The low-toxicity versions of LPS, MPL® adjuvant and RC529, are efficient adjuvants for CD4+ T cells

Journal of Leukocyte Biology

Volumn 78, Issue 6, 2005, Pages 1273-1280

  Thompson, Bruce S ^a   Chilton, Paula M ^a   Ward, Jon R ^b   Evans, Jay T ^b   Mitchell, Thomas C ^a,c  

^a University of Louisville School of Medicine   (United States)

^b GLAXOSMITHKLINE   (United States)

^c UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

AGP compounds; Clonal expansion; Mice; T cell survival; Toll like receptors

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CD4 ANTIGEN; CYTOKINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; PHOSPHORYL LIPID A; SERUM AMYLOID A; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ACUTE TOXICITY; ANIMAL CELL; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HELPER CELL; IMMUNIZATION; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TH1 CELL;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; IMMUNITY; INFLAMMATION; INTERFERON TYPE II; LIPID A; LIPOPOLYSACCHARIDES; MICE; MICE, TRANSGENIC; TH1 CELLS; TOLL-LIKE RECEPTORS;

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 28844442949     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0305172     Document Type: Article

References (27)

1. Vella, A. T., McCormack, J. E., Linsley, P. S., Kappler, J. W., Marrack, P. (1995) Lipopolysaccharide interferes with the induction of peripheral T cell death. Immunity 2, 261-270.
2. Mitchell, T. C., Hildeman, D., Kedl, R. M., Teague, T. K., Schaefer, B. C., White, J., Zhu, Y., Kappler, J., Marrack, P. (2001) Immunological adjuvants promote activated T cell survival via induction of Bcl-3. Nat. Immunol. 2, 397-402.
3. Maxwell, J. R., Ruby, C., Kerkvliet, N. I., Vella, A. T. (2002) Contrasting the roles of costimulation and the natural adjuvant lipopolysaccharide during the induction of T cell immunity. J. Immunol. 168, 4372-4381.
4. Ribi, E., Parker, R., Strain, S. M., Mizuno, Y., Nowotny, A., von Eschen, K. B., Cantrell, J. L. McLaughlin, C. A., Hwang, K. M., Goren, M. B. (1979) Peptides as requirement for immunotherapy of the guinea-pig line-10 tumor with endotoxins. Cancer Immunol. Immunother. 7, 43-58.
5. Ulrich, J. T., Myers, K. R. (1995) Monophosphoryl lipid A as an adjuvant. Past experiences and new directions. Pharm. Biotechnol. 6, 495-524.
6. De Becker, G., Moulin, V., Pajak, B., Bruck, C., Francotte, M., Thiriart, C., Urbain, J., Moser, M. (2000) The adjuvant monophosphoryl lipid A increases the function of antigen-presenting cells. Int. Immunol. 12, 807-815.
7. Ismaili, J., Rennesson, J., Aksoy, E., Vekemans, J., Vincart, B., Amraoui, Z., Van, L. F., Goldman, M., Dubois, P. M. (2002) Monophosphoryl lipid A activates both human dendritic cells and T cells. J. Immunol. 168, 926-932.
8. Evans, J. T., Cluff, C. W., Johnson, D. A., Lacy, M. J., Persing, D. H., Baldridge, J. R. (2003) Enhancement of antigen-specific immunity via the TLR4 ligands MPL adjuvant and Ribi.529. Expert Rev. Vaccines 2, 219-229.
9. Baldridge, J. R., McGowan, P., Evans, J. T., Cluff, C., Mossman, S., Johnson, D., Persing, D. (2004) Taking a Toll on human disease: Toll-like receptor 4 agonists as vaccine adjuvants and monotherapeutic agents. Expert Opin. Biol. Ther. 4, 1129-1138.
10. Johnson, D. A., Sowell, C. G., Johnson, C. L., Livesay, M. T., Keegan, D. S., Rhodes, M. J., Ulrich, J. T., Ward, J. R., Cantrell, J. L., Brookshire, V. G. (1999) Synthesis and biological evaluation of a new class of vaccine adjuvants: aminoalkyl glucosaminide 4-phosphates (AGPs). Bioorg. Med. Chem. Lett. 9, 2273-2278.
11. Murphy, K. M., Heimberger, A. B., Loh, D. Y. (1990) Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo. Science 250, 1720-1723.
12. Gomez-Angelats, M., Bortner, C. D., Cidlowski, J. A. (2000) Cell volume regulation in immune cell apoptosis. Cell Tissue Res. 301, 33-42.
13. Thompson, B. S., Mitchell, T. C. (2004) Measurement of daughter cell accumulation during lymphocyte proliferation in vivo. J. Immunol. Methods 295, 79-87.
14. Stover, A. G., Da Silva, C. J., Evans, J. T., Cluff, C. W., Elliott, M. W., Jeffery, E. W., Johnson, D. A., Lacy, M. J., Baldridge, J. R., Probst, P., Ulevitch, R. J., Persing, D. H., Hershberg, R. M. (2004) Structure-activity relationship of synthetic Toll-like receptor 4 agonists. J. Biol. Chem. 279, 4440-4449.
15. Mitchell, T. C., Teague, T. K., Hildeman, D. A., Bender, J., Rees, W. A., Kedl, R. M., Swanson, B., Kappler, J. W., Marrack, P. (2002) Stronger correlation of bcl-3 than bcl-2, bcl-xL, costimulation, or antioxidants with adjuvant-induced T cell survival. Ann. N. Y. Acad. Sci. 975, 114-131.
16. Marhaug, G., Permin, H., Husby, G. (1983) Amyloid-related serum protein (SAA) as an indicator of lung infection in cystic fibrosis. Acta Paediatr. Scand. 72, 861-866.
17. Ochrietor, J. D., Harrison, K. A., Zahedi, K., Mortensen, R. F. (2000) Role of STAT3 and C/EBP in cytokine-dependent expression of the mouse serum amyloid P-component (SAP) and C-reactive protein (CRP) genes. Cytokine 12, 888-899.
18. Pasare, C., Medzhitov, R. (2004) Toll-dependent control mechanisms of CD4 T cell activation. Immunity 21, 733-741.
19. Sporri, R., Reis e Sousa, C. (2005) Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4+ T cell populations lacking helper function. Nat. Immunol. 6, 163-170.
20. Croft, M. (2003) Co-stimulatory members of the TNFR family: keys to effective T-cell immunity? Nat. Rev. Immunol. 3, 609-620.
21. Khoruts, A., Osness, R. E., Jenkins, M. K. (2004) IL-1 acts on antigen-presenting cells to enhance the in vivo proliferation of antigen-stimulated naive CD4 T cells via a CD28-dependent mechanism that does not involve increased expression of CD28 ligands. Eur. J. Immunol. 34, 1085-1090.
22. Dooms, H., Kahn, E., Knoechel, B., Abbas, A. K. (2004) IL-2 induces a competitive survival advantage in T lymphocytes. J. Immunol. 172, 5973-5979.
23. Li, J., Huston, G., Swain, S. L. (2003) IL-7 promotes the transition of CD4 effectors to persistent memory cells. J. Exp. Med. 198, 1807-1815.
24. Khan, I. A., MacLean, J. A., Lee, F. S., Casciotti, L., DeHaan, E., Schwartzman, J. D., Luster, A. D. (2000) IP-10 is critical for effector T cell trafficking and host survival in Toxoplasma gondii infection. Immunity 12, 483-494.
25. Wornle, M., Schmid, H., Merkle, M., Banas, B. (2004) Effects of chemokines on proliferation and apoptosis of human mesangial cells. BMC Nephrol. 5, 8.
26. Leung, T. H., Hoffmann, A., Baltimore, D. (2004) One nucleotide in a κB site can determine cofactor specificity for NF-κB dimers. Cell 118, 453-464.
27. Tylaska, L. A., Boring, L., Weng, W., Aiello, R., Charo, I. F., Rollins, B. J., Gladue, R. P. (2002) CCR2 regulates the level of MCP-1/CCL2 in vitro and at inflammatory sites and controls T cell activation in response to alloantigen. Cytokine 18, 184-190.