Human lipopolysaccharide-binding protein (LBP) and CD14 independently deliver triacylated lipoproteins to toll-like receptor 1 (TLR1) and TLR2 and enhance formation of the ternary signaling complex

Journal of Biological Chemistry

Volumn 288, Issue 14, 2013, Pages 9729-9741

  Ranoa, Diana Rose E ^a   Kelley, Stacy L ^a   Tapping, Richard I ^a,b  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BORRELIA BURGDORFERI; CELLULAR ACTIVATION; EXTRACELLULAR DOMAINS; HOST IMMUNE RESPONSE; INTRACELLULAR SIGNALING; NATURALLY OCCURRING; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTORS;

PATTERN RECOGNITION;

LIPOPROTEINS;

BACTERIUM LIPOPROTEIN; CD14 ANTIGEN; LIPOPOLYSACCHARIDE BINDING PROTEIN; LIPOPROTEIN; OUTER SURFACE PROTEIN A; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; UNCLASSIFIED DRUG;

ARTICLE; BORRELIA BURGDORFERI; CELL STIMULATION; COMPLEX FORMATION; CONTROLLED STUDY; GEL PERMEATION CHROMATOGRAPHY; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; STOICHIOMETRY;

ACUTE-PHASE PROTEINS; ANTIGENS, CD14; BACTEREMIA; BACTERIAL PROTEINS; BINDING, COMPETITIVE; CARRIER PROTEINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HEK293 CELLS; HUMANS; IMMUNITY, INNATE; INFLAMMATION; LIPOPEPTIDES; MEMBRANE GLYCOPROTEINS; PROTEIN BINDING; RECOMBINANT PROTEINS; SEPSIS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 1; TOLL-LIKE RECEPTOR 2;

BACTERIA (MICROORGANISMS); BORRELIA BURGDORFERI;

EID: 84875979474     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.453266     Document Type: Article

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