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Volumn 19, Issue 2, 2017, Pages 204-217

In vitro generated hepatocyte-like cells: A novel tool in regenerative medicine and drug discovery

Author keywords

Cell therapy; Drug discovery; Gene therapy; Hepatocyte

Indexed keywords

BIOMEDICAL ENGINEERING; BIOREACTOR; CELL DIFFERENTIATION; CELL FUNCTION; CELL THERAPY; CRISPR CAS SYSTEM; DRUG DEVELOPMENT; EMBRYONIC STEM CELL; END STAGE LIVER DISEASE; HEPATOCYTE LIKE CELL; HUMAN; IN VITRO STUDY; INDUCED PLURIPOTENT STEM CELL; LIVER CELL; LIVER TOXICITY; LIVER TRANSPLANTATION; MESENCHYMAL STROMA CELL; REGENERATIVE MEDICINE; REVIEW;

EID: 85016268657     PISSN: 22285806     EISSN: 22285814     Source Type: Journal    
DOI: 10.22074/cellj.2016.4362     Document Type: Review
Times cited : (12)

References (139)
  • 1
    • 2442701299 scopus 로고    scopus 로고
    • Hepatocyte transplantation
    • Fox IJ, Roy-Chowdhury J. Hepatocyte transplantation. J Hepatol. 2004; 40(6): 878-886.
    • (2004) J Hepatol. , vol.40 , Issue.6 , pp. 878-886
    • Fox, I.J.1    Roy-Chowdhury, J.2
  • 2
    • 84921898883 scopus 로고    scopus 로고
    • Clinical hepatocyte transplantation: Practical limits and possible solutions
    • Gramignoli R, Vosough M, Kannisto K, Srinivasan RC, Strom SC. Clinical hepatocyte transplantation: practical limits and possible solutions. Eur Surg Res. 2015; 54(3-4): 162-177.
    • (2015) Eur Surg Res. , vol.54 , Issue.3-4 , pp. 162-177
    • Gramignoli, R.1    Vosough, M.2    Kannisto, K.3    Srinivasan, R.C.4    Strom, S.C.5
  • 3
    • 84877314691 scopus 로고    scopus 로고
    • New potential cell source for hepatocyte transplantation: Discarded livers from metabolic disease liver transplants
    • Gramignoli R, Tahan V, Dorko K, Skvorak KJ, Hansel MC, Zhao W, et al. New potential cell source for hepatocyte transplantation: discarded livers from metabolic disease liver transplants. Stem Cell Res. 2013; 11(1): 563-573.
    • (2013) Stem Cell Res. , vol.11 , Issue.1 , pp. 563-573
    • Gramignoli, R.1    Tahan, V.2    Dorko, K.3    Skvorak, K.J.4    Hansel, M.C.5    Zhao, W.6
  • 4
    • 77952091621 scopus 로고    scopus 로고
    • Human hepatocyte transplantation: Current experience and future challenges
    • Dhawan A, Puppi J, Hughes RD, Mitry RR. Human hepatocyte transplantation: current experience and future challenges. Nat Rev Gastroenterol Hepatol. 2010; 7(5): 288-298.
    • (2010) Nat Rev Gastroenterol Hepatol. , vol.7 , Issue.5 , pp. 288-298
    • Dhawan, A.1    Puppi, J.2    Hughes, R.D.3    Mitry, R.R.4
  • 6
    • 84938079812 scopus 로고    scopus 로고
    • Cell therapy for liver disease: From liver transplantation to cell factory
    • Forbes SJ, Gupta S, Dhawan A. Cell therapy for liver disease: from liver transplantation to cell factory. J Hepatol. 2015; 62(1 Suppl): S157-169.
    • (2015) J Hepatol. , vol.62 , Issue.1 , pp. S157-169
    • Forbes, S.J.1    Gupta, S.2    Dhawan, A.3
  • 7
    • 33745219691 scopus 로고    scopus 로고
    • Hepatocyte transplantation: Clinical experience and potential for future use
    • Strom SC, Bruzzone P, Cai H, Ellis E, Lehmann T, Mitamura K, et al. Hepatocyte transplantation: clinical experience and potential for future use. Cell Transplant. 2006; 15 Suppl 1: S105-110.
    • (2006) Cell Transplant. , vol.15 , pp. S105-110
    • Strom, S.C.1    Bruzzone, P.2    Cai, H.3    Ellis, E.4    Lehmann, T.5    Mitamura, K.6
  • 8
    • 84940565386 scopus 로고    scopus 로고
    • Stem cell-derived liver cells for drug testing and disease modeling
    • Davidson MD, Ware BR, Khetani SR. Stem cell-derived liver cells for drug testing and disease modeling. Discov Med. 2015; 19(106): 349-358.
    • (2015) Discov Med. , vol.19 , Issue.106 , pp. 349-358
    • Davidson, M.D.1    Ware, B.R.2    Khetani, S.R.3
  • 9
    • 84885108863 scopus 로고    scopus 로고
    • Generation of functional hepatocyte-like cells from human pluripotent stem cells in a scalable suspension culture
    • Vosough M, Omidinia E, Kadivar M, Shokrgozar MA, Pournasr B, Aghdami N, et al. Generation of functional hepatocyte-like cells from human pluripotent stem cells in a scalable suspension culture. Stem Cells Dev. 2013; 22(20): 2693-2705.
    • (2013) Stem Cells Dev. , vol.22 , Issue.20 , pp. 2693-2705
    • Vosough, M.1    Omidinia, E.2    Kadivar, M.3    Shokrgozar, M.A.4    Pournasr, B.5    Aghdami, N.6
  • 10
    • 84873326803 scopus 로고    scopus 로고
    • Hepatic differentiation and maturation of human embryonic stem cells cultured in a perfused three-dimensional bioreactor
    • Sivertsson L, Synnergren J, Jensen J, Bjorquist P, Ingelman-Sundberg M. Hepatic differentiation and maturation of human embryonic stem cells cultured in a perfused three-dimensional bioreactor. Stem Cells Dev. 2013; 22(4): 581-594.
    • (2013) Stem Cells Dev. , vol.22 , Issue.4 , pp. 581-594
    • Sivertsson, L.1    Synnergren, J.2    Jensen, J.3    Bjorquist, P.4    Ingelman-Sundberg, M.5
  • 11
    • 84873326803 scopus 로고    scopus 로고
    • Hepatic differentiation and maturation of human embryonic stem cells cultured in a perfused three-dimensional bioreactor
    • Sivertsson L, Synnergren J, Jensen J, Bjorquist P, Ingelman-Sundberg M. Hepatic differentiation and maturation of human embryonic stem cells cultured in a perfused three-dimensional bioreactor. Stem Cells Dev. 2013; 22(4): 581-594.
    • (2013) Stem Cells Dev. , vol.22 , Issue.4 , pp. 581-594
    • Sivertsson, L.1    Synnergren, J.2    Jensen, J.3    Bjorquist, P.4    Ingelman-Sundberg, M.5
  • 12
    • 0034101804 scopus 로고    scopus 로고
    • Embryonic stem cell lines from human blastocysts: Somatic differentiation in vitro
    • Reubinoff BE, Pera MF, Fong CY, Trounson A, Bongso A. Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. Nat Biotechnol. 2000; 18(4): 399-404.
    • (2000) Nat Biotechnol. , vol.18 , Issue.4 , pp. 399-404
    • Reubinoff, B.E.1    Pera, M.F.2    Fong, C.Y.3    Trounson, A.4    Bongso, A.5
  • 14
    • 79960311063 scopus 로고    scopus 로고
    • New approaches in the differentiation of human embryonic stem cells and induced pluripotent stem cells toward hepatocytes
    • Behbahan IS, Duan Y, Lam A, Khoobyari S, Ma X, Ahuja TP, et al. New approaches in the differentiation of human embryonic stem cells and induced pluripotent stem cells toward hepatocytes. Stem Cell Rev. 2011; 7(3): 748-759.
    • (2011) Stem Cell Rev. , vol.7 , Issue.3 , pp. 748-759
    • Behbahan, I.S.1    Duan, Y.2    Lam, A.3    Khoobyari, S.4    Ma, X.5    Ahuja, T.P.6
  • 15
    • 0034136393 scopus 로고    scopus 로고
    • Differentiation of human embryonic stem cells into embryoid bodies compromising the three embryonic germ layers
    • Itskovitz-Eldor J, Schuldiner M, Karsenti D, Eden A, Yanuka O, Amit M, et al. Differentiation of human embryonic stem cells into embryoid bodies compromising the three embryonic germ layers. Mol Med. 2000; 6(2): 88-95.
    • (2000) Mol Med. , vol.6 , Issue.2 , pp. 88-95
    • Itskovitz-Eldor, J.1    Schuldiner, M.2    Karsenti, D.3    Eden, A.4    Yanuka, O.5    Amit, M.6
  • 16
    • 0034633526 scopus 로고    scopus 로고
    • Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells
    • Schuldiner M, Yanuka O, Itskovitz-Eldor J, Melton DA, Benvenisty N. Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells. Proc Natl Acad Sci USA. 2000; 97(21): 11307-11312.
    • (2000) Proc Natl Acad Sci USA. , vol.97 , Issue.21 , pp. 11307-11312
    • Schuldiner, M.1    Yanuka, O.2    Itskovitz-Eldor, J.3    Melton, D.A.4    Benvenisty, N.5
  • 17
    • 9644282186 scopus 로고    scopus 로고
    • Differentiation and isolation of hepatic-like cells from human embryonic stem cells
    • Lavon N, Yanuka O, Benvenisty N. Differentiation and isolation of hepatic-like cells from human embryonic stem cells. Differentiation. 2004; 72(5): 230-238.
    • (2004) Differentiation. , vol.72 , Issue.5 , pp. 230-238
    • Lavon, N.1    Yanuka, O.2    Benvenisty, N.3
  • 18
    • 27944455549 scopus 로고    scopus 로고
    • Study of hepatocyte differentiation using embryonic stem cells
    • Lavon N, Benvenisty N. Study of hepatocyte differentiation using embryonic stem cells. J Cell Biochem. 2005; 96(6): 1193-1202.
    • (2005) J Cell Biochem. , vol.96 , Issue.6 , pp. 1193-1202
    • Lavon, N.1    Benvenisty, N.2
  • 19
    • 47949092668 scopus 로고    scopus 로고
    • Efficient differentiation of functional hepatocytes from human embryonic stem cells
    • Agarwal S, Holton KL, Lanza R. Efficient differentiation of functional hepatocytes from human embryonic stem cells. Stem Cells. 2008; 26(5): 1117-1127.
    • (2008) Stem Cells. , vol.26 , Issue.5 , pp. 1117-1127
    • Agarwal, S.1    Holton, K.L.2    Lanza, R.3
  • 21
    • 44249101136 scopus 로고    scopus 로고
    • Differentiation of human embryonic stem cells into functional hepatocyte-like cells in a serum-free adherent culture condition
    • Baharvand H, Hashemi SM, Shahsavani M. Differentiation of human embryonic stem cells into functional hepatocyte-like cells in a serum-free adherent culture condition. Differentiation. 2008; 76(5): 465-477.
    • (2008) Differentiation. , vol.76 , Issue.5 , pp. 465-477
    • Baharvand, H.1    Hashemi, S.M.2    Shahsavani, M.3
  • 22
    • 33749596610 scopus 로고    scopus 로고
    • Differentiation of human embryonic stem cells into hepatocytes in 2D and 3D culture systems in vitro
    • Baharvand H, Hashemi SM, Kazemi Ashtiani S, Farrokhi A. Differentiation of human embryonic stem cells into hepatocytes in 2D and 3D culture systems in vitro. Int J Dev Biol. 2006; 50(7): 645-652.
    • (2006) Int J Dev Biol. , vol.50 , Issue.7 , pp. 645-652
    • Baharvand, H.1    Hashemi, S.M.2    Kazemi Ashtiani, S.3    Farrokhi, A.4
  • 23
    • 84866991340 scopus 로고    scopus 로고
    • Generation, characterization and potential therapeutic applications of mature and functional hepatocytes from stem cells
    • Zhang Z, Liu J, Liu Y, Li Z, Gao WQ, He Z. Generation, characterization and potential therapeutic applications of mature and functional hepatocytes from stem cells. J Cell Physiol. 2013; 228(2): 298-305.
    • (2013) J Cell Physiol. , vol.228 , Issue.2 , pp. 298-305
    • Zhang, Z.1    Liu, J.2    Liu, Y.3    Li, Z.4    Gao, W.Q.5    He, Z.6
  • 24
    • 84929291312 scopus 로고    scopus 로고
    • Small-molecule-driven hepatocyte differentiation of human pluripotent stem cells
    • Siller R, Greenhough S, Naumovska E, Sullivan GJ. Small-molecule-driven hepatocyte differentiation of human pluripotent stem cells. Stem Cell Reports. 2015; 4(5): 939-952.
    • (2015) Stem Cell Reports. , vol.4 , Issue.5 , pp. 939-952
    • Siller, R.1    Greenhough, S.2    Naumovska, E.3    Sullivan, G.J.4
  • 25
    • 77958149418 scopus 로고    scopus 로고
    • Inhibition of GSK3beta enhances both adhesive and signalling activities of beta-catenin in mouse embryonic stem cells
    • Sineva GS, Pospelov VA. Inhibition of GSK3beta enhances both adhesive and signalling activities of beta-catenin in mouse embryonic stem cells. Biol Cell. 2010; 102(10): 549-560.
    • (2010) Biol Cell. , vol.102 , Issue.10 , pp. 549-560
    • Sineva, G.S.1    Pospelov, V.A.2
  • 26
    • 84871699216 scopus 로고    scopus 로고
    • Evaluation of metabolically stabilized angiotensin IV analogs as procognitive/antidementia agents
    • McCoy AT, Benoist CC, Wright JW, Kawas LH, Bule-Ghogare JM, Zhu M, et al. Evaluation of metabolically stabilized angiotensin IV analogs as procognitive/antidementia agents. J Pharmacol Exp Ther. 2013; 344(1): 141-154.
    • (2013) J Pharmacol Exp Ther. , vol.344 , Issue.1 , pp. 141-154
    • McCoy, A.T.1    Benoist, C.C.2    Wright, J.W.3    Kawas, L.H.4    Bule-Ghogare, J.M.5    Zhu, M.6
  • 27
    • 78049407985 scopus 로고    scopus 로고
    • Generation of hepatocytes from human embryonic stem cells
    • Lavon N. Generation of hepatocytes from human embryonic stem cells. Methods Mol Biol. 2010; 640: 237-246.
    • (2010) Methods Mol Biol. , vol.640 , pp. 237-246
    • Lavon, N.1
  • 28
    • 84880312802 scopus 로고    scopus 로고
    • Three-dimensional culture and cAMP signaling promote the maturation of human pluripotent stem cell-derived hepatocytes
    • Ogawa S, Surapisitchat J, Virtanen C, Ogawa M, Niapour M, Sugamori KS, et al. Three-dimensional culture and cAMP signaling promote the maturation of human pluripotent stem cell-derived hepatocytes. Development. 2013; 140(15): 3285-3296.
    • (2013) Development. , vol.140 , Issue.15 , pp. 3285-3296
    • Ogawa, S.1    Surapisitchat, J.2    Virtanen, C.3    Ogawa, M.4    Niapour, M.5    Sugamori, K.S.6
  • 29
    • 84881184980 scopus 로고    scopus 로고
    • Vascularized and functional human liver from an iPSC-derived organ bud transplant
    • Takebe T, Sekine K, Enomura M, Koike H, Kimura M, Ogaeri T, et al. Vascularized and functional human liver from an iPSC-derived organ bud transplant. Nature. 2013; 499(7459): 481-484.
    • (2013) Nature. , vol.499 , Issue.7459 , pp. 481-484
    • Takebe, T.1    Sekine, K.2    Enomura, M.3    Koike, H.4    Kimura, M.5    Ogaeri, T.6
  • 30
    • 84893223076 scopus 로고    scopus 로고
    • Generation of a vascularized and functional human liver from an iPSC-derived organ bud transplant
    • Takebe T, Zhang RR, Koike H, Kimura M, Yoshizawa E, Enomura M, et al. Generation of a vascularized and functional human liver from an iPSC-derived organ bud transplant. Nat Protoc. 2014; 9(2): 396-409.
    • (2014) Nat Protoc. , vol.9 , Issue.2 , pp. 396-409
    • Takebe, T.1    Zhang, R.R.2    Koike, H.3    Kimura, M.4    Yoshizawa, E.5    Enomura, M.6
  • 31
    • 84905012364 scopus 로고    scopus 로고
    • Differentiation of human embryonic stem cells to hepatocyte-like cells on a new developed xeno-free extracellular matrix
    • Farzaneh Z, Pakzad M, Vosough M, Pournasr B, Baharvand H. Differentiation of human embryonic stem cells to hepatocyte-like cells on a new developed xeno-free extracellular matrix. Histochem Cell Biol. 2014; 142(2): 217-226.
    • (2014) Histochem Cell Biol. , vol.142 , Issue.2 , pp. 217-226
    • Farzaneh, Z.1    Pakzad, M.2    Vosough, M.3    Pournasr, B.4    Baharvand, H.5
  • 32
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006; 126(4): 663-676.
    • (2006) Cell. , vol.126 , Issue.4 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 33
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007; 131(5): 861-872.
    • (2007) Cell. , vol.131 , Issue.5 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3    Narita, M.4    Ichisaka, T.5    Tomoda, K.6
  • 34
    • 61349100729 scopus 로고    scopus 로고
    • Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors
    • Soldner F, Hockemeyer D, Beard C, Gao Q, Bell GW, Cook EG, et al. Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell. 2009; 136(5): 964-977.
    • (2009) Cell. , vol.136 , Issue.5 , pp. 964-977
    • Soldner, F.1    Hockemeyer, D.2    Beard, C.3    Gao, Q.4    Bell, G.W.5    Cook, E.G.6
  • 35
    • 70450265981 scopus 로고    scopus 로고
    • Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome
    • Fusaki N, Ban H, Nishiyama A, Saeki K, Hasegawa M. Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome. Proc Jpn Acad Ser B Phys Biol Sci. 2009; 85(8): 348-362.
    • (2009) Proc Jpn Acad Ser B Phys Biol Sci. , vol.85 , Issue.8 , pp. 348-362
    • Fusaki, N.1    Ban, H.2    Nishiyama, A.3    Saeki, K.4    Hasegawa, M.5
  • 36
    • 65649116572 scopus 로고    scopus 로고
    • Human induced pluripotent stem cells free of vector and transgene sequences
    • Yu J, Hu K, Smuga-Otto K, Tian S, Stewart R, Slukvin II, et al. Human induced pluripotent stem cells free of vector and transgene sequences. Science. 2009; 324(5928): 797-801.
    • (2009) Science. , vol.324 , Issue.5928 , pp. 797-801
    • Yu, J.1    Hu, K.2    Smuga-Otto, K.3    Tian, S.4    Stewart, R.5    Slukvin, I.I.6
  • 37
    • 79957855262 scopus 로고    scopus 로고
    • Reprogramming of mouse and human cells to pluripotency using mature microRNAs
    • Miyoshi N, Ishii H, Nagano H, Haraguchi N, Dewi DL, Kano Y, et al. Reprogramming of mouse and human cells to pluripotency using mature microRNAs. Cell Stem Cell. 2011; 8(6): 633-638.
    • (2011) Cell Stem Cell. , vol.8 , Issue.6 , pp. 633-638
    • Miyoshi, N.1    Ishii, H.2    Nagano, H.3    Haraguchi, N.4    Dewi, D.L.5    Kano, Y.6
  • 38
    • 77958536106 scopus 로고    scopus 로고
    • Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA
    • Warren L, Manos PD, Ahfeldt T, Loh YH, Li H, Lau F, et al. Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell. 2010; 7(5): 618-630.
    • (2010) Cell Stem Cell. , vol.7 , Issue.5 , pp. 618-630
    • Warren, L.1    Manos, P.D.2    Ahfeldt, T.3    Loh, Y.H.4    Li, H.5    Lau, F.6
  • 39
    • 84881256653 scopus 로고    scopus 로고
    • Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds
    • Hou P, Li Y, Zhang X, Liu C, Guan J, Li H, et al. Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science. 2013; 341(6146): 651-654.
    • (2013) Science. , vol.341 , Issue.6146 , pp. 651-654
    • Hou, P.1    Li, Y.2    Zhang, X.3    Liu, C.4    Guan, J.5    Li, H.6
  • 40
    • 73449100783 scopus 로고    scopus 로고
    • Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells
    • Si-Tayeb K, Noto FK, Nagaoka M, Li J, Battle MA, Duris C, et al. Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells. Hepatology. 2010; 51(1): 297-305.
    • (2010) Hepatology. , vol.51 , Issue.1 , pp. 297-305
    • Si-Tayeb, K.1    Noto, F.K.2    Nagaoka, M.3    Li, J.4    Battle, M.A.5    Duris, C.6
  • 41
    • 70449534874 scopus 로고    scopus 로고
    • Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells
    • Song Z, Cai J, Liu Y, Zhao D, Yong J, Duo S, et al. Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells. Cell Res. 2009; 19(11): 1233-1242.
    • (2009) Cell Res. , vol.19 , Issue.11 , pp. 1233-1242
    • Song, Z.1    Cai, J.2    Liu, Y.3    Zhao, D.4    Yong, J.5    Duo, S.6
  • 42
    • 77957347780 scopus 로고    scopus 로고
    • Generation of liver disease-specific induced pluripotent stem cells along with efficient differentiation to functional hepatocyte-like cells
    • Ghodsizadeh A, Taei A, Totonchi M, Seifinejad A, Gourabi H, Pournasr B, et al. Generation of liver disease-specific induced pluripotent stem cells along with efficient differentiation to functional hepatocyte-like cells. Stem Cell Rev. 2010; 6(4): 622-632.
    • (2010) Stem Cell Rev. , vol.6 , Issue.4 , pp. 622-632
    • Ghodsizadeh, A.1    Taei, A.2    Totonchi, M.3    Seifinejad, A.4    Gourabi, H.5    Pournasr, B.6
  • 43
    • 84881614465 scopus 로고    scopus 로고
    • Differentiation and transplantation of human induced pluripotent stem cell-derived hepatocyte-like cells
    • Asgari S, Moslem M, Bagheri-Lankarani K, Pournasr B, Miryounesi M, Baharvand H. Differentiation and transplantation of human induced pluripotent stem cell-derived hepatocyte-like cells. Stem Cell Rev. 2013; 9(4): 493-504.
    • (2013) Stem Cell Rev. , vol.9 , Issue.4 , pp. 493-504
    • Asgari, S.1    Moslem, M.2    Bagheri-Lankarani, K.3    Pournasr, B.4    Miryounesi, M.5    Baharvand, H.6
  • 45
    • 84923035739 scopus 로고    scopus 로고
    • Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes
    • Baxter M, Withey S, Harrison S, Segeritz CP, Zhang F, Atkinson-Dell R, et al. Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes. J Hepatol. 2015; 62(3): 581-589.
    • (2015) J Hepatol. , vol.62 , Issue.3 , pp. 581-589
    • Baxter, M.1    Withey, S.2    Harrison, S.3    Segeritz, C.P.4    Zhang, F.5    Atkinson-Dell, R.6
  • 46
    • 84899644210 scopus 로고    scopus 로고
    • Maturation of induced pluripotent stem cell derived hepatocytes by 3D-culture
    • Gieseck RL 3rd, Hannan NR, Bort R, Hanley NA, Drake RA, Cameron GW, et al. Maturation of induced pluripotent stem cell derived hepatocytes by 3D-culture. PLoS One. 2014; 9(1): e86372.
    • (2014) PLoS One. , vol.9 , Issue.1 , pp. e86372
    • Gieseck, R.L.1    Hannan, N.R.2    Bort, R.3    Hanley, N.A.4    Drake, R.A.5    Cameron, G.W.6
  • 47
    • 70449534874 scopus 로고    scopus 로고
    • Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells
    • Song Z, Cai J, Liu Y, Zhao D, Yong J, Duo S, et al. Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells. Cell Res. 2009; 19(11): 1233-1242.
    • (2009) Cell Res. , vol.19 , Issue.11 , pp. 1233-1242
    • Song, Z.1    Cai, J.2    Liu, Y.3    Zhao, D.4    Yong, J.5    Duo, S.6
  • 49
    • 84991246060 scopus 로고    scopus 로고
    • Recapitulating cell-cell interactions for organoid construction-are biomaterials dispensable?
    • Wan AC. Recapitulating cell-cell interactions for organoid construction-are biomaterials dispensable? Trends Biotechnol. 2016; 34(9): 711-721.
    • (2016) Trends Biotechnol. , vol.34 , Issue.9 , pp. 711-721
    • Wan, A.C.1
  • 50
    • 84959357347 scopus 로고    scopus 로고
    • Organoids as an in vitro model of human development and disease
    • Fatehullah A, Tan SH, Barker N. Organoids as an in vitro model of human development and disease. Nat Cell Biol. 2016; 18(3): 246-254.
    • (2016) Nat Cell Biol. , vol.18 , Issue.3 , pp. 246-254
    • Fatehullah, A.1    Tan, S.H.2    Barker, N.3
  • 51
    • 84903593865 scopus 로고    scopus 로고
    • An efficient method for differentiation of human induced pluripotent stem cells into hepatocyte-like cells retaining drug metabolizing activity
    • Kondo Y, Iwao T, Nakamura K, Sasaki T, Takahashi S, Kamada N, et al. An efficient method for differentiation of human induced pluripotent stem cells into hepatocyte-like cells retaining drug metabolizing activity. Drug Metab Pharmacokinet. 2014; 29(3): 237-243.
    • (2014) Drug Metab Pharmacokinet. , vol.29 , Issue.3 , pp. 237-243
    • Kondo, Y.1    Iwao, T.2    Nakamura, K.3    Sasaki, T.4    Takahashi, S.5    Kamada, N.6
  • 52
    • 34547913091 scopus 로고    scopus 로고
    • Stem cells: A revolution in therapeutics-recent advances in stem cell biology and their therapeutic applications in regenerative medicine and cancer therapies
    • Mimeault M, Hauke R, Batra SK. Stem cells: a revolution in therapeutics-recent advances in stem cell biology and their therapeutic applications in regenerative medicine and cancer therapies. Clin Pharmacol Ther. 2007; 82(3): 252-264.
    • (2007) Clin Pharmacol Ther. , vol.82 , Issue.3 , pp. 252-264
    • Mimeault, M.1    Hauke, R.2    Batra, S.K.3
  • 53
    • 75449116328 scopus 로고    scopus 로고
    • Bone marrow-derived stem cells in liver repair: 10 years down the line
    • Gilchrist ES, Plevris JN. Bone marrow-derived stem cells in liver repair: 10 years down the line. Liver Transpl. 2010; 16(2): 118-129.
    • (2010) Liver Transpl. , vol.16 , Issue.2 , pp. 118-129
    • Gilchrist, E.S.1    Plevris, J.N.2
  • 54
    • 64149125603 scopus 로고    scopus 로고
    • Stem and progenitor cells for liver repopulation: Can we standardise the process from bench to bedside?
    • Sancho-Bru P, Najimi M, Caruso M, Pauwelyn K, Cantz T, Forbes S, et al. Stem and progenitor cells for liver repopulation: can we standardise the process from bench to bedside? Gut. 2009; 58(4): 594-603.
    • (2009) Gut. , vol.58 , Issue.4 , pp. 594-603
    • Sancho-Bru, P.1    Najimi, M.2    Caruso, M.3    Pauwelyn, K.4    Cantz, T.5    Forbes, S.6
  • 55
    • 25144481014 scopus 로고    scopus 로고
    • Human cordonal stem cell intraperitoneal injection can represent a rescue therapy after an acute hepatic damage in immunocompetent rats
    • Piscaglia AC, Di Campli C, Zocco MA, Di Gioacchino G, Novi M, Rutella S, et al. Human cordonal stem cell intraperitoneal injection can represent a rescue therapy after an acute hepatic damage in immunocompetent rats. Transplant Proc. 2005; 37(6): 2711-2714.
    • (2005) Transplant Proc. , vol.37 , Issue.6 , pp. 2711-2714
    • Piscaglia, A.C.1    Di Campli, C.2    Zocco, M.A.3    Di Gioacchino, G.4    Novi, M.5    Rutella, S.6
  • 56
    • 33749048777 scopus 로고    scopus 로고
    • In vitro differentiation of human placenta-derived multipotent cells into hepatocyte-like cells
    • Chien CC, Yen BL, Lee FK, Lai TH, Chen YC, Chan SH, et al. In vitro differentiation of human placenta-derived multipotent cells into hepatocyte-like cells. Stem Cells. 2006; 24(7): 1759-1768.
    • (2006) Stem Cells. , vol.24 , Issue.7 , pp. 1759-1768
    • Chien, C.C.1    Yen, B.L.2    Lee, F.K.3    Lai, T.H.4    Chen, Y.C.5    Chan, S.H.6
  • 57
    • 79958812975 scopus 로고    scopus 로고
    • Stem cell-based therapies for liver diseases: State of the art and new perspectives
    • Piscaglia AC, Campanale M, Gasbarrini A, Gasbarrini G. Stem cell-based therapies for liver diseases: state of the art and new perspectives. Stem Cells Int. 2010; 2010: 259461.
    • (2010) Stem Cells Int. , vol.2010 , pp. 259461
    • Piscaglia, A.C.1    Campanale, M.2    Gasbarrini, A.3    Gasbarrini, G.4
  • 58
    • 84949058150 scopus 로고    scopus 로고
    • Stem cell-based regenerative opportunities for the liver: State of the art and beyond
    • Tsolaki E, Yannaki E. Stem cell-based regenerative opportunities for the liver: state of the art and beyond. World J Gastroenterol. 2015; 21(43): 12334-12350.
    • (2015) World J Gastroenterol. , vol.21 , Issue.43 , pp. 12334-12350
    • Tsolaki, E.1    Yannaki, E.2
  • 59
    • 35548972917 scopus 로고    scopus 로고
    • Phase 1 trial of autologous bone marrow mesenchymal stem cell transplantation in patients with decompensated liver cirrhosis
    • Mohamadnejad M, Alimoghaddam K, Mohyeddin-Bonab M, Bagheri M, Bashtar M, Ghanaati H, et al. Phase 1 trial of autologous bone marrow mesenchymal stem cell transplantation in patients with decompensated liver cirrhosis. Arch Iran Med. 2007; 10(4): 459-466.
    • (2007) Arch Iran Med. , vol.10 , Issue.4 , pp. 459-466
    • Mohamadnejad, M.1    Alimoghaddam, K.2    Mohyeddin-Bonab, M.3    Bagheri, M.4    Bashtar, M.5    Ghanaati, H.6
  • 60
    • 70349733505 scopus 로고    scopus 로고
    • Improvement of liver function in liver cirrhosis patients after autologous mesenchymal stem cell injection: A phase I-II clinical trial
    • Kharaziha P, Hellström PM, Noorinayer B, Farzaneh F, Aghajani K, Jafari F, et al. Improvement of liver function in liver cirrhosis patients after autologous mesenchymal stem cell injection: a phase I-II clinical trial. Eur J Gastroenterol Hepatol. 2009; 21(10): 1199-1205.
    • (2009) Eur J Gastroenterol Hepatol. , vol.21 , Issue.10 , pp. 1199-1205
    • Kharaziha, P.1    Hellström, P.M.2    Noorinayer, B.3    Farzaneh, F.4    Aghajani, K.5    Jafari, F.6
  • 61
    • 80052024072 scopus 로고    scopus 로고
    • Autologous bone marrow mesenchymal stem cell transplantation in liver failure patients caused by hepatitis B: Short-term and long-term outcomes
    • Peng L, Xie DY, Lin BL, Liu J, Zhu HP, Xie C, et al. Autologous bone marrow mesenchymal stem cell transplantation in liver failure patients caused by hepatitis B: short-term and long-term outcomes. Hepatology. 2011; 54(3): 820-828.
    • (2011) Hepatology. , vol.54 , Issue.3 , pp. 820-828
    • Peng, L.1    Xie, D.Y.2    Lin, B.L.3    Liu, J.4    Zhu, H.P.5    Xie, C.6
  • 62
    • 84863337962 scopus 로고    scopus 로고
    • Intra venous injection of mesenchymal stem cells is effective in treating liver fibrosis
    • Zhao W, Li JJ, Cao DY, Li X, Zhang LY, He Y, et al. Intra venous injection of mesenchymal stem cells is effective in treating liver fibrosis. World J Gastroenterol. 2012; 18(10): 1048-1058.
    • (2012) World J Gastroenterol. , vol.18 , Issue.10 , pp. 1048-1058
    • Zhao, W.1    Li, J.J.2    Cao, D.Y.3    Li, X.4    Zhang, L.Y.5    He, Y.6
  • 63
    • 84957599728 scopus 로고    scopus 로고
    • Repeated intraportal injection of mesenchymal stem cells in combination with pioglitazone in patients with compensated cirrhosis: A clinical report of two cases
    • Vosough M, Moossavi S, Mardpour S, Akhlaghpoor S, Azimian V, Jarughi N, et al. Repeated intraportal injection of mesenchymal stem cells in combination with pioglitazone in patients with compensated cirrhosis: a clinical report of two cases. Arch Iran Med. 2016; 19(2): 131-136.
    • (2016) Arch Iran Med. , vol.19 , Issue.2 , pp. 131-136
    • Vosough, M.1    Moossavi, S.2    Mardpour, S.3    Akhlaghpoor, S.4    Azimian, V.5    Jarughi, N.6
  • 64
    • 84923477365 scopus 로고    scopus 로고
    • The multiple functional roles of mesenchymal stem cells in participating in treating liver diseases
    • Liu WH, Song FQ, Ren LN, Guo WQ, Wang T, Feng YX, et al. The multiple functional roles of mesenchymal stem cells in participating in treating liver diseases. J Cell Mol Med. 2015; 19(3): 511-520.
    • (2015) J Cell Mol Med. , vol.19 , Issue.3 , pp. 511-520
    • Liu, W.H.1    Song, F.Q.2    Ren, L.N.3    Guo, W.Q.4    Wang, T.5    Feng, Y.X.6
  • 65
    • 34548502436 scopus 로고    scopus 로고
    • In vitro differentiation of mouse bone marrow stromal stem cells into hepatocytes induced by conditioned culture medium of hepatocytes
    • Chen Y, Dong XJ, Zhang GR, Shao JZ, Xiang LX. In vitro differentiation of mouse bone marrow stromal stem cells into hepatocytes induced by conditioned culture medium of hepatocytes. J Cell Biochem. 2007; 102(1): 52-63.
    • (2007) J Cell Biochem. , vol.102 , Issue.1 , pp. 52-63
    • Chen, Y.1    Dong, X.J.2    Zhang, G.R.3    Shao, J.Z.4    Xiang, L.X.5
  • 66
    • 68049127958 scopus 로고    scopus 로고
    • In vitro hepatic differentiation of human bone marrow mesenchymal stem cells under differential exposure to liver-specific factors
    • Chivu M, Dima SO, Stancu CI, Dobrea C, Uscatescu V, Necula LG, et al. In vitro hepatic differentiation of human bone marrow mesenchymal stem cells under differential exposure to liver-specific factors. Transl Res. 2009; 154(3): 122-132.
    • (2009) Transl Res. , vol.154 , Issue.3 , pp. 122-132
    • Chivu, M.1    Dima, S.O.2    Stancu, C.I.3    Dobrea, C.4    Uscatescu, V.5    Necula, L.G.6
  • 67
    • 84863712753 scopus 로고    scopus 로고
    • Hepatogenic differentiation of mesenchymal stem cells induced by insulin like growth factor-I
    • Ayatollahi M, Soleimani M, Tabei SZ, Kabir Salmani M. Hepatogenic differentiation of mesenchymal stem cells induced by insulin like growth factor-I. World J Stem Cells. 2011; 3(12): 113-121.
    • (2011) World J Stem Cells. , vol.3 , Issue.12 , pp. 113-121
    • Ayatollahi, M.1    Soleimani, M.2    Tabei, S.Z.3    Kabir Salmani, M.4
  • 68
    • 81855168305 scopus 로고    scopus 로고
    • Concise review: Alchemy of biology: Generating desired cell types from abundant and accessible cells
    • Pournasr B, Khaloughi K, Salekdeh GH, Totonchi M, Shahbazi E, Baharvand H. Concise review: alchemy of biology: generating desired cell types from abundant and accessible cells. Stem Cells. 2011; 29(12): 1933-1941.
    • (2011) Stem Cells. , vol.29 , Issue.12 , pp. 1933-1941
    • Pournasr, B.1    Khaloughi, K.2    Salekdeh, G.H.3    Totonchi, M.4    Shahbazi, E.5    Baharvand, H.6
  • 69
    • 84865786819 scopus 로고    scopus 로고
    • Lineage conversion methodologies meet the reprogramming toolbox
    • Sancho-Martinez I, Baek SH, Izpisua Belmonte JC. Lineage conversion methodologies meet the reprogramming toolbox. Nat Cell Biol. 2012; 14(9): 892-899.
    • (2012) Nat Cell Biol. , vol.14 , Issue.9 , pp. 892-899
    • Sancho-Martinez, I.1    Baek, S.H.2    Izpisua Belmonte, J.C.3
  • 70
    • 79960649307 scopus 로고    scopus 로고
    • Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors
    • Sekiya S, Suzuki A. Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors. Nature. 2011; 475(7356): 390-393.
    • (2011) Nature. , vol.475 , Issue.7356 , pp. 390-393
    • Sekiya, S.1    Suzuki, A.2
  • 71
    • 79960637387 scopus 로고    scopus 로고
    • Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors
    • Huang P, He Z, Ji S, Sun H, Xiang D, Liu C, et al. Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors. Nature. 2011; 475(7356): 386-389.
    • (2011) Nature. , vol.475 , Issue.7356 , pp. 386-389
    • Huang, P.1    He, Z.2    Ji, S.3    Sun, H.4    Xiang, D.5    Liu, C.6
  • 72
    • 84896132644 scopus 로고    scopus 로고
    • Human hepatocytes with drug metabolic function induced from fibroblasts by lineage reprogramming
    • Du Y, Wang J, Jia J, Song N, Xiang C, Xu J, et al. Human hepatocytes with drug metabolic function induced from fibroblasts by lineage reprogramming. Cell Stem Cell. 2014; 14(3): 394-403.
    • (2014) Cell Stem Cell. , vol.14 , Issue.3 , pp. 394-403
    • Du, Y.1    Wang, J.2    Jia, J.3    Song, N.4    Xiang, C.5    Xu, J.6
  • 73
    • 84896142695 scopus 로고    scopus 로고
    • Direct reprogramming of human fibroblasts to functional and expandable hepatocytes
    • Huang P, Zhang L, Gao Y, He Z, Yao D, Wu Z, et al. Direct reprogramming of human fibroblasts to functional and expandable hepatocytes. Cell Stem Cell. 2014; 14(3): 370-384.
    • (2014) Cell Stem Cell. , vol.14 , Issue.3 , pp. 370-384
    • Huang, P.1    Zhang, L.2    Gao, Y.3    He, Z.4    Yao, D.5    Wu, Z.6
  • 74
    • 84951137927 scopus 로고    scopus 로고
    • Transcription factor-mediated reprograming of fibroblasts to hepatocyte-like cells
    • Pournasr B, Asghari-Vostikolaee MH, Baharvand H. Transcription factor-mediated reprograming of fibroblasts to hepatocyte-like cells. Eur J Cell Biol. 2015; 94(12): 603-610.
    • (2015) Eur J Cell Biol. , vol.94 , Issue.12 , pp. 603-610
    • Pournasr, B.1    Asghari-Vostikolaee, M.H.2    Baharvand, H.3
  • 76
    • 85016336321 scopus 로고    scopus 로고
    • Application of induced pluripotent stem cells in liver diseases
    • Yu Y, Wang X, Nyberg SL. Application of induced pluripotent stem cells in liver diseases. Cell Med. 2014; 7(1): 1-13.
    • (2014) Cell Med. , vol.7 , Issue.1 , pp. 1-13
    • Yu, Y.1    Wang, X.2    Nyberg, S.L.3
  • 77
    • 84971578735 scopus 로고    scopus 로고
    • Human pluripotent stem cells: Myths and future realities for liver cell therapy
    • Goldman O, Gouon-Evans V. Human pluripotent stem cells: myths and future realities for liver cell therapy. Cell Stem Cell. 2016; 18(6): 703-706.
    • (2016) Cell Stem Cell. , vol.18 , Issue.6 , pp. 703-706
    • Goldman, O.1    Gouon-Evans, V.2
  • 78
    • 84959149568 scopus 로고    scopus 로고
    • Direct reprogramming of hepatic myofibroblasts into hepatocytes in vivo attenuates liver fibrosis
    • Song G, Pacher M, Balakrishnan A, Yuan Q, Tsay HC, Yang D, et al. Direct reprogramming of hepatic myofibroblasts into hepatocytes in vivo attenuates liver fibrosis. Cell Stem Cell. 2016; 18(6): 797-808.
    • (2016) Cell Stem Cell. , vol.18 , Issue.6 , pp. 797-808
    • Song, G.1    Pacher, M.2    Balakrishnan, A.3    Yuan, Q.4    Tsay, H.C.5    Yang, D.6
  • 79
    • 84971570649 scopus 로고    scopus 로고
    • In vivo hepatic reprogramming of myofibroblasts with AAV vectors as a therapeutic strategy for liver fibrosis
    • Rezvani M, Espanol-Suner R, Malato Y, Dumont L, Grimm AA, Kienle E, et al. In vivo hepatic reprogramming of myofibroblasts with AAV vectors as a therapeutic strategy for liver fibrosis. Cell Stem Cell. 2016; 18(6): 809-816.
    • (2016) Cell Stem Cell. , vol.18 , Issue.6 , pp. 809-816
    • Rezvani, M.1    Espanol-Suner, R.2    Malato, Y.3    Dumont, L.4    Grimm, A.A.5    Kienle, E.6
  • 83
    • 0344142526 scopus 로고    scopus 로고
    • Hepatocyte transplantation for the treatment of human disease
    • Strom SC, Chowdhury JR, Fox IJ. Hepatocyte transplantation for the treatment of human disease. Semin Liver Dis. 1999; 19(1): 39-48.
    • (1999) Semin Liver Dis. , vol.19 , Issue.1 , pp. 39-48
    • Strom, S.C.1    Chowdhury, J.R.2    Fox, I.J.3
  • 85
    • 75449118729 scopus 로고    scopus 로고
    • Hepatocyte cryopreservation: Is it time to change the strategy?
    • Stephenne X, Najimi M, Sokal EM. Hepatocyte cryopreservation: is it time to change the strategy? World J Gastroenterol. 2010; 16(1): 1-14.
    • (2010) World J Gastroenterol. , vol.16 , Issue.1 , pp. 1-14
    • Stephenne, X.1    Najimi, M.2    Sokal, E.M.3
  • 86
    • 84862849950 scopus 로고    scopus 로고
    • Human induced pluripotent stem cells derived hepatocytes: Rising promise for disease modeling, drug development and cell therapy
    • Yi F, Liu GH, Izpisua Belmonte JC. Human induced pluripotent stem cells derived hepatocytes: rising promise for disease modeling, drug development and cell therapy. Protein Cell. 2012; 3(4): 246-250.
    • (2012) Protein Cell. , vol.3 , Issue.4 , pp. 246-250
    • Yi, F.1    Liu, G.H.2    Izpisua Belmonte, J.C.3
  • 87
    • 84862824246 scopus 로고    scopus 로고
    • Rapid generation of mature hepatocyte-like cells from human induced pluripotent stem cells by an efficient three-step protocol
    • Chen YF, Tseng CY, Wang HW, Kuo HC, Yang VW, Lee OK. Rapid generation of mature hepatocyte-like cells from human induced pluripotent stem cells by an efficient three-step protocol. Hepatology. 2012; 55(4): 1193-1203.
    • (2012) Hepatology. , vol.55 , Issue.4 , pp. 1193-1203
    • Chen, Y.F.1    Tseng, C.Y.2    Wang, H.W.3    Kuo, H.C.4    Yang, V.W.5    Lee, O.K.6
  • 88
    • 84943329552 scopus 로고    scopus 로고
    • Personalized medicine: Cell and gene therapy based on patient-specific iPSC-derived retinal pigment epithelium cells
    • Li Y, Chan L, Nguyen HV, Tsang SH. Personalized medicine: cell and gene therapy based on patient-specific iPSC-derived retinal pigment epithelium cells. Adv Exp Med Biol. 2016; 854: 549-555.
    • (2016) Adv Exp Med Biol. , vol.854 , pp. 549-555
    • Li, Y.1    Chan, L.2    Nguyen, H.V.3    Tsang, S.H.4
  • 89
    • 63849329673 scopus 로고    scopus 로고
    • Hepatocyte differentiation of mesenchymal stem cells from human adipose tissue in vitro promotes hepatic integration in vivo
    • Aurich H, Sgodda M, Kaltwasser P, Vetter M, Weise A, Liehr T, et al. Hepatocyte differentiation of mesenchymal stem cells from human adipose tissue in vitro promotes hepatic integration in vivo. Gut. 2009; 58(4): 570-581.
    • (2009) Gut. , vol.58 , Issue.4 , pp. 570-581
    • Aurich, H.1    Sgodda, M.2    Kaltwasser, P.3    Vetter, M.4    Weise, A.5    Liehr, T.6
  • 90
    • 84885185290 scopus 로고    scopus 로고
    • Randomized placebo-controlled trial of mesenchymal stem cell transplantation in decompensated cirrhosis
    • Mohamadnejad M, Alimoghaddam K, Bagheri M, Ashrafi M, Abdollahzadeh L, Akhlaghpoor S, et al. Randomized placebo-controlled trial of mesenchymal stem cell transplantation in decompensated cirrhosis. Liver Int. 2013; 33(10): 1490-1496.
    • (2013) Liver Int. , vol.33 , Issue.10 , pp. 1490-1496
    • Mohamadnejad, M.1    Alimoghaddam, K.2    Bagheri, M.3    Ashrafi, M.4    Abdollahzadeh, L.5    Akhlaghpoor, S.6
  • 91
    • 49249091550 scopus 로고    scopus 로고
    • Efficient differentiation of hepatocytes from human embryonic stem cells exhibiting markers recapitulating liver development in vivo
    • Hay DC, Zhao D, Fletcher J, Hewitt ZA, McLean D, Urruticoechea-Uriguen A, et al. Efficient differentiation of hepatocytes from human embryonic stem cells exhibiting markers recapitulating liver development in vivo. Stem Cells. 2008; 26(4): 894-902.
    • (2008) Stem Cells. , vol.26 , Issue.4 , pp. 894-902
    • Hay, D.C.1    Zhao, D.2    Fletcher, J.3    Hewitt, Z.A.4    McLean, D.5    Urruticoechea-Uriguen, A.6
  • 92
    • 73449100456 scopus 로고    scopus 로고
    • Generation of functional human hepatic endoderm from human induced pluripotent stem cells
    • Sullivan GJ, Hay DC, Park IH, Fletcher J, Hannoun Z, Payne CM, et al. Generation of functional human hepatic endoderm from human induced pluripotent stem cells. Hepatology. 2010; 51(1): 329-335.
    • (2010) Hepatology. , vol.51 , Issue.1 , pp. 329-335
    • Sullivan, G.J.1    Hay, D.C.2    Park, I.H.3    Fletcher, J.4    Hannoun, Z.5    Payne, C.M.6
  • 93
    • 84865572084 scopus 로고    scopus 로고
    • Phase II trial: Undifferentiated versus differentiated autologous mesenchymal stem cells transplantation in Egyptian patients with HCV induced liver cirrhosis
    • El-Ansary M, Abdel-Aziz I, Mogawer S, Abdel-Hamid S, Hammam O, Teaema S, et al. Phase II trial: undifferentiated versus differentiated autologous mesenchymal stem cells transplantation in Egyptian patients with HCV induced liver cirrhosis. Stem Cell Rev. 2012; 8(3): 972-981.
    • (2012) Stem Cell Rev. , vol.8 , Issue.3 , pp. 972-981
    • El-Ansary, M.1    Abdel-Aziz, I.2    Mogawer, S.3    Abdel-Hamid, S.4    Hammam, O.5    Teaema, S.6
  • 94
    • 84856974289 scopus 로고    scopus 로고
    • Efficient generation of functional hepatocytes from human embryonic stem cells and induced pluripotent stem cells by HNF4alpha transduction
    • Takayama K, Inamura M, Kawabata K, Katayama K, Higuchi M, Tashiro K, et al. Efficient generation of functional hepatocytes from human embryonic stem cells and induced pluripotent stem cells by HNF4alpha transduction. Mol Ther. 2012; 20(1): 127-137.
    • (2012) Mol Ther. , vol.20 , Issue.1 , pp. 127-137
    • Takayama, K.1    Inamura, M.2    Kawabata, K.3    Katayama, K.4    Higuchi, M.5    Tashiro, K.6
  • 95
    • 85007583151 scopus 로고    scopus 로고
    • A robust model of natural hepatitis C infection using hepatocyte-like cells derived from human induced pluripotent stem cells as a long-term host
    • Sa-Ngiamsuntorn K, Wongkajornsilp A, Phanthong P, Borwornpinyo S, Kitiyanant N, Chantratita W, et al. A robust model of natural hepatitis C infection using hepatocyte-like cells derived from human induced pluripotent stem cells as a long-term host. Virol J. 2016; 13:59.
    • (2016) Virol J. , vol.13 , pp. 59
    • Sa-Ngiamsuntorn, K.1    Wongkajornsilp, A.2    Phanthong, P.3    Borwornpinyo, S.4    Kitiyanant, N.5    Chantratita, W.6
  • 96
    • 34248634898 scopus 로고    scopus 로고
    • Directed differentiation of human embryonic stem cells into functional hepatic cells
    • Cai J, Zhao Y, Liu Y, Ye F, Song Z, Qin H, et al. Directed differentiation of human embryonic stem cells into functional hepatic cells. Hepatology. 2007; 45(5): 1229-1239.
    • (2007) Hepatology. , vol.45 , Issue.5 , pp. 1229-1239
    • Cai, J.1    Zhao, Y.2    Liu, Y.3    Ye, F.4    Song, Z.5    Qin, H.6
  • 97
    • 50449101603 scopus 로고    scopus 로고
    • Highly efficient differentiation of hESCs to functional hepatic endoderm requires Activin A and Wnt3a signaling
    • Hay DC, Fletcher J, Payne C, Terrace JD, Gallagher RC, Snoeys J, et al. Highly efficient differentiation of hESCs to functional hepatic endoderm requires Activin A and Wnt3a signaling. Proc Natl Acad Sci USA. 2008; 105(34): 12301-12306.
    • (2008) Proc Natl Acad Sci USA. , vol.105 , Issue.34 , pp. 12301-12306
    • Hay, D.C.1    Fletcher, J.2    Payne, C.3    Terrace, J.D.4    Gallagher, R.C.5    Snoeys, J.6
  • 98
    • 60449098836 scopus 로고    scopus 로고
    • Differentiation and transplantation of human embryonic stem cell-derived hepatocytes
    • Basma H, Soto-Gutierrez A, Yannam GR, Liu L, Ito R, Yamamoto T, et al. Differentiation and transplantation of human embryonic stem cell-derived hepatocytes. Gastroenterology. 2009; 136(3): 990-999.
    • (2009) Gastroenterology. , vol.136 , Issue.3 , pp. 990-999
    • Basma, H.1    Soto-Gutierrez, A.2    Yannam, G.R.3    Liu, L.4    Ito, R.5    Yamamoto, T.6
  • 99
    • 74149094915 scopus 로고    scopus 로고
    • Hepatocyte-like cells derived from human embryonic stem cells specifically via definitive endoderm and a progenitor stage
    • Brolen G, Sivertsson L, Bjorquist P, Eriksson G, Ek M, Semb H, et al. Hepatocyte-like cells derived from human embryonic stem cells specifically via definitive endoderm and a progenitor stage. J Biotechnol. 2010; 145(3): 284-294.
    • (2010) J Biotechnol. , vol.145 , Issue.3 , pp. 284-294
    • Brolen, G.1    Sivertsson, L.2    Bjorquist, P.3    Eriksson, G.4    Ek, M.5    Semb, H.6
  • 100
    • 77950994754 scopus 로고    scopus 로고
    • Differentiation and characterization of metabolically functioning hepatocytes from human embryonic stem cells
    • Duan Y, Ma X, Zou W, Wang C, Bahbahan IS, Ahuja TP, et al. Differentiation and characterization of metabolically functioning hepatocytes from human embryonic stem cells. Stem Cells. 2010; 28(4): 674-686.
    • (2010) Stem Cells. , vol.28 , Issue.4 , pp. 674-686
    • Duan, Y.1    Ma, X.2    Zou, W.3    Wang, C.4    Bahbahan, I.S.5    Ahuja, T.P.6
  • 101
    • 77951480489 scopus 로고    scopus 로고
    • Generation of functional hepatocytes from human embryonic stem cells under chemically defined conditions that recapitulate liver development
    • Touboul T, Hannan NR, Corbineau S, Martinez A, Martinet C, Branchereau S, et al. Generation of functional hepatocytes from human embryonic stem cells under chemically defined conditions that recapitulate liver development. Hepatology. 2010; 51(5): 1754-1765.
    • (2010) Hepatology. , vol.51 , Issue.5 , pp. 1754-1765
    • Touboul, T.1    Hannan, N.R.2    Corbineau, S.3    Martinez, A.4    Martinet, C.5    Branchereau, S.6
  • 102
    • 85048840746 scopus 로고    scopus 로고
    • Potential and challenges of induced pluripotent stem cells in liver diseases treatment
    • Yu Y, Wang X, Nyberg SL. Potential and challenges of induced pluripotent stem cells in liver diseases treatment. J Clin Med. 2014; 3(3): 997-1017.
    • (2014) J Clin Med. , vol.3 , Issue.3 , pp. 997-1017
    • Yu, Y.1    Wang, X.2    Nyberg, S.L.3
  • 103
    • 80054987997 scopus 로고    scopus 로고
    • Targeted gene correction of alpha1-antitrypsin deficiency in induced pluripotent stem cells
    • Yusa K, Rashid ST, Strick-Marchand H, Varela I, Liu PQ, Paschon DE, et al. Targeted gene correction of alpha1-antitrypsin deficiency in induced pluripotent stem cells. Nature. 2011; 478(7369): 391-394.
    • (2011) Nature. , vol.478 , Issue.7369 , pp. 391-394
    • Yusa, K.1    Rashid, S.T.2    Strick-Marchand, H.3    Varela, I.4    Liu, P.Q.5    Paschon, D.E.6
  • 104
    • 79960831061 scopus 로고    scopus 로고
    • Rescue of ATP7B function in hepatocyte-like cells from Wilson's disease induced pluripotent stem cells using gene therapy or the chaperone drug curcumin
    • Zhang S, Chen S, Li W, Guo X, Zhao P, Xu J, et al. Rescue of ATP7B function in hepatocyte-like cells from Wilson's disease induced pluripotent stem cells using gene therapy or the chaperone drug curcumin. Hum Mol Genet. 2011; 20(16): 3176-3187.
    • (2011) Hum Mol Genet. , vol.20 , Issue.16 , pp. 3176-3187
    • Zhang, S.1    Chen, S.2    Li, W.3    Guo, X.4    Zhao, P.5    Xu, J.6
  • 106
    • 84957818403 scopus 로고    scopus 로고
    • The future of iPS cells in advancing regenerative medicine
    • Liu P, Li KE, Xu S. The future of iPS cells in advancing regenerative medicine. Genet Res (Camb). 2016; 98: e4.
    • (2016) Genet Res (Camb). , vol.98 , pp. e4
    • Liu, P.1    Li, K.E.2    Xu, S.3
  • 107
    • 84960863986 scopus 로고    scopus 로고
    • A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn mice
    • Yang Y, Wang L, Bell P, McMenamin D, He Z, White J, et al. A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn mice. Nat Biotechnol. 2016; 34(3): 334-338.
    • (2016) Nat Biotechnol. , vol.34 , Issue.3 , pp. 334-338
    • Yang, Y.1    Wang, L.2    Bell, P.3    McMenamin, D.4    He, Z.5    White, J.6
  • 108
    • 84960882884 scopus 로고    scopus 로고
    • Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo
    • Yin H, Song CQ, Dorkin JR, Zhu LJ, Li Y, Wu Q, et al. Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo. Nat Biotechnol. 2016; 34(3): 328-333.
    • (2016) Nat Biotechnol. , vol.34 , Issue.3 , pp. 328-333
    • Yin, H.1    Song, C.Q.2    Dorkin, J.R.3    Zhu, L.J.4    Li, Y.5    Wu, Q.6
  • 109
    • 84884903479 scopus 로고    scopus 로고
    • Drug metabolizing enzyme and transporter protein profiles of hepatocytes derived from human embryonic and induced pluripotent stem cells
    • Ulvestad M, Nordell P, Asplund A, Rehnstrom M, Jacobsson S, Holmgren G, et al. Drug metabolizing enzyme and transporter protein profiles of hepatocytes derived from human embryonic and induced pluripotent stem cells. Biochem Pharmacol. 2013; 86(5): 691-702.
    • (2013) Biochem Pharmacol. , vol.86 , Issue.5 , pp. 691-702
    • Ulvestad, M.1    Nordell, P.2    Asplund, A.3    Rehnstrom, M.4    Jacobsson, S.5    Holmgren, G.6
  • 110
    • 84940869392 scopus 로고    scopus 로고
    • Cost-effective differentiation of hepatocyte-like cells from human pluripotent stem cells using small molecules
    • Tasnim F, Phan D, Toh YC, Yu H. Cost-effective differentiation of hepatocyte-like cells from human pluripotent stem cells using small molecules. Biomaterials. 2015; 70: 115-125.
    • (2015) Biomaterials. , vol.70 , pp. 115-125
    • Tasnim, F.1    Phan, D.2    Toh, Y.C.3    Yu, H.4
  • 111
    • 84882941221 scopus 로고    scopus 로고
    • Fluorescence-based screening of cytochrome P450 activities in intact cells
    • Donato MT, Gomez-Lechon MJ. Fluorescence-based screening of cytochrome P450 activities in intact cells. Methods Mol Biol. 2013; 987: 135-148.
    • (2013) Methods Mol Biol. , vol.987 , pp. 135-148
    • Donato, M.T.1    Gomez-Lechon, M.J.2
  • 112
    • 3042544349 scopus 로고    scopus 로고
    • Fluorescence-based assays for screening nine cytochrome P450 (P450) activities in intact cells expressing individual human P450 enzymes
    • Donato MT, Jimenez N, Castell JV, Gomez-Lechon MJ. Fluorescence-based assays for screening nine cytochrome P450 (P450) activities in intact cells expressing individual human P450 enzymes. Drug Metab Dispos. 2004; 32(7): 699-706.
    • (2004) Drug Metab Dispos. , vol.32 , Issue.7 , pp. 699-706
    • Donato, M.T.1    Jimenez, N.2    Castell, J.V.3    Gomez-Lechon, M.J.4
  • 113
    • 78650469789 scopus 로고    scopus 로고
    • Applications of patient-specific induced pluripotent stem cells; Focused on disease modeling, drug screening and therapeutic potentials for liver disease
    • Chun YS, Chaudhari P, Jang YY. Applications of patient-specific induced pluripotent stem cells; focused on disease modeling, drug screening and therapeutic potentials for liver disease. Int J Biol Sci. 2010; 6(7): 796-805.
    • (2010) Int J Biol Sci. , vol.6 , Issue.7 , pp. 796-805
    • Chun, Y.S.1    Chaudhari, P.2    Jang, Y.Y.3
  • 114
    • 84928310555 scopus 로고    scopus 로고
    • The application of engineered liver tissues for novel drug discovery
    • Lin C, Ballinger KR, Khetani SR. The application of engineered liver tissues for novel drug discovery. Expert Opin Drug Discov. 2015; 10(5): 519-540.
    • (2015) Expert Opin Drug Discov. , vol.10 , Issue.5 , pp. 519-540
    • Lin, C.1    Ballinger, K.R.2    Khetani, S.R.3
  • 115
    • 33644636333 scopus 로고    scopus 로고
    • Gelatin based microfluidic devices for cell culture
    • Paguirigan A, Beebe DJ. Gelatin based microfluidic devices for cell culture. Lab Chip. 2006; 6(3): 407-413.
    • (2006) Lab Chip. , vol.6 , Issue.3 , pp. 407-413
    • Paguirigan, A.1    Beebe, D.J.2
  • 117
    • 84956889140 scopus 로고    scopus 로고
    • Microfluidics for cell-based high throughput screening platforms - A review
    • Du G, Fang Q, den Toonder JM. Microfluidics for cell-based high throughput screening platforms - a review. Anal Chim Acta. 2016; 903: 36-50.
    • (2016) Anal Chim Acta. , vol.903 , pp. 36-50
    • Du, G.1    Fang, Q.2    Den Toonder, J.M.3
  • 118
    • 77950438544 scopus 로고    scopus 로고
    • Microfluidic cell culture systems for drug research
    • Wu MH, Huang SB, Lee GB. Microfluidic cell culture systems for drug research. Lab Chip. 2010; 10(8): 939-956.
    • (2010) Lab Chip. , vol.10 , Issue.8 , pp. 939-956
    • Wu, M.H.1    Huang, S.B.2    Lee, G.B.3
  • 119
    • 78049374383 scopus 로고    scopus 로고
    • Chimeric mice with humanized liver: Tools for the study of drug metabolism, excretion, and toxicity
    • Strom SC, Davila J, Grompe M. Chimeric mice with humanized liver: tools for the study of drug metabolism, excretion, and toxicity. Methods Mol Biol. 2010; 640: 491-509.
    • (2010) Methods Mol Biol. , vol.640 , pp. 491-509
    • Strom, S.C.1    Davila, J.2    Grompe, M.3
  • 121
    • 84941309262 scopus 로고    scopus 로고
    • Differences in the epigenetic regulation of cytochrome P450 genes between human embryonic stem cell-derived hepatocytes and primary hepatocytes
    • Park HJ, Choi YJ, Kim JW, Chun HS, Im I, Yoon S, et al. Differences in the epigenetic regulation of cytochrome P450 genes between human embryonic stem cell-derived hepatocytes and primary hepatocytes. PLoS One. 2015; 10(7): e0132992.
    • (2015) PLoS One. , vol.10 , Issue.7 , pp. e0132992
    • Park, H.J.1    Choi, Y.J.2    Kim, J.W.3    Chun, H.S.4    Im, I.5    Yoon, S.6
  • 122
    • 84940652333 scopus 로고    scopus 로고
    • Enhanced metabolizing activity of human ES cell-derived hepatocytes using a 3D culture system with repeated exposures to Xenobiotics
    • Kim JH, Jang YJ, An SY, Son J, Lee J, Lee G, et al. Enhanced metabolizing activity of human ES cell-derived hepatocytes using a 3D culture system with repeated exposures to Xenobiotics. Toxicol Sci. 2015; 147(1): 190-206.
    • (2015) Toxicol Sci. , vol.147 , Issue.1 , pp. 190-206
    • Kim, J.H.1    Jang, Y.J.2    An, S.Y.3    Son, J.4    Lee, J.5    Lee, G.6
  • 123
    • 84881341670 scopus 로고    scopus 로고
    • Improved hepatic differentiation strategies for human induced pluripotent stem cells
    • Sgodda M, Mobus S, Hoepfner J, Sharma AD, Schambach A, Greber B, et al. Improved hepatic differentiation strategies for human induced pluripotent stem cells. Curr Mol Med. 2013; 13(5): 842-855.
    • (2013) Curr Mol Med. , vol.13 , Issue.5 , pp. 842-855
    • Sgodda, M.1    Mobus, S.2    Hoepfner, J.3    Sharma, A.D.4    Schambach, A.5    Greber, B.6
  • 124
    • 84943252793 scopus 로고    scopus 로고
    • Rapid and high-efficiency generation of mature functional hepatocyte-like cells from adipose-derived stem cells by a three-step protocol
    • Xu F, Liu J, Deng J, Chen X, Wang Y, Xu P, et al. Rapid and high-efficiency generation of mature functional hepatocyte-like cells from adipose-derived stem cells by a three-step protocol. Stem Cell Res Ther. 2015; 6:193.
    • (2015) Stem Cell Res Ther. , vol.6 , pp. 193
    • Xu, F.1    Liu, J.2    Deng, J.3    Chen, X.4    Wang, Y.5    Xu, P.6
  • 125
    • 84959432476 scopus 로고    scopus 로고
    • Effect of microenvironment on differentiation of human umbilical cord mesenchymal stem cells into hepatocytes in vitro and in vivo
    • Xue G, Han X, Ma X, Wu H, Qin Y, Liu J, et al. Effect of microenvironment on differentiation of human umbilical cord mesenchymal stem cells into hepatocytes in vitro and in vivo. Biomed Res Int. 2016; 2016: 8916534.
    • (2016) Biomed Res Int. , vol.2016 , pp. 8916534
    • Xue, G.1    Han, X.2    Ma, X.3    Wu, H.4    Qin, Y.5    Liu, J.6
  • 126
    • 84892609704 scopus 로고    scopus 로고
    • Mice with chimeric livers are an improved model for human lipoprotein metabolism
    • Ellis EC, Naugler WE, Parini P, Mork LM, Jorns C, Zemack H, et al. Mice with chimeric livers are an improved model for human lipoprotein metabolism. PLoS One. 2013; 8(11): e78550.
    • (2013) PLoS One. , vol.8 , Issue.11 , pp. e78550
    • Ellis, E.C.1    Naugler, W.E.2    Parini, P.3    Mork, L.M.4    Jorns, C.5    Zemack, H.6
  • 127
    • 84901477570 scopus 로고    scopus 로고
    • Fumarylacetoacetate hydrolase deficient pigs are a novel large animal model of metabolic liver disease
    • Hickey RD, Mao SA, Glorioso J, Lillegard JB, Fisher JE, Amiot B, et al. Fumarylacetoacetate hydrolase deficient pigs are a novel large animal model of metabolic liver disease. Stem Cell Res. 2014; 13(1): 144-153.
    • (2014) Stem Cell Res. , vol.13 , Issue.1 , pp. 144-153
    • Hickey, R.D.1    Mao, S.A.2    Glorioso, J.3    Lillegard, J.B.4    Fisher, J.E.5    Amiot, B.6
  • 128
    • 84991215535 scopus 로고    scopus 로고
    • Efficient engraftment of human induced pluripotent stem cell-derived hepatocyte-like cells in uPA/SCID mice by overexpression of FNK, a Bcl-xL mutant gene
    • Nagamoto Y, Takayama K, Tashiro K, Tateno C, Sakurai F, Tachibana M, et al. Efficient engraftment of human induced pluripotent stem cell-derived hepatocyte-like cells in uPA/SCID mice by overexpression of FNK, a Bcl-xL mutant gene. Cell Transplant. 2015; 24(6): 1127-1138.
    • (2015) Cell Transplant. , vol.24 , Issue.6 , pp. 1127-1138
    • Nagamoto, Y.1    Takayama, K.2    Tashiro, K.3    Tateno, C.4    Sakurai, F.5    Tachibana, M.6
  • 130
    • 84906079358 scopus 로고    scopus 로고
    • Permanent alteration of PCSK9 with in vivo CRISPR-Cas9 genome editing
    • Ding Q, Strong A, Patel KM, Ng SL, Gosis BS, Regan SN, et al. Permanent alteration of PCSK9 with in vivo CRISPR-Cas9 genome editing. Circ Res. 2014; 115(5): 488-492.
    • (2014) Circ Res. , vol.115 , Issue.5 , pp. 488-492
    • Ding, Q.1    Strong, A.2    Patel, K.M.3    Ng, S.L.4    Gosis, B.S.5    Regan, S.N.6
  • 131
    • 84908245956 scopus 로고    scopus 로고
    • Efficient gene editing in adult mouse livers via adenoviral delivery of CRISPR/Cas9
    • Cheng R, Peng J, Yan Y, Cao P, Wang J, Qiu C, et al. Efficient gene editing in adult mouse livers via adenoviral delivery of CRISPR/Cas9. FEBS Lett. 2014; 588(21): 3954-3958.
    • (2014) FEBS Lett. , vol.588 , Issue.21 , pp. 3954-3958
    • Cheng, R.1    Peng, J.2    Yan, Y.3    Cao, P.4    Wang, J.5    Qiu, C.6
  • 132
    • 84990230511 scopus 로고    scopus 로고
    • Expansion of human induced pluripotent stem cells in stirred suspension bioreactors
    • Almutawaa W, Rohani L, Rancourt DE. Expansion of human induced pluripotent stem cells in stirred suspension bioreactors. Methods Mol Biol. 2016; 1502: 53-61.
    • (2016) Methods Mol Biol. , vol.1502 , pp. 53-61
    • Almutawaa, W.1    Rohani, L.2    Rancourt, D.E.3
  • 133
    • 84924582240 scopus 로고    scopus 로고
    • Human iPSC-derived hepatocyte-like cells support Plasmodium liver-stage infection in vitro
    • Ng S, Schwartz RE, March S, Galstian A, Gural N, Shan J, et al. Human iPSC-derived hepatocyte-like cells support Plasmodium liver-stage infection in vitro. Stem Cell Reports. 2015; 4(3): 348-359.
    • (2015) Stem Cell Reports. , vol.4 , Issue.3 , pp. 348-359
    • Ng, S.1    Schwartz, R.E.2    March, S.3    Galstian, A.4    Gural, N.5    Shan, J.6
  • 134
    • 84908627887 scopus 로고    scopus 로고
    • Engrafted human stem cell-derived hepatocytes establish an infectious HCV murine model
    • Carpentier A, Tesfaye A, Chu V, Nimgaonkar I, Zhang F, Lee SB, et al. Engrafted human stem cell-derived hepatocytes establish an infectious HCV murine model. J Clin Invest. 2014; 124(11): 4953-4964.
    • (2014) J Clin Invest. , vol.124 , Issue.11 , pp. 4953-4964
    • Carpentier, A.1    Tesfaye, A.2    Chu, V.3    Nimgaonkar, I.4    Zhang, F.5    Lee, S.B.6
  • 135
    • 84927762648 scopus 로고    scopus 로고
    • Transplantation of iPS-derived hepatocytes into a mouse liver: A new murine model of hepatitis C virus infection
    • Carpentier A, Jake Liang T. Transplantation of iPS-derived hepatocytes into a mouse liver: a new murine model of hepatitis C virus infection. Med Sci (Paris). 2015; 31(3): 256-259.
    • (2015) Med Sci (Paris). , vol.31 , Issue.3 , pp. 256-259
    • Carpentier, A.1    Jake Liang, T.2
  • 136
    • 84955291040 scopus 로고    scopus 로고
    • Patient-specific induced pluripotent stem cells for disease Modeling and phenotypic drug discovery
    • Tang S, Xie M, Cao N, Ding S. Patient-specific induced pluripotent stem cells for disease Modeling and phenotypic drug discovery. J Med Chem. 2016; 59(1): 2-15.
    • (2016) J Med Chem. , vol.59 , Issue.1 , pp. 2-15
    • Tang, S.1    Xie, M.2    Cao, N.3    Ding, S.4
  • 137
    • 84990817521 scopus 로고    scopus 로고
    • Emerging in vitro liver technologies for drug metabolism and inter-organ interactions
    • ahead of print
    • Bale SS, Moore L, Yarmush M, Jindal R. Emerging in vitro liver technologies for drug metabolism and inter-organ interactions. Tissue Eng Part B Rev. 2016. (ahead of print).
    • (2016) Tissue Eng Part B Rev.
    • Bale, S.S.1    Moore, L.2    Yarmush, M.3    Jindal, R.4
  • 138
    • 84888233058 scopus 로고    scopus 로고
    • Mice with human livers
    • Grompe M, Strom S. Mice with human livers. Gastroenterology. 2013; 145(6): 1209-1214.
    • (2013) Gastroenterology. , vol.145 , Issue.6 , pp. 1209-1214
    • Grompe, M.1    Strom, S.2


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