Enhanced metabolizing activity of human ES cell-derived hepatocytes using a 3D culture system with repeated exposures to xenobiotics

Toxicological Sciences

Volumn 147, Issue 1, 2015, Pages 190-206

  Kim, Jong Hyun ^a   Jang, Yu Jin ^a   An, Su Yeon ^a   Son, Jeongsang ^a   Lee, Jaehun ^a   Lee, Gyunggyu ^a   Park, Ji Young ^a   Park, Han Jin ^b   Hwang, Dong Youn ^c   Kim, Jong Hoon ^a   Han, Jiyou ^a  

^a Korea University   (South Korea)

^b Korea Institute of Toxicology   (South Korea)

^c CHA University   (South Korea)

Author keywords

3D culture; CYP450 enzymes; Drug metabolism; Hepatic maturation; Human embryonic stem cell; Repeated exposure

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR; ALBUMIN; CCAAT ENHANCER BINDING PROTEIN ALPHA; CELL NUCLEUS RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450 1A2; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; DRUG METABOLIZING ENZYME; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE A2; GLUTATHIONE TRANSFERASE A4; LIVER ENZYME; OCTAMER TRANSCRIPTION FACTOR 4; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PREGNANE X RECEPTOR; TRANSCRIPTION FACTOR; UREA; XENOBIOTIC AGENT; CYTOCHROME; MIXED FUNCTION OXIDASE;

APOPTOSIS ASSAY; ARTICLE; CELL AGGREGATION; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; CELL STRUCTURE; CELL ULTRASTRUCTURE; CONTROLLED STUDY; CULTURE OPTIMIZATION; CULTURE TECHNIQUE; DRUG METABOLISM; EMBRYONIC STEM CELL; ENZYME ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LIVER CELL; LIVER DEVELOPMENT; LIVER FUNCTION; LIVER METABOLISM; LIVER TOXICITY; SPHEROID CELL; THREE DIMENSIONAL CULTURE SYSTEM; APOPTOSIS; BIOSYNTHESIS; CELL ADHESION; CELL CULTURE TECHNIQUE; CELL LINE; DRUG EFFECTS; ENZYMOLOGY; GENETICS; HUMAN EMBRYONIC STEM CELL; LIVER FUNCTION TEST; METABOLISM;

APOPTOSIS; CELL ADHESION; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; CYTOCHROMES; GENE EXPRESSION; HEPATOCYTES; HUMAN EMBRYONIC STEM CELLS; HUMANS; LIVER FUNCTION TESTS; MIXED FUNCTION OXYGENASES; TRANSCRIPTION FACTORS; XENOBIOTICS;

EID: 84940652333     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfv121     Document Type: Article

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