiquitination

Indexed keywords

AMP ACTIVATED PROTEIN KINASE ALPHA 1; AMP ACTIVATED PROTEIN KINASE ALPHA 2; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MAMMALIAN TARGET OF RAPAMYCIN; RAPAMYCIN; UBIQUITIN CONJUGATING ENZYME; UBIQUITIN CONJUGATING ENZYME E2O; UNCLASSIFIED DRUG; HIF1A PROTEIN, HUMAN; MAGEA3 PROTEIN, HUMAN; PRKAA2 PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE; TUMOR ANTIGEN; TUMOR PROTEIN; UBE2O PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER CARCINOMA; BREAST CANCER; BREAST CARCINOGENESIS; CANCER GROWTH; CANCER PATIENT; CANCER SURVIVAL; CARCINOGENESIS; CELL METABOLISM; CONTROLLED STUDY; EMBRYO; ENZYMATIC DEGRADATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INACTIVATION; FEMALE; GENE DELETION; GENE TARGETING; HUMAN; HUMAN TISSUE; INVASIVE CARCINOMA; KNOCKOUT MOUSE; LIVER CELL CARCINOMA; LUNG CARCINOMA; LUNG METASTASIS; MALE; MOUSE; MOUSE EMBRYONIC STEM CELL; NONHUMAN; NUCLEAR REPROGRAMMING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROSTATE CARCINOMA; PROTEIN TARGETING; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; UBIQUITINATION; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; DISEASE COURSE; METABOLISM; NEOPLASMS; PHYSIOLOGY;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANTIGENS, NEOPLASM; DISEASE PROGRESSION; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; MICE, INBRED C57BL; NEOPLASM PROTEINS; NEOPLASMS; TOR SERINE-THREONINE KINASES; UBIQUITIN-CONJUGATING ENZYMES; UBIQUITINATION;

EID: 85011269383     PISSN: 15356108     EISSN: 18783686     Source Type: Journal    
DOI: 10.1016/j.ccell.2017.01.003     Document Type: Article

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