-
1
-
-
0035524488
-
Toll-like receptors and innate immunity
-
Medzhitov, R. 2001. Toll-like receptors and innate immunity. Nat. Rev. Immunol. 1:135.
-
(2001)
Nat. Rev. Immunol.
, vol.1
, pp. 135
-
-
Medzhitov, R.1
-
2
-
-
0034972226
-
Toll-like receptors and innate immunity
-
Akira, S. 2001. Toll-like receptors and innate immunity. Adv. Immunol. 78:1.
-
(2001)
Adv. Immunol.
, vol.78
, pp. 1
-
-
Akira, S.1
-
3
-
-
0141959224
-
LPS-TLR4 signaling to IRF-3/7 and NF-κB involves the Toll adapters TRAM and TRIF
-
Fitzgerald, K., D. Rowe, B. Barnes, D. Caffrey, A. Visintin, E. Latz, B. Monks, P. Pitha, and D. Golenbock. 2003. LPS-TLR4 signaling to IRF-3/7 and NF-κB involves the Toll adapters TRAM and TRIF. J. Exp. Med. 198:1043.
-
(2003)
J. Exp. Med.
, vol.198
, pp. 1043
-
-
Fitzgerald, K.1
Rowe, D.2
Barnes, B.3
Caffrey, D.4
Visintin, A.5
Latz, E.6
Monks, B.7
Pitha, P.8
Golenbock, D.9
-
4
-
-
0242624622
-
TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway
-
Yamamoto, M., S. Sato, H. Hemmi, S. Uematsu, K. Hoshino, T. Kaisho, O. Takeuchi, K. Takeda, and S. Akira. 2003. TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat. Immunol. 4:1144.
-
(2003)
Nat. Immunol.
, vol.4
, pp. 1144
-
-
Yamamoto, M.1
Sato, S.2
Hemmi, H.3
Uematsu, S.4
Hoshino, K.5
Kaisho, T.6
Takeuchi, O.7
Takeda, K.8
Akira, S.9
-
5
-
-
0043176281
-
Role of adaptor TRIF in the MyD88-independent Toll-like receptor signaling pathway
-
Yamamoto, M., S. Sato, H. Hemmi, K. Hoshino, T. Kaisho, H. Sanjo, O. Takeuchi, M. Sugiyama, M. Okabe, K. Takeda, et al. 2003. Role of adaptor TRIF in the MyD88-independent Toll-like receptor signaling pathway. Science 301:640.
-
(2003)
Science
, vol.301
, pp. 640
-
-
Yamamoto, M.1
Sato, S.2
Hemmi, H.3
Hoshino, K.4
Kaisho, T.5
Sanjo, H.6
Takeuchi, O.7
Sugiyama, M.8
Okabe, M.9
Takeda, K.10
-
7
-
-
0037672694
-
Myeloid differentiation factor 88-dependent and -independent pathways in Toll-like receptor signaling
-
Akira, S., and K. Hoshino. 2003. Myeloid differentiation factor 88-dependent and -independent pathways in Toll-like receptor signaling. J. Infect. Dis. 187 Suppl. 2:S356.
-
(2003)
J. Infect. Dis. 187 Suppl.
, vol.2
-
-
Akira, S.1
Hoshino, K.2
-
8
-
-
0030831210
-
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
-
Medzhitov, R., P. Preston Hurlburt, and C. A. Janeway. 1997. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388:394.
-
(1997)
Nature
, vol.388
, pp. 394
-
-
Medzhitov, R.1
Preston Hurlburt, P.2
Janeway, C.A.3
-
9
-
-
0035179882
-
Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells
-
Jarrossay, D., G. Napolitani, M. Colonna, F. Sallusto, and A. Lanzavecchia. 2001. Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells. Eur. J. Immunol. 31:3388.
-
(2001)
Eur. J. Immunol.
, vol.31
, pp. 3388
-
-
Jarrossay, D.1
Napolitani, G.2
Colonna, M.3
Sallusto, F.4
Lanzavecchia, A.5
-
10
-
-
0037013830
-
Interferon-α and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets
-
Ito, T., R. Amakawa, T. Kaisho, H. Hemmi, K. Tajima, K. Uehira, Y. Ozaki, H. Tomizawa, S. Akira, and S. Fukuhara. 2002. Interferon-α and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets. J. Exp. Med. 195:1507.
-
(2002)
J. Exp. Med.
, vol.195
, pp. 1507
-
-
Ito, T.1
Amakawa, R.2
Kaisho, T.3
Hemmi, H.4
Tajima, K.5
Uehira, K.6
Ozaki, Y.7
Tomizawa, H.8
Akira, S.9
Fukuhara, S.10
-
11
-
-
0034777579
-
Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12
-
Krug, A., A. Towarowski, S. Britsch, S. Rothenfusser, V. Hornung, R. Bals, T. Giese, H. Engelmann, S. Endres, A. M. Krieg, et al. 2001. Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12. Eur. J. Immunol. 31:3026.
-
(2001)
Eur. J. Immunol.
, vol.31
, pp. 3026
-
-
Krug, A.1
Towarowski, A.2
Britsch, S.3
Rothenfusser, S.4
Hornung, V.5
Bals, R.6
Giese, T.7
Engelmann, H.8
Endres, S.9
Krieg, A.M.10
-
12
-
-
0035903288
-
Subsets of human dendritic cell precursors express different Toll-like receptors and respond to different microbial antigens
-
Kadowaki, N., S. Ho, S. Antonenko, R. W. Malefyt, R. A. Kastelein, F. Bazan, and Y. J. Liu. 2001. Subsets of human dendritic cell precursors express different Toll-like receptors and respond to different microbial antigens. J. Exp. Med. 194:863.
-
(2001)
J. Exp. Med.
, vol.194
, pp. 863
-
-
Kadowaki, N.1
Ho, S.2
Antonenko, S.3
Malefyt, R.W.4
Kastelein, R.A.5
Bazan, F.6
Liu, Y.J.7
-
13
-
-
0033168728
-
Cutting edge: Recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2
-
Yoshimura, A., E. Lien, R. R. Ingalls, E. Tuomanen, R. Dziarski, and D. Golenbock. 1999. Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2. J. Immunol. 163:1.
-
(1999)
J. Immunol.
, vol.163
, pp. 1
-
-
Yoshimura, A.1
Lien, E.2
Ingalls, R.R.3
Tuomanen, E.4
Dziarski, R.5
Golenbock, D.6
-
14
-
-
0035909372
-
Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
-
Alexopoulou, L., A. C. Holt, R. Medzhitov, and R. A. Flavell. 2001. Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3. Nature 413:732.
-
(2001)
Nature
, vol.413
, pp. 732
-
-
Alexopoulou, L.1
Holt, A.C.2
Medzhitov, R.3
Flavell, R.A.4
-
15
-
-
0033120081
-
Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product
-
Hoshino, K., O. Takeuchi, T. Kawai, H. Sanjo, T. Ogawa, Y. Takeda, K. Takeda, and S. Akira. 1999. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J. Immunol. 162:3749.
-
(1999)
J. Immunol.
, vol.162
, pp. 3749
-
-
Hoshino, K.1
Takeuchi, O.2
Kawai, T.3
Sanjo, H.4
Ogawa, T.5
Takeda, Y.6
Takeda, K.7
Akira, S.8
-
16
-
-
0032170215
-
Genetic and physical mapping of the Lps locus: Identification of the Toll-4 receptor as a candidate gene in the critical region
-
Poltorak, A., I. Smirnova, X. He, M. Y. Liu, C. Van Huffel, O. McNally, D. Birdwell, E. Alejos, M. Silva, X. Du, et al. 1998. Genetic and physical mapping of the Lps locus: identification of the Toll-4 receptor as a candidate gene in the critical region. Blood Cells Mol. Dis. 24:340.
-
(1998)
Blood Cells Mol. Dis.
, vol.24
, pp. 340
-
-
Poltorak, A.1
Smirnova, I.2
He, X.3
Liu, M.Y.4
Van Huffel, C.5
McNally, O.6
Birdwell, D.7
Alejos, E.8
Silva, M.9
Du, X.10
-
17
-
-
0035953543
-
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
-
Hayashi, F., K. D. Smith, A. Ozinsky, T. R. Hawn, E. C. Yi, D. R. Goodlett, J. K. Eng, S. Akira, D. M. Underhill, and A. Aderem. 2001. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 410:1099.
-
(2001)
Nature
, vol.410
, pp. 1099
-
-
Hayashi, F.1
Smith, K.D.2
Ozinsky, A.3
Hawn, T.R.4
Yi, E.C.5
Goodlett, D.R.6
Eng, J.K.7
Akira, S.8
Underhill, D.M.9
Aderem, A.10
-
18
-
-
0034619794
-
A Toll-like receptor recognizes bacterial DNA
-
Hemmi, H., O. Takeuchi, T. Kawai, T. Kaisho, S. Sato, H. Sanjo, M. Matsumoto, K. Hoshino, H. Wagner, K. Takeda, et al. 2000. A Toll-like receptor recognizes bacterial DNA. Nature 408:740.
-
(2000)
Nature
, vol.408
, pp. 740
-
-
Hemmi, H.1
Takeuchi, O.2
Kawai, T.3
Kaisho, T.4
Sato, S.5
Sanjo, H.6
Matsumoto, M.7
Hoshino, K.8
Wagner, H.9
Takeda, K.10
-
19
-
-
1542317550
-
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
-
Diebold, S., T. Kaisho, H. Hemmi, S. Akira, and C. Reis e Sousa. 2004. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 5663:1529.
-
(2004)
Science
, vol.5663
, pp. 1529
-
-
Diebold, S.1
Kaisho, T.2
Hemmi, H.3
Akira, S.4
Reis, C.5
Sousa, E.6
-
20
-
-
1542317578
-
Species-specific recognition of single-stranded RNA via Toll-like receptor 7 and 8
-
Heil, F., H. Hemmi, H. Hochrein, F. Ampenberger, C. Kirschning, S. Akira, G. Lipford, H. Wagner, and S. Bauer. 2004. Species-specific recognition of single-stranded RNA via Toll-like receptor 7 and 8. Science 5663:1526.
-
(2004)
Science
, vol.5663
, pp. 1526
-
-
Heil, F.1
Hemmi, H.2
Hochrein, H.3
Ampenberger, F.4
Kirschning, C.5
Akira, S.6
Lipford, G.7
Wagner, H.8
Bauer, S.9
-
21
-
-
0036008014
-
Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
-
Hemmi, H., T. Kaisho, O. Takeuchi, S. Sato, H. Sanjo, K. Hoshino, T. Horiuchi, H. Tomizawa, K. Takeda, and S. Akira. 2002. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat. Immunol. 3:196.
-
(2002)
Nat. Immunol.
, vol.3
, pp. 196
-
-
Hemmi, H.1
Kaisho, T.2
Takeuchi, O.3
Sato, S.4
Sanjo, H.5
Hoshino, K.6
Horiuchi, T.7
Tomizawa, H.8
Takeda, K.9
Akira, S.10
-
22
-
-
0036924110
-
Plasmacytoid dendritic cells produce cytokines and mature in response to the TLR7 agonists, imiquimod and resiquimod
-
Gibson, S. J., J. M. Lindh, T. R. Riter, R. M. Gleason, L. M. Rogers, A. E. Fuller, J. L. Oesterich, K. B. Corden, X. Qiu, S. W. McKane, et al. 2002. Plasmacytoid dendritic cells produce cytokines and mature in response to the TLR7 agonists, imiquimod and resiquimod. Cell. Immunol. 218:74.
-
(2002)
Cell. Immunol.
, vol.218
, pp. 74
-
-
Gibson, S.J.1
Lindh, J.M.2
Riter, T.R.3
Gleason, R.M.4
Rogers, L.M.5
Fuller, A.E.6
Oesterich, J.L.7
Corden, K.B.8
Qiu, X.9
McKane, S.W.10
-
23
-
-
0036088492
-
Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848
-
Jurk, M., F. Heil, J. Vollmer, C. Schetter, A. M. Krieg, H. Wagner, G. Lipford, and S. Bauer. 2002. Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848. Nat. Immunol. 3:499.
-
(2002)
Nat. Immunol.
, vol.3
, pp. 499
-
-
Jurk, M.1
Heil, F.2
Vollmer, J.3
Schetter, C.4
Krieg, A.M.5
Wagner, H.6
Lipford, G.7
Bauer, S.8
-
24
-
-
0035979192
-
Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition
-
Bauer, S., C. J. Kirschning, H. Hacker, V. Redecke, S. Hausmann, S. Akira, H. Wagner, and G. B. Lipford. 2001. Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc. Natl. Acad. Sci. USA 98:9237.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 9237
-
-
Bauer, S.1
Kirschning, C.J.2
Hacker, H.3
Redecke, V.4
Hausmann, S.5
Akira, S.6
Wagner, H.7
Lipford, G.B.8
-
25
-
-
0036925295
-
Plasmacytoid dendritic cells: From specific surface markers to specific cellular functions
-
Dzionek, A., Y. Inagaki, K. Okawa, J. Nagafune, J. Rock, Y. Sohma, G. Winkels, M. Zysk, Y. Yamaguchi, and J. Schmitz. 2002. Plasmacytoid dendritic cells: from specific surface markers to specific cellular functions. Hum. Immunol. 63:1133.
-
(2002)
Hum. Immunol.
, vol.63
, pp. 1133
-
-
Dzionek, A.1
Inagaki, Y.2
Okawa, K.3
Nagafune, J.4
Rock, J.5
Sohma, Y.6
Winkels, G.7
Zysk, M.8
Yamaguchi, Y.9
Schmitz, J.10
-
26
-
-
0033540341
-
Modulation of TH1 and TH2 cytokine production with the immune response modifiers, R-848 and imiquimod
-
Wagner, T. L., C. L. Ahonen, A. M. Couture, S. J. Gibson, R. L. Miller, R. M. Smith, M. J. Reiter, J. P. Vasilakos, and M. A. Tomai. 1999. Modulation of TH1 and TH2 cytokine production with the immune response modifiers, R-848 and imiquimod. Cell. Immunol. 191:10.
-
(1999)
Cell. Immunol.
, vol.191
, pp. 10
-
-
Wagner, T.L.1
Ahonen, C.L.2
Couture, A.M.3
Gibson, S.J.4
Miller, R.L.5
Smith, R.M.6
Reiter, M.J.7
Vasilakos, J.P.8
Tomai, M.A.9
-
27
-
-
0033543947
-
Dendritic cell maturation and subsequent enhanced T-cell stimulation induced with the novel synthetic immune response modifier R-848
-
Ahonen, C. L., S. J. Gibson, R. M. Smith, L. K. Pederson, J. M. Lindh, M. A. Tomai, and J. P. Vasilakos. 1999. Dendritic cell maturation and subsequent enhanced T-cell stimulation induced with the novel synthetic immune response modifier R-848. Cell Immunol. 197:62.
-
(1999)
Cell Immunol.
, vol.197
, pp. 62
-
-
Ahonen, C.L.1
Gibson, S.J.2
Smith, R.M.3
Pederson, L.K.4
Lindh, J.M.5
Tomai, M.A.6
Vasilakos, J.P.7
-
28
-
-
0141886220
-
IFN-α skews monocyte differentiation into Toll-like receptor 7-expressing dendritic cells with potent functional activities
-
Mohty, M., A. Vialle-Castellano, J. A. Nunes, D. Isnardon, D. Olive, and B. Gaugler. 2003. IFN-α skews monocyte differentiation into Toll-like receptor 7-expressing dendritic cells with potent functional activities. J. Immunol. 171:3385.
-
(2003)
J. Immunol.
, vol.171
, pp. 3385
-
-
Mohty, M.1
Vialle-Castellano, A.2
Nunes, J.A.3
Isnardon, D.4
Olive, D.5
Gaugler, B.6
-
29
-
-
0034457684
-
Cloning and characterization of a sub-family of human Toll-like receptors: HTLR7, hTLR8 and hTLR9
-
Chuang, T. H., and R. J. Ulevitch. 2000. Cloning and characterization of a sub-family of human Toll-like receptors: hTLR7, hTLR8 and hTLR9. Eur. Cytokine Network 11:372.
-
(2000)
Eur. Cytokine Network
, vol.11
, pp. 372
-
-
Chuang, T.H.1
Ulevitch, R.J.2
-
30
-
-
0034456693
-
Three novel mammalian Toll-like receptors: Gene structure, expression, and evolution
-
Du, X., A. Poltorak, Y. Wei, and B. Beutler. 2000. Three novel mammalian Toll-like receptors: gene structure, expression, and evolution. Eur. Cytokine Network 11:362.
-
(2000)
Eur. Cytokine Network
, vol.11
, pp. 362
-
-
Du, X.1
Poltorak, A.2
Wei, Y.3
Beutler, B.4
-
31
-
-
0038651180
-
Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: Activation of Toll-like receptor 7
-
Lee, J., T. H. Chuang, V. Redecke, L. She, P. M. Pitha, D. A. Carson, E. Raz, and H. B. Cottam. 2003. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc. Natl. Acad. Sci. USA 100:6646.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 6646
-
-
Lee, J.1
Chuang, T.H.2
Redecke, V.3
She, L.4
Pitha, P.M.5
Carson, D.A.6
Raz, E.7
Cottam, H.B.8
-
32
-
-
0038222345
-
The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells
-
Means, T. K., F. Hayashi, K. D. Smith, A. Aderem, and A. D. Luster. 2003. The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells. J. Immunol. 170:5165.
-
(2003)
J. Immunol.
, vol.170
, pp. 5165
-
-
Means, T.K.1
Hayashi, F.2
Smith, K.D.3
Aderem, A.4
Luster, A.D.5
-
33
-
-
0037446777
-
CpG-A-induced monocyte IFN-γ-inducible protein-10 production is regulated by plasmacytoid dendritic cell-derived IFN-α
-
Blackwell, S. E., and A. M. Krieg. 2003. CpG-A-induced monocyte IFN-γ-inducible protein-10 production is regulated by plasmacytoid dendritic cell-derived IFN-α. J. Immunol. 170:4061.
-
(2003)
J. Immunol.
, vol.170
, pp. 4061
-
-
Blackwell, S.E.1
Krieg, A.M.2
-
34
-
-
0037080024
-
Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines
-
Zarember, K. A., and P. J. Godowski. 2002. Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines. J. Immunol. 168:554.
-
(2002)
J. Immunol.
, vol.168
, pp. 554
-
-
Zarember, K.A.1
Godowski, P.J.2
-
35
-
-
0036570169
-
Quantitative expression of Toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides
-
Hornung, V., S. Rothenfusser, S. Britsch, A. Krug, B. Jahrsdorfer, T. Giese, S. Endres, and G. Hartmann. 2002. Quantitative expression of Toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J. Immunol. 168:4531.
-
(2002)
J. Immunol.
, vol.168
, pp. 4531
-
-
Hornung, V.1
Rothenfusser, S.2
Britsch, S.3
Krug, A.4
Jahrsdorfer, B.5
Giese, T.6
Endres, S.7
Hartmann, G.8
-
36
-
-
0038142387
-
A role for Toll-like receptors in acquired immunity: Up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells
-
Bernasconi, N. L., N. Onai, and A. Lanzavecchia. 2003. A role for Toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells. Blood 101:4500.
-
(2003)
Blood
, vol.101
, pp. 4500
-
-
Bernasconi, N.L.1
Onai, N.2
Lanzavecchia, A.3
|