-
1
-
-
0036591972
-
Activation of GLUT1 by metabolic and osmotic stress: Potential involvement of AMP-activated protein kinase (AMPK)
-
K. Barnes, J.C. Ingram, O.H. Porras, L.F. Barros, E.R. Hudson, L.G. Fryer, F. Foufelle, D. Carling, D.G. Hardie, and S.A. Baldwin Activation of GLUT1 by metabolic and osmotic stress: potential involvement of AMP-activated protein kinase (AMPK) J. Cell Sci. 115 2002 2433 2442
-
(2002)
J. Cell Sci.
, vol.115
, pp. 2433-2442
-
-
Barnes, K.1
Ingram, J.C.2
Porras, O.H.3
Barros, L.F.4
Hudson, E.R.5
Fryer, L.G.6
Foufelle, F.7
Carling, D.8
Hardie, D.G.9
Baldwin, S.A.10
-
2
-
-
84905029258
-
Comprehensive molecular profiling of lung adenocarcinoma
-
Cancer Genome Atlas Research Network Erratum in Nature 2014;514:262. Rogers, K [corrected to Rodgers, K]
-
Cancer Genome Atlas Research Network Comprehensive molecular profiling of lung adenocarcinoma Nature 511 2014 543 550 Erratum in Nature 2014;514:262. Rogers, K [corrected to Rodgers, K]
-
(2014)
Nature
, vol.511
, pp. 543-550
-
-
-
3
-
-
67349276169
-
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
-
C. Cantó, Z. Gerhart-Hines, J.N. Feige, M. Lagouge, L. Noriega, J.C. Milne, P.J. Elliott, P. Puigserver, and J. Auwerx AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity Nature 458 2009 1056 1060
-
(2009)
Nature
, vol.458
, pp. 1056-1060
-
-
Cantó, C.1
Gerhart-Hines, Z.2
Feige, J.N.3
Lagouge, M.4
Noriega, L.5
Milne, J.C.6
Elliott, P.J.7
Puigserver, P.8
Auwerx, J.9
-
4
-
-
0023642627
-
A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis
-
D. Carling, V.A. Zammit, and D.G. Hardie A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis FEBS Lett. 223 1987 217 222
-
(1987)
FEBS Lett.
, vol.223
, pp. 217-222
-
-
Carling, D.1
Zammit, V.A.2
Hardie, D.G.3
-
6
-
-
0035879005
-
An overview of the MAGE gene family with the identification of all human members of the family
-
P. Chomez, O. De Backer, M. Bertrand, E. De Plaen, T. Boon, and S. Lucas An overview of the MAGE gene family with the identification of all human members of the family Cancer Res. 61 2001 5544 5551
-
(2001)
Cancer Res.
, vol.61
, pp. 5544-5551
-
-
Chomez, P.1
De Backer, O.2
Bertrand, M.3
De Plaen, E.4
Boon, T.5
Lucas, S.6
-
7
-
-
84907048181
-
AMPK reverses the mesenchymal phenotype of cancer cells by targeting the Akt-MDM2-Foxo3a signaling axis
-
C.C. Chou, K.H. Lee, I.L. Lai, D. Wang, X. Mo, S.K. Kulp, C.L. Shapiro, and C.S. Chen AMPK reverses the mesenchymal phenotype of cancer cells by targeting the Akt-MDM2-Foxo3a signaling axis Cancer Res. 74 2014 4783 4795
-
(2014)
Cancer Res.
, vol.74
, pp. 4783-4795
-
-
Chou, C.C.1
Lee, K.H.2
Lai, I.L.3
Wang, D.4
Mo, X.5
Kulp, S.K.6
Shapiro, C.L.7
Chen, C.S.8
-
8
-
-
33744514139
-
Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome
-
B. Cool, B. Zinker, W. Chiou, L. Kifle, N. Cao, M. Perham, R. Dickinson, A. Adler, G. Gagne, and R. Iyengar Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome Cell Metab. 3 2006 403 416
-
(2006)
Cell Metab.
, vol.3
, pp. 403-416
-
-
Cool, B.1
Zinker, B.2
Chiou, W.3
Kifle, L.4
Cao, N.5
Perham, M.6
Dickinson, R.7
Adler, A.8
Gagne, G.9
Iyengar, R.10
-
9
-
-
0028050181
-
Structure, chromosomal localization, and expression of 12 genes of the MAGE family
-
E. De Plaen, K. Arden, C. Traversari, J.J. Gaforio, J.P. Szikora, C. De Smet, F. Brasseur, P. van der Bruggen, B. Lethé, and C. Lurquin Structure, chromosomal localization, and expression of 12 genes of the MAGE family Immunogenetics 40 1994 360 369
-
(1994)
Immunogenetics
, vol.40
, pp. 360-369
-
-
De Plaen, E.1
Arden, K.2
Traversari, C.3
Gaforio, J.J.4
Szikora, J.P.5
De Smet, C.6
Brasseur, F.7
Van Der Bruggen, P.8
Lethé, B.9
Lurquin, C.10
-
10
-
-
77956936946
-
MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases
-
J.M. Doyle, J. Gao, J. Wang, M. Yang, and P.R. Potts MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases Mol. Cell 39 2010 963 974
-
(2010)
Mol. Cell
, vol.39
, pp. 963-974
-
-
Doyle, J.M.1
Gao, J.2
Wang, J.3
Yang, M.4
Potts, P.R.5
-
11
-
-
79251587803
-
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy
-
D.F. Egan, D.B. Shackelford, M.M. Mihaylova, S. Gelino, R.A. Kohnz, W. Mair, D.S. Vasquez, A. Joshi, D.M. Gwinn, and R. Taylor Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy Science 331 2011 456 461
-
(2011)
Science
, vol.331
, pp. 456-461
-
-
Egan, D.F.1
Shackelford, D.B.2
Mihaylova, M.M.3
Gelino, S.4
Kohnz, R.A.5
Mair, W.6
Vasquez, D.S.7
Joshi, A.8
Gwinn, D.M.9
Taylor, R.10
-
12
-
-
62849094740
-
Uncoupling of the LKB1-AMPKalpha energy sensor pathway by growth factors and oncogenic BRAF
-
R. Esteve-Puig, F. Canals, N. Colomé, G. Merlino, and J.A. Recio Uncoupling of the LKB1-AMPKalpha energy sensor pathway by growth factors and oncogenic BRAF PLoS ONE 4 2009 e4771
-
(2009)
PLoS ONE
, vol.4
, pp. e4771
-
-
Esteve-Puig, R.1
Canals, F.2
Colomé, N.3
Merlino, G.4
Recio, J.A.5
-
13
-
-
84872159532
-
AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo
-
B. Faubert, G. Boily, S. Izreig, T. Griss, B. Samborska, Z. Dong, F. Dupuy, C. Chambers, B.J. Fuerth, and B. Viollet AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo Cell Metab. 17 2013 113 124
-
(2013)
Cell Metab.
, vol.17
, pp. 113-124
-
-
Faubert, B.1
Boily, G.2
Izreig, S.3
Griss, T.4
Samborska, B.5
Dong, Z.6
Dupuy, F.7
Chambers, C.8
Fuerth, B.J.9
Viollet, B.10
-
14
-
-
79953214941
-
When MAGE meets RING: Insights into biological functions of MAGE proteins
-
Y. Feng, J. Gao, and M. Yang When MAGE meets RING: insights into biological functions of MAGE proteins Protein Cell 2 2011 7 12
-
(2011)
Protein Cell
, vol.2
, pp. 7-12
-
-
Feng, Y.1
Gao, J.2
Yang, M.3
-
15
-
-
42949139481
-
AMPK phosphorylation of raptor mediates a metabolic checkpoint
-
D.M. Gwinn, D.B. Shackelford, D.F. Egan, M.M. Mihaylova, A. Mery, D.S. Vasquez, B.E. Turk, and R.J. Shaw AMPK phosphorylation of raptor mediates a metabolic checkpoint Mol. Cell 30 2008 214 226
-
(2008)
Mol. Cell
, vol.30
, pp. 214-226
-
-
Gwinn, D.M.1
Shackelford, D.B.2
Egan, D.F.3
Mihaylova, M.M.4
Mery, A.5
Vasquez, D.S.6
Turk, B.E.7
Shaw, R.J.8
-
16
-
-
70349883650
-
Histological evaluation of AMPK signalling in primary breast cancer
-
S.M. Hadad, L. Baker, P.R. Quinlan, K.E. Robertson, S.E. Bray, G. Thomson, D. Kellock, L.B. Jordan, C.A. Purdie, and D.G. Hardie Histological evaluation of AMPK signalling in primary breast cancer BMC Cancer 9 2009 307
-
(2009)
BMC Cancer
, vol.9
, pp. 307
-
-
Hadad, S.M.1
Baker, L.2
Quinlan, P.R.3
Robertson, K.E.4
Bray, S.E.5
Thomson, G.6
Kellock, D.7
Jordan, L.B.8
Purdie, C.A.9
Hardie, D.G.10
-
17
-
-
79960845901
-
Evidence for biological effects of metformin in operable breast cancer: A pre-operative, window-of-opportunity, randomized trial
-
S. Hadad, T. Iwamoto, L. Jordan, C. Purdie, S. Bray, L. Baker, G. Jellema, S. Deharo, D.G. Hardie, and L. Pusztai Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial Breast Cancer Res. Treat. 128 2011 783 794
-
(2011)
Breast Cancer Res. Treat.
, vol.128
, pp. 783-794
-
-
Hadad, S.1
Iwamoto, T.2
Jordan, L.3
Purdie, C.4
Bray, S.5
Baker, L.6
Jellema, G.7
Deharo, S.8
Hardie, D.G.9
Pusztai, L.10
-
18
-
-
84874765742
-
Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination
-
Y.H. Hao, J.M. Doyle, S. Ramanathan, T.S. Gomez, D. Jia, M. Xu, Z.J. Chen, D.D. Billadeau, M.K. Rosen, and P.R. Potts Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination Cell 152 2013 1051 1064
-
(2013)
Cell
, vol.152
, pp. 1051-1064
-
-
Hao, Y.H.1
Doyle, J.M.2
Ramanathan, S.3
Gomez, T.S.4
Jia, D.5
Xu, M.6
Chen, Z.J.7
Billadeau, D.D.8
Rosen, M.K.9
Potts, P.R.10
-
19
-
-
84876320551
-
LKB1 and AMPK and the cancer-metabolism link - Ten years after
-
D.G. Hardie, and D.R. Alessi LKB1 and AMPK and the cancer-metabolism link - ten years after BMC Biol. 11 2013 36
-
(2013)
BMC Biol.
, vol.11
, pp. 36
-
-
Hardie, D.G.1
Alessi, D.R.2
-
20
-
-
84868005485
-
AMP-activated protein kinase: A target for drugs both ancient and modern
-
D.G. Hardie, F.A. Ross, and S.A. Hawley AMP-activated protein kinase: a target for drugs both ancient and modern Chem. Biol. 19 2012 1222 1236
-
(2012)
Chem. Biol.
, vol.19
, pp. 1222-1236
-
-
Hardie, D.G.1
Ross, F.A.2
Hawley, S.A.3
-
21
-
-
84858782079
-
AMPK: A nutrient and energy sensor that maintains energy homeostasis
-
D.G. Hardie, F.A. Ross, and S.A. Hawley AMPK: a nutrient and energy sensor that maintains energy homeostasis Nat. Rev. Mol. Cell Biol. 13 2012 251 262
-
(2012)
Nat. Rev. Mol. Cell Biol.
, vol.13
, pp. 251-262
-
-
Hardie, D.G.1
Ross, F.A.2
Hawley, S.A.3
-
22
-
-
0345107247
-
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade
-
S.A. Hawley, J. Boudeau, J.L. Reid, K.J. Mustard, L. Udd, T.P. Mäkelä, D.R. Alessi, and D.G. Hardie Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade J. Biol. 2 2003 28
-
(2003)
J. Biol.
, vol.2
, pp. 28
-
-
Hawley, S.A.1
Boudeau, J.2
Reid, J.L.3
Mustard, K.J.4
Udd, L.5
Mäkelä, T.P.6
Alessi, D.R.7
Hardie, D.G.8
-
23
-
-
23044432463
-
Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase
-
S.A. Hawley, D.A. Pan, K.J. Mustard, L. Ross, J. Bain, A.M. Edelman, B.G. Frenguelli, and D.G. Hardie Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase Cell Metab. 2 2005 9 19
-
(2005)
Cell Metab.
, vol.2
, pp. 9-19
-
-
Hawley, S.A.1
Pan, D.A.2
Mustard, K.J.3
Ross, L.4
Bain, J.5
Edelman, A.M.6
Frenguelli, B.G.7
Hardie, D.G.8
-
24
-
-
0035929359
-
Cell cycle regulation via p53 phosphorylation by a 5′-AMP activated protein kinase activator, 5-aminoimidazole- 4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line
-
K. Imamura, T. Ogura, A. Kishimoto, M. Kaminishi, and H. Esumi Cell cycle regulation via p53 phosphorylation by a 5′-AMP activated protein kinase activator, 5-aminoimidazole- 4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line Biochem. Biophys. Res. Commun. 287 2001 562 567
-
(2001)
Biochem. Biophys. Res. Commun.
, vol.287
, pp. 562-567
-
-
Imamura, K.1
Ogura, T.2
Kishimoto, A.3
Kaminishi, M.4
Esumi, H.5
-
25
-
-
0345167800
-
TSC2 mediates cellular energy response to control cell growth and survival
-
K. Inoki, T. Zhu, and K.L. Guan TSC2 mediates cellular energy response to control cell growth and survival Cell 115 2003 577 590
-
(2003)
Cell
, vol.115
, pp. 577-590
-
-
Inoki, K.1
Zhu, T.2
Guan, K.L.3
-
26
-
-
0035503239
-
Activation of melanoma antigen tumor antigens occurs early in lung carcinogenesis
-
S.J. Jang, J.C. Soria, L. Wang, K.A. Hassan, R.C. Morice, G.L. Walsh, W.K. Hong, and L. Mao Activation of melanoma antigen tumor antigens occurs early in lung carcinogenesis Cancer Res. 61 2001 7959 7963
-
(2001)
Cancer Res.
, vol.61
, pp. 7959-7963
-
-
Jang, S.J.1
Soria, J.C.2
Wang, L.3
Hassan, K.A.4
Morice, R.C.5
Walsh, G.L.6
Hong, W.K.7
Mao, L.8
-
27
-
-
20844449238
-
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint
-
R.G. Jones, D.R. Plas, S. Kubek, M. Buzzai, J. Mu, Y. Xu, M.J. Birnbaum, and C.B. Thompson AMP-activated protein kinase induces a p53-dependent metabolic checkpoint Mol. Cell 18 2005 283 293
-
(2005)
Mol. Cell
, vol.18
, pp. 283-293
-
-
Jones, R.G.1
Plas, D.R.2
Kubek, S.3
Buzzai, M.4
Mu, J.5
Xu, Y.6
Birnbaum, M.J.7
Thompson, C.B.8
-
28
-
-
79551598347
-
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
-
J. Kim, M. Kundu, B. Viollet, and K.L. Guan AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1 Nat. Cell Biol. 13 2011 132 141
-
(2011)
Nat. Cell Biol.
, vol.13
, pp. 132-141
-
-
Kim, J.1
Kundu, M.2
Viollet, B.3
Guan, K.L.4
-
29
-
-
84872586081
-
Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy
-
J. Kim, Y.C. Kim, C. Fang, R.C. Russell, J.H. Kim, W. Fan, R. Liu, Q. Zhong, and K.L. Guan Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy Cell 152 2013 290 303
-
(2013)
Cell
, vol.152
, pp. 290-303
-
-
Kim, J.1
Kim, Y.C.2
Fang, C.3
Russell, R.C.4
Kim, J.H.5
Fan, W.6
Liu, R.7
Zhong, Q.8
Guan, K.L.9
-
30
-
-
84905962247
-
5′-AMP-activated protein kinase (AMPK) supports the growth of aggressive experimental human breast cancer tumors
-
K.R. Laderoute, J.M. Calaoagan, W.R. Chao, D. Dinh, N. Denko, S. Duellman, J. Kalra, X. Liu, I. Papandreou, L. Sambucetti, and L.G. Boros 5′-AMP-activated protein kinase (AMPK) supports the growth of aggressive experimental human breast cancer tumors J. Biol. Chem. 289 2014 22850 22864
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 22850-22864
-
-
Laderoute, K.R.1
Calaoagan, J.M.2
Chao, W.R.3
Dinh, D.4
Denko, N.5
Duellman, S.6
Kalra, J.7
Liu, X.8
Papandreou, I.9
Sambucetti, L.10
Boros, L.G.11
-
31
-
-
84887408835
-
Activation of AMP-activated protein kinase revealed by hydrogen/deuterium exchange mass spectrometry
-
R.R. Landgraf, D. Goswami, F. Rajamohan, M.S. Harris, M.F. Calabrese, L.R. Hoth, R. Magyar, B.D. Pascal, M.J. Chalmers, and S.A. Busby Activation of AMP-activated protein kinase revealed by hydrogen/deuterium exchange mass spectrometry Structure 21 2013 1942 1953
-
(2013)
Structure
, vol.21
, pp. 1942-1953
-
-
Landgraf, R.R.1
Goswami, D.2
Rajamohan, F.3
Harris, M.S.4
Calabrese, M.F.5
Hoth, L.R.6
Magyar, R.7
Pascal, B.D.8
Chalmers, M.J.9
Busby, S.A.10
-
32
-
-
84865793242
-
AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells
-
C.W. Lee, L.L. Wong, E.Y. Tse, H.F. Liu, V.Y. Leong, J.M. Lee, D.G. Hardie, I.O. Ng, and Y.P. Ching AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells Cancer Res. 72 2012 4394 4404
-
(2012)
Cancer Res.
, vol.72
, pp. 4394-4404
-
-
Lee, C.W.1
Wong, L.L.2
Tse, E.Y.3
Liu, H.F.4
Leong, V.Y.5
Lee, J.M.6
Hardie, D.G.7
Ng, I.O.8
Ching, Y.P.9
-
33
-
-
33947250696
-
The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis
-
J. Liang, S.H. Shao, Z.X. Xu, B. Hennessy, Z. Ding, M. Larrea, S. Kondo, D.J. Dumont, J.U. Gutterman, and C.L. Walker The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis Nat. Cell Biol. 9 2007 218 224
-
(2007)
Nat. Cell Biol.
, vol.9
, pp. 218-224
-
-
Liang, J.1
Shao, S.H.2
Xu, Z.X.3
Hennessy, B.4
Ding, Z.5
Larrea, M.6
Kondo, S.7
Dumont, D.J.8
Gutterman, J.U.9
Walker, C.L.10
-
34
-
-
54249136353
-
The melanoma-associated antigen A3 mediates fibronectin-controlled cancer progression and metastasis
-
W. Liu, S. Cheng, S.L. Asa, and S. Ezzat The melanoma-associated antigen A3 mediates fibronectin-controlled cancer progression and metastasis Cancer Res. 68 2008 8104 8112
-
(2008)
Cancer Res.
, vol.68
, pp. 8104-8112
-
-
Liu, W.1
Cheng, S.2
Asa, S.L.3
Ezzat, S.4
-
35
-
-
78650390294
-
Mage-A cancer/testis antigens inhibit p53 function by blocking its interaction with chromatin
-
L. Marcar, N.J. Maclaine, T.R. Hupp, and D.W. Meek Mage-A cancer/testis antigens inhibit p53 function by blocking its interaction with chromatin Cancer Res. 70 2010 10362 10370
-
(2010)
Cancer Res.
, vol.70
, pp. 10362-10370
-
-
Marcar, L.1
Maclaine, N.J.2
Hupp, T.R.3
Meek, D.W.4
-
36
-
-
34748845413
-
Prevalence and specificity of LKB1 genetic alterations in lung cancers
-
S. Matsumoto, R. Iwakawa, K. Takahashi, T. Kohno, Y. Nakanishi, Y. Matsuno, K. Suzuki, M. Nakamoto, E. Shimizu, J.D. Minna, and J. Yokota Prevalence and specificity of LKB1 genetic alterations in lung cancers Oncogene 26 2007 5911 5918
-
(2007)
Oncogene
, vol.26
, pp. 5911-5918
-
-
Matsumoto, S.1
Iwakawa, R.2
Takahashi, K.3
Kohno, T.4
Nakanishi, Y.5
Matsuno, Y.6
Suzuki, K.7
Nakamoto, M.8
Shimizu, E.9
Minna, J.D.10
Yokota, J.11
-
37
-
-
33746610114
-
MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents
-
M. Monte, M. Simonatto, L.Y. Peche, D.R. Bublik, S. Gobessi, M.A. Pierotti, M. Rodolfo, and C. Schneider MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents Proc. Natl. Acad. Sci. USA 103 2006 11160 11165
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 11160-11165
-
-
Monte, M.1
Simonatto, M.2
Peche, L.Y.3
Bublik, D.R.4
Gobessi, S.5
Pierotti, M.A.6
Rodolfo, M.7
Schneider, C.8
-
38
-
-
18844468287
-
Metabolism of round spermatids: Evidence that lactate is preferred substrate
-
M. Nakamura, S. Okinaga, and K. Arai Metabolism of round spermatids: evidence that lactate is preferred substrate Am. J. Physiol. 247 1984 E234 E242
-
(1984)
Am. J. Physiol.
, vol.247
, pp. E234-E242
-
-
Nakamura, M.1
Okinaga, S.2
Arai, K.3
-
39
-
-
84866538325
-
Metformin in early breast cancer: A prospective window of opportunity neoadjuvant study
-
S. Niraula, R.J. Dowling, M. Ennis, M.C. Chang, S.J. Done, N. Hood, J. Escallon, W.L. Leong, D.R. McCready, and M. Reedijk Metformin in early breast cancer: a prospective window of opportunity neoadjuvant study Breast Cancer Res. Treat. 135 2012 821 830
-
(2012)
Breast Cancer Res. Treat.
, vol.135
, pp. 821-830
-
-
Niraula, S.1
Dowling, R.J.2
Ennis, M.3
Chang, M.C.4
Done, S.J.5
Hood, N.6
Escallon, J.7
Leong, W.L.8
McCready, D.R.9
Reedijk, M.10
-
40
-
-
84905757105
-
Metformin - Mode of action and clinical implications for diabetes and cancer
-
I. Pernicova, and M. Korbonits Metformin - mode of action and clinical implications for diabetes and cancer Nat. Rev. Endocrinol. 10 2014 143 156
-
(2014)
Nat. Rev. Endocrinol.
, vol.10
, pp. 143-156
-
-
Pernicova, I.1
Korbonits, M.2
-
41
-
-
84883165443
-
Repositioning metformin for cancer prevention and treatment
-
B.J. Quinn, H. Kitagawa, R.M. Memmott, J.J. Gills, and P.A. Dennis Repositioning metformin for cancer prevention and treatment Trends Endocrinol. Metab. 24 2013 469 480
-
(2013)
Trends Endocrinol. Metab.
, vol.24
, pp. 469-480
-
-
Quinn, B.J.1
Kitagawa, H.2
Memmott, R.M.3
Gills, J.J.4
Dennis, P.A.5
-
42
-
-
77249105997
-
Immortalized epithelial cells derived from human colon biopsies express stem cell markers and differentiate in vitro
-
e1011-1015
-
A.I. Roig, U. Eskiocak, S.K. Hight, S.B. Kim, O. Delgado, R.F. Souza, S.J. Spechler, W.E. Wright, and J.W. Shay Immortalized epithelial cells derived from human colon biopsies express stem cell markers and differentiate in vitro Gastroenterology 138 2010 1012 1021 e1011-1015
-
(2010)
Gastroenterology
, vol.138
, pp. 1012-1021
-
-
Roig, A.I.1
Eskiocak, U.2
Hight, S.K.3
Kim, S.B.4
Delgado, O.5
Souza, R.F.6
Spechler, S.J.7
Wright, W.E.8
Shay, J.W.9
-
43
-
-
0036645286
-
Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung
-
M. Sanchez-Cespedes, P. Parrella, M. Esteller, S. Nomoto, B. Trink, J.M. Engles, W.H. Westra, J.G. Herman, and D. Sidransky Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung Cancer Res. 62 2002 3659 3662
-
(2002)
Cancer Res.
, vol.62
, pp. 3659-3662
-
-
Sanchez-Cespedes, M.1
Parrella, P.2
Esteller, M.3
Nomoto, S.4
Trink, B.5
Engles, J.M.6
Westra, W.H.7
Herman, J.G.8
Sidransky, D.9
-
44
-
-
67749111502
-
The LKB1-AMPK pathway: Metabolism and growth control in tumour suppression
-
D.B. Shackelford, and R.J. Shaw The LKB1-AMPK pathway: metabolism and growth control in tumour suppression Nat. Rev. Cancer 9 2009 563 575
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 563-575
-
-
Shackelford, D.B.1
Shaw, R.J.2
-
45
-
-
67650480092
-
MTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome
-
D.B. Shackelford, D.S. Vasquez, J. Corbeil, S. Wu, M. Leblanc, C.L. Wu, D.R. Vera, and R.J. Shaw mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome Proc. Natl. Acad. Sci. USA 106 2009 11137 11142
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 11137-11142
-
-
Shackelford, D.B.1
Vasquez, D.S.2
Corbeil, J.3
Wu, S.4
Leblanc, M.5
Wu, C.L.6
Vera, D.R.7
Shaw, R.J.8
-
46
-
-
84872059948
-
MAGE-A3 is highly expressed in a subset of colorectal cancer patients
-
H.M. Shantha Kumara, M.J. Grieco, O.L. Caballero, T. Su, A. Ahmed, E. Ritter, S. Gnjatic, V. Cekic, L.J. Old, and A.J. Simpson MAGE-A3 is highly expressed in a subset of colorectal cancer patients Cancer Immun. 12 2012 16
-
(2012)
Cancer Immun.
, vol.12
, pp. 16
-
-
Shantha Kumara, H.M.1
Grieco, M.J.2
Caballero, O.L.3
Su, T.4
Ahmed, A.5
Ritter, E.6
Gnjatic, S.7
Cekic, V.8
Old, L.J.9
Simpson, A.J.10
-
47
-
-
1542618348
-
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
-
R.J. Shaw, M. Kosmatka, N. Bardeesy, R.L. Hurley, L.A. Witters, R.A. DePinho, and L.C. Cantley The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress Proc. Natl. Acad. Sci. USA 101 2004 3329 3335
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 3329-3335
-
-
Shaw, R.J.1
Kosmatka, M.2
Bardeesy, N.3
Hurley, R.L.4
Witters, L.A.5
Depinho, R.A.6
Cantley, L.C.7
-
48
-
-
23144464171
-
Cancer/testis antigens, gametogenesis and cancer
-
A.J. Simpson, O.L. Caballero, A. Jungbluth, Y.T. Chen, and L.J. Old Cancer/testis antigens, gametogenesis and cancer Nat. Rev. Cancer 5 2005 615 625
-
(2005)
Nat. Rev. Cancer
, vol.5
, pp. 615-625
-
-
Simpson, A.J.1
Caballero, O.L.2
Jungbluth, A.3
Chen, Y.T.4
Old, L.J.5
-
49
-
-
33845949733
-
Dissecting the role of 5′-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase
-
M. Suter, U. Riek, R. Tuerk, U. Schlattner, T. Wallimann, and D. Neumann Dissecting the role of 5′-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase J. Biol. Chem. 281 2006 32207 32216
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 32207-32216
-
-
Suter, M.1
Riek, U.2
Tuerk, R.3
Schlattner, U.4
Wallimann, T.5
Neumann, D.6
-
50
-
-
56049117647
-
A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis
-
M.C. Towler, S. Fogarty, S.A. Hawley, D.A. Pan, D.M. Martin, N.A. Morrice, A. McCarthy, M.N. Galardo, S.B. Meroni, and S.B. Cigorraga A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis Biochem. J. 416 2008 1 14
-
(2008)
Biochem. J.
, vol.416
, pp. 1-14
-
-
Towler, M.C.1
Fogarty, S.2
Hawley, S.A.3
Pan, D.A.4
Martin, D.M.5
Morrice, N.A.6
McCarthy, A.7
Galardo, M.N.8
Meroni, S.B.9
Cigorraga, S.B.10
-
51
-
-
25144496653
-
MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation
-
C. Wang, A. Ivanov, L. Chen, W.J. Fredericks, E. Seto, F.J. Rauscher 3rd, and J. Chen MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation EMBO J. 24 2005 3279 3290
-
(2005)
EMBO J.
, vol.24
, pp. 3279-3290
-
-
Wang, C.1
Ivanov, A.2
Chen, L.3
Fredericks, W.J.4
Seto, E.5
Rauscher, F.J.6
Chen, J.7
-
52
-
-
0028328854
-
Expression of the MAGE-1 tumor antigen is up-regulated by the demethylating agent 5-aza-2′-deoxycytidine
-
J. Weber, M. Salgaller, D. Samid, B. Johnson, M. Herlyn, N. Lassam, J. Treisman, and S.A. Rosenberg Expression of the MAGE-1 tumor antigen is up-regulated by the demethylating agent 5-aza-2′-deoxycytidine Cancer Res. 54 1994 1766 1771
-
(1994)
Cancer Res.
, vol.54
, pp. 1766-1771
-
-
Weber, J.1
Salgaller, M.2
Samid, D.3
Johnson, B.4
Herlyn, M.5
Lassam, N.6
Treisman, J.7
Rosenberg, S.A.8
-
53
-
-
0036340070
-
Germ cell expression of the transcriptional co-repressor TIF1beta is required for the maintenance of spermatogenesis in the mouse
-
P. Weber, F. Cammas, C. Gerard, D. Metzger, P. Chambon, R. Losson, and M. Mark Germ cell expression of the transcriptional co-repressor TIF1beta is required for the maintenance of spermatogenesis in the mouse Development 129 2002 2329 2337
-
(2002)
Development
, vol.129
, pp. 2329-2337
-
-
Weber, P.1
Cammas, F.2
Gerard, C.3
Metzger, D.4
Chambon, P.5
Losson, R.6
Mark, M.7
-
54
-
-
84884262668
-
EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance
-
Y. Wei, Z. Zou, N. Becker, M. Anderson, R. Sumpter, G. Xiao, L. Kinch, P. Koduru, C.S. Christudass, and R.W. Veltri EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance Cell 154 2013 1269 1284
-
(2013)
Cell
, vol.154
, pp. 1269-1284
-
-
Wei, Y.1
Zou, Z.2
Becker, N.3
Anderson, M.4
Sumpter, R.5
Xiao, G.6
Kinch, L.7
Koduru, P.8
Christudass, C.S.9
Veltri, R.W.10
-
55
-
-
0037025173
-
Cancer. Addiction to oncogenes - The Achilles heal of cancer
-
I.B. Weinstein Cancer. Addiction to oncogenes - the Achilles heal of cancer Science 297 2002 63 64
-
(2002)
Science
, vol.297
, pp. 63-64
-
-
Weinstein, I.B.1
-
56
-
-
84861526009
-
Deconvoluting the context-dependent role for autophagy in cancer
-
E. White Deconvoluting the context-dependent role for autophagy in cancer Nat. Rev. Cancer 12 2012 401 410
-
(2012)
Nat. Rev. Cancer
, vol.12
, pp. 401-410
-
-
White, E.1
-
57
-
-
0033949848
-
Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle
-
W.W. Winder, B.F. Holmes, D.S. Rubink, E.B. Jensen, M. Chen, and J.O. Holloszy Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle J. Appl. Physiol. 88 2000 2219 2226
-
(2000)
J. Appl. Physiol.
, vol.88
, pp. 2219-2226
-
-
Winder, W.W.1
Holmes, B.F.2
Rubink, D.S.3
Jensen, E.B.4
Chen, M.5
Holloszy, J.O.6
-
58
-
-
64549113040
-
Somatic LKB1 mutations promote cervical cancer progression
-
S.N. Wingo, T.D. Gallardo, E.A. Akbay, M.C. Liang, C.M. Contreras, T. Boren, T. Shimamura, D.S. Miller, N.E. Sharpless, and N. Bardeesy Somatic LKB1 mutations promote cervical cancer progression PLoS ONE 4 2009 e5137
-
(2009)
PLoS ONE
, vol.4
, pp. e5137
-
-
Wingo, S.N.1
Gallardo, T.D.2
Akbay, E.A.3
Liang, M.C.4
Contreras, C.M.5
Boren, T.6
Shimamura, T.7
Miller, D.S.8
Sharpless, N.E.9
Bardeesy, N.10
-
59
-
-
23044437445
-
Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells
-
A. Woods, K. Dickerson, R. Heath, S.P. Hong, M. Momcilovic, S.R. Johnstone, M. Carlson, and D. Carling Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells Cell Metab. 2 2005 21 33
-
(2005)
Cell Metab.
, vol.2
, pp. 21-33
-
-
Woods, A.1
Dickerson, K.2
Heath, R.3
Hong, S.P.4
Momcilovic, M.5
Johnstone, S.R.6
Carlson, M.7
Carling, D.8
-
60
-
-
35449006644
-
MAGE-A, mMage-b, and MAGE-C proteins form complexes with KAP1 and suppress p53-dependent apoptosis in MAGE-positive cell lines
-
B. Yang, S.M. O'Herrin, J. Wu, S. Reagan-Shaw, Y. Ma, K.M. Bhat, C. Gravekamp, V. Setaluri, N. Peters, and F.M. Hoffmann MAGE-A, mMage-b, and MAGE-C proteins form complexes with KAP1 and suppress p53-dependent apoptosis in MAGE-positive cell lines Cancer Res. 67 2007 9954 9962
-
(2007)
Cancer Res.
, vol.67
, pp. 9954-9962
-
-
Yang, B.1
O'Herrin, S.M.2
Wu, J.3
Reagan-Shaw, S.4
Ma, Y.5
Bhat, K.M.6
Gravekamp, C.7
Setaluri, V.8
Peters, N.9
Hoffmann, F.M.10
-
61
-
-
58649110598
-
Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation
-
B. Zheng, J.H. Jeong, J.M. Asara, Y.Y. Yuan, S.R. Granter, L. Chin, and L.C. Cantley Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation Mol. Cell 33 2009 237 247
-
(2009)
Mol. Cell
, vol.33
, pp. 237-247
-
-
Zheng, B.1
Jeong, J.H.2
Asara, J.M.3
Yuan, Y.Y.4
Granter, S.R.5
Chin, L.6
Cantley, L.C.7
-
62
-
-
84886419154
-
Prognostic significance of AMPK activation and therapeutic effects of metformin in hepatocellular carcinoma
-
L. Zheng, W. Yang, F. Wu, C. Wang, L. Yu, L. Tang, B. Qiu, Y. Li, L. Guo, and M. Wu Prognostic significance of AMPK activation and therapeutic effects of metformin in hepatocellular carcinoma Clin. Cancer Res. 19 2013 5372 5380
-
(2013)
Clin. Cancer Res.
, vol.19
, pp. 5372-5380
-
-
Zheng, L.1
Yang, W.2
Wu, F.3
Wang, C.4
Yu, L.5
Tang, L.6
Qiu, B.7
Li, Y.8
Guo, L.9
Wu, M.10
-
63
-
-
41049094208
-
High-throughput real-time quantitative reverse transcription PCR
-
CHAPTER Unit 15 18
-
A.L. Bookout, C.L. Cummins, D.J. Mangelsdorf, J.M. Pesola, and M.F. Kramer High-throughput real-time quantitative reverse transcription PCR Curr. Protoc. Mol. Biol. Chapter 15 2006 Unit 15 18
-
(2006)
Curr. Protoc. Mol. Biol.
, vol.15
-
-
Bookout, A.L.1
Cummins, C.L.2
Mangelsdorf, D.J.3
Pesola, J.M.4
Kramer, M.F.5
-
64
-
-
33747154772
-
Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network
-
A.L. Bookout, Y. Jeong, M. Downes, R.T. Yu, R.M. Evans, and D.J. Mangelsdorf Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network Cell 126 2006 789 799
-
(2006)
Cell
, vol.126
, pp. 789-799
-
-
Bookout, A.L.1
Jeong, Y.2
Downes, M.3
Yu, R.T.4
Evans, R.M.5
Mangelsdorf, D.J.6
-
65
-
-
77957376253
-
Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse
-
K. Fon Tacer, A.L. Bookout, X. Ding, H. Kurosu, G.B. John, L. Wang, R. Goetz, M. Mohammadi, M. Kuro-o, D.J. Mangelsdorf, and S.A. Kliewer Research resource: comprehensive expression atlas of the fibroblast growth factor system in adult mouse Mol. Endocrinol. 24 2010 2050 2064
-
(2010)
Mol. Endocrinol.
, vol.24
, pp. 2050-2064
-
-
Fon Tacer, K.1
Bookout, A.L.2
Ding, X.3
Kurosu, H.4
John, G.B.5
Wang, L.6
Goetz, R.7
Mohammadi, M.8
Kuro-O, M.9
Mangelsdorf, D.J.10
Kliewer, S.A.11
-
66
-
-
10844284696
-
Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins
-
R.D. Ramirez, S. Sheridan, L. Girard, M. Sato, Y. Kim, J. Pollack, M. Peyton, Y. Zou, J.M. Kurie, and J.M. Dimaio Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins Cancer Res. 64 2004 9027 9034
-
(2004)
Cancer Res.
, vol.64
, pp. 9027-9034
-
-
Ramirez, R.D.1
Sheridan, S.2
Girard, L.3
Sato, M.4
Kim, Y.5
Pollack, J.6
Peyton, M.7
Zou, Y.8
Kurie, J.M.9
Dimaio, J.M.10
-
67
-
-
33644507072
-
Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells
-
M. Sato, M.B. Vaughan, L. Girard, M. Peyton, W. Lee, D.S. Shames, R.D. Ramirez, N. Sunaga, A.F. Gazdar, J.W. Shay, and J.D. Minna Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells Cancer Res. 66 2006 2116 2128
-
(2006)
Cancer Res.
, vol.66
, pp. 2116-2128
-
-
Sato, M.1
Vaughan, M.B.2
Girard, L.3
Peyton, M.4
Lee, W.5
Shames, D.S.6
Ramirez, R.D.7
Sunaga, N.8
Gazdar, A.F.9
Shay, J.W.10
Minna, J.D.11
|