메뉴 건너뛰기




Volumn 2, Issue 2, 2014, Pages 323-353

Immune adjuvant effect of molecularly-defined Toll-like receptor ligands

Author keywords

Cancer; Immune response; Microbial pathogens; TLR; Vaccine adjuvant

Indexed keywords

HEPATITIS B VACCINE; HILTONOL; LYME DISEASE VACCINE; MELACINE; PATTERN RECOGNITION RECEPTOR; PHOSPHORYL LIPID A; RINTATOLIMOD; TECEMOTIDE; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG; WART VIRUS VACCINE;

EID: 85019440984     PISSN: None     EISSN: 2076393X     Source Type: Journal    
DOI: 10.3390/vaccines2020323     Document Type: Review
Times cited : (125)

References (229)
  • 2
    • 2342487329 scopus 로고    scopus 로고
    • Advances in vaccine adjuvants for infectious diseases
    • Singh, M.; Srivastava, I. Advances in vaccine adjuvants for infectious diseases. Curr. HIV. Res. 2003, 1, 309-320.
    • (2003) Curr. HIV. Res , vol.1 , pp. 309-320
    • Singh, M.1    Srivastava, I.2
  • 3
    • 34250331531 scopus 로고    scopus 로고
    • The perfect mix: Recent progress in adjuvant research
    • Guy, B. The perfect mix: Recent progress in adjuvant research. Nat. Rev. Microbiol. 2007, 5, 505-517.
    • (2007) Nat. Rev. Microbiol , vol.5 , pp. 505-517
    • Guy, B.1
  • 4
    • 0001815978 scopus 로고
    • Immunological notes: Antigenic value of toxoid precipitated by potassium alum
    • Glenny, A. T. Immunological notes: Antigenic value of toxoid precipitated by potassium alum. J. Pathol. Bacteriol. 1926, 29, 38-39.
    • (1926) J. Pathol. Bacteriol , vol.29 , pp. 38-39
    • Glenny, A.T.1
  • 5
    • 77049248972 scopus 로고
    • The mode of action of immunologic adjuvants
    • Freund, J. The mode of action of immunologic adjuvants. Bibl. Tuberc. 1956, 10, 130-148.
    • (1956) Bibl. Tuberc , vol.10 , pp. 130-148
    • Freund, J.1
  • 6
    • 84879880507 scopus 로고    scopus 로고
    • The adjuvant effect of MF59 is due to the oil-in-water emulsion formulation, none of the individual components induce a comparable adjuvant effect
    • Calabro, S.; Tritto, E.; Pezzotti, A.; Taccone, M.; Muzzi, A.; Bertholet, S.; de Gregorio, E.; O'Hagan, D. T.; Baudner, B.; Seubert, A. The adjuvant effect of MF59 is due to the oil-in-water emulsion formulation, none of the individual components induce a comparable adjuvant effect. Vaccine 2013, 31, 3363-3369.
    • (2013) Vaccine , vol.31 , pp. 3363-3369
    • Calabro, S.1    Tritto, E.2    Pezzotti, A.3    Taccone, M.4    Muzzi, A.5    Bertholet, S.6    de Gregorio, E.7    O'Hagan, D.T.8    Baudner, B.9    Seubert, A.10
  • 9
    • 0024721339 scopus 로고
    • Immunogenecity: Signal 1, 2, 3. and 0
    • Janeway, C. A., Jr. Immunogenecity: Signal 1, 2, 3. and 0. Immunol. Today 1989, 10, 283-287.
    • (1989) Immunol. Today , vol.10 , pp. 283-287
    • Janeway Jr., C.A.1
  • 10
    • 84883817330 scopus 로고    scopus 로고
    • Mechanisms of action of adjuvants
    • doi: 10. 3389/fimmu. 2013. 00114
    • Awate, S.; Babiuk, L. A.; Mutwiri, G. Mechanisms of action of adjuvants. Front. Immunol. 2013, 4, doi: 10. 3389/fimmu. 2013. 00114.
    • (2013) Front. Immunol , vol.4
    • Awate, S.1    Babiuk, L.A.2    Mutwiri, G.3
  • 11
    • 0022640843 scopus 로고
    • Two types of murine helper T cell clones. I. Definition according to the profiles of lymphokine activity and secreted proteins
    • Mosmann, T. R.; Cherwinski, H. M.; Bond, M. W.; Giedlin, M. A.; Coffman, R. L. Two types of murine helper T cell clones. I. Definition according to the profiles of lymphokine activity and secreted proteins. J. Immunol. 1986, 136, 2348-2357.
    • (1986) J. Immunol , vol.136 , pp. 2348-2357
    • Mosmann, T.R.1    Cherwinski, H.M.2    Bond, M.W.3    Giedlin, M.A.4    Coffman, R.L.5
  • 12
    • 33646164439 scopus 로고    scopus 로고
    • Expanding the effector CD4 T-cell repertoire: The Th17 lineage
    • Harrington, L. E.; Mangan, P. R.; Weaver, C. T. Expanding the effector CD4 T-cell repertoire: The Th17 lineage. Curr. Opin. Immunol. 2006, 18, 349-356.
    • (2006) Curr. Opin. Immunol , vol.18 , pp. 349-356
    • Harrington, L.E.1    Mangan, P.R.2    Weaver, C.T.3
  • 13
    • 41549135632 scopus 로고    scopus 로고
    • The biological functions of T helper 17 cell effector cytokines in inflammation
    • Ouyang, W.; Kolls, J. K.; Zheng, Y. The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity 2008, 28, 454-467.
    • (2008) Immunity , vol.28 , pp. 454-467
    • Ouyang, W.1    Kolls, J.K.2    Zheng, Y.3
  • 14
    • 47549090286 scopus 로고    scopus 로고
    • Detection of S-phase cell cycle progression using 5-ethynyl-2'-deoxyuridine incorporation with click chemistry, an alternative to using 5-bromo-2'-deoxyuridine antibodies
    • Buck, S. B.; Bradford, J.; Gee, K. R.; Agnew, B. J.; Clarke, S. T.; Salic, A. Detection of S-phase cell cycle progression using 5-ethynyl-2'-deoxyuridine incorporation with click chemistry, an alternative to using 5-bromo-2'-deoxyuridine antibodies. Biotechniques 2008, 44, 927-929.
    • (2008) Biotechniques , vol.44 , pp. 927-929
    • Buck, S.B.1    Bradford, J.2    Gee, K.R.3    Agnew, B.J.4    Clarke, S.T.5    Salic, A.6
  • 15
    • 84879243447 scopus 로고    scopus 로고
    • Th17 cell based vaccines in mucosal immunity
    • Kumar, P.; Chen, K.; Kolls, J. K. Th17 cell based vaccines in mucosal immunity. Curr. Opin. Immunol. 2013, 25, 373-380.
    • (2013) Curr. Opin. Immunol , vol.25 , pp. 373-380
    • Kumar, P.1    Chen, K.2    Kolls, J.K.3
  • 16
    • 0032756730 scopus 로고    scopus 로고
    • Aluminium hydroxide adjuvant initiates strong antigen-specific Th2 responses in the absence of IL-4-or IL-13-mediated signaling
    • Brewer, J. M.; Conacher, M.; Hunter, C. A.; Mohrs, M.; Brombacher, F.; Alexander, J. Aluminium hydroxide adjuvant initiates strong antigen-specific Th2 responses in the absence of IL-4-or IL-13-mediated signaling. J. Immunol. 1999, 163, 6448-6454.
    • (1999) J. Immunol , vol.163 , pp. 6448-6454
    • Brewer, J.M.1    Conacher, M.2    Hunter, C.A.3    Mohrs, M.4    Brombacher, F.5    Alexander, J.6
  • 17
    • 0030831210 scopus 로고    scopus 로고
    • A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
    • Medzhitov, R.; Preston-Hurlburt, P.; Janeway, C. A., Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997, 388, 394-397.
    • (1997) Nature , vol.388 , pp. 394-397
    • Medzhitov, R.1    Preston-Hurlburt, P.2    Janeway Jr., C.A.3
  • 18
    • 0037070113 scopus 로고    scopus 로고
    • Toll-like receptors as adjuvant receptors
    • Kaisho, T.; Akira, S. Toll-like receptors as adjuvant receptors. Biochim. Biophys. Acta 2002, 1589, 1-13.
    • (2002) Biochim. Biophys. Acta , vol.1589 , pp. 1-13
    • Kaisho, T.1    Akira, S.2
  • 19
    • 78650576197 scopus 로고    scopus 로고
    • Use of defined TLR ligands as adjuvants within human vaccines
    • Duthie, M. S.; Windish, H. P.; Fox, C. B.; Reed, S. G. Use of defined TLR ligands as adjuvants within human vaccines. Immunol. Rev. 2011, 239, 178-196.
    • (2011) Immunol. Rev , vol.239 , pp. 178-196
    • Duthie, M.S.1    Windish, H.P.2    Fox, C.B.3    Reed, S.G.4
  • 20
    • 77957982756 scopus 로고    scopus 로고
    • Toll-like receptor agonists: Are they good adjuvants?
    • Gnjatic, S.; Sawhney, N. B.; Bhardwaj, N. Toll-like receptor agonists: Are they good adjuvants? Cancer J. 2010, 16, 382-391.
    • (2010) Cancer J , vol.16 , pp. 382-391
    • Gnjatic, S.1    Sawhney, N.B.2    Bhardwaj, N.3
  • 21
    • 84863690997 scopus 로고    scopus 로고
    • The effects of TLR activation on T-cell development and differentiation
    • doi: 10. 1155/2012/836485
    • Jin, B.; Sun, T.; Yu, X. H.; Yang, Y. X.; Yeo, A. E. The effects of TLR activation on T-cell development and differentiation. Clin. Dev. Immunol. 2012, 2012,. doi: 10. 1155/2012/836485.
    • (2012) Clin. Dev. Immunol , vol.2012
    • Jin, B.1    Sun, T.2    Yu, X.H.3    Yang, Y.X.4    Yeo, A.E.5
  • 22
    • 37849046096 scopus 로고    scopus 로고
    • TLR ligand suppression or enhancement of Treg cells? A double-edged sword in immunity to tumours
    • Conroy, H.; Marshall, N. A.; Mills, K. H. TLR ligand suppression or enhancement of Treg cells? A double-edged sword in immunity to tumours. Oncogene 2008, 27, 168-180.
    • (2008) Oncogene , vol.27 , pp. 168-180
    • Conroy, H.1    Marshall, N.A.2    Mills, K.H.3
  • 23
    • 84883733883 scopus 로고    scopus 로고
    • Treg inducing adjuvants for therapeutic vaccination against chronic inflammatory diseases
    • doi: 10. 3389/fimmu. 2013. 00245
    • Keijzer, C.; van der Zee, R.; van, E. W.; Broere, F. Treg inducing adjuvants for therapeutic vaccination against chronic inflammatory diseases. Front. Immunol. 2013, 4, doi: 10. 3389/fimmu. 2013. 00245.
    • (2013) Front. Immunol , vol.4
    • Keijzer, C.1    van der Zee, R.2    van, E.W.3    Broere, F.4
  • 24
    • 0037460116 scopus 로고    scopus 로고
    • Recognition of pathogen-associated molecular patterns by TLR family
    • Akira, S.; Hemmi, H. Recognition of pathogen-associated molecular patterns by TLR family. Immunol. Lett. 2003, 85, 85-95.
    • (2003) Immunol. Lett , vol.85 , pp. 85-95
    • Akira, S.1    Hemmi, H.2
  • 25
    • 0036144233 scopus 로고    scopus 로고
    • Commensal-associated molecular patterns induce selective toll-like receptor-trafficking from apical membrane to cytoplasmic compartments in polarized intestinal epithelium
    • Cario, E.; Brown, D.; McKee, M.; Lynch-Devaney, K.; Gerken, G.; Podolsky, D. K. Commensal-associated molecular patterns induce selective toll-like receptor-trafficking from apical membrane to cytoplasmic compartments in polarized intestinal epithelium. Am. J. Pathol. 2002, 160, 165-173.
    • (2002) Am. J. Pathol , vol.160 , pp. 165-173
    • Cario, E.1    Brown, D.2    McKee, M.3    Lynch-Devaney, K.4    Gerken, G.5    Podolsky, D.K.6
  • 26
    • 0028201732 scopus 로고
    • Tolerance, danger, and the extended family
    • Matzinger, P. Tolerance, danger, and the extended family. Annu. Rev. Immunol. 1994, 12, 991-1045.
    • (1994) Annu. Rev. Immunol , vol.12 , pp. 991-1045
    • Matzinger, P.1
  • 30
    • 0037505362 scopus 로고    scopus 로고
    • The Toll-IL-1 receptor adaptor family grows to five members
    • O'Neill, L. A.; Fitzgerald, K. A.; Bowie, A. G. The Toll-IL-1 receptor adaptor family grows to five members. Trends Immunol. 2003, 24, 286-289.
    • (2003) Trends Immunol , vol.24 , pp. 286-289
    • O'Neill, L.A.1    Fitzgerald, K.A.2    Bowie, A.G.3
  • 31
    • 0030694108 scopus 로고    scopus 로고
    • IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
    • Muzio, M.; Ni, J.; Feng, P.; Dixit, V. M. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 1997, 278, 1612-1615.
    • (1997) Science , vol.278 , pp. 1612-1615
    • Muzio, M.1    Ni, J.2    Feng, P.3    Dixit, V.M.4
  • 32
    • 4344613405 scopus 로고    scopus 로고
    • Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/IL-1 receptor domain-containing adaptor-inducing IFN-beta (TRIF)-dependent pathway in TLR signaling
    • Gohda, J.; Matsumura, T.; Inoue, J. Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/IL-1 receptor domain-containing adaptor-inducing IFN-beta (TRIF)-dependent pathway in TLR signaling. J. Immunol. 2004, 173, 2913-2917.
    • (2004) J. Immunol , vol.173 , pp. 2913-2917
    • Gohda, J.1    Matsumura, T.2    Inoue, J.3
  • 36
    • 30544447047 scopus 로고    scopus 로고
    • Critical role of TRAF3 in the Toll-like receptor-dependent and-independent antiviral response
    • Oganesyan, G.; Saha, S. K.; Guo, B.; He, J. Q.; Shahangian, A.; Zarnegar, B.; Perry, A.; Cheng, G. Critical role of TRAF3 in the Toll-like receptor-dependent and-independent antiviral response. Nature 2006, 439, 208-211.
    • (2006) Nature , vol.439 , pp. 208-211
    • Oganesyan, G.1    Saha, S.K.2    Guo, B.3    He, J.Q.4    Shahangian, A.5    Zarnegar, B.6    Perry, A.7    Cheng, G.8
  • 37
    • 0033844166 scopus 로고    scopus 로고
    • Toll-like receptors: A growing family of immune receptors that are differentially expressed and regulated by different leukocytes
    • Muzio, M.; Polentarutti, N.; Bosisio, D.; Prahladan, M. K.; Mantovani, A. Toll-like receptors: A growing family of immune receptors that are differentially expressed and regulated by different leukocytes. J. Leukoc. Biol. 2000, 67, 450-456.
    • (2000) J. Leukoc. Biol , vol.67 , pp. 450-456
    • Muzio, M.1    Polentarutti, N.2    Bosisio, D.3    Prahladan, M.K.4    Mantovani, A.5
  • 38
    • 42349090335 scopus 로고    scopus 로고
    • Structural basis of toll-like receptor 3 signaling with double-stranded RNA
    • Liu, L.; Botos, I.; Wang, Y.; Leonard, J. N.; Shiloach, J.; Segal, D. M.; Davies, D. R. Structural basis of toll-like receptor 3 signaling with double-stranded RNA. Science 2008, 320, 379-381.
    • (2008) Science , vol.320 , pp. 379-381
    • Liu, L.1    Botos, I.2    Wang, Y.3    Leonard, J.N.4    Shiloach, J.5    Segal, D.M.6    Davies, D.R.7
  • 39
    • 0035909372 scopus 로고    scopus 로고
    • Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
    • Alexopoulou, L.; Holt, A. C.; Medzhitov, R.; Flavell, R. A. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 2001, 413, 732-738.
    • (2001) Nature , vol.413 , pp. 732-738
    • Alexopoulou, L.1    Holt, A.C.2    Medzhitov, R.3    Flavell, R.A.4
  • 41
    • 57749186869 scopus 로고    scopus 로고
    • The TLR3 agonist poly(I: C) targets CD8+ T cells and augments their antigen-specific responses upon their adoptive transfer into naive recipient mice
    • Salem, M. L.; Diaz-Montero, C. M.; El-Naggar, S. A.; Chen, Y.; Moussa, O.; Cole, D. J. The TLR3 agonist poly(I: C) targets CD8+ T cells and augments their antigen-specific responses upon their adoptive transfer into naive recipient mice. Vaccine 2009, 27, 549-557.
    • (2009) Vaccine , vol.27 , pp. 549-557
    • Salem, M.L.1    Diaz-Montero, C.M.2    El-Naggar, S.A.3    Chen, Y.4    Moussa, O.5    Cole, D.J.6
  • 42
    • 0014738954 scopus 로고
    • Inhibition of biologic activity of poly I: Poly C by human plasma
    • Nordlund, J. J.; Wolff, S. M.; Levy, H. B. Inhibition of biologic activity of poly I: poly C by human plasma. Proc. Soc. Exp. Biol. Med. 1970, 133, 439-444.
    • (1970) Proc. Soc. Exp. Biol. Med , vol.133 , pp. 439-444
    • Nordlund, J.J.1    Wolff, S.M.2    Levy, H.B.3
  • 44
    • 0346098026 scopus 로고    scopus 로고
    • Polyriboinosinic polyribocytidylic acid [poly(I: C)]/TLR3 signaling allows class I processing of exogenous protein and induction of HIV-specific CD8+ cytotoxic T lymphocytes
    • Fujimoto, C.; Nakagawa, Y.; Ohara, K.; Takahashi, H. Polyriboinosinic polyribocytidylic acid [poly(I: C)]/TLR3 signaling allows class I processing of exogenous protein and induction of HIV-specific CD8+ cytotoxic T lymphocytes. Int. Immunol. 2004, 16, 55-63.
    • (2004) Int. Immunol , vol.16 , pp. 55-63
    • Fujimoto, C.1    Nakagawa, Y.2    Ohara, K.3    Takahashi, H.4
  • 46
    • 84872231984 scopus 로고    scopus 로고
    • An adenovirus-based vaccine with a double-stranded RNA adjuvant protects mice and ferrets against H5N1 avian influenza in oral delivery models
    • Scallan, C. D.; Tingley, D. W.; Lindbloom, J. D.; Toomey, J. S.; Tucker, S. N. An adenovirus-based vaccine with a double-stranded RNA adjuvant protects mice and ferrets against H5N1 avian influenza in oral delivery models. Clin. Vaccine Immunol. 2013, 20, 85-94.
    • (2013) Clin. Vaccine Immunol , vol.20 , pp. 85-94
    • Scallan, C.D.1    Tingley, D.W.2    Lindbloom, J.D.3    Toomey, J.S.4    Tucker, S.N.5
  • 47
    • 70349328115 scopus 로고    scopus 로고
    • TLR3-stimulated dendritic cells up-regulate B7-H1 expression and influence the magnitude of CD8 T cell responses to tumor vaccination
    • Pulko, V.; Liu, X.; Krco, C. J.; Harris, K. J.; Frigola, X.; Kwon, E. D.; Dong, H. TLR3-stimulated dendritic cells up-regulate B7-H1 expression and influence the magnitude of CD8 T cell responses to tumor vaccination. J. Immunol. 2009, 183, 3634-3641.
    • (2009) J. Immunol , vol.183 , pp. 3634-3641
    • Pulko, V.1    Liu, X.2    Krco, C.J.3    Harris, K.J.4    Frigola, X.5    Kwon, E.D.6    Dong, H.7
  • 50
    • 57349153494 scopus 로고    scopus 로고
    • A phase II clinical trial of poly-ICLC with radiation for adult patients with newly diagnosed supratentorial glioblastoma: A North American Brain Tumor Consortium (NABTC01-05)
    • Butowski, N.; Chang, S. M.; Junck, L.; DeAngelis, L. M.; Abrey, L.; Fink, K.; Cloughesy, T.; Lamborn, K. R.; Salazar, A. M.; Prados, M. D. A phase II clinical trial of poly-ICLC with radiation for adult patients with newly diagnosed supratentorial glioblastoma: A North American Brain Tumor Consortium (NABTC01-05). J. Neurooncol. 2009, 91, 175-182.
    • (2009) J. Neurooncol , vol.91 , pp. 175-182
    • Butowski, N.1    Chang, S.M.2    Junck, L.3    DeAngelis, L.M.4    Abrey, L.5    Fink, K.6    Cloughesy, T.7    Lamborn, K.R.8    Salazar, A.M.9    Prados, M.D.10
  • 52
    • 70349188458 scopus 로고    scopus 로고
    • A novel liposome-based adjuvant CAF01 for induction of CD8+ cytotoxic T-lymphocytes (CTL) to HIV-1 minimal CTL peptides in HLA-A*0201 transgenic mice
    • Gram, G. J.; Karlsson, I.; Agger, E. M.; Andersen, P.; Fomsgaard, A. A novel liposome-based adjuvant CAF01 for induction of CD8+ cytotoxic T-lymphocytes (CTL) to HIV-1 minimal CTL peptides in HLA-A*0201 transgenic mice. PLoS One 2009, 4, e6950.
    • (2009) PLoS One , vol.4
    • Gram, G.J.1    Karlsson, I.2    Agger, E.M.3    Andersen, P.4    Fomsgaard, A.5
  • 53
    • 35148824709 scopus 로고    scopus 로고
    • Intranasal immunization with H5N1 vaccine plus Poly I: Poly C12U, a Toll-like receptor agonist, protects mice against homologous and heterologous virus challenge
    • Ichinohe, T.; Kawaguchi, A.; Tamura, S.; Takahashi, H.; Sawa, H.; Ninomiya, A.; Imai, M.; Itamura, S.; Odagiri, T.; Tashiro, M.; et al. Intranasal immunization with H5N1 vaccine plus Poly I: Poly C12U, a Toll-like receptor agonist, protects mice against homologous and heterologous virus challenge. Microbes Infect. 2007, 9, 1333-1340.
    • (2007) Microbes Infect , vol.9 , pp. 1333-1340
    • Ichinohe, T.1    Kawaguchi, A.2    Tamura, S.3    Takahashi, H.4    Sawa, H.5    Ninomiya, A.6    Imai, M.7    Itamura, S.8    Odagiri, T.9    Tashiro, M.10
  • 54
    • 0037472447 scopus 로고    scopus 로고
    • Dendritic cell (DC) based therapy for cervical cancer: Use of DC pulsed with tumour lysate and matured with a novel synthetic clinically non-toxic double stranded RNA analogue poly [I]: Poly [C(12)U] (Ampligen R)
    • Adams, M.; Navabi, H.; Jasani, B.; Man, S.; Fiander, A.; Evans, A. S.; Donninger, C.; Mason, M. Dendritic cell (DC) based therapy for cervical cancer: Use of DC pulsed with tumour lysate and matured with a novel synthetic clinically non-toxic double stranded RNA analogue poly [I]: poly [C(12)U] (Ampligen R). Vaccine 2003, 21, 787-790.
    • (2003) Vaccine , vol.21 , pp. 787-790
    • Adams, M.1    Navabi, H.2    Jasani, B.3    Man, S.4    Fiander, A.5    Evans, A.S.6    Donninger, C.7    Mason, M.8
  • 55
    • 33845366891 scopus 로고    scopus 로고
    • A controlled clinical trial comparing the safety and immunogenicity of a new adjuvanted hepatitis B vaccine with a standard hepatitis B vaccine
    • Dupont, J.; Altclas, J.; Lepetic, A.; Lombardo, M.; Vazquez, V.; Salgueira, C.; Seigelchifer, M.; Arndtz, N.; Antunez, E.; von Eschen, K.; et al. A controlled clinical trial comparing the safety and immunogenicity of a new adjuvanted hepatitis B vaccine with a standard hepatitis B vaccine. Vaccine 2006, 24, 7167-7174.
    • (2006) Vaccine , vol.24 , pp. 7167-7174
    • Dupont, J.1    Altclas, J.2    Lepetic, A.3    Lombardo, M.4    Vazquez, V.5    Salgueira, C.6    Seigelchifer, M.7    Arndtz, N.8    Antunez, E.9    von Eschen, K.10
  • 56
    • 78751581622 scopus 로고    scopus 로고
    • Immunogenicity and safety of an investigational AS02(v)-adjuvanted hepatitis B vaccine in patients with renal insufficiency who failed to respond or to maintain antibody levels after prior vaccination: Results of two open, randomized, comparative trials
    • Tielemans, C. L.; Vlasak, J.; Kosa, D.; Billiouw, J. M.; Verpooten, G. A.; Mezei, I.; Ryba, M.; Peeters, P. C.; Mat, O.; Jadoul, M. Y.; et al. Immunogenicity and safety of an investigational AS02(v)-adjuvanted hepatitis B vaccine in patients with renal insufficiency who failed to respond or to maintain antibody levels after prior vaccination: results of two open, randomized, comparative trials. Vaccine 2011, 29, 1159-1166.
    • (2011) Vaccine , vol.29 , pp. 1159-1166
    • Tielemans, C.L.1    Vlasak, J.2    Kosa, D.3    Billiouw, J.M.4    Verpooten, G.A.5    Mezei, I.6    Ryba, M.7    Peeters, P.C.8    Mat, O.9    Jadoul, M.Y.10
  • 57
    • 34247234090 scopus 로고    scopus 로고
    • New hepatitis B vaccine formulated with an improved adjuvant system
    • Kundi, M. New hepatitis B vaccine formulated with an improved adjuvant system. Expert Rev. Vaccines 2007, 6, 133-140.
    • (2007) Expert Rev. Vaccines , vol.6 , pp. 133-140
    • Kundi, M.1
  • 58
    • 0035925605 scopus 로고    scopus 로고
    • A prophylactic hepatitis B vaccine with a novel adjuvant system
    • Thoelen, S.; de Clercq, N.; Tornieporth, N. A prophylactic hepatitis B vaccine with a novel adjuvant system. Vaccine 2001, 19, 2400-2403.
    • (2001) Vaccine , vol.19 , pp. 2400-2403
    • Thoelen, S.1    de Clercq, N.2    Tornieporth, N.3
  • 60
    • 77956432699 scopus 로고    scopus 로고
    • A clinical trial to evaluate the safety and immunogenicity of the LEISH-F1+MPL-SE vaccine when used in combination with meglumine antimoniate for the treatment of cutaneous leishmaniasis
    • Nascimento, E.; Fernandes, D. F.; Vieira, E. P.; Campos-Neto, A.; Ashman, J. A.; Alves, F. P.; Coler, R. N.; Bogatzki, L. Y.; Kahn, S. J.; Beckmann, A. M.; et al. A clinical trial to evaluate the safety and immunogenicity of the LEISH-F1+MPL-SE vaccine when used in combination with meglumine antimoniate for the treatment of cutaneous leishmaniasis. Vaccine 2010, 28, 6581-6587.
    • (2010) Vaccine , vol.28 , pp. 6581-6587
    • Nascimento, E.1    Fernandes, D.F.2    Vieira, E.P.3    Campos-Neto, A.4    Ashman, J.A.5    Alves, F.P.6    Coler, R.N.7    Bogatzki, L.Y.8    Kahn, S.J.9    Beckmann, A.M.10
  • 61
    • 40249104607 scopus 로고    scopus 로고
    • Vaccination with recombinant Mycobacterium avium subsp. paratuberculosis proteins induces differential immune responses and protects calves against infection by oral challenge
    • Kathaperumal, K.; Park, S. U.; McDonough, S.; Stehman, S.; Akey, B.; Huntley, J.; Wong, S.; Chang, C. F.; Chang, Y. F. Vaccination with recombinant Mycobacterium avium subsp. paratuberculosis proteins induces differential immune responses and protects calves against infection by oral challenge. Vaccine 2008, 26, 1652-1663.
    • (2008) Vaccine , vol.26 , pp. 1652-1663
    • Kathaperumal, K.1    Park, S.U.2    McDonough, S.3    Stehman, S.4    Akey, B.5    Huntley, J.6    Wong, S.7    Chang, C.F.8    Chang, Y.F.9
  • 63
    • 84880870892 scopus 로고    scopus 로고
    • Safety and immunogenicity of an AS01-adjuvanted varicella zoster virus subunit candidate vaccine (HZ/su): A phase-I, open-label study in Japanese adults
    • Lal, H.; Zahaf, T.; Heineman, T. C. Safety and immunogenicity of an AS01-adjuvanted varicella zoster virus subunit candidate vaccine (HZ/su): A phase-I, open-label study in Japanese adults. Hum. Vaccin. Immunother. 2013, 9, 1425-1429.
    • (2013) Hum. Vaccin. Immunother , vol.9 , pp. 1425-1429
    • Lal, H.1    Zahaf, T.2    Heineman, T.C.3
  • 65
    • 28844483001 scopus 로고    scopus 로고
    • Duration of protection with RTS, S/AS02A malaria vaccine in prevention of Plasmodium falciparum disease in Mozambican children: Single-blind extended follow-up of a randomised controlled trial
    • Alonso, P. L.; Sacarlal, J.; Aponte, J. J.; Leach, A.; Macete, E.; Aide, P.; Sigauque, B.; Milman, J.; Mandomando, I.; Bassat, Q.; et al. Duration of protection with RTS, S/AS02A malaria vaccine in prevention of Plasmodium falciparum disease in Mozambican children: single-blind extended follow-up of a randomised controlled trial. Lancet 2005, 366, 2012-2018.
    • (2005) Lancet , vol.366 , pp. 2012-2018
    • Alonso, P.L.1    Sacarlal, J.2    Aponte, J.J.3    Leach, A.4    Macete, E.5    Aide, P.6    Sigauque, B.7    Milman, J.8    Mandomando, I.9    Bassat, Q.10
  • 67
    • 70349485373 scopus 로고    scopus 로고
    • Five-year safety and immunogenicity of GlaxoSmithKline's candidate malaria vaccine RTS, S/AS02 following administration to semi-immune adult men living in a malaria-endemic region of The Gambia
    • Bojang, K.; Milligan, P.; Pinder, M.; Doherty, T.; Leach, A.; Ofori-Anyinam, O.; Lievens, M.; Kester, K.; Schaecher, K.; Ballou, W. R.; et al. Five-year safety and immunogenicity of GlaxoSmithKline's candidate malaria vaccine RTS, S/AS02 following administration to semi-immune adult men living in a malaria-endemic region of The Gambia. Hum. Vaccin. 2009, 5, 242-247.
    • (2009) Hum. Vaccin , vol.5 , pp. 242-247
    • Bojang, K.1    Milligan, P.2    Pinder, M.3    Doherty, T.4    Leach, A.5    Ofori-Anyinam, O.6    Lievens, M.7    Kester, K.8    Schaecher, K.9    Ballou, W.R.10
  • 68
    • 0033522812 scopus 로고    scopus 로고
    • The adjuvant combination monophosphoryl lipid A and QS21 switches T cell responses induced with a soluble recombinant HIV protein from Th2 to Th1
    • Moore, A.; McCarthy, L.; Mills, K. H. The adjuvant combination monophosphoryl lipid A and QS21 switches T cell responses induced with a soluble recombinant HIV protein from Th2 to Th1. Vaccine 1999, 17, 2517-2527.
    • (1999) Vaccine , vol.17 , pp. 2517-2527
    • Moore, A.1    McCarthy, L.2    Mills, K.H.3
  • 69
    • 77957357557 scopus 로고    scopus 로고
    • Strong and persistent CD4+ T-cell response in healthy adults immunized with a candidate HIV-1 vaccine containing gp120, Nef and Tat antigens formulated in three adjuvant systems
    • Leroux-Roels, I.; Koutsoukos, M.; Clement, F.; Steyaert, S.; Janssens, M.; Bourguignon, P.; Cohen, K.; Altfeld, M.; Vandepapeliere, P.; Pedneault, L.; et al. Strong and persistent CD4+ T-cell response in healthy adults immunized with a candidate HIV-1 vaccine containing gp120, Nef and Tat antigens formulated in three adjuvant systems. Vaccine 2010, 28, 7016-7024.
    • (2010) Vaccine , vol.28 , pp. 7016-7024
    • Leroux-Roels, I.1    Koutsoukos, M.2    Clement, F.3    Steyaert, S.4    Janssens, M.5    Bourguignon, P.6    Cohen, K.7    Altfeld, M.8    Vandepapeliere, P.9    Pedneault, L.10
  • 70
    • 67651049056 scopus 로고    scopus 로고
    • Efficacy of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by oncogenic HPV types (PATRICIA): Final analysis of a double-blind, randomised study in young women
    • Paavonen, J.; Naud, P.; Salmeron, J.; Wheeler, C. M.; Chow, S. N.; Apter, D.; Kitchener, H.; Castellsague, X.; Teixeira, J. C.; Skinner, S. R.; et al. Efficacy of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by oncogenic HPV types (PATRICIA): Final analysis of a double-blind, randomised study in young women. Lancet 2009, 374, 301-314.
    • (2009) Lancet , vol.374 , pp. 301-314
    • Paavonen, J.1    Naud, P.2    Salmeron, J.3    Wheeler, C.M.4    Chow, S.N.5    Apter, D.6    Kitchener, H.7    Castellsague, X.8    Teixeira, J.C.9    Skinner, S.R.10
  • 71
    • 76349117863 scopus 로고    scopus 로고
    • Immunogenicity and safety of human papillomavirus-16/18 AS04-adjuvanted cervical cancer vaccine in healthy Indian women
    • Bhatla, N.; Suri, V.; Basu, P.; Shastri, S.; Datta, S. K.; Bi, D.; Descamps, D. J.; Bock, H. L. Immunogenicity and safety of human papillomavirus-16/18 AS04-adjuvanted cervical cancer vaccine in healthy Indian women. J. Obstet. Gynaecol. Res. 2010, 36, 123-132.
    • (2010) J. Obstet. Gynaecol. Res , vol.36 , pp. 123-132
    • Bhatla, N.1    Suri, V.2    Basu, P.3    Shastri, S.4    Datta, S.K.5    Bi, D.6    Descamps, D.J.7    Bock, H.L.8
  • 72
    • 71649087760 scopus 로고    scopus 로고
    • Sustained efficacy and immunogenicity of the human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine: Analysis of a randomised placebo-controlled trial up to 6. 4 years
    • Romanowski, B.; de Borba, P. C.; Naud, P. S.; Roteli-Martins, C. M.; de Carvalho, N. S.; Teixeira, J. C.; Aoki, F.; Ramjattan, B.; Shier, R. M.; Somani, R.; et al. Sustained efficacy and immunogenicity of the human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine: Analysis of a randomised placebo-controlled trial up to 6. 4 years. Lancet 2009, 374, 1975-1985.
    • (2009) Lancet , vol.374 , pp. 1975-1985
    • Romanowski, B.1    de Borba, P.C.2    Naud, P.S.3    Roteli-Martins, C.M.4    de Carvalho, N.S.5    Teixeira, J.C.6    Aoki, F.7    Ramjattan, B.8    Shier, R.M.9    Somani, R.10
  • 73
    • 84877264017 scopus 로고    scopus 로고
    • Safety and immunogenicity of human papillomavirus-16/18 AS04-adjuvanted vaccine: A randomized trial in 10-25-year-old HIV-seronegative African girls and young women
    • Sow, P. S.; Watson-Jones, D.; Kiviat, N.; Changalucha, J.; Mbaye, K. D.; Brown, J.; Bousso, K.; Kavishe, B.; Andreasen, A.; Toure, M.; et al. Safety and immunogenicity of human papillomavirus-16/18 AS04-adjuvanted vaccine: A randomized trial in 10-25-year-old HIV-seronegative African girls and young women. J. Infect. Dis. 2013, 207, 1753-1763.
    • (2013) J. Infect. Dis , vol.207 , pp. 1753-1763
    • Sow, P.S.1    Watson-Jones, D.2    Kiviat, N.3    Changalucha, J.4    Mbaye, K.D.5    Brown, J.6    Bousso, K.7    Kavishe, B.8    Andreasen, A.9    Toure, M.10
  • 75
    • 39149121505 scopus 로고    scopus 로고
    • Recombinant gp350 vaccine for infectious mononucleosis: A phase 2, randomized, double-blind, placebo-controlled trial to evaluate the safety, immunogenicity, and efficacy of an Epstein-Barr virus vaccine in healthy young adults
    • Sokal, E. M.; Hoppenbrouwers, K.; Vandermeulen, C.; Moutschen, M.; Leonard, P.; Moreels, A.; Haumont, M.; Bollen, A.; Smets, F.; Denis, M. Recombinant gp350 vaccine for infectious mononucleosis: A phase 2, randomized, double-blind, placebo-controlled trial to evaluate the safety, immunogenicity, and efficacy of an Epstein-Barr virus vaccine in healthy young adults. J. Infect. Dis. 2007, 196, 1749-1753.
    • (2007) J. Infect. Dis , vol.196 , pp. 1749-1753
    • Sokal, E.M.1    Hoppenbrouwers, K.2    Vandermeulen, C.3    Moutschen, M.4    Leonard, P.5    Moreels, A.6    Haumont, M.7    Bollen, A.8    Smets, F.9    Denis, M.10
  • 76
    • 0742321971 scopus 로고    scopus 로고
    • Results of clinical trials with an allogenic melanoma tumor cell lysate vaccine: Melacine
    • Sondak, V. K.; Sosman, J. A. Results of clinical trials with an allogenic melanoma tumor cell lysate vaccine: Melacine. Semin. Cancer Biol. 2003, 13, 409-415.
    • (2003) Semin. Cancer Biol , vol.13 , pp. 409-415
    • Sondak, V.K.1    Sosman, J.A.2
  • 77
    • 34748815649 scopus 로고    scopus 로고
    • GSK's antigen-specific cancer immunotherapy programme: Pilot results leading to Phase III clinical development
    • Brichard, V. G.; Lejeune, D. GSK's antigen-specific cancer immunotherapy programme: Pilot results leading to Phase III clinical development. Vaccine 2007, 25, B61-B71.
    • (2007) Vaccine , vol.25
    • Brichard, V.G.1    Lejeune, D.2
  • 78
    • 22144483806 scopus 로고    scopus 로고
    • Vaccination with BLP25 liposome vaccine to treat non-small cell lung and prostate cancers
    • North, S.; Butts, C. Vaccination with BLP25 liposome vaccine to treat non-small cell lung and prostate cancers. Expert Rev. Vaccines 2005, 4, 249-257.
    • (2005) Expert Rev. Vaccines , vol.4 , pp. 249-257
    • North, S.1    Butts, C.2
  • 79
    • 9644265336 scopus 로고    scopus 로고
    • Vaccination with Theratope (STn-KLH) as treatment for breast cancer
    • Holmberg, L. A.; Sandmaier, B. M. Vaccination with Theratope (STn-KLH) as treatment for breast cancer. Expert Rev. Vaccines 2004, 3, 655-663.
    • (2004) Expert Rev. Vaccines , vol.3 , pp. 655-663
    • Holmberg, L.A.1    Sandmaier, B.M.2
  • 82
    • 84886950936 scopus 로고    scopus 로고
    • Evaluation of safety and immunogenicity of recombinant influenza hemagglutinin (H5/Indonesia/05/2005) formulated with and without a stable oil-in-water emulsion containing glucopyranosyl-lipid A (SE+GLA) adjuvant
    • Treanor, J. J.; Essink, B.; Hull, S.; Reed, S.; Izikson, R.; Patriarca, P.; Goldenthal, K. L.; Kohberger, R.; Dunkle, L. M. Evaluation of safety and immunogenicity of recombinant influenza hemagglutinin (H5/Indonesia/05/2005) formulated with and without a stable oil-in-water emulsion containing glucopyranosyl-lipid A (SE+GLA) adjuvant. Vaccine 2013, 31, 5760-5765.
    • (2013) Vaccine , vol.31 , pp. 5760-5765
    • Treanor, J.J.1    Essink, B.2    Hull, S.3    Reed, S.4    Izikson, R.5    Patriarca, P.6    Goldenthal, K.L.7    Kohberger, R.8    Dunkle, L.M.9
  • 83
    • 18944395052 scopus 로고    scopus 로고
    • Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: Results from a randomized vehicle-controlled phase III study in Europe
    • Schulze, H. J.; Cribier, B.; Requena, L.; Reifenberger, J.; Ferrandiz, C.; Garcia, D. A.; Tebbs, V.; McRae, S. Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: Results from a randomized vehicle-controlled phase III study in Europe. Br. J. Dermatol. 2005, 152, 939-947.
    • (2005) Br. J. Dermatol , vol.152 , pp. 939-947
    • Schulze, H.J.1    Cribier, B.2    Requena, L.3    Reifenberger, J.4    Ferrandiz, C.5    Garcia, D.A.6    Tebbs, V.7    McRae, S.8
  • 84
    • 2342450044 scopus 로고    scopus 로고
    • Imiquimod 5% cream for the treatment of actinic keratosis: Results from two phase III, randomized, double-blind, parallel group, vehicle-controlled trials
    • Lebwohl, M.; Dinehart, S.; Whiting, D.; Lee, P. K.; Tawfik, N.; Jorizzo, J.; Lee, J. H.; Fox, T. L. Imiquimod 5% cream for the treatment of actinic keratosis: Results from two phase III, randomized, double-blind, parallel group, vehicle-controlled trials. J. Am. Acad. Dermatol. 2004, 50, 714-721.
    • (2004) J. Am. Acad. Dermatol , vol.50 , pp. 714-721
    • Lebwohl, M.1    Dinehart, S.2    Whiting, D.3    Lee, P.K.4    Tawfik, N.5    Jorizzo, J.6    Lee, J.H.7    Fox, T.L.8
  • 86
    • 30644467155 scopus 로고    scopus 로고
    • Imiquimod and S-27609 as adjuvants of DNA vaccination in a transgenic murine model of HER2/neu-positive mammary carcinoma
    • Smorlesi, A.; Papalini, F.; Orlando, F.; Donnini, A.; Re, F.; Provinciali, M. Imiquimod and S-27609 as adjuvants of DNA vaccination in a transgenic murine model of HER2/neu-positive mammary carcinoma. Gene Ther. 2005, 12, 1324-1332.
    • (2005) Gene Ther , vol.12 , pp. 1324-1332
    • Smorlesi, A.1    Papalini, F.2    Orlando, F.3    Donnini, A.4    Re, F.5    Provinciali, M.6
  • 87
    • 47949129948 scopus 로고    scopus 로고
    • Immunization of malignant melanoma patients with full-length NY-ESO-1 protein using TLR7 agonist imiquimod as vaccine adjuvant
    • Adams, S.; O'Neill, D. W.; Nonaka, D.; Hardin, E.; Chiriboga, L.; Siu, K.; Cruz, C. M.; Angiulli, A.; Angiulli, F.; Ritter, E.; et al. Immunization of malignant melanoma patients with full-length NY-ESO-1 protein using TLR7 agonist imiquimod as vaccine adjuvant. J. Immunol. 2008, 181, 776-784.
    • (2008) J. Immunol , vol.181 , pp. 776-784
    • Adams, S.1    O'Neill, D.W.2    Nonaka, D.3    Hardin, E.4    Chiriboga, L.5    Siu, K.6    Cruz, C.M.7    Angiulli, A.8    Angiulli, F.9    Ritter, E.10
  • 88
    • 27244443079 scopus 로고    scopus 로고
    • HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates
    • Wille-Reece, U.; Flynn, B. J.; Lore, K.; Koup, R. A.; Kedl, R. M.; Mattapallil, J. J.; Weiss, W. R.; Roederer, M.; Seder, R. A. HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates. Proc. Natl. Acad. Sci. USA 2005, 102, 15190-15194.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 15190-15194
    • Wille-Reece, U.1    Flynn, B.J.2    Lore, K.3    Koup, R.A.4    Kedl, R.M.5    Mattapallil, J.J.6    Weiss, W.R.7    Roederer, M.8    Seder, R.A.9
  • 90
    • 84874716873 scopus 로고    scopus 로고
    • TLR9 adjuvants enhance immunogenicity and protective efficacy of the SE36/AHG malaria vaccine in nonhuman primate models
    • Tougan, T.; Aoshi, T.; Coban, C.; Katakai, Y.; Kai, C.; Yasutomi, Y.; Ishii, K. J.; Horii, T. TLR9 adjuvants enhance immunogenicity and protective efficacy of the SE36/AHG malaria vaccine in nonhuman primate models. Hum. Vaccin. Immunother. 2013, 9, 283-290.
    • (2013) Hum. Vaccin. Immunother , vol.9 , pp. 283-290
    • Tougan, T.1    Aoshi, T.2    Coban, C.3    Katakai, Y.4    Kai, C.5    Yasutomi, Y.6    Ishii, K.J.7    Horii, T.8
  • 91
    • 77749319159 scopus 로고    scopus 로고
    • Phase 1 trial of the Plasmodium falciparum blood stage vaccine MSP1(42)-C1/Alhydrogel with and without CPG 7909 in malaria naive adults
    • Ellis, R. D.; Martin, L. B.; Shaffer, D.; Long, C. A.; Miura, K.; Fay, M. P.; Narum, D. L.; Zhu, D.; Mullen, G. E.; Mahanty, S.; et al. Phase 1 trial of the Plasmodium falciparum blood stage vaccine MSP1(42)-C1/Alhydrogel with and without CPG 7909 in malaria naive adults. PLoS One 2010, 5, e8787.
    • (2010) PLoS One , vol.5
    • Ellis, R.D.1    Martin, L.B.2    Shaffer, D.3    Long, C.A.4    Miura, K.5    Fay, M.P.6    Narum, D.L.7    Zhu, D.8    Mullen, G.E.9    Mahanty, S.10
  • 92
    • 84867134168 scopus 로고    scopus 로고
    • Phase 1 study in malaria naive adults of BSAM2/Alhydrogel(R)+CPG 7909, a blood stage vaccine against P. falciparum malaria
    • Ellis, R. D.; Wu, Y.; Martin, L. B.; Shaffer, D.; Miura, K.; Aebig, J.; Orcutt, A.; Rausch, K.; Zhu, D.; Mogensen, A.; et al. Phase 1 study in malaria naive adults of BSAM2/Alhydrogel(R)+CPG 7909, a blood stage vaccine against P. falciparum malaria. PLoS One 2012, 7, e46094.
    • (2012) PLoS One , vol.7
    • Ellis, R.D.1    Wu, Y.2    Martin, L.B.3    Shaffer, D.4    Miura, K.5    Aebig, J.6    Orcutt, A.7    Rausch, K.8    Zhu, D.9    Mogensen, A.10
  • 94
    • 31144441904 scopus 로고    scopus 로고
    • Testing of CpG-optimized protein and DNA vaccines against the hepatitis B virus in chimpanzees for immunogenicity and protection from challenge
    • Payette, P. J.; Ma, X.; Weeratna, R. D.; McCluskie, M. J.; Shapiro, M.; Engle, R. E.; Davis, H. L.; Purcell, R. H. Testing of CpG-optimized protein and DNA vaccines against the hepatitis B virus in chimpanzees for immunogenicity and protection from challenge. Intervirology 2006, 49, 144-151.
    • (2006) Intervirology , vol.49 , pp. 144-151
    • Payette, P.J.1    Ma, X.2    Weeratna, R.D.3    McCluskie, M.J.4    Shapiro, M.5    Engle, R.E.6    Davis, H.L.7    Purcell, R.H.8
  • 95
    • 0037726807 scopus 로고    scopus 로고
    • A phase I study of the safety and immunogenicity of recombinant hepatitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide adjuvant
    • Halperin, S. A.; van Nest, G.; Smith, B.; Abtahi, S.; Whiley, H.; Eiden, J. J. A phase I study of the safety and immunogenicity of recombinant hepatitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide adjuvant. Vaccine 2003, 21, 2461-2467.
    • (2003) Vaccine , vol.21 , pp. 2461-2467
    • Halperin, S.A.1    van Nest, G.2    Smith, B.3    Abtahi, S.4    Whiley, H.5    Eiden, J.J.6
  • 96
    • 84864008155 scopus 로고    scopus 로고
    • Safety and immunogenicity of different two-dose regimens of an investigational hepatitis B vaccine (hepatitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligodeoxyribonucleotide) in healthy young adults
    • Halperin, S. A.; McNeil, S.; Langley, J. M.; Smith, B.; MacKinnon-Cameron, D.; McCall-Sani, R.; Heyward, W. L.; Martin, J. T. Safety and immunogenicity of different two-dose regimens of an investigational hepatitis B vaccine (hepatitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligodeoxyribonucleotide) in healthy young adults. Vaccine 2012, 30, 5445-5448.
    • (2012) Vaccine , vol.30 , pp. 5445-5448
    • Halperin, S.A.1    McNeil, S.2    Langley, J.M.3    Smith, B.4    McKinnon-Cameron, D.5    McCall-Sani, R.6    Heyward, W.L.7    Martin, J.T.8
  • 97
    • 84862785552 scopus 로고    scopus 로고
    • Demonstration of safety and enhanced seroprotection against hepatitis B with investigational HBsAg-1018 ISS vaccine compared to a licensed hepatitis B vaccine
    • Sablan, B. P.; Kim, D. J.; Barzaga, N. G.; Chow, W. C.; Cho, M.; Ahn, S. H.; Hwang, S. G.; Lee, J. H.; Namini, H.; Heyward, W. L. Demonstration of safety and enhanced seroprotection against hepatitis B with investigational HBsAg-1018 ISS vaccine compared to a licensed hepatitis B vaccine. Vaccine 2012, 30, 2689-2696.
    • (2012) Vaccine , vol.30 , pp. 2689-2696
    • Sablan, B.P.1    Kim, D.J.2    Barzaga, N.G.3    Chow, W.C.4    Cho, M.5    Ahn, S.H.6    Hwang, S.G.7    Lee, J.H.8    Namini, H.9    Heyward, W.L.10
  • 98
    • 84878963646 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled, safety and immunogenicity study of 4 formulations of Anthrax Vaccine Adsorbed plus CPG 7909 (AV7909) in healthy adult volunteers
    • Hopkins, R. J.; Daczkowski, N. F.; Kaptur, P. E.; Muse, D.; Sheldon, E.; LaForce, C.; Sari, S.; Rudge, T. L.; Bernton, E. Randomized, double-blind, placebo-controlled, safety and immunogenicity study of 4 formulations of Anthrax Vaccine Adsorbed plus CPG 7909 (AV7909) in healthy adult volunteers. Vaccine 2013, 31, 3051-3058.
    • (2013) Vaccine , vol.31 , pp. 3051-3058
    • Hopkins, R.J.1    Daczkowski, N.F.2    Kaptur, P.E.3    Muse, D.4    Sheldon, E.5    LaForce, C.6    Sari, S.7    Rudge, T.L.8    Bernton, E.9
  • 99
    • 84891881802 scopus 로고    scopus 로고
    • In vitro and in vivo evaluations of human papillomavirus type 16 (HPV16)-derived peptide-loaded dendritic cells (DCs) with a CpG oligodeoxynucleotide (CpG-ODN) adjuvant as tumor vaccines for immunotherapy of cervical cancer
    • Wang, H. L.; Xu, H.; Lu, W. H.; Zhu, L.; Yu, Y. H.; Hong, F. Z. In vitro and in vivo evaluations of human papillomavirus type 16 (HPV16)-derived peptide-loaded dendritic cells (DCs) with a CpG oligodeoxynucleotide (CpG-ODN) adjuvant as tumor vaccines for immunotherapy of cervical cancer. Arch. Gynecol. Obstet. 2014, 289, 155-162.
    • (2014) Arch. Gynecol. Obstet , vol.289 , pp. 155-162
    • Wang, H.L.1    Xu, H.2    Lu, W.H.3    Zhu, L.4    Yu, Y.H.5    Hong, F.Z.6
  • 102
    • 55249083982 scopus 로고    scopus 로고
    • Phase 1 evaluation of intralesionally injected TLR9-agonist PF-3512676 in patients with basal cell carcinoma or metastatic melanoma
    • Hofmann, M. A.; Kors, C.; Audring, H.; Walden, P.; Sterry, W.; Trefzer, U. Phase 1 evaluation of intralesionally injected TLR9-agonist PF-3512676 in patients with basal cell carcinoma or metastatic melanoma. J. Immunother. 2008, 31, 520-527.
    • (2008) J. Immunother , vol.31 , pp. 520-527
    • Hofmann, M.A.1    Kors, C.2    Audring, H.3    Walden, P.4    Sterry, W.5    Trefzer, U.6
  • 103
    • 50549084485 scopus 로고    scopus 로고
    • Randomized phase II trial of a toll-like receptor 9 agonist oligodeoxynucleotide, PF-3512676, in combination with first-line taxane plus platinum chemotherapy for advanced-stage non-small-cell lung cancer
    • Manegold, C.; Gravenor, D.; Woytowitz, D.; Mezger, J.; Hirsh, V.; Albert, G.; Al-Adhami, M.; Readett, D.; Krieg, A. M.; Leichman, C. G. Randomized phase II trial of a toll-like receptor 9 agonist oligodeoxynucleotide, PF-3512676, in combination with first-line taxane plus platinum chemotherapy for advanced-stage non-small-cell lung cancer. J. Clin. Oncol. 2008, 26, 3979-3986.
    • (2008) J. Clin. Oncol , vol.26 , pp. 3979-3986
    • Manegold, C.1    Gravenor, D.2    Woytowitz, D.3    Mezger, J.4    Hirsh, V.5    Albert, G.6    Al-Adhami, M.7    Readett, D.8    Krieg, A.M.9    Leichman, C.G.10
  • 105
    • 84880730418 scopus 로고    scopus 로고
    • Selection of immunostimulant AS15 for active immunization with MAGE-A3 protein: Results of a randomized phase II study of the European Organisation for Research and Treatment of Cancer Melanoma Group in Metastatic Melanoma
    • Kruit, W. H.; Suciu, S.; Dreno, B.; Mortier, L.; Robert, C.; Chiarion-Sileni, V.; Maio, M.; Testori, A.; Dorval, T.; Grob, J. J.; et al. Selection of immunostimulant AS15 for active immunization with MAGE-A3 protein: results of a randomized phase II study of the European Organisation for Research and Treatment of Cancer Melanoma Group in Metastatic Melanoma. J. Clin. Oncol. 2013, 31, 2413-2420.
    • (2013) J. Clin. Oncol , vol.31 , pp. 2413-2420
    • Kruit, W.H.1    Suciu, S.2    Dreno, B.3    Mortier, L.4    Robert, C.5    Chiarion-Sileni, V.6    Maio, M.7    Testori, A.8    Dorval, T.9    Grob, J.J.10
  • 106
    • 52949113396 scopus 로고    scopus 로고
    • Efficient immune responses against Intimin and EspB of enterohaemorragic Escherichia coli after intranasal vaccination using the TLR2/6 agonist MALP-2 as adjuvant
    • Cataldi, A.; Yevsa, T.; Vilte, D. A.; Schulze, K.; Castro-Parodi, M.; Larzabal, M.; Ibarra, C.; Mercado, E. C.; Guzman, C. A. Efficient immune responses against Intimin and EspB of enterohaemorragic Escherichia coli after intranasal vaccination using the TLR2/6 agonist MALP-2 as adjuvant. Vaccine 2008, 26, 5662-5667.
    • (2008) Vaccine , vol.26 , pp. 5662-5667
    • Cataldi, A.1    Yevsa, T.2    Vilte, D.A.3    Schulze, K.4    Castro-Parodi, M.5    Larzabal, M.6    Ibarra, C.7    Mercado, E.C.8    Guzman, C.A.9
  • 107
    • 84894294907 scopus 로고    scopus 로고
    • Efficacy and safety of a patch vaccine containing heat-labile toxin from Escherichia coli against travellers' diarrhoea: A phase 3, randomised, double-blind, placebo-controlled field trial in travellers from Europe to Mexico and Guatemala
    • Behrens, R. H.; Cramer, J. P.; Jelinek, T.; Shaw, H.; von, S. F.; Wilbraham, D.; Weinke, T.; Bell, D. J.; Asturias, E.; Pauwells, H. L.; et al. Efficacy and safety of a patch vaccine containing heat-labile toxin from Escherichia coli against travellers' diarrhoea: A phase 3, randomised, double-blind, placebo-controlled field trial in travellers from Europe to Mexico and Guatemala. Lancet Infect. Dis. 2013, 14, 197-204.
    • (2013) Lancet Infect. Dis , vol.14 , pp. 197-204
    • Behrens, R.H.1    Cramer, J.P.2    Jelinek, T.3    Shaw, H.4    von, S.F.5    Wilbraham, D.6    Weinke, T.7    Bell, D.J.8    Asturias, E.9    Pauwells, H.L.10
  • 109
  • 110
    • 0035168781 scopus 로고    scopus 로고
    • A totally synthetic polyoxime malaria vaccine containing Plasmodium falciparum B cell and universal T cell epitopes elicits immune responses in volunteers of diverse HLA types
    • Nardin, E. H.; Calvo-Calle, J. M.; Oliveira, G. A.; Nussenzweig, R. S.; Schneider, M.; Tiercy, J. M.; Loutan, L.; Hochstrasser, D.; Rose, K. A totally synthetic polyoxime malaria vaccine containing Plasmodium falciparum B cell and universal T cell epitopes elicits immune responses in volunteers of diverse HLA types. J. Immunol. 2001, 166, 481-489.
    • (2001) J. Immunol , vol.166 , pp. 481-489
    • Nardin, E.H.1    Calvo-Calle, J.M.2    Oliveira, G.A.3    Nussenzweig, R.S.4    Schneider, M.5    Tiercy, J.M.6    Loutan, L.7    Hochstrasser, D.8    Rose, K.9
  • 111
    • 0023943993 scopus 로고
    • Proteosome-lipopeptide vaccines: Enhancement of immunogenicity for malaria CS peptides
    • Lowell, G. H.; Ballou, W. R.; Smith, L. F.; Wirtz, R. A.; Zollinger, W. D.; Hockmeyer, W. T. Proteosome-lipopeptide vaccines: Enhancement of immunogenicity for malaria CS peptides. Science 1988, 240, 800-802.
    • (1988) Science , vol.240 , pp. 800-802
    • Lowell, G.H.1    Ballou, W.R.2    Smith, L.F.3    Wirtz, R.A.4    Zollinger, W.D.5    Hockmeyer, W.T.6
  • 112
    • 0028876917 scopus 로고
    • Development of a lipopeptide-based therapeutic vaccine to treat chronic HBV infection. I. Induction of a primary cytotoxic T lymphocyte response in humans
    • Vitiello, A.; Ishioka, G.; Grey, H. M.; Rose, R.; Farness, P.; LaFond, R.; Yuan, L.; Chisari, F. V.; Furze, J.; Bartholomeuz, R. Development of a lipopeptide-based therapeutic vaccine to treat chronic HBV infection. I. Induction of a primary cytotoxic T lymphocyte response in humans. J. Clin. Invest. 1995, 95, 341-349.
    • (1995) J. Clin. Invest , vol.95 , pp. 341-349
    • Vitiello, A.1    Ishioka, G.2    Grey, H.M.3    Rose, R.4    Farness, P.5    LaFond, R.6    Yuan, L.7    Chisari, F.V.8    Furze, J.9    Bartholomeuz, R.10
  • 113
    • 0032752883 scopus 로고    scopus 로고
    • Immunization with the HBV core 18-27 epitope elicits CTL responses in humans expressing different HLA-A2 supertype molecules
    • Livingston, B. D.; Crimi, C.; Fikes, J.; Chesnut, R. W.; Sidney, J.; Sette, A. Immunization with the HBV core 18-27 epitope elicits CTL responses in humans expressing different HLA-A2 supertype molecules. Hum. Immunol. 1999, 60, 1013-1017.
    • (1999) Hum. Immunol , vol.60 , pp. 1013-1017
    • Livingston, B.D.1    Crimi, C.2    Fikes, J.3    Chesnut, R.W.4    Sidney, J.5    Sette, A.6
  • 115
    • 0033797049 scopus 로고    scopus 로고
    • Genetically detoxified mutants of heat-labile enterotoxin from Escherichia coli are effective adjuvants for induction of cytotoxic T-cell responses against HIV-1 gag-p55
    • Neidleman, J. A.; Vajdy, M.; Ugozzoli, M.; Ott, G.; O'Hagan, D. Genetically detoxified mutants of heat-labile enterotoxin from Escherichia coli are effective adjuvants for induction of cytotoxic T-cell responses against HIV-1 gag-p55. Immunology 2000, 101, 154-160.
    • (2000) Immunology , vol.101 , pp. 154-160
    • Neidleman, J.A.1    Vajdy, M.2    Ugozzoli, M.3    Ott, G.4    O'Hagan, D.5
  • 116
    • 84871890561 scopus 로고    scopus 로고
    • Toll-Like receptor 2-dependent activity of native major outer membrane protein proteosomes of Chlamydia trachomatis
    • Massari, P.; Toussi, D. N.; Tifrea, D. F.; de la Maza, L. M. Toll-Like receptor 2-dependent activity of native major outer membrane protein proteosomes of Chlamydia trachomatis. Infect. Immun. 2013, 81, 303-310.
    • (2013) Infect. Immun , vol.81 , pp. 303-310
    • Massari, P.1    Toussi, D.N.2    Tifrea, D.F.3    de la Maza, L.M.4
  • 118
    • 0030759230 scopus 로고    scopus 로고
    • Neisserial porins may provide critical second signals to polysaccharide-activated murine B cells for induction of immunoglobulin secretion
    • Snapper, C. M.; Rosas, F. R.; Kehry, M. R.; Mond, J. J.; Wetzler, L. M. Neisserial porins may provide critical second signals to polysaccharide-activated murine B cells for induction of immunoglobulin secretion. Infect. Immun. 1997, 65, 3203-3208.
    • (1997) Infect. Immun , vol.65 , pp. 3203-3208
    • Snapper, C.M.1    Rosas, F.R.2    Kehry, M.R.3    Mond, J.J.4    Wetzler, L.M.5
  • 120
    • 0025133403 scopus 로고
    • Immunogenicity of a Haemophilus influenzae polysaccharide-Neisseria meningitidis outer membrane protein vaccine
    • Donnelly, J. J.; Deck, R. R.; Liu, M. A. Immunogenicity of a Haemophilus influenzae polysaccharide-Neisseria meningitidis outer membrane protein vaccine. J. Immunol. 1990, 145, 3071-3079.
    • (1990) J. Immunol , vol.145 , pp. 3071-3079
    • Donnelly, J.J.1    Deck, R.R.2    Liu, M.A.3
  • 121
    • 0032210729 scopus 로고    scopus 로고
    • Preclinical studies on a recombinant group B meningococcal porin as a carrier for a novel Haemophilus influenzae type B conjugate vaccine
    • Fusco, P. C.; Michon, F.; Laude-Sharp, M.; Minetti, C. A.; Huang, C. H.; Heron, I.; Blake, M. S. Preclinical studies on a recombinant group B meningococcal porin as a carrier for a novel Haemophilus influenzae type B conjugate vaccine. Vaccine 1998, 16, 1842-1849.
    • (1998) Vaccine , vol.16 , pp. 1842-1849
    • Fusco, P.C.1    Michon, F.2    Laude-Sharp, M.3    Minetti, C.A.4    Huang, C.H.5    Heron, I.6    Blake, M.S.7
  • 122
    • 38449095416 scopus 로고    scopus 로고
    • Neisseria meningitidis PorB, a TLR2 ligand, induces an antigen-specific eosinophil recall response: Potential adjuvant for helminth vaccines?
    • Burke, J. M.; Ganley-Leal, L. M.; Khatri, A.; Wetzler, L. M. Neisseria meningitidis PorB, a TLR2 ligand, induces an antigen-specific eosinophil recall response: Potential adjuvant for helminth vaccines? J. Immunol. 2007, 179, 3222-3230.
    • (2007) J. Immunol , vol.179 , pp. 3222-3230
    • Burke, J.M.1    Ganley-Leal, L.M.2    Khatri, A.3    Wetzler, L.M.4
  • 123
    • 51649099771 scopus 로고    scopus 로고
    • Neisseria meningitidis PorB, a Toll-like receptor 2 ligand, improves the capacity of Francisella tularensis lipopolysaccharide to protect mice against experimental tularemia
    • Chiavolini, D.; Weir, S.; Murphy, J. R.; Wetzler, L. M. Neisseria meningitidis PorB, a Toll-like receptor 2 ligand, improves the capacity of Francisella tularensis lipopolysaccharide to protect mice against experimental tularemia. Clin. Vaccine Immunol. 2008, 15, 1322-1329.
    • (2008) Clin. Vaccine Immunol , vol.15 , pp. 1322-1329
    • Chiavolini, D.1    Weir, S.2    Murphy, J.R.3    Wetzler, L.M.4
  • 126
    • 84855184185 scopus 로고    scopus 로고
    • Prophylactic and therapeutic implications of toll-like receptor ligands
    • Hedayat, M.; Takeda, K.; Rezaei, N. Prophylactic and therapeutic implications of toll-like receptor ligands. Med. Res. Rev. 2012, 32, 294-325.
    • (2012) Med. Res. Rev , vol.32 , pp. 294-325
    • Hedayat, M.1    Takeda, K.2    Rezaei, N.3
  • 127
    • 33845224163 scopus 로고    scopus 로고
    • Vaccination with recombinant fusion proteins incorporating Toll-like receptor ligands induces rapid cellular and humoral immunity
    • Huleatt, J. W.; Jacobs, A. R.; Tang, J.; Desai, P.; Kopp, E. B.; Huang, Y.; Song, L.; Nakaar, V.; Powell, T. J. Vaccination with recombinant fusion proteins incorporating Toll-like receptor ligands induces rapid cellular and humoral immunity. Vaccine 2007, 25, 763-775.
    • (2007) Vaccine , vol.25 , pp. 763-775
    • Huleatt, J.W.1    Jacobs, A.R.2    Tang, J.3    Desai, P.4    Kopp, E.B.5    Huang, Y.6    Song, L.7    Nakaar, V.8    Powell, T.J.9
  • 128
    • 84891692328 scopus 로고    scopus 로고
    • Protective humoral immunity elicited by a needle-free malaria vaccine comprised of a chimeric Plasmodium falciparum circumsporozoite protein and a Toll-like receptor 5 agonist, flagellin
    • Carapau, D.; Mitchell, R.; Nacer, A.; Shaw, A.; Othoro, C.; Frevert, U.; Nardin, E. Protective humoral immunity elicited by a needle-free malaria vaccine comprised of a chimeric Plasmodium falciparum circumsporozoite protein and a Toll-like receptor 5 agonist, flagellin. Infect. Immun. 2013, 81, 4350-4362.
    • (2013) Infect. Immun , vol.81 , pp. 4350-4362
    • Carapau, D.1    Mitchell, R.2    Nacer, A.3    Shaw, A.4    Othoro, C.5    Frevert, U.6    Nardin, E.7
  • 130
    • 79953759607 scopus 로고    scopus 로고
    • Flagellin administration protects gut mucosal tissue from irradiation-induced apoptosis via MKP-7 activity
    • Jones, R. M.; Sloane, V. M.; Wu, H.; Luo, L.; Kumar, A.; Kumar, M. V.; Gewirtz, A. T.; Neish, A. S. Flagellin administration protects gut mucosal tissue from irradiation-induced apoptosis via MKP-7 activity. Gut 2011, 60, 648-657.
    • (2011) Gut , vol.60 , pp. 648-657
    • Jones, R.M.1    Sloane, V.M.2    Wu, H.3    Luo, L.4    Kumar, A.5    Kumar, M.V.6    Gewirtz, A.T.7    Neish, A.S.8
  • 131
    • 84881558642 scopus 로고    scopus 로고
    • Flagellin enhances tumor-specific CD8+ T cell immune responses through TLR5 stimulation in a therapeutic cancer vaccine model
    • Nguyen, C. T.; Hong, S. H.; Sin, J. I.; Vu, H. V.; Jeong, K.; Cho, K. O.; Uematsu, S.; Akira, S.; Lee, S. E.; Rhee, J. H. Flagellin enhances tumor-specific CD8+ T cell immune responses through TLR5 stimulation in a therapeutic cancer vaccine model. Vaccine 2013, 31, 3879-3887.
    • (2013) Vaccine , vol.31 , pp. 3879-3887
    • Nguyen, C.T.1    Hong, S.H.2    Sin, J.I.3    Vu, H.V.4    Jeong, K.5    Cho, K.O.6    Uematsu, S.7    Akira, S.8    Lee, S.E.9    Rhee, J.H.10
  • 132
    • 77953124392 scopus 로고    scopus 로고
    • Salmonella flagellins are potent adjuvants for intranasally administered whole inactivated influenza vaccine
    • Skountzou, I.; Martin, M. P.; Wang, B.; Ye, L.; Koutsonanos, D.; Weldon, W.; Jacob, J.; Compans, R. W. Salmonella flagellins are potent adjuvants for intranasally administered whole inactivated influenza vaccine. Vaccine 2010, 28, 4103-4112.
    • (2010) Vaccine , vol.28 , pp. 4103-4112
    • Skountzou, I.1    Martin, M.P.2    Wang, B.3    Ye, L.4    Koutsonanos, D.5    Weldon, W.6    Jacob, J.7    Compans, R.W.8
  • 133
    • 84355161545 scopus 로고    scopus 로고
    • Intranasal administration of a flagellin-adjuvanted inactivated influenza vaccine enhances mucosal immune responses to protect mice against lethal infection
    • Hong, S. H.; Byun, Y. H.; Nguyen, C. T.; Kim, S. Y.; Seong, B. L.; Park, S.; Woo, G. J.; Yoon, Y.; Koh, J. T.; Fujihashi, K.; et al. Intranasal administration of a flagellin-adjuvanted inactivated influenza vaccine enhances mucosal immune responses to protect mice against lethal infection. Vaccine 2012, 30, 466-474.
    • (2012) Vaccine , vol.30 , pp. 466-474
    • Hong, S.H.1    Byun, Y.H.2    Nguyen, C.T.3    Kim, S.Y.4    Seong, B.L.5    Park, S.6    Woo, G.J.7    Yoon, Y.8    Koh, J.T.9    Fujihashi, K.10
  • 134
    • 84864945063 scopus 로고    scopus 로고
    • Development of VAX128, a recombinant hemagglutinin (HA) influenza-flagellin fusion vaccine with improved safety and immune response
    • Taylor, D. N.; Treanor, J. J.; Sheldon, E. A.; Johnson, C.; Umlauf, S.; Song, L.; Kavita, U.; Liu, G.; Tussey, L.; Ozer, K.; et al. Development of VAX128, a recombinant hemagglutinin (HA) influenza-flagellin fusion vaccine with improved safety and immune response. Vaccine 2012, 30, 5761-5769.
    • (2012) Vaccine , vol.30 , pp. 5761-5769
    • Taylor, D.N.1    Treanor, J.J.2    Sheldon, E.A.3    Johnson, C.4    Umlauf, S.5    Song, L.6    Kavita, U.7    Liu, G.8    Tussey, L.9    Ozer, K.10
  • 135
    • 78649741148 scopus 로고    scopus 로고
    • Safety and immunogenicity of a recombinant hemagglutinin influenza-flagellin fusion vaccine (VAX125) in healthy young adults
    • Treanor, J. J.; Taylor, D. N.; Tussey, L.; Hay, C.; Nolan, C.; Fitzgerald, T.; Liu, G.; Kavita, U.; Song, L.; Dark, I.; et al. Safety and immunogenicity of a recombinant hemagglutinin influenza-flagellin fusion vaccine (VAX125) in healthy young adults. Vaccine 2010, 28, 8268-8274.
    • (2010) Vaccine , vol.28 , pp. 8268-8274
    • Treanor, J.J.1    Taylor, D.N.2    Tussey, L.3    Hay, C.4    Nolan, C.5    Fitzgerald, T.6    Liu, G.7    Kavita, U.8    Song, L.9    Dark, I.10
  • 136
    • 79958104636 scopus 로고    scopus 로고
    • Immunogenicity and efficacy of flagellin-fused vaccine candidates targeting 2009 pandemic H1N1 influenza in mice
    • Liu, G.; Tarbet, B.; Song, L.; Reiserova, L.; Weaver, B.; Chen, Y.; Li, H.; Hou, F.; Liu, X.; Parent, J.; et al. Immunogenicity and efficacy of flagellin-fused vaccine candidates targeting 2009 pandemic H1N1 influenza in mice. PLoS. One 2011, 6, e20928.
    • (2011) PLoS. One , vol.6
    • Liu, G.1    Tarbet, B.2    Song, L.3    Reiserova, L.4    Weaver, B.5    Chen, Y.6    Li, H.7    Hou, F.8    Liu, X.9    Parent, J.10
  • 137
    • 78650827526 scopus 로고    scopus 로고
    • Immunopotentiation of trivalent influenza vaccine when given with VAX102, a recombinant influenza M2e vaccine fused to the TLR5 ligand flagellin
    • Talbot, H. K.; Rock, M. T.; Johnson, C.; Tussey, L.; Kavita, U.; Shanker, A.; Shaw, A. R.; Taylor, D. N. Immunopotentiation of trivalent influenza vaccine when given with VAX102, a recombinant influenza M2e vaccine fused to the TLR5 ligand flagellin. PLoS One 2010, 5, e14442.
    • (2010) PLoS One , vol.5
    • Talbot, H.K.1    Rock, M.T.2    Johnson, C.3    Tussey, L.4    Kavita, U.5    Shanker, A.6    Shaw, A.R.7    Taylor, D.N.8
  • 138
    • 79960308363 scopus 로고    scopus 로고
    • Safety and immunogenicity of a recombinant M2e-flagellin influenza vaccine (STF2. 4xM2e) in healthy adults
    • Turley, C. B.; Rupp, R. E.; Johnson, C.; Taylor, D. N.; Wolfson, J.; Tussey, L.; Kavita, U.; Stanberry, L.; Shaw, A. Safety and immunogenicity of a recombinant M2e-flagellin influenza vaccine (STF2. 4xM2e) in healthy adults. Vaccine 2011, 29, 5145-5152.
    • (2011) Vaccine , vol.29 , pp. 5145-5152
    • Turley, C.B.1    Rupp, R.E.2    Johnson, C.3    Taylor, D.N.4    Wolfson, J.5    Tussey, L.6    Kavita, U.7    Stanberry, L.8    Shaw, A.9
  • 139
    • 67349117313 scopus 로고    scopus 로고
    • Ampligen: A potential toll-like 3 receptor adjuvant for immunotherapy of cancer
    • Jasani, B.; Navabi, H.; Adams, M. Ampligen: A potential toll-like 3 receptor adjuvant for immunotherapy of cancer. Vaccine 2009, 27, 3401-3404.
    • (2009) Vaccine , vol.27 , pp. 3401-3404
    • Jasani, B.1    Navabi, H.2    Adams, M.3
  • 141
    • 79955065280 scopus 로고    scopus 로고
    • Immunity by formulation design: Induction of high CD8+ T-cell responses by poly(I: C) incorporated into the CAF01 adjuvant via a double emulsion method
    • Nordly, P.; Rose, F.; Christensen, D.; Nielsen, H. M.; Andersen, P.; Agger, E. M.; Foged, C. Immunity by formulation design: induction of high CD8+ T-cell responses by poly(I: C) incorporated into the CAF01 adjuvant via a double emulsion method. J. Control. Release 2011, 150, 307-317.
    • (2011) J. Control. Release , vol.150 , pp. 307-317
    • Nordly, P.1    Rose, F.2    Christensen, D.3    Nielsen, H.M.4    Andersen, P.5    Agger, E.M.6    Foged, C.7
  • 143
    • 0033574415 scopus 로고    scopus 로고
    • Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction
    • Chow, J. C.; Young, D. W.; Golenbock, D. T.; Christ, W. J.; Gusovsky, F. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction. J. Biol. Chem. 1999, 274, 10689-10692.
    • (1999) J. Biol. Chem , vol.274 , pp. 10689-10692
    • Chow, J.C.1    Young, D.W.2    Golenbock, D.T.3    Christ, W.J.4    Gusovsky, F.5
  • 144
    • 0036021109 scopus 로고    scopus 로고
    • Saccharomyces cerevisiae-and Candida albicans-derived mannan induced production of tumor necrosis factor alpha by human monocytes in a CD14-and Toll-like receptor 4-dependent manner
    • Tada, H.; Nemoto, E.; Shimauchi, H.; Watanabe, T.; Mikami, T.; Matsumoto, T.; Ohno, N.; Tamura, H.; Shibata, K.; Akashi, S.; et al. Saccharomyces cerevisiae-and Candida albicans-derived mannan induced production of tumor necrosis factor alpha by human monocytes in a CD14-and Toll-like receptor 4-dependent manner. Microbiol. Immunol. 2002, 46, 503-512.
    • (2002) Microbiol. Immunol , vol.46 , pp. 503-512
    • Tada, H.1    Nemoto, E.2    Shimauchi, H.3    Watanabe, T.4    Mikami, T.5    Matsumoto, T.6    Ohno, N.7    Tamura, H.8    Shibata, K.9    Akashi, S.10
  • 147
    • 84900320851 scopus 로고    scopus 로고
    • Toll-like Receptor 4 (TLR4) modulation by synthetic and natural compounds: An update
    • doi: 10. 1021/jm401006s
    • Peri, F.; Calabrese, V. Toll-like Receptor 4 (TLR4) modulation by synthetic and natural compounds: An update. J. Med. Chem. 2013, doi: 10. 1021/jm401006s.
    • (2013) J. Med. Chem
    • Peri, F.1    Calabrese, V.2
  • 150
    • 0037033073 scopus 로고    scopus 로고
    • Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction
    • Latz, E.; Visintin, A.; Lien, E.; Fitzgerald, K. A.; Monks, B. G.; Kurt-Jones, E. A.; Golenbock, D. T.; Espevik, T. Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction. J. Biol. Chem. 2002, 277, 47834-47843.
    • (2002) J. Biol. Chem , vol.277 , pp. 47834-47843
    • Latz, E.1    Visintin, A.2    Lien, E.3    Fitzgerald, K.A.4    Monks, B.G.5    Kurt-Jones, E.A.6    Golenbock, D.T.7    Espevik, T.8
  • 151
    • 28844442949 scopus 로고    scopus 로고
    • The low-toxicity versions of LPS, MPL adjuvant and RC529, are efficient adjuvants for CD4+ T cells
    • Thompson, B. S.; Chilton, P. M.; Ward, J. R.; Evans, J. T.; Mitchell, T. C. The low-toxicity versions of LPS, MPL adjuvant and RC529, are efficient adjuvants for CD4+ T cells. J. Leukoc. Biol. 2005, 78, 1273-1280.
    • (2005) J. Leukoc. Biol , vol.78 , pp. 1273-1280
    • Thompson, B.S.1    Chilton, P.M.2    Ward, J.R.3    Evans, J.T.4    Mitchell, T.C.5
  • 152
    • 34250854079 scopus 로고    scopus 로고
    • The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4
    • Mata-Haro, V.; Cekic, C.; Martin, M.; Chilton, P. M.; Casella, C. R.; Mitchell, T. C. The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4. Science 2007, 316, 1628-1632.
    • (2007) Science , vol.316 , pp. 1628-1632
    • Mata-Haro, V.1    Cekic, C.2    Martin, M.3    Chilton, P.M.4    Casella, C.R.5    Mitchell, T.C.6
  • 153
    • 35349028297 scopus 로고    scopus 로고
    • GlaxoSmithKline adjuvant systems in vaccines: Concepts, achievements and perspectives
    • Garcon, N.; Chomez, P.; van Mechelen, M. GlaxoSmithKline adjuvant systems in vaccines: Concepts, achievements and perspectives. Expert Rev. Vaccines 2007, 6, 723-739.
    • (2007) Expert Rev. Vaccines , vol.6 , pp. 723-739
    • Garcon, N.1    Chomez, P.2    van Mechelen, M.3
  • 154
    • 77249176352 scopus 로고    scopus 로고
    • AS04, an aluminum salt-and TLR4 agonist-based adjuvant system, induces a transient localized innate immune response leading to enhanced adaptive immunity
    • Didierlaurent, A. M.; Morel, S.; Lockman, L.; Giannini, S. L.; Bisteau, M.; Carlsen, H.; Kielland, A.; Vosters, O.; Vanderheyde, N.; Schiavetti, F.; et al. AS04, an aluminum salt-and TLR4 agonist-based adjuvant system, induces a transient localized innate immune response leading to enhanced adaptive immunity. J. Immunol. 2009, 183, 6186-6197.
    • (2009) J. Immunol , vol.183 , pp. 6186-6197
    • Didierlaurent, A.M.1    Morel, S.2    Lockman, L.3    Giannini, S.L.4    Bisteau, M.5    Carlsen, H.6    Kielland, A.7    Vosters, O.8    Vanderheyde, N.9    Schiavetti, F.10
  • 155
    • 37349033531 scopus 로고    scopus 로고
    • Synthetic Toll-like receptor 4 agonist enhances vaccine efficacy in an experimental model of toxic shock syndrome
    • Morefield, G. L.; Hawkins, L. D.; Ishizaka, S. T.; Kissner, T. L.; Ulrich, R. G. Synthetic Toll-like receptor 4 agonist enhances vaccine efficacy in an experimental model of toxic shock syndrome. Clin. Vaccine Immunol. 2007, 14, 1499-1504.
    • (2007) Clin. Vaccine Immunol , vol.14 , pp. 1499-1504
    • Morefield, G.L.1    Hawkins, L.D.2    Ishizaka, S.T.3    Kissner, T.L.4    Ulrich, R.G.5
  • 157
    • 0037013830 scopus 로고    scopus 로고
    • Interferon-alpha and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets
    • Ito, T.; Amakawa, R.; Kaisho, T.; Hemmi, H.; Tajima, K.; Uehira, K.; Ozaki, Y.; Tomizawa, H.; Akira, S.; Fukuhara, S. Interferon-alpha and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets. J. Exp. Med. 2002, 195, 1507-1512.
    • (2002) J. Exp. Med , vol.195 , pp. 1507-1512
    • Ito, T.1    Amakawa, R.2    Kaisho, T.3    Hemmi, H.4    Tajima, K.5    Uehira, K.6    Ozaki, Y.7    Tomizawa, H.8    Akira, S.9    Fukuhara, S.10
  • 158
    • 0034669965 scopus 로고    scopus 로고
    • Molecular mechanisms of B lymphocyte activation by the immune response modifier R-848
    • Bishop, G. A.; Hsing, Y.; Hostager, B. S.; Jalukar, S. V.; Ramirez, L. M.; Tomai, M. A. Molecular mechanisms of B lymphocyte activation by the immune response modifier R-848. J. Immunol. 2000, 165, 5552-5557.
    • (2000) J. Immunol , vol.165 , pp. 5552-5557
    • Bishop, G.A.1    Hsing, Y.2    Hostager, B.S.3    Jalukar, S.V.4    Ramirez, L.M.5    Tomai, M.A.6
  • 159
    • 22544473593 scopus 로고    scopus 로고
    • TLR7/8-mediated activation of human NK cells results in accessory cell-dependent IFN-gamma production
    • Hart, O. M.; Athie-Morales, V.; O'Connor, G. M.; Gardiner, C. M. TLR7/8-mediated activation of human NK cells results in accessory cell-dependent IFN-gamma production. J. Immunol. 2005, 175, 1636-1642.
    • (2005) J. Immunol , vol.175 , pp. 1636-1642
    • Hart, O.M.1    Athie-Morales, V.2    O'Connor, G.M.3    Gardiner, C.M.4
  • 162
    • 0036088492 scopus 로고    scopus 로고
    • Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848
    • doi: 10. 1038/ni0602-499
    • Jurk, M.; Heil, F.; Vollmer, J.; Schetter, C.; Krieg, A. M.; Wagner, H.; Lipford, G.; Bauer, S. Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848. Nat. Immunol. 2002, 3, doi: 10. 1038/ni0602-499.
    • (2002) Nat. Immunol , vol.3
    • Jurk, M.1    Heil, F.2    Vollmer, J.3    Schetter, C.4    Krieg, A.M.5    Wagner, H.6    Lipford, G.7    Bauer, S.8
  • 163
    • 0036570169 scopus 로고    scopus 로고
    • Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides
    • Hornung, V.; Rothenfusser, S.; Britsch, S.; Krug, A.; Jahrsdorfer, B.; Giese, T.; Endres, S.; Hartmann, G. Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J. Immunol. 2002, 168, 4531-4537.
    • (2002) J. Immunol , vol.168 , pp. 4531-4537
    • Hornung, V.1    Rothenfusser, S.2    Britsch, S.3    Krug, A.4    Jahrsdorfer, B.5    Giese, T.6    Endres, S.7    Hartmann, G.8
  • 164
    • 0029984358 scopus 로고    scopus 로고
    • CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma
    • Klinman, D. M.; Yi, A. K.; Beaucage, S. L.; Conover, J.; Krieg, A. M. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma. Proc. Natl. Acad. Sci. USA 1996, 93, 2879-2883.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 2879-2883
    • Klinman, D.M.1    Yi, A.K.2    Beaucage, S.L.3    Conover, J.4    Krieg, A.M.5
  • 165
    • 74249083537 scopus 로고    scopus 로고
    • CpG-enhanced CD8+ T-cell responses to peptide immunization are severely inhibited by B cells
    • Overstreet, M. G.; Freyberger, H.; Cockburn, I. A.; Chen, Y. C.; Tse, S. W.; Zavala, F. CpG-enhanced CD8+ T-cell responses to peptide immunization are severely inhibited by B cells. Eur. J. Immunol. 2010, 40, 124-133.
    • (2010) Eur. J. Immunol , vol.40 , pp. 124-133
    • Overstreet, M.G.1    Freyberger, H.2    Cockburn, I.A.3    Chen, Y.C.4    Tse, S.W.5    Zavala, F.6
  • 166
    • 0034777579 scopus 로고    scopus 로고
    • Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12
    • Krug, A.; Towarowski, A.; Britsch, S.; Rothenfusser, S.; Hornung, V.; Bals, R.; Giese, T.; Engelmann, H.; Endres, S.; Krieg, A. M.; et al. Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12. Eur. J. Immunol. 2001, 31, 3026-3037.
    • (2001) Eur. J. Immunol , vol.31 , pp. 3026-3037
    • Krug, A.1    Towarowski, A.2    Britsch, S.3    Rothenfusser, S.4    Hornung, V.5    Bals, R.6    Giese, T.7    Engelmann, H.8    Endres, S.9    Krieg, A.M.10
  • 169
    • 0035865054 scopus 로고    scopus 로고
    • Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs
    • Verthelyi, D.; Ishii, K. J.; Gursel, M.; Takeshita, F.; Klinman, D. M. Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs. J. Immunol. 2001, 166, 2372-2377.
    • (2001) J. Immunol , vol.166 , pp. 2372-2377
    • Verthelyi, D.1    Ishii, K.J.2    Gursel, M.3    Takeshita, F.4    Klinman, D.M.5
  • 171
    • 0142153984 scopus 로고    scopus 로고
    • Immunoregulatory activity of CpG oligonucleotides in humans and nonhuman primates
    • Verthelyi, D.; Klinman, D. M. Immunoregulatory activity of CpG oligonucleotides in humans and nonhuman primates. Clin. Immunol. 2003, 109, 64-71.
    • (2003) Clin. Immunol , vol.109 , pp. 64-71
    • Verthelyi, D.1    Klinman, D.M.2
  • 172
    • 84893053165 scopus 로고    scopus 로고
    • Recent progress concerning CpG DNA and its use as a vaccine adjuvant
    • Shirota, H.; Klinman, D. M. Recent progress concerning CpG DNA and its use as a vaccine adjuvant. Expert Rev. Vaccines 2014, 13, 299-312.
    • (2014) Expert Rev. Vaccines , vol.13 , pp. 299-312
    • Shirota, H.1    Klinman, D.M.2
  • 174
    • 0036644042 scopus 로고    scopus 로고
    • Cutting edge: Role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins
    • Takeuchi, O.; Sato, S.; Horiuchi, T.; Hoshino, K.; Takeda, K.; Dong, Z.; Modlin, R. L.; Akira, S. Cutting edge: Role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J. Immunol. 2002, 169, 10-14.
    • (2002) J. Immunol , vol.169 , pp. 10-14
    • Takeuchi, O.1    Sato, S.2    Horiuchi, T.3    Hoshino, K.4    Takeda, K.5    Dong, Z.6    Modlin, R.L.7    Akira, S.8
  • 176
    • 84875979474 scopus 로고    scopus 로고
    • Human lipopolysaccharide-binding protein (LBP) and CD14 independently deliver triacylated lipoproteins to Toll-like receptor 1 (TLR1) and TLR2 and enhance formation of the ternary signaling complex
    • Ranoa, D. R.; Kelley, S. L.; Tapping, R. I. Human lipopolysaccharide-binding protein (LBP) and CD14 independently deliver triacylated lipoproteins to Toll-like receptor 1 (TLR1) and TLR2 and enhance formation of the ternary signaling complex. J. Biol. Chem. 2013, 288, 9729-9741.
    • (2013) J. Biol. Chem , vol.288 , pp. 9729-9741
    • Ranoa, D.R.1    Kelley, S.L.2    Tapping, R.I.3
  • 179
    • 0038448227 scopus 로고    scopus 로고
    • Mycobacterial lipoarabinomannan mediates physical interactions between TLR1 and TLR2 to induce signaling
    • Tapping, R. I.; Tobias, P. S. Mycobacterial lipoarabinomannan mediates physical interactions between TLR1 and TLR2 to induce signaling. J. Endotoxin. Res. 2003, 9, 264-268.
    • (2003) J. Endotoxin. Res , vol.9 , pp. 264-268
    • Tapping, R.I.1    Tobias, P.S.2
  • 180
    • 33751176262 scopus 로고    scopus 로고
    • The beta-glucan receptor dectin-1 functions together with TLR2 to mediate macrophage activation by mycobacteria
    • Yadav, M.; Schorey, J. S. The beta-glucan receptor dectin-1 functions together with TLR2 to mediate macrophage activation by mycobacteria. Blood 2006, 108, 3168-3175.
    • (2006) Blood , vol.108 , pp. 3168-3175
    • Yadav, M.1    Schorey, J.S.2
  • 181
    • 0038205797 scopus 로고    scopus 로고
    • Direct binding of Toll-like receptor 2 to zymosan, and zymosan-induced NF-kappa B activation and TNF-alpha secretion are down-regulated by lung collectin surfactant protein A
    • Sato, M.; Sano, H.; Iwaki, D.; Kudo, K.; Konishi, M.; Takahashi, H.; Takahashi, T.; Imaizumi, H.; Asai, Y.; Kuroki, Y. Direct binding of Toll-like receptor 2 to zymosan, and zymosan-induced NF-kappa B activation and TNF-alpha secretion are down-regulated by lung collectin surfactant protein A. J. Immunol. 2003, 171, 417-425.
    • (2003) J. Immunol , vol.171 , pp. 417-425
    • Sato, M.1    Sano, H.2    Iwaki, D.3    Kudo, K.4    Konishi, M.5    Takahashi, H.6    Takahashi, T.7    Imaizumi, H.8    Asai, Y.9    Kuroki, Y.10
  • 182
    • 70350441863 scopus 로고    scopus 로고
    • Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands
    • Barbalat, R.; Lau, L.; Locksley, R. M.; Barton, G. M. Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands. Nat. Immunol. 2009, 10, 1200-1207.
    • (2009) Nat. Immunol , vol.10 , pp. 1200-1207
    • Barbalat, R.1    Lau, L.2    Locksley, R.M.3    Barton, G.M.4
  • 183
    • 0036453356 scopus 로고    scopus 로고
    • TLR2: Cellular sensor for microbial and endogenous molecular patterns
    • Kirschning, C. J.; Schumann, R. R. TLR2: Cellular sensor for microbial and endogenous molecular patterns. Curr. Top. Microbiol Immunol. 2002, 270, 121-144.
    • (2002) Curr. Top. Microbiol Immunol , vol.270 , pp. 121-144
    • Kirschning, C.J.1    Schumann, R.R.2
  • 186
    • 34548608447 scopus 로고    scopus 로고
    • Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide
    • Jin, M. S.; Kim, S. E.; Heo, J. Y.; Lee, M. E.; Kim, H. M.; Paik, S. G.; Lee, H.; Lee, J. O. Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell 2007, 130, 1071-1082.
    • (2007) Cell , vol.130 , pp. 1071-1082
    • Jin, M.S.1    Kim, S.E.2    Heo, J.Y.3    Lee, M.E.4    Kim, H.M.5    Paik, S.G.6    Lee, H.7    Lee, J.O.8
  • 187
  • 188
    • 84894451153 scopus 로고    scopus 로고
    • Crystallographic analysis of Neisseria meningitidis PorB extracellular loops potentially implicated in TLR2 recognition
    • Kattner, C.; Toussi, D. N.; Zaucha, J.; Wetzler, L. M.; Ruppel, N.; Zachariae, U.; Massari, P.; Tanabe, M. Crystallographic analysis of Neisseria meningitidis PorB extracellular loops potentially implicated in TLR2 recognition. J. Struct. Biol. 2013, 185, 440-447.
    • (2013) J. Struct. Biol , vol.185 , pp. 440-447
    • Kattner, C.1    Toussi, D.N.2    Zaucha, J.3    Wetzler, L.M.4    Ruppel, N.5    Zachariae, U.6    Massari, P.7    Tanabe, M.8
  • 189
    • 84899441022 scopus 로고    scopus 로고
    • The use of a TLR2 agonist-based adjuvant for enhancing effector and memory CD8 T-cell responses
    • doi: 10. 1038/icb. 2013. 102
    • Chua, B. Y.; Olson, M. R.; Bedoui, S.; Sekiya, T.; Wong, C. Y.; Turner, S. J.; Jackson, D. C. The use of a TLR2 agonist-based adjuvant for enhancing effector and memory CD8 T-cell responses. Immunol. Cell Biol. 2014, doi: 10. 1038/icb. 2013. 102.
    • (2014) Immunol. Cell Biol
    • Chua, B.Y.1    Olson, M.R.2    Bedoui, S.3    Sekiya, T.4    Wong, C.Y.5    Turner, S.J.6    Jackson, D.C.7
  • 190
    • 84866480526 scopus 로고    scopus 로고
    • A specific role for TLR1 in protective T(H)17 immunity during mucosal infection
    • DePaolo, R. W.; Kamdar, K.; Khakpour, S.; Sugiura, Y.; Wang, W.; Jabri, B. A specific role for TLR1 in protective T(H)17 immunity during mucosal infection. J. Exp. Med. 2012, 209, 1437-1444.
    • (2012) J. Exp. Med , vol.209 , pp. 1437-1444
    • DePaolo, R.W.1    Kamdar, K.2    Khakpour, S.3    Sugiura, Y.4    Wang, W.5    Jabri, B.6
  • 193
    • 0347479229 scopus 로고    scopus 로고
    • Molecular basis of bacterial outer membrane permeability revisited
    • Nikaido, H. Molecular basis of bacterial outer membrane permeability revisited. Microbiol. Mol. Biol. Rev. 2003, 67, 593-656.
    • (2003) Microbiol. Mol. Biol. Rev , vol.67 , pp. 593-656
    • Nikaido, H.1
  • 195
    • 38349075841 scopus 로고    scopus 로고
    • The PorB porin from commensal Neisseria lactamica induces Th1 and Th2 immune responses to ovalbumin in mice and is a potential immune adjuvant
    • Liu, X.; Wetzler, L. M.; Massari, P. The PorB porin from commensal Neisseria lactamica induces Th1 and Th2 immune responses to ovalbumin in mice and is a potential immune adjuvant. Vaccine 2008, 26, 786-796.
    • (2008) Vaccine , vol.26 , pp. 786-796
    • Liu, X.1    Wetzler, L.M.2    Massari, P.3
  • 196
    • 84863555191 scopus 로고    scopus 로고
    • The fomA porin from Fusobacterium nucleatum is a toll-like receptor 2 agonist with immune adjuvant activity
    • Toussi, D. N.; Liu, X.; Massari, P. The fomA porin from Fusobacterium nucleatum is a toll-like receptor 2 agonist with immune adjuvant activity. Clin. Vaccine Immunol. 2012, 19, 1093-1101.
    • (2012) Clin. Vaccine Immunol , vol.19 , pp. 1093-1101
    • Toussi, D.N.1    Liu, X.2    Massari, P.3
  • 197
    • 0344082190 scopus 로고    scopus 로고
    • Porin of Shigella dysenteriae enhances mRNA levels for Toll-like receptor 2 and MyD88, up-regulates CD80 of murine macrophage, and induces the release of interleukin-12
    • Ray, A.; Chatterjee, N. S.; Bhattacharya, S. K.; Biswas, T. Porin of Shigella dysenteriae enhances mRNA levels for Toll-like receptor 2 and MyD88, up-regulates CD80 of murine macrophage, and induces the release of interleukin-12. FEMS Immunol. Med. Microbiol. 2003, 39, 213-219.
    • (2003) FEMS Immunol. Med. Microbiol , vol.39 , pp. 213-219
    • Ray, A.1    Chatterjee, N.S.2    Bhattacharya, S.K.3    Biswas, T.4
  • 198
    • 57049128125 scopus 로고    scopus 로고
    • Porin-incorporated liposome induces Toll-like receptors 2-and 6-dependent maturation and type 1 response of dendritic cell
    • Banerjee, P.; Biswas, A.; Biswas, T. Porin-incorporated liposome induces Toll-like receptors 2-and 6-dependent maturation and type 1 response of dendritic cell. Int. Immunol. 2008, 20, 1551-1563.
    • (2008) Int. Immunol , vol.20 , pp. 1551-1563
    • Banerjee, P.1    Biswas, A.2    Biswas, T.3
  • 199
    • 0029935132 scopus 로고    scopus 로고
    • Neisserial porins induce B lymphocytes to express costimulatory B7-2 molecules and to proliferate
    • Wetzler, L. M.; Ho, Y.; Reiser, H. Neisserial porins induce B lymphocytes to express costimulatory B7-2 molecules and to proliferate. J. Exp. Med. 1996, 183, 1151-1159.
    • (1996) J. Exp. Med , vol.183 , pp. 1151-1159
    • Wetzler, L.M.1    Ho, Y.2    Reiser, H.3
  • 200
    • 84892405164 scopus 로고    scopus 로고
    • In vivo and In vitro characterization of the immune stimulating activity of the Neisserial Porin PorB
    • Platt, A.; Macleod, H.; Massari, P.; Liu, X.; Wetzler, L. In vivo and In vitro characterization of the immune stimulating activity of the Neisserial Porin PorB. PLoS One 2013, 8, e82171.
    • (2013) PLoS One , vol.8
    • Platt, A.1    Macleod, H.2    Massari, P.3    Liu, X.4    Wetzler, L.5
  • 201
    • 0027494015 scopus 로고
    • GD3/proteosome vaccines induce consistent IgM antibodies against the ganglioside GD3
    • Livingston, P. O.; Calves, M. J.; Helling, F.; Zollinger, W. D.; Blake, M. S.; Lowell, G. H. GD3/proteosome vaccines induce consistent IgM antibodies against the ganglioside GD3. Vaccine 1993, 11, 1199-1204.
    • (1993) Vaccine , vol.11 , pp. 1199-1204
    • Livingston, P.O.1    Calves, M.J.2    Helling, F.3    Zollinger, W.D.4    Blake, M.S.5    Lowell, G.H.6
  • 202
    • 0026458260 scopus 로고
    • Structure and function of cholera toxin and the related Escherichia coli heat-labile enterotoxin
    • Spangler, B. D. Structure and function of cholera toxin and the related Escherichia coli heat-labile enterotoxin. Microbiol. Rev. 1992, 56, 622-647.
    • (1992) Microbiol. Rev , vol.56 , pp. 622-647
    • Spangler, B.D.1
  • 204
    • 78650578052 scopus 로고    scopus 로고
    • LT-IIc, a new member of the type II heat-labile enterotoxin family, exhibits potent immunomodulatory properties that are different from those induced by LT-IIa or LT-IIb
    • Nawar, H. F.; Greene, C. J.; Lee, C. H.; Mandell, L. M.; Hajishengallis, G.; Connell, T. D. LT-IIc, a new member of the type II heat-labile enterotoxin family, exhibits potent immunomodulatory properties that are different from those induced by LT-IIa or LT-IIb. Vaccine 2011, 29, 721-727.
    • (2011) Vaccine , vol.29 , pp. 721-727
    • Nawar, H.F.1    Greene, C.J.2    Lee, C.H.3    Mandell, L.M.4    Hajishengallis, G.5    Connell, T.D.6
  • 205
    • 0033982070 scopus 로고    scopus 로고
    • Mucosal vaccination and immune responses in the elderly
    • Fujihashi, K.; Koga, T.; McGhee, J. R. Mucosal vaccination and immune responses in the elderly. Vaccine 2000, 18, 1675-1680.
    • (2000) Vaccine , vol.18 , pp. 1675-1680
    • Fujihashi, K.1    Koga, T.2    McGhee, J.R.3
  • 206
    • 79954535010 scopus 로고    scopus 로고
    • Characterization of a mutant Escherichia coli heat-labile toxin, LT(R192G/L211A), as a safe and effective oral adjuvant
    • Norton, E. B.; Lawson, L. B.; Freytag, L. C.; Clements, J. D. Characterization of a mutant Escherichia coli heat-labile toxin, LT(R192G/L211A), as a safe and effective oral adjuvant. Clin. Vaccine Immunol. 2011, 18, 546-551.
    • (2011) Clin. Vaccine Immunol , vol.18 , pp. 546-551
    • Norton, E.B.1    Lawson, L.B.2    Freytag, L.C.3    Clements, J.D.4
  • 207
    • 0031986493 scopus 로고    scopus 로고
    • Protection against Helicobacter pylori infection in mice by intragastric vaccination with H. pylori antigens is achieved using a non-toxic mutant of E. coli heat-labile enterotoxin (LT) as adjuvant
    • Marchetti, M.; Rossi, M.; Giannelli, V.; Giuliani, M. M.; Pizza, M.; Censini, S.; Covacci, A.; Massari, P.; Pagliaccia, C.; Manetti, R.; et al. Protection against Helicobacter pylori infection in mice by intragastric vaccination with H. pylori antigens is achieved using a non-toxic mutant of E. coli heat-labile enterotoxin (LT) as adjuvant. Vaccine 1998, 16, 33-37.
    • (1998) Vaccine , vol.16 , pp. 33-37
    • Marchetti, M.1    Rossi, M.2    Giannelli, V.3    Giuliani, M.M.4    Pizza, M.5    Censini, S.6    Covacci, A.7    Massari, P.8    Pagliaccia, C.9    Manetti, R.10
  • 208
    • 70349621646 scopus 로고    scopus 로고
    • Transient facial nerve paralysis (Bell's palsy) following intranasal delivery of a genetically detoxified mutant of Escherichia coli heat labile toxin
    • Lewis, D. J.; Huo, Z.; Barnett, S.; Kromann, I.; Giemza, R.; Galiza, E.; Woodrow, M.; Thierry-Carstensen, B.; Andersen, P.; Novicki, D.; et al. Transient facial nerve paralysis (Bell's palsy) following intranasal delivery of a genetically detoxified mutant of Escherichia coli heat labile toxin. PLoS One 2009, 4 e6999.
    • (2009) PLoS One , vol.4
    • Lewis, D.J.1    Huo, Z.2    Barnett, S.3    Kromann, I.4    Giemza, R.5    Galiza, E.6    Woodrow, M.7    Thierry-Carstensen, B.8    Andersen, P.9    Novicki, D.10
  • 209
    • 34247174980 scopus 로고    scopus 로고
    • The A subunit of type IIb enterotoxin (LT-IIb) suppresses the proinflammatory potential of the B subunit and its ability to recruit and interact with TLR2
    • Liang, S.; Wang, M.; Triantafilou, K.; Triantafilou, M.; Nawar, H. F.; Russell, M. W.; Connell, T. D.; Hajishengallis, G. The A subunit of type IIb enterotoxin (LT-IIb) suppresses the proinflammatory potential of the B subunit and its ability to recruit and interact with TLR2. J. Immunol. 2007, 178, 4811-4819.
    • (2007) J. Immunol , vol.178 , pp. 4811-4819
    • Liang, S.1    Wang, M.2    Triantafilou, K.3    Triantafilou, M.4    Nawar, H.F.5    Russell, M.W.6    Connell, T.D.7    Hajishengallis, G.8
  • 210
    • 80055096366 scopus 로고    scopus 로고
    • TLR2-dependent modulation of dendritic cells by LT-IIa-B5, a novel mucosal adjuvant derived from a type II heat-labile enterotoxin
    • Lee, C. H.; Masso-Welch, P.; Hajishengallis, G.; Connell, T. D. TLR2-dependent modulation of dendritic cells by LT-IIa-B5, a novel mucosal adjuvant derived from a type II heat-labile enterotoxin. J. Leukoc. Biol. 2011, 90, 911-921.
    • (2011) J. Leukoc. Biol , vol.90 , pp. 911-921
    • Lee, C.H.1    Masso-Welch, P.2    Hajishengallis, G.3    Connell, T.D.4
  • 211
    • 0033972890 scopus 로고    scopus 로고
    • Comparative analysis of the mucosal adjuvanticity of the type II heat-labile enterotoxins LT-IIa and LT-IIb
    • Martin, M.; Metzger, D. J.; Michalek, S. M.; Connell, T. D.; Russell, M. W. Comparative analysis of the mucosal adjuvanticity of the type II heat-labile enterotoxins LT-IIa and LT-IIb. Infect. Immun. 2000, 68, 281-287.
    • (2000) Infect. Immun , vol.68 , pp. 281-287
    • Martin, M.1    Metzger, D.J.2    Michalek, S.M.3    Connell, T.D.4    Russell, M.W.5
  • 212
    • 79961115546 scopus 로고    scopus 로고
    • Distinctive immunomodulatory and inflammatory properties of the Escherichia coli type II heat-labile enterotoxin LT-IIa and its B pentamer following intradermal administration
    • Mathias-Santos, C.; Rodrigues, J. F.; Sbrogio-Almeida, M. E.; Connell, T. D.; Ferreira, L. C. Distinctive immunomodulatory and inflammatory properties of the Escherichia coli type II heat-labile enterotoxin LT-IIa and its B pentamer following intradermal administration. Clin. Vaccine Immunol. 2011, 18, 1243-1251.
    • (2011) Clin. Vaccine Immunol , vol.18 , pp. 1243-1251
    • Mathias-Santos, C.1    Rodrigues, J.F.2    Sbrogio-Almeida, M.E.3    Connell, T.D.4    Ferreira, L.C.5
  • 213
    • 17644386241 scopus 로고    scopus 로고
    • Differential binding of Escherichia coli enterotoxins LT-IIa and LT-IIb and of cholera toxin elicits differences in apoptosis, proliferation, and activation of lymphoid cells
    • Arce, S.; Nawar, H. F.; Russell, M. W.; Connell, T. D. Differential binding of Escherichia coli enterotoxins LT-IIa and LT-IIb and of cholera toxin elicits differences in apoptosis, proliferation, and activation of lymphoid cells. Infect. Immun. 2005, 73, 2718-2727.
    • (2005) Infect. Immun , vol.73 , pp. 2718-2727
    • Arce, S.1    Nawar, H.F.2    Russell, M.W.3    Connell, T.D.4
  • 214
    • 77953167145 scopus 로고    scopus 로고
    • Binding to gangliosides containing N-acetylneuraminic acid is sufficient to mediate the immunomodulatory properties of the nontoxic mucosal adjuvant LT-IIb(T13I)
    • Nawar, H. F.; Berenson, C. S.; Hajishengallis, G.; Takematsu, H.; Mandell, L.; Clare, R. L.; Connell, T. D. Binding to gangliosides containing N-acetylneuraminic acid is sufficient to mediate the immunomodulatory properties of the nontoxic mucosal adjuvant LT-IIb(T13I). Clin. Vaccine Immunol. 2010, 17, 969-978.
    • (2010) Clin. Vaccine Immunol , vol.17 , pp. 969-978
    • Nawar, H.F.1    Berenson, C.S.2    Hajishengallis, G.3    Takematsu, H.4    Mandell, L.5    Clare, R.L.6    Connell, T.D.7
  • 215
    • 84881021363 scopus 로고    scopus 로고
    • LT-IIb(T13I), a non-toxic type II heat-labile enterotoxin, augments the capacity of a ricin toxin subunit vaccine to evoke neutralizing antibodies and protective immunity
    • Greene, C. J.; Chadwick, C. M.; Mandell, L. M.; Hu, J. C.; O'Hara, J. M.; Brey, R. N., III; Mantis, N. J.; Connell, T. D. LT-IIb(T13I), a non-toxic type II heat-labile enterotoxin, augments the capacity of a ricin toxin subunit vaccine to evoke neutralizing antibodies and protective immunity. PLoS One 2013, 8, e69678.
    • (2013) PLoS One , vol.8
    • Greene, C.J.1    Chadwick, C.M.2    Mandell, L.M.3    Hu, J.C.4    O'Hara, J.M.5    Brey III, R.N.6    Mantis, N.J.7    Connell, T.D.8
  • 216
    • 4444340990 scopus 로고    scopus 로고
    • Direct bacterial protein PAMP recognition by human NK cells involves TLRs and triggers alpha-defensin production
    • Chalifour, A.; Jeannin, P.; Gauchat, J. F.; Blaecke, A.; Malissard, M.; N'Guyen, T.; Thieblemont, N.; Delneste, Y. Direct bacterial protein PAMP recognition by human NK cells involves TLRs and triggers alpha-defensin production. Blood 2004, 104, 1778-1783.
    • (2004) Blood , vol.104 , pp. 1778-1783
    • Chalifour, A.1    Jeannin, P.2    Gauchat, J.F.3    Blaecke, A.4    Malissard, M.5    N'Guyen, T.6    Thieblemont, N.7    Delneste, Y.8
  • 217
    • 0038222345 scopus 로고    scopus 로고
    • The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells
    • Means, T. K.; Hayashi, F.; Smith, K. D.; Aderem, A.; Luster, A. D. The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells. J. Immunol. 2003, 170, 5165-5175.
    • (2003) J. Immunol , vol.170 , pp. 5165-5175
    • Means, T.K.1    Hayashi, F.2    Smith, K.D.3    Aderem, A.4    Luster, A.D.5
  • 219
    • 59849094301 scopus 로고    scopus 로고
    • Activated human neonatal CD8+ T cells are subject to immunomodulation by direct TLR2 or TLR5 stimulation
    • McCarron, M.; Reen, D. J. Activated human neonatal CD8+ T cells are subject to immunomodulation by direct TLR2 or TLR5 stimulation. J. Immunol. 2009, 182, 55-62.
    • (2009) J. Immunol , vol.182 , pp. 55-62
    • McCarron, M.1    Reen, D.J.2
  • 220
    • 67649209809 scopus 로고    scopus 로고
    • Direct stimulation of tlr5+/+ CD11c+ cells is necessary for the adjuvant activity of flagellin
    • Bates, J. T.; Uematsu, S.; Akira, S.; Mizel, S. B. Direct stimulation of tlr5+/+ CD11c+ cells is necessary for the adjuvant activity of flagellin. J. Immunol. 2009, 182, 7539-7547.
    • (2009) J. Immunol , vol.182 , pp. 7539-7547
    • Bates, J.T.1    Uematsu, S.2    Akira, S.3    Mizel, S.B.4
  • 222
    • 76749122801 scopus 로고    scopus 로고
    • Recombinant flagellins with partial deletions of the hypervariable domain lose antigenicity but not mucosal adjuvancy
    • Liu, F.; Yang, J.; Zhang, Y.; Zhou, D.; Chen, Y.; Gai, W.; Shi, W.; Li, Q.; Tien, P.; Yan, H. Recombinant flagellins with partial deletions of the hypervariable domain lose antigenicity but not mucosal adjuvancy. Biochem. Biophys. Res. Commun. 2010, 392, 582-587.
    • (2010) Biochem. Biophys. Res. Commun , vol.392 , pp. 582-587
    • Liu, F.1    Yang, J.2    Zhang, Y.3    Zhou, D.4    Chen, Y.5    Gai, W.6    Shi, W.7    Li, Q.8    Tien, P.9    Yan, H.10
  • 223
    • 84876986561 scopus 로고    scopus 로고
    • Antigen replacement of domains D2 and D3 in flagellin promotes mucosal IgA production and attenuates flagellin-induced inflammatory response after intranasal immunization
    • Yang, J.; Zhong, M.; Zhang, Y.; Zhang, E.; Sun, Y.; Cao, Y.; Li, Y.; Zhou, D.; He, B.; Chen, Y.; et al. Antigen replacement of domains D2 and D3 in flagellin promotes mucosal IgA production and attenuates flagellin-induced inflammatory response after intranasal immunization. Hum. Vaccin. Immunother. 2013, 9, 1084-1092.
    • (2013) Hum. Vaccin. Immunother , vol.9 , pp. 1084-1092
    • Yang, J.1    Zhong, M.2    Zhang, Y.3    Zhang, E.4    Sun, Y.5    Cao, Y.6    Li, Y.7    Zhou, D.8    He, B.9    Chen, Y.10
  • 224
    • 78649605448 scopus 로고    scopus 로고
    • TLR5 or NLRC4 is necessary and sufficient for promotion of humoral immunity by flagellin
    • Vijay-Kumar, M.; Carvalho, F. A.; Aitken, J. D.; Fifadara, N. H.; Gewirtz, A. T. TLR5 or NLRC4 is necessary and sufficient for promotion of humoral immunity by flagellin. Eur. J. Immunol. 2010, 40, 3528-3534.
    • (2010) Eur. J. Immunol , vol.40 , pp. 3528-3534
    • Vijay-Kumar, M.1    Carvalho, F.A.2    Aitken, J.D.3    Fifadara, N.H.4    Gewirtz, A.T.5
  • 225
    • 84890933681 scopus 로고    scopus 로고
    • CD103-CD11b+ dendritic cells regulate the sensitivity of CD4 T-cell responses to bacterial flagellin
    • Atif, S. M.; Uematsu, S.; Akira, S.; McSorley, S. J. CD103-CD11b+ dendritic cells regulate the sensitivity of CD4 T-cell responses to bacterial flagellin. Mucosal. Immunol. 2014, 7, 68-77.
    • (2014) Mucosal. Immunol , vol.7 , pp. 68-77
    • Atif, S.M.1    Uematsu, S.2    Akira, S.3    McSorley, S.J.4
  • 226
    • 84873079109 scopus 로고    scopus 로고
    • Vaccination with recombinant FimH fused with flagellin enhances cellular and humoral immunity against urinary tract infection in mice
    • Asadi Karam, M. R.; Oloomi, M.; Mahdavi, M.; Habibi, M.; Bouzari, S. Vaccination with recombinant FimH fused with flagellin enhances cellular and humoral immunity against urinary tract infection in mice. Vaccine 2013, 31, 1210-1216.
    • (2013) Vaccine , vol.31 , pp. 1210-1216
    • Asadi Karam, M.R.1    Oloomi, M.2    Mahdavi, M.3    Habibi, M.4    Bouzari, S.5
  • 227
    • 77953948201 scopus 로고    scopus 로고
    • A recombinant flagellin-poxvirus fusion protein vaccine elicits complement-dependent protection against respiratory challenge with vaccinia virus in mice
    • Delaney, K. N.; Phipps, J. P.; Johnson, J. B.; Mizel, S. B. A recombinant flagellin-poxvirus fusion protein vaccine elicits complement-dependent protection against respiratory challenge with vaccinia virus in mice. Viral Immunol. 2010, 23, 201-210.
    • (2010) Viral Immunol , vol.23 , pp. 201-210
    • Delaney, K.N.1    Phipps, J.P.2    Johnson, J.B.3    Mizel, S.B.4
  • 228
    • 70350564882 scopus 로고    scopus 로고
    • Immunization of young African green monkeys with OprF epitope 8-OprI-type A-and B-flagellin fusion proteins promotes the production of protective antibodies against nonmucoid Pseudomonas aeruginosa
    • Weimer, E. T.; Ervin, S. E.; Wozniak, D. J.; Mizel, S. B. Immunization of young African green monkeys with OprF epitope 8-OprI-type A-and B-flagellin fusion proteins promotes the production of protective antibodies against nonmucoid Pseudomonas aeruginosa. Vaccine 2009, 27, 6762-6769.
    • (2009) Vaccine , vol.27 , pp. 6762-6769
    • Weimer, E.T.1    Ervin, S.E.2    Wozniak, D.J.3    Mizel, S.B.4
  • 229
    • 72049122659 scopus 로고    scopus 로고
    • Drugs targeting Toll-like receptors
    • Krishnan, J.; Lee, G.; Choi, S. Drugs targeting Toll-like receptors. Arch. Pharm. Res. 2009, 32, 1485-1502.
    • (2009) Arch. Pharm. Res , vol.32 , pp. 1485-1502
    • Krishnan, J.1    Lee, G.2    Choi, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.